Extracellular Acidosis Modulates the Expression of Epithelial-Mesenchymal Transition (EMT) Markers and Adhesion of Epithelial and Tumor Cells.

abstract：:The tumor-selective cytotoxic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) makes TRAIL an attractive candidate as an anticancer agent. However, resistance to TRAIL poses a challenge in anticancer therapy with TRAIL. Therefore, characterizing the mechanisms of resistance and developing stra...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang L,Zhu H,Teraishi F,Davis JJ,Guo W,Fan Z,Fang B

更新日期：2005-06-01 00:00:00

abstract：:With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely understood. Three of the recently approved ADCs contain payloads exh...

journal_title：Neoplasia (New York, N.Y.)

authors： Khera E,Cilliers C,Smith MD,Ganno ML,Lai KC,Keating TA,Kopp A,Nessler I,Abu-Yousif AO,Thurber GM

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto-oncogene is based on several Pim-1 target proteins involved in pivotal cellular processes. Here, we explore the functional relevance of Pim...

journal_title：Neoplasia (New York, N.Y.)

authors： Weirauch U,Beckmann N,Thomas M,Grünweller A,Huber K,Bracher F,Hartmann RK,Aigner A

更新日期：2013-07-01 00:00:00

abstract：:Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise to some doubts concerning the effectiveness of the senescence-induced anticancer therapy. Similarly, it is post...

journal_title：Neoplasia (New York, N.Y.)

authors： Mosieniak G,Sliwinska MA,Alster O,Strzeszewska A,Sunderland P,Piechota M,Was H,Sikora E

更新日期：2015-12-01 00:00:00

abstract：:SEMA3F is a secreted semaphorin with potent antitumor activity, which is frequently downregulated in lung cancer. In cancer cell lines, SEMA3F overexpression decreases hypoxia-induced factor 1alpha protein and vascular endothelial growth factor mRNA, and inhibits multiple signaling components. Therefore, understanding...

journal_title：Neoplasia (New York, N.Y.)

authors： Clarhaut J,Gemmill RM,Potiron VA,Ait-Si-Ali S,Imbert J,Drabkin HA,Roche J

更新日期：2009-02-01 00:00:00

abstract：:Previous studies have suggested that tumor hypoxia could be exploited for cancer gene therapy. Using hypoxia-responsive elements derived from the human vascular endothelial growth factor gene, we have generated vectors expressing a bacterial nitroreductase (NTR) gene that can activate the anticancer prodrug CB1954. St...

journal_title：Neoplasia (New York, N.Y.)

authors： Shibata T,Giaccia AJ,Brown JM

更新日期：2002-01-01 00:00:00

abstract：:Mutation of the PARK2 gene can promote both Parkinson's Disease and cancer, yet the underlying mechanisms of how PARK2 controls cellular physiology is incompletely understood. Here, we show that the PARK2 tumor suppressor controls the apoptotic regulator BCL-XL and modulates programmed cell death. Analysis of approxim...

journal_title：Neoplasia (New York, N.Y.)

authors： Gong Y,Schumacher SE,Wu WH,Tang F,Beroukhim R,Chan TA

更新日期：2017-02-01 00:00:00

abstract：:Previously, we identified the transcription factor CUX1 as an important modulator of invasion and resistance to apoptosis. Expression profiles suggested that CUX1 regulates a complex transcriptional program mediating tumor progression. We aimed to identify functionally relevant targets of CUX1 by using RNA interferenc...

journal_title：Neoplasia (New York, N.Y.)

authors： Ripka S,Riedel J,Neesse A,Griesmann H,Buchholz M,Ellenrieder V,Moeller F,Barth P,Gress TM,Michl P

更新日期：2010-08-01 00:00:00

abstract：:c-Cbl, a RING-type ubiquitin E3 ligase, downregulates various receptor tyrosine kinases (e.g., epidermal growth factor receptor (EGFR)), leading to inhibition of cell proliferation. Moreover, patients with myeloid neoplasm frequently harbor c-Cbl mutations, implicating the role of c-Cbl as a tumor suppressor. Recently...

journal_title：Neoplasia (New York, N.Y.)

authors： Seong MW,Ka SH,Park JH,Park JH,Yoo HM,Yang SW,Park JM,Park D,Lee ST,Seol JH,Chung CH

更新日期：2015-06-01 00:00:00

abstract：:Mutations of the NF2 gene on chromosome 22q are thought to initiate tumorigenesis in nearly 50% of meningiomas, and 22q deletion is the earliest and most frequent large-scale chromosomal abnormality observed in these tumors. In aggressive meningiomas, 22q deletions are generally accompanied by the presence of large-sc...

journal_title：Neoplasia (New York, N.Y.)

authors： Yang HW,Kim TM,Song SS,Shrinath N,Park R,Kalamarides M,Park PJ,Black PM,Carroll RS,Johnson MD

更新日期：2012-01-01 00:00:00

abstract：:We determined whether the implantation of human pancreatic cancer cells into the pancreas of nude mice can be used to select variants with increasing metastatic potential. COLO 357 line fast-growing cells were injected into the spleen or pancreas of nude mice. Hepatic metastases were harvested, and tumor cells were re...

journal_title：Neoplasia (New York, N.Y.)

authors： Bruns CJ,Harbison MT,Kuniyasu H,Eue I,Fidler IJ

更新日期：1999-04-01 00:00:00

abstract：:One of the puzzles in cancer predisposition is that women carrying BRCA-1 mutations preferentially develop tumors in epithelial tissues of the breast and ovary. Moreover, sporadic breast tumors contain lower levels of BRCA-1 in the absence of mutations in the BRCA-1 gene. The problem of tissue specificity requires ana...

journal_title：Neoplasia (New York, N.Y.)

authors： Jeffy BD,Hockings JK,Kemp MQ,Morgan SS,Hager JA,Beliakoff J,Whitesell LJ,Bowden GT,Romagnolo DF

更新日期：2005-09-01 00:00:00

abstract：:We examined correlations between TGF-beta1, TbetaR-I and TbetaR-II, p12(CDK2-AP1), p21(WAF1), p27(KIP1), Smad2, and p-Smad2 in 125 cases of human oral squamous cell carcinoma (OSCC) to test the hypothesis that resistance to TGF-beta1-induced growth suppression is due to the disruption of its signaling pathway as a con...

journal_title：Neoplasia (New York, N.Y.)

authors： Peng H,Shintani S,Kim Y,Wong DT

更新日期：2006-12-01 00:00:00

abstract：:Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies demonstrating a cor...

journal_title：Neoplasia (New York, N.Y.)

authors： Chiu RK,Carpenito C,Dougherty ST,Hayes GM,Dougherty GJ

更新日期：1999-11-01 00:00:00

abstract：:Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex. Consequently, low expression or loss of FBXW7 in breast ca...

journal_title：Neoplasia (New York, N.Y.)

authors： Meyer AE,Furumo Q,Stelloh C,Minella AC,Rao S

更新日期：2020-11-01 00:00:00

abstract：:The Nup98-HoxD13 (NHD13) fusion gene was identified in a patient with therapy-related myelodysplastic syndrome (MDS). When transgenically expressed in hematopoietic cells, mice faithfully recapitulate human disease with serial progression from peripheral blood (PB) cytopenias and increased bone marrow (BM) blasts to a...

journal_title：Neoplasia (New York, N.Y.)

authors： Byrne M,Bennett RL,Cheng X,May WS

更新日期：2014-08-01 00:00:00

abstract：:The receptor tyrosine kinase MET is a major component controlling the invasive growth program in embryonic development and in invasive malignancies. The discovery of therapeutic antibodies against MET has been difficult, and antibodies that compete with hepatocyte growth factor (HGF) act as agonists. By applying phage...

journal_title：Neoplasia (New York, N.Y.)

authors： van der Horst EH,Chinn L,Wang M,Velilla T,Tran H,Madrona Y,Lam A,Ji M,Hoey TC,Sato AK

更新日期：2009-04-01 00:00:00

abstract：:Several studies have linked vascular density, identified in histologic sections, to "metastatic risk." Functional information of the vasculature, not readily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims were to determine if hum...

journal_title：Neoplasia (New York, N.Y.)

authors： Bhujwalla ZM,Artemov D,Natarajan K,Ackerstaff E,Solaiyappan M

更新日期：2001-03-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) can be tumor-suppressive through the activation of the Smad-mediated signaling pathway. TGF-beta1 can also enhance tumor progression by stimulating epithelial-to-mesenchymal transition (EMT) through additional pathways. EMT is characterized by the acquisition of a fibroblas...

journal_title：Neoplasia (New York, N.Y.)

authors： Xie L,Law BK,Chytil AM,Brown KA,Aakre ME,Moses HL

更新日期：2004-09-01 00:00:00

abstract：:Angiogenesis is a central cancer hallmark, necessary for supporting tumor growth and metastasis. In vivo imaging of angiogenesis is commonly applied, to understand dynamic processes in cancer development and treatment strategies. However, most radiological modalities today assess angiogenesis based on indirect mechani...

journal_title：Neoplasia (New York, N.Y.)

authors： Omar M,Schwarz M,Soliman D,Symvoulidis P,Ntziachristos V

更新日期：2015-02-01 00:00:00

abstract：:Tel is an Ets transcription factor that is the target of chromosome translocations in lymphoid and myeloid leukemias and in solid tumors. It contains two functional domains, a pointed oligomerization domain and a DNA-binding domain. Retroviral transduction of a wild-type Tel cDNA into a clonal subline of NIH3T3 fibrob...

journal_title：Neoplasia (New York, N.Y.)

authors： Van Rompaey L,Dou W,Buijs A,Grosveld G

更新日期：1999-12-01 00:00:00

abstract：:SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported. Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomita...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen S,Yang X,Yu M,Wang Z,Liu B,Liu M,Liu L,Ren M,Qi H,Zou J,Vucenik I,Zhu WG,Luo J

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Inflammatory breast cancer (IBC) is arguably the deadliest form of breast cancer due to its rapid onset and highly invasive nature. IBC carries 5- and 10-year disease-free survival rates of ~45% and <20%, respectively. Multiple studies demonstrate that in comparison with conventional breast cancer, IBC has a un...

journal_title：Neoplasia (New York, N.Y.)

authors： Joglekar-Javadekar M,Van Laere S,Bourne M,Moalwi M,Finetti P,Vermeulen PB,Birnbaum D,Dirix LY,Ueno N,Carter M,Rains J,Ramachandran A,Bertucci F,van Golen KL

更新日期：2017-07-01 00:00:00

abstract：:The genetic mechanisms underlying adrenocortical tumor development are still largely unknown. We used high-resolution single nucleotide polymorphism microarrays (Affymetrix SNP 6.0) to detect copy number alterations (CNAs) and copy-neutral losses of heterozygosity (cnLOH) in 15 cortisol-secreting adrenocortical adenom...

journal_title：Neoplasia (New York, N.Y.)

authors： Ronchi CL,Leich E,Sbiera S,Weismann D,Rosenwald A,Allolio B,Fassnacht M

更新日期：2012-03-01 00:00:00

abstract：:A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG. The TMPRSS2-ERG fusion is observed in around 90% of tumors that overexpress the oncogene ERG. The goal o...

journal_title：Neoplasia (New York, N.Y.)

authors： Pflueger D,Rickman DS,Sboner A,Perner S,LaFargue CJ,Svensson MA,Moss BJ,Kitabayashi N,Pan Y,de la Taille A,Kuefer R,Tewari AK,Demichelis F,Chee MS,Gerstein MB,Rubin MA

更新日期：2009-08-01 00:00:00

abstract：:Aberrant signaling through the AKT kinase mediates oncogenic phenotypes including cell proliferation, survival, and therapeutic resistance. Here, we utilize a bioluminescence reporter for AKT kinase activity (BAR) to noninvasively assess the therapeutic efficacy of the EGFR inhibitor erlotinib in KRAS-mutated lung can...

journal_title：Neoplasia (New York, N.Y.)

authors： Suchowski K,Pöschinger T,Rehemtulla A,Stürzl M,Scheuer W

更新日期：2017-04-01 00:00:00

abstract：:BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with improved survival compared with chemotherapy. Unfortunately, reactiva...

journal_title：Neoplasia (New York, N.Y.)

authors： Mologni L,Costanza M,Sharma GG,Viltadi M,Massimino L,Citterio S,Purgante S,Raman H,Pirola A,Zucchetti M,Piazza R,Gambacorti-Passerini C

更新日期：2018-05-01 00:00:00

abstract：:Multidrug resistance (MDR) presents a major obstacle for the successful chemotherapy of cancer. Its emergence during chemotherapy is attributed to a selective process, which gives a growth advantage to MDR cells within the genetically unstable neoplastic cell population. The pleiotropic nature of clinical MDR poses a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Preise D,Mazor O,Koudinova N,Liscovitch M,Scherz A,Salomon Y

更新日期：2003-11-01 00:00:00

abstract：:The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types of cancer. However, the role of H19 in the tumorigenesis of colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between H19 and vitamin D receptor (VDR) signaling. Considering the pivotal role of...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen S,Bu D,Ma Y,Zhu J,Chen G,Sun L,Zuo S,Li T,Pan Y,Wang X,Liu Y,Wang P

更新日期：2017-03-01 00:00:00

abstract：:Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolution single nucleotide polymorphism arrays, digital karyotyping, and ...

journal_title：Neoplasia (New York, N.Y.)

authors： Nakahara Y,Northcott PA,Li M,Kongkham PN,Smith C,Yan H,Croul S,Ra YS,Eberhart C,Huang A,Bigner D,Grajkowska W,Van Meter T,Rutka JT,Taylor MD

更新日期：2010-01-01 00:00:00