Characterization and Targeting of Platelet-Derived Growth Factor Receptor alpha (PDGFRA) in Inflammatory Breast Cancer (IBC).

abstract：:The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model to activate platelet derived growth factor receptor-alpha (PDGFRα) specifically in the stroma. Hyperactivati...

journal_title：Neoplasia (New York, N.Y.)

authors： Hammer AM,Sizemore GM,Shukla VC,Avendano A,Sizemore ST,Chang JJ,Kladney RD,Cuitiño MC,Thies KA,Verfurth Q,Chakravarti A,Yee LD,Leone G,Song JW,Ghadiali SN,Ostrowski MC

更新日期：2017-06-01 00:00:00

abstract：:Mutation of the PARK2 gene can promote both Parkinson's Disease and cancer, yet the underlying mechanisms of how PARK2 controls cellular physiology is incompletely understood. Here, we show that the PARK2 tumor suppressor controls the apoptotic regulator BCL-XL and modulates programmed cell death. Analysis of approxim...

journal_title：Neoplasia (New York, N.Y.)

authors： Gong Y,Schumacher SE,Wu WH,Tang F,Beroukhim R,Chan TA

更新日期：2017-02-01 00:00:00

abstract：:Pancreatic carcinoma has an extremely bad prognosis due to lack of early diagnostic markers and lack of effective therapeutic strategies. Recently, we have established an in vitro model recapitulating the first steps in the carcinogenesis of the pancreas. SV40 large T antigen-immortalized bovine pancreatic duct cells ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jesnowski R,Zubakov D,Faissner R,Ringel J,Hoheisel JD,Lösel R,Schnölzer M,Löhr M

更新日期：2007-02-01 00:00:00

abstract：:PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1alpha, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanced (DCE) and diffusi...

journal_title：Neoplasia (New York, N.Y.)

authors： Jordan BF,Runquist M,Raghunand N,Baker A,Williams R,Kirkpatrick L,Powis G,Gillies RJ

更新日期：2005-05-01 00:00:00

abstract：:In spite of intensive and increasingly successful attempts to determine the multiple steps involved in colorectal carcinogenesis, the mechanisms responsible for metastasis of colorectal tumors to the liver remain to be clarified. To identify genes that are candidates for involvement in the metastatic process, we analy...

journal_title：Neoplasia (New York, N.Y.)

authors： Yanagawa R,Furukawa Y,Tsunoda T,Kitahara O,Kameyama M,Murata K,Ishikawa O,Nakamura Y

更新日期：2001-09-01 00:00:00

abstract：:There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)-derived EVs on gastric organoids (gastroids) and elucidated molecular mechanisms underlying the...

journal_title：Neoplasia (New York, N.Y.)

authors： Ke X,Yan R,Sun Z,Cheng Y,Meltzer A,Lu N,Shu X,Wang Z,Huang B,Liu X,Wang Z,Song JH,Ng CK,Ibrahim S,Abraham JM,Shin EJ,He S,Meltzer SJ

更新日期：2017-11-01 00:00:00

abstract：:A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG. The TMPRSS2-ERG fusion is observed in around 90% of tumors that overexpress the oncogene ERG. The goal o...

journal_title：Neoplasia (New York, N.Y.)

authors： Pflueger D,Rickman DS,Sboner A,Perner S,LaFargue CJ,Svensson MA,Moss BJ,Kitabayashi N,Pan Y,de la Taille A,Kuefer R,Tewari AK,Demichelis F,Chee MS,Gerstein MB,Rubin MA

更新日期：2009-08-01 00:00:00

abstract：:Aberrant activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) 3 has been implicated in cell proliferation and survival of many cancers including head and neck squamous cell carcinoma (HNSCC). AZD1480, an orally active pharmacologic inhibitor of JAK1/JAK2, has been tested in seve...

journal_title：Neoplasia (New York, N.Y.)

authors： Sen M,Pollock NI,Black J,DeGrave KA,Wheeler S,Freilino ML,Joyce S,Lui VW,Zeng Y,Chiosea SI,Grandis JR

更新日期：2015-03-01 00:00:00

abstract：:Glucose transport across glioblastoma membranes plays a crucial role in maintaining the enhanced glycolysis typical of high-grade gliomas and glioblastoma. We tested the ability of two inhibitors of the glucose transporters GLUT/SLC2A superfamily, indinavir (IDV) and ritonavir (RTV), and of one inhibitor of the Na/glu...

journal_title：Neoplasia (New York, N.Y.)

authors： Azzalin A,Nato G,Parmigiani E,Garello F,Buffo A,Magrassi L

更新日期：2017-04-01 00:00:00

abstract：:Monocytes/macrophages are an influential component of the glioma microenvironment. However, understanding their diversity and plasticity constitute one of the most challenging areas of research due to the paucity of models to study these cells' inherent complexity. Herein, we analyzed the role of monocytes/macrophages...

journal_title：Neoplasia (New York, N.Y.)

authors： Gabrusiewicz K,Hossain MB,Cortes-Santiago N,Fan X,Kaminska B,Marini FC,Fueyo J,Gomez-Manzano C

更新日期：2015-04-01 00:00:00

abstract：:For improved tumor staging and therapy control, imaging biomarkers are of great interest allowing a noninvasive characterization of invasiveness. In squamous epithelial skin and cervix lesions, transition to invasive stages is associated with enhanced matrix metalloproteinase (MMP) activity, increased angiogenesis, an...

journal_title：Neoplasia (New York, N.Y.)

authors： Al Rawashdeh W,Arns S,Gremse F,Ehling J,Knüchel-Clarke R,Kray S,Spöler F,Kiessling F,Lederle W

更新日期：2014-03-01 00:00:00

abstract：:Research efforts in the area of palaeopathology have been seen as an avenue to improve our understanding of the pathogenesis of cancer. Answers to questions of whether dinosaurs had cancer, or if cancer plagued ancient civilizations, have captured the imagination as well as the popular media. Evidence for dinosaurian ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rehemtulla A

更新日期：2010-12-01 00:00:00

abstract：:Peritoneal metastasis (PM) is a very serious complication of gastrointestinal and gynecological malignancies which is poorly documented. Modified mesothelial cell layer and their microenvironments can favor fibrin deposition for cancer cell adhesion. Scanning and transmission electron microscopy of peritoneal surface ...

journal_title：Neoplasia (New York, N.Y.)

authors： Shahid S,Iman A,Matti U,Rachid K,Assaf A,Eveno C,Marc P,Massoud M

更新日期：2019-11-01 00:00:00

abstract：:This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies, with a prevalence of <200,000 in the United States, which makes it an orphan disease (Basu et al., 2010).1 For functional purposes, NENs are divided into two grou...

journal_title：Neoplasia (New York, N.Y.)

authors： Oronsky B,Ma PC,Morgensztern D,Carter CA

更新日期：2017-12-01 00:00:00

abstract：:This white paper discusses prospects for advancing hyperpolarization technology to better understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13C magnetic resonance imaging's (MRI's) widespread clinical use, and provide recommendations for overcoming them. Since the publication of the first...

journal_title：Neoplasia (New York, N.Y.)

authors： Kurhanewicz J,Vigneron DB,Ardenkjaer-Larsen JH,Bankson JA,Brindle K,Cunningham CH,Gallagher FA,Keshari KR,Kjaer A,Laustsen C,Mankoff DA,Merritt ME,Nelson SJ,Pauly JM,Lee P,Ronen S,Tyler DJ,Rajan SS,Spielman DM,Wald

更新日期：2019-01-01 00:00:00

abstract：:Pediatric rhabdomyosarcoma (RMS) is a morphologically and genetically heterogeneous malignancy commonly classified into three histologic subtypes, namely, alveolar, embryonal, and anaplastic. An issue that continues to challenge effective RMS patient prognosis is the dearth of molecular markers predictive of disease s...

journal_title：Neoplasia (New York, N.Y.)

authors： Jacob AG,O'Brien D,Singh RK,Comiskey DF Jr,Littleton RM,Mohammad F,Gladman JT,Widmann MC,Jeyaraj SC,Bolinger C,Anderson JR,Barkauskas DA,Boris-Lawrie K,Chandler DS

更新日期：2013-09-01 00:00:00

abstract：:Ras-transformed intestinal epithelial cells are resistant to the growth inhibitory actions of TGFbeta and have a marked decrease in expression of the TGFbeta type II receptor (TGFbetaRII). Rat intestinal epithelial cells (RIE) were stably transfected with activated Ras, Sos and Raf constructs and tested for expression...

journal_title：Neoplasia (New York, N.Y.)

authors： Bulus NM,Sheng HM,Sizemore N,Oldham SM,Barnett JV,Coffey RJ,Beauchamp DR,Barnard JA

更新日期：2000-07-01 00:00:00

abstract：:TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer. Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo model systems. Transgenic mice expressing the ERG gene fusion product under androgen-regulation develop mouse prostatic intraepithelial neoplasia (...

journal_title：Neoplasia (New York, N.Y.)

authors： Tomlins SA,Laxman B,Varambally S,Cao X,Yu J,Helgeson BE,Cao Q,Prensner JR,Rubin MA,Shah RB,Mehra R,Chinnaiyan AM

更新日期：2008-02-01 00:00:00

abstract：:Although it is well known that nasopharyngeal carcinoma (NPC) is closely related with Epstein-Barr virus (EBV), few data are available about which and how EBV-expressed gene is involved in the carcinogenesis of human nasopharyngeal epithelial cells. EBV-encoded BARF1 (BamH I-A right frame 1) gene has been shown to be ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jiang R,Cabras G,Sheng W,Zeng Y,Ooka T

更新日期：2009-09-01 00:00:00

abstract：:The noninvasive assessment of anticancer treatment efficacy is very important for the improvement of therapeutic window. The purpose of the present study was to evaluate the antitumoral effects of the vascular targeting agent, combretastatin A-4 phosphate (CA-4-P), at selected time points after repeated intraperitonea...

journal_title：Neoplasia (New York, N.Y.)

authors： Thoeny HC,De Keyzer F,Chen F,Vandecaveye V,Verbeken EK,Ahmed B,Sun X,Ni Y,Bosmans H,Hermans R,van Oosterom A,Marchal G,Landuyt W

更新日期：2005-08-01 00:00:00

abstract：:We previously demonstrated the synergistic therapeutic effect of the cetuximab (anti-epidermal growth factor receptor [EGFR] monoclonal antibody, mAb)-trastuzumab (anti-HER2 mAb) combination (2mAbs therapy) in HER2(low) human pancreatic carcinoma xenografts. Here, we compared the 2mAbs therapy, the erlotinib (EGFR tyr...

journal_title：Neoplasia (New York, N.Y.)

authors： Larbouret C,Gaborit N,Chardès T,Coelho M,Campigna E,Bascoul-Mollevi C,Mach JP,Azria D,Robert B,Pèlegrin A

更新日期：2012-02-01 00:00:00

abstract：:Cancers originating from epithelial cells are the most common malignancies. No common expression profile of solid tumors compared to normal tissues has been described so far. Therefore we were interested if genes differentially expressed in the majority of carcinomas could be identified using bioinformatic methods. Co...

journal_title：Neoplasia (New York, N.Y.)

authors： Pilarsky C,Wenzig M,Specht T,Saeger HD,Grützmann R

更新日期：2004-11-01 00:00:00

abstract：:Tumor cells in the bone interact with the microenvironment to promote tumor cell survival and proliferation, resulting in a lethal phenotype for patients with advanced prostate cancer. Monocyte chemoattractant protein 1 (CCL2) is a member of the CC chemokine family and is known to promote monocyte chemotaxis to sites ...

journal_title：Neoplasia (New York, N.Y.)

authors： Loberg RD,Day LL,Harwood J,Ying C,St John LN,Giles R,Neeley CK,Pienta KJ

更新日期：2006-07-01 00:00:00

abstract：:We previously discovered that a fat-metabolizing enzyme, 15-lipoxygenase-1 (15-LO-1), is high in human prostate cancer (PCa) and correlates with disease progression. The biologic link between the aberrant 15-LO-1/linoleic acid (LA) metabolism and fat (which is a rich source of growth factors) in PCa is unknown. Theref...

journal_title：Neoplasia (New York, N.Y.)

authors： Kelavkar UP,Cohen C

更新日期：2004-01-01 00:00:00

abstract：:Chordoma is a rare tumor arising in the sacrum, clivus, or vertebrae. It is often not completely resectable and shows a high incidence of recurrence and progression with shortened patient survival and impaired quality of life. Chemotherapeutic options are limited to investigational therapies at present. Therefore, adj...

journal_title：Neoplasia (New York, N.Y.)

authors： Diaz RJ,Guduk M,Romagnuolo R,Smith CA,Northcott P,Shih D,Berisha F,Flanagan A,Munoz DG,Cusimano MD,Pamir MN,Rutka JT

更新日期：2012-09-01 00:00:00

abstract：:c-Cbl, a RING-type ubiquitin E3 ligase, downregulates various receptor tyrosine kinases (e.g., epidermal growth factor receptor (EGFR)), leading to inhibition of cell proliferation. Moreover, patients with myeloid neoplasm frequently harbor c-Cbl mutations, implicating the role of c-Cbl as a tumor suppressor. Recently...

journal_title：Neoplasia (New York, N.Y.)

authors： Seong MW,Ka SH,Park JH,Park JH,Yoo HM,Yang SW,Park JM,Park D,Lee ST,Seol JH,Chung CH

更新日期：2015-06-01 00:00:00

abstract：:Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous chemotherapeutics, there is still a considerable uncertainty regarding their role in modulation of anticancer potential of platinum-based drugs. Here we newly demonstrate...

journal_title：Neoplasia (New York, N.Y.)

authors： Herůdková J,Paruch K,Khirsariya P,Souček K,Krkoška M,Vondálová Blanářová O,Sova P,Kozubík A,Hyršlová Vaculová A

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto-oncogene is based on several Pim-1 target proteins involved in pivotal cellular processes. Here, we explore the functional relevance of Pim...

journal_title：Neoplasia (New York, N.Y.)

authors： Weirauch U,Beckmann N,Thomas M,Grünweller A,Huber K,Bracher F,Hartmann RK,Aigner A

更新日期：2013-07-01 00:00:00

abstract：:Human carcinoembryonic antigen (CEA) and the CEA family member CEACAM6 (formerly nonspecific cross-reacting antigen [NCA]) function in vitro, at least, as homotypic intercellular adhesion molecules and, in model systems, can block the terminal differentiation and anoikis of several different cell types. We have recent...

journal_title：Neoplasia (New York, N.Y.)

authors： Ilantzis C,DeMarte L,Screaton RA,Stanners CP

更新日期：2002-03-01 00:00:00

abstract：:Mouse models are powerful tools to study lung cancer initiation and progression in vivo and have contributed significantly to recent advances in therapy. Using micro-computed tomography to monitor and study parenchymal and extra-parenchymal metastases in existing murine models of lung cancer is challenging owing to a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Viswanath P,Peng S,Singh R,Kingsley C,Balter PA,Johnson FM

更新日期：2018-10-01 00:00:00