Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data.

abstract：:The p27KIP1 gene, which encodes a cyclin-dependent kinase (CDK) inhibitor, has been assigned to chromosome band 12p12, a region often affected by cytogenetically apparent deletions or translocations in childhood acute lymphoblastic leukemia (ALL). As described here, fluorescence in situ hybridization (FISH) analysis o...

journal_title：Neoplasia (New York, N.Y.)

authors： Komuro H,Valentine MB,Rubnitz JE,Saito M,Raimondi SC,Carroll AJ,Yi T,Sherr CJ,Look AT

更新日期：1999-08-01 00:00:00

abstract：:Aberrant signaling through the AKT kinase mediates oncogenic phenotypes including cell proliferation, survival, and therapeutic resistance. Here, we utilize a bioluminescence reporter for AKT kinase activity (BAR) to noninvasively assess the therapeutic efficacy of the EGFR inhibitor erlotinib in KRAS-mutated lung can...

journal_title：Neoplasia (New York, N.Y.)

authors： Suchowski K,Pöschinger T,Rehemtulla A,Stürzl M,Scheuer W

更新日期：2017-04-01 00:00:00

abstract：:It is known that total telomere length is shorter in invasive breast cancer than in normal breast tissue but the status of individual telomere lengths has not been studied. Part of the difficulty is that usually telomere length in interphase cells is measured on all chromosomes together. In this study we compared norm...

journal_title：Neoplasia (New York, N.Y.)

authors： Rashid-Kolvear F,Pintilie M,Done SJ

更新日期：2007-04-01 00:00:00

abstract：:Forkhead Box F1 (FOXF1) has been recently implicated in cancer progression and metastasis of lung cancer and breast cancer. However, the biological functions and underlying mechanisms of FOXF1 in the regulation of the progression of colorectal cancer (CRC) are largely unknown. We showed that FOXF1 was up-regulated in ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang S,Yan S,Zhu S,Zhao Y,Yan J,Xiao Z,Bi J,Qiu J,Zhang D,Hong Z,Zhang L,Huang C,Li T,Liang L,Liao W,Jiao H,Ding Y,Ye Y

更新日期：2018-10-01 00:00:00

abstract：:The human gyrovirus derived protein Apoptin (HGV-Apoptin) a homologue of the chicken anemia virus Apoptin (CAV-Apoptin), a protein with high cancer cells selective toxicity, triggers apoptosis selectively in cancer cells. In this paper, we show that HGV-Apoptin acts independently from the death receptor pathway as it ...

journal_title：Neoplasia (New York, N.Y.)

authors： Chaabane W,Cieślar-Pobuda A,El-Gazzah M,Jain MV,Rzeszowska-Wolny J,Rafat M,Stetefeld J,Ghavami S,Los MJ

更新日期：2014-09-01 00:00:00

abstract：:The Wilms tumor gene (WT1) is mutated or deleted in patients with heredofamilial syndromes associated with the development of Wilms tumors, but is infrequently mutated in sporadic Wilms tumors. By comparing the microarray profiles of syndromic versus sporadic Wilms tumors and WT1-inducible Saos-2 osteosarcoma cells, w...

journal_title：Neoplasia (New York, N.Y.)

authors： Kim MK,Mason JM,Li CM,Berkofsky-Fessler W,Jiang L,Choubey D,Grundy PE,Tycko B,Licht JD

更新日期：2008-01-01 00:00:00

abstract：:Conventional comparative genomic hybridization (CGH) profiling of neuroblastomas has identified many genomic aberrations, although the limited resolution has precluded a precise localization of sequences of interest within amplicons. To map high copy number genomic gains in clinically matched stage IV neuroblastomas, ...

journal_title：Neoplasia (New York, N.Y.)

authors： Beheshti B,Braude I,Marrano P,Thorner P,Zielenska M,Squire JA

更新日期：2003-01-01 00:00:00

abstract：:Sporadic ovarian cancer is a particularly aggressive tumor characterized by highly abnormal karyotypes exhibiting many features of genomic instability. More complex genomic changes in tumors arise as a consequence of chromosomal instability (CIN), which can generate both numerical [(N)-CIN] and structural chromosomal ...

journal_title：Neoplasia (New York, N.Y.)

authors： Bayani J,Paderova J,Murphy J,Rosen B,Zielenska M,Squire JA

更新日期：2008-10-01 00:00:00

abstract：:Multidrug resistance (MDR) presents a major obstacle for the successful chemotherapy of cancer. Its emergence during chemotherapy is attributed to a selective process, which gives a growth advantage to MDR cells within the genetically unstable neoplastic cell population. The pleiotropic nature of clinical MDR poses a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Preise D,Mazor O,Koudinova N,Liscovitch M,Scherz A,Salomon Y

更新日期：2003-11-01 00:00:00

abstract：:The maspin gene is not expressed in normal human pancreas, but its expression is acquired during human pancreatic carcinogenesis. In other normal human cells and their malignant counterparts, maspin expression is controlled through the epigenetic state of its promoter. In studies presented herein, we used bisulfite ge...

journal_title：Neoplasia (New York, N.Y.)

authors： Fitzgerald M,Oshiro M,Holtan N,Krager K,Cullen JJ,Futscher BW,Domann FE

更新日期：2003-09-01 00:00:00

abstract：:We determined whether the implantation of human pancreatic cancer cells into the pancreas of nude mice can be used to select variants with increasing metastatic potential. COLO 357 line fast-growing cells were injected into the spleen or pancreas of nude mice. Hepatic metastases were harvested, and tumor cells were re...

journal_title：Neoplasia (New York, N.Y.)

authors： Bruns CJ,Harbison MT,Kuniyasu H,Eue I,Fidler IJ

更新日期：1999-04-01 00:00:00

abstract：:Substantial heterogeneity exists within cervical cancer that is generally infected by human papillomavirus (HPV). However, the most common histological subtype of cervical cancer, cervical squamous cell carcinoma (CSCC), is poorly characterized regarding the association between its heterogeneity and HPV oncoprotein ex...

journal_title：Neoplasia (New York, N.Y.)

authors： Lu X,Jiang L,Zhang L,Zhu Y,Hu W,Wang J,Ruan X,Xu Z,Meng X,Gao J,Su X,Yan F

更新日期：2019-06-01 00:00:00

abstract：:Glucose transport across glioblastoma membranes plays a crucial role in maintaining the enhanced glycolysis typical of high-grade gliomas and glioblastoma. We tested the ability of two inhibitors of the glucose transporters GLUT/SLC2A superfamily, indinavir (IDV) and ritonavir (RTV), and of one inhibitor of the Na/glu...

journal_title：Neoplasia (New York, N.Y.)

authors： Azzalin A,Nato G,Parmigiani E,Garello F,Buffo A,Magrassi L

更新日期：2017-04-01 00:00:00

abstract：:It has long been a puzzle in cancer treatment that despite the initial appearance of apoptosis, the process could be reversed in some cancer cells and often results in more aggressive tumors and metastasis. The mechanism for this recurrence is yet unknown. Here we report that human mammary carcinoma cells induced to u...

journal_title：Neoplasia (New York, N.Y.)

authors： Xu Y,So C,Lam HM,Fung MC,Tsang SY

更新日期：2018-03-01 00:00:00

abstract：:Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective that cancer-microenvi...

journal_title：Neoplasia (New York, N.Y.)

authors： Uthamacumaran A

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND AIMS:BACKGROUND AND AIMSGemcitabine is the standard therapy for patients with pancreatic cancer with metastatic disease. Patients with metastatic pancreatic cancer presenting with increased values of C-reactive protein do not respond to gemcitabine. So far, no studies have evaluated the correlation betwe...

journal_title：Neoplasia (New York, N.Y.)

authors： Knoop RF,Sparn M,Waldmann J,Plassmeier L,Bartsch DK,Lauth M,Hudemann C,Fendrich V

更新日期：2014-06-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the major gastrointestinal mesenchymal tumors with a variable malignancy ranging from a curable disorder to highly malignant sarcomas. Metastasis and recurrence are the main causes of death in GIST patients. To further explore the mechanism of metastasis and to more accurate...

journal_title：Neoplasia (New York, N.Y.)

authors： Ma MZ,Zhuang C,Yang XM,Zhang ZZ,Ma H,Zhang WM,You H,Qin W,Gu J,Yang S,Cao H,Zhang ZG

更新日期：2014-03-01 00:00:00

abstract：:There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)-derived EVs on gastric organoids (gastroids) and elucidated molecular mechanisms underlying the...

journal_title：Neoplasia (New York, N.Y.)

authors： Ke X,Yan R,Sun Z,Cheng Y,Meltzer A,Lu N,Shu X,Wang Z,Huang B,Liu X,Wang Z,Song JH,Ng CK,Ibrahim S,Abraham JM,Shin EJ,He S,Meltzer SJ

更新日期：2017-11-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand these critical cells in tumor progression, we screened a portfolio of rationally selected, injectable agents to image endogenous TAMs ubiquitously in three differen...

journal_title：Neoplasia (New York, N.Y.)

authors： Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ

更新日期：2009-05-01 00:00:00

abstract：:Interstitial fluid pressure (IFP) has been shown to be an independent prognostic parameter for disease-free survival in cervical carcinoma patients treated with radiation therapy. However, the underlying mechanisms are not fully understood. The main aims of this study were to investigate whether tumor radiocurability ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rofstad EK,Gaustad JV,Brurberg KG,Mathiesen B,Galappathi K,Simonsen TG

更新日期：2009-11-01 00:00:00

abstract：:We previously discovered that a fat-metabolizing enzyme, 15-lipoxygenase-1 (15-LO-1), is high in human prostate cancer (PCa) and correlates with disease progression. The biologic link between the aberrant 15-LO-1/linoleic acid (LA) metabolism and fat (which is a rich source of growth factors) in PCa is unknown. Theref...

journal_title：Neoplasia (New York, N.Y.)

authors： Kelavkar UP,Cohen C

更新日期：2004-01-01 00:00:00

abstract：:Antagonists of growth hormone-releasing hormone(GH-RH)inhibit the growth of various cancers by mechanisms that involve the suppression of the insulin-like growth factor (IGF)-I and/or IGF-II. In view of the importance of the IGF system in glioma tumorigenesis, the effects of GH-RH antagonists MZ-5-156 and JV-1-36 were...

journal_title：Neoplasia (New York, N.Y.)

authors： Kiaris H,Schally AV,Varga JL

更新日期：2000-05-01 00:00:00

abstract：:Preclinical studies have shown that gefitinib, licofelone, atorvastatin, and α-difluoromethylornithine (GLAD) are promising colon cancer chemopreventive agents. Because low-dose combination regimens can offer potential additive or synergistic effects without toxicity, GLAD combination was tested for toxicity and chemo...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohammed A,Janakiram NB,Brewer M,Vedala K,Steele VE,Rao CV

更新日期：2013-05-01 00:00:00

abstract：:Bcl-2 is commonly overexpressed in tumors, where it is often associated with unfavorable outcome. However, it has also been linked to a favorable sensitivity to microtubule-targeting agents (MTAs). We show that Bcl-2-overexpressing lung and breast cancer cells were more sensitive to both paclitaxel and vinorelbine. Bc...

journal_title：Neoplasia (New York, N.Y.)

authors： Savry A,Carre M,Berges R,Rovini A,Pobel I,Chacon C,Braguer D,Bourgarel-Rey V

更新日期：2013-01-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors that are rarely curable, even with aggressive therapy (surgery, chemotherapy, and radiation). Glioblastomas frequently display loss of PTEN and/or epidermal growth factor receptor activation, both of which activate the PI3K pathway. This pathway can increase vascular endothelia...

journal_title：Neoplasia (New York, N.Y.)

authors： Pore N,Gupta AK,Cerniglia GJ,Maity A

更新日期：2006-11-01 00:00:00

abstract：:The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth fac...

journal_title：Neoplasia (New York, N.Y.)

authors： Duignan IJ,Corcoran E,Pennello A,Plym MJ,Amatulli M,Claros N,Iacolina M,Youssoufian H,Witte L,Samakoglu S,Schwartz J,Surguladze D,Tonra JR

更新日期：2011-01-01 00:00:00

abstract：:Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rates of polyploidization. We now sho...

journal_title：Neoplasia (New York, N.Y.)

authors： Christodoulidou A,Raftopoulou C,Chiourea M,Papaioannou GK,Hoshiyama H,Wright WE,Shay JW,Gagos S

更新日期：2013-02-01 00:00:00

abstract：:Activation of the Wnt-signaling pathway is known to play a crucial role in carcinogenesis of various human organs including the colon, liver, prostate, and endometrium. To investigate the mechanisms underlying hepatocellular carcinogenesis, we attempted to identify genes regulated by beta-catenin/Tcf complex in a huma...

journal_title：Neoplasia (New York, N.Y.)

authors： Kato T,Satoh S,Okabe H,Kitahara O,Ono K,Kihara C,Tanaka T,Tsunoda T,Yamaoka Y,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00

abstract：:p300/CBP-associated factor (PCAF) is a coactivator of the tumor suppressor, p53. PCAF participates in p53's transactivation of target genes through acetylation of both bound p53 and histones within p53 target promoters. Using microarrays, we discovered that PCAF itself is induced by p53 in a panel of breast tumor cell...

journal_title：Neoplasia (New York, N.Y.)

authors： Watts GS,Oshiro MM,Junk DJ,Wozniak RJ,Watterson S,Domann FE,Futscher BW

更新日期：2004-05-01 00:00:00

abstract：:This issue marks the end of the 10-year anniversary of Neoplasia where we have seen exciting growth in both number of submitted and published articles in Neoplasia. Neoplasia was first published in 1999. During the past 10 years, Neoplasia has dynamically adapted to the needs of the cancer research community as techno...

journal_title：Neoplasia (New York, N.Y.)

authors： Rehemtulla A

更新日期：2008-12-01 00:00:00