Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.

abstract：:Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous chemotherapeutics, there is still a considerable uncertainty regarding their role in modulation of anticancer potential of platinum-based drugs. Here we newly demonstrate...

journal_title：Neoplasia (New York, N.Y.)

authors： Herůdková J,Paruch K,Khirsariya P,Souček K,Krkoška M,Vondálová Blanářová O,Sova P,Kozubík A,Hyršlová Vaculová A

更新日期：2017-10-01 00:00:00

abstract：:Metastatic dissemination of primary tumors is responsible for 90% of colorectal cancer (CRC) deaths. The presence of positive lymph nodes, which separates stage I/II from stage III CRC, is a particularly key factor in patient management. Here, we describe results of a quantitative proteomic survey to identify molecula...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin Y,Buckhaults PJ,Lee JR,Xiong H,Farrell C,Podolsky RH,Schade RR,Dynan WS

更新日期：2009-09-01 00:00:00

abstract：:Preclinical studies have shown that gefitinib, licofelone, atorvastatin, and α-difluoromethylornithine (GLAD) are promising colon cancer chemopreventive agents. Because low-dose combination regimens can offer potential additive or synergistic effects without toxicity, GLAD combination was tested for toxicity and chemo...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohammed A,Janakiram NB,Brewer M,Vedala K,Steele VE,Rao CV

更新日期：2013-05-01 00:00:00

abstract：:Gemcitabine is widely used as first-line chemotherapeutic drug in the treatment of pancreatic cancer. Our previous experimental chemotherapy studies have shown that treatment of human pancreatic carcinoma cells with 5-fluorouracil (5-FU) alters the cellular transporter expression profile and that modulation of the exp...

journal_title：Neoplasia (New York, N.Y.)

authors： Hagmann W,Jesnowski R,Löhr JM

更新日期：2010-09-01 00:00:00

abstract：:While normal cells in the human breast are organized into acinar structures, disruption of the acinar architecture is a hallmark of cancer. In a three-dimensional model of morphogenesis, we show that down-regulation of the matrix-associated tumor suppressor protein CCN6 (WNT1-inducible-signaling pathway protein 3) dis...

journal_title：Neoplasia (New York, N.Y.)

authors： Pal A,Huang W,Toy KA,Kleer CG

更新日期：2012-11-01 00:00:00

abstract：:Modulation of the antitumor immune response through the engagement of NKG2D receptors with their ligands (L) on targets represents a promising therapeutic approach against cancer. In this study, we tested the effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, on the expression of NKG2D ligands in m...

journal_title：Neoplasia (New York, N.Y.)

authors： Wu X,Tao Y,Hou J,Meng X,Shi J

更新日期：2012-12-01 00:00:00

abstract：:BUB1 (budding uninhibited by benzimidazoles-1) is required for efficient TGF-β signaling, through its role in stabilizing the TGFBR1 and TGFBR2 complex. Here we demonstrate that TGFBR2 phosphorylates BUB1 at Serine-318, which is conserved in primates. S318 phosphorylation abrogates the interaction of BUB1 with TGFBR1 ...

journal_title：Neoplasia (New York, N.Y.)

authors： Nyati S,Gregg BS,Xu J,Young G,Kimmel L,Nyati MK,Ray D,Speers C,Rehemtulla A

更新日期：2020-04-01 00:00:00

abstract：:Pediatric rhabdomyosarcoma (RMS) is a morphologically and genetically heterogeneous malignancy commonly classified into three histologic subtypes, namely, alveolar, embryonal, and anaplastic. An issue that continues to challenge effective RMS patient prognosis is the dearth of molecular markers predictive of disease s...

journal_title：Neoplasia (New York, N.Y.)

authors： Jacob AG,O'Brien D,Singh RK,Comiskey DF Jr,Littleton RM,Mohammad F,Gladman JT,Widmann MC,Jeyaraj SC,Bolinger C,Anderson JR,Barkauskas DA,Boris-Lawrie K,Chandler DS

更新日期：2013-09-01 00:00:00

abstract：:The present study focuses on the influence of the tumor microenvironment on the expression of HLA-G in ovarian cancer and its impact on immune cells. We used carcinomatosis fluids (n = 16) collected from patients diagnosed with epithelial ovarian cancer, detected by an increase in CA125 levels. Our results indicate th...

journal_title：Neoplasia (New York, N.Y.)

authors： Ullah M,Azazzen D,Kaci R,Benabbou N,Pujade Lauraine E,Pocard M,Mirshahi M

更新日期：2019-03-01 00:00:00

abstract：:Bcl-2 is commonly overexpressed in tumors, where it is often associated with unfavorable outcome. However, it has also been linked to a favorable sensitivity to microtubule-targeting agents (MTAs). We show that Bcl-2-overexpressing lung and breast cancer cells were more sensitive to both paclitaxel and vinorelbine. Bc...

journal_title：Neoplasia (New York, N.Y.)

authors： Savry A,Carre M,Berges R,Rovini A,Pobel I,Chacon C,Braguer D,Bourgarel-Rey V

更新日期：2013-01-01 00:00:00

abstract：:Multidrug resistance (MDR) presents a major obstacle for the successful chemotherapy of cancer. Its emergence during chemotherapy is attributed to a selective process, which gives a growth advantage to MDR cells within the genetically unstable neoplastic cell population. The pleiotropic nature of clinical MDR poses a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Preise D,Mazor O,Koudinova N,Liscovitch M,Scherz A,Salomon Y

更新日期：2003-11-01 00:00:00

abstract：:Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise to some doubts concerning the effectiveness of the senescence-induced anticancer therapy. Similarly, it is post...

journal_title：Neoplasia (New York, N.Y.)

authors： Mosieniak G,Sliwinska MA,Alster O,Strzeszewska A,Sunderland P,Piechota M,Was H,Sikora E

更新日期：2015-12-01 00:00:00

abstract：:We present an in vivo fluorescence microscopic evaluation of intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6 (NPe6) in an intradermal mouse EMT6 tumor model. Although the identification of favorable photophysical and pharmacological properties has led to the development of new photosensitizers...

journal_title：Neoplasia (New York, N.Y.)

authors： Mitra S,Foster TH

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:This study was performed to evaluate the safety and efficacy of paclitaxel with cisplatin as salvage therapy in patients previously treated with gemcitabine and cisplatin (G/C) for advanced transitional cell carcinoma (TCC) of the urothelial tract. METHODS:Twenty-eight patients with metastatic or locally ad...

journal_title：Neoplasia (New York, N.Y.)

authors： Uhm JE,Lim HY,Kim WS,Choi HY,Lee HM,Park BB,Park K,Kang WK

更新日期：2007-01-01 00:00:00

abstract：:Survival in high-risk neuroblastoma (HR-NB) patients remains poor despite multimodal treatment. We aimed to identify HR-NB patients with worse outcomes by analyzing the genomic instability derived from segmental chromosomal aberrations. We calculated 3 genomic instability indexes for primary tumor SNP array profiles f...

journal_title：Neoplasia (New York, N.Y.)

authors： Fernández-Blanco B,Berbegall AP,Martin-Vañó S,Castel V,Navarro S,Noguera R

更新日期：2021-01-01 00:00:00

abstract：:Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1 expression. Reverse transcription-polymerase chain reaction analysis...

journal_title：Neoplasia (New York, N.Y.)

authors： Rao G,Liu D,Xing M,Tauler J,Prinz RA,Xu X

更新日期：2010-11-01 00:00:00

abstract：:It is known that total telomere length is shorter in invasive breast cancer than in normal breast tissue but the status of individual telomere lengths has not been studied. Part of the difficulty is that usually telomere length in interphase cells is measured on all chromosomes together. In this study we compared norm...

journal_title：Neoplasia (New York, N.Y.)

authors： Rashid-Kolvear F,Pintilie M,Done SJ

更新日期：2007-04-01 00:00:00

abstract：:We previously reported that overexpression of an O-type glycosyltransferase, GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6) played critical roles in mammary carcinogenesis. To further investigate the biological function of GALNT6, we screened a substrate protein(s) of GALNT6 using a VVA (Vicia villosa agglut...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin J,Chung S,Ueda K,Matsuda K,Nakamura Y,Park JH

更新日期：2017-01-01 00:00:00

abstract：:SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our previous studies showed that Sag/Rbx2 co-operated with Kras or Pten loss to promote tumorigenesis in the lung and prostate, respectively, but antagonized Kras to inhibit skin t...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang Q,Wei D,Tan M,Li H,Morgan MA,Sun Y

更新日期：2020-04-24 00:00:00

abstract：:To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against slowly proliferating cells, we performed a comparative study of topotecan and gimatecan in human bladder cancer models (HT1376 and MCR). Gimatecan was significantly more effective than topotecan ...

journal_title：Neoplasia (New York, N.Y.)

authors： Ulivi P,Zoli W,Fabbri F,Brigliadori G,Ricotti L,Tesei A,Rosetti M,De Cesare M,Beretta GL,Corna E,Supino R,Zunino F

更新日期：2005-02-01 00:00:00

abstract：:Several observations suggest a potential role of T-cell-mediated immunity in the control of neuroblastoma (NB). However, the generation of NB-specific cytotoxic T lymphocytes (CTL) on T-cell priming with tumor mRNA-transfected dendritic cells (DC) has never been investigated before. In the present study, the feasibili...

journal_title：Neoplasia (New York, N.Y.)

authors： Morandi F,Chiesa S,Bocca P,Millo E,Salis A,Solari M,Pistoia V,Prigione I

更新日期：2006-10-01 00:00:00

abstract：:Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies demonstrating a cor...

journal_title：Neoplasia (New York, N.Y.)

authors： Chiu RK,Carpenito C,Dougherty ST,Hayes GM,Dougherty GJ

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Foxhead box M1 (FOXM1) expression has been shown to be linked with human papillomavirus (HPV) 16/18-infected cervical cancer. However, the mechanism underlying the induction of FOXM1 in HPV 16/18-infected cancers remains elusive. EXPERIMENTAL DESIGN:The mechanistic actions of FOXM1 induced by the E6/NKX2-1 axi...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen PM,Cheng YW,Wang YC,Wu TC,Chen CY,Lee H

更新日期：2014-11-20 00:00:00

abstract：:Research efforts in the area of palaeopathology have been seen as an avenue to improve our understanding of the pathogenesis of cancer. Answers to questions of whether dinosaurs had cancer, or if cancer plagued ancient civilizations, have captured the imagination as well as the popular media. Evidence for dinosaurian ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rehemtulla A

更新日期：2010-12-01 00:00:00

abstract：:The activated mutants of the α-subunits of G proteins G(12) and G(13) have been designated as the gep oncogenes owing to their ability to stimulate diverse oncogenic signaling pathways that lead to neoplastic transformation of fibroblast cell lines and tumorigenesis in nude mice models. Studies from our laboratory as ...

journal_title：Neoplasia (New York, N.Y.)

authors： Kashef K,Radhakrishnan R,Lee CM,Reddy EP,Dhanasekaran DN

更新日期：2011-04-01 00:00:00

abstract：:A theoretical model for the intraperitoneal (i.p.) delivery of cisplatin and heat to tumor metastases in tissues adjacent to the peritoneal cavity is presented. The penetration distance (the depth to which drug diffuses directly from the cavity into tissues) is predicted to be on the order of 0.5 mm. The model shows t...

journal_title：Neoplasia (New York, N.Y.)

authors： El-Kareh AW,Secomb TW

更新日期：2004-03-01 00:00:00

abstract：:Activation of the insulin-like growth factor-1 receptor (IGF-1R) by IGF-1 is associated with the risk and progression of many types of cancer, although despite this it remains unclear how activated IGF-1R contributes to cancer progression. In this study, gene expression changes elicited by IGF-1 were profiled in breas...

journal_title：Neoplasia (New York, N.Y.)

authors： Oh JS,Kucab JE,Bushel PR,Martin K,Bennett L,Collins J,DiAugustine RP,Barrett JC,Afshari CA,Dunn SE

更新日期：2002-05-01 00:00:00

abstract：:Aberrant activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) 3 has been implicated in cell proliferation and survival of many cancers including head and neck squamous cell carcinoma (HNSCC). AZD1480, an orally active pharmacologic inhibitor of JAK1/JAK2, has been tested in seve...

journal_title：Neoplasia (New York, N.Y.)

authors： Sen M,Pollock NI,Black J,DeGrave KA,Wheeler S,Freilino ML,Joyce S,Lui VW,Zeng Y,Chiosea SI,Grandis JR

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Well-differentiated gastroenteropancreatic neuroendocrine neoplasms are rare tumors with a slow proliferation. They are virtually resistant to many DNA-damaging therapeutic approaches, such as chemo- and external beam therapy, which might be overcome by DNA damage inhibition induced by proteasome inhibitors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Briest F,Koziolek EJ,Albrecht J,Schmidt F,Bernsen MR,Haeck J,Kühl AA,Sedding D,Hartung T,Exner S,Welzel M,Fischer C,Grötzinger C,Brenner W,Baum RP,Grabowski P

更新日期：2021-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) latent infection is a critical event in nasopharyngeal carcinoma (NPC) tumorigenesis. EBV-encoded genes have been shown to be involved in immune evasion and in the regulation of various cellular signaling cascades. To elucidate the roles of EBV in NPC development, stable infection of EBV in na...

journal_title：Neoplasia (New York, N.Y.)

authors： Lo AK,Lo KW,Tsao SW,Wong HL,Hui JW,To KF,Hayward DS,Chui YL,Lau YL,Takada K,Huang DP

更新日期：2006-03-01 00:00:00