Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts.

Abstract:

:Several studies have linked vascular density, identified in histologic sections, to "metastatic risk." Functional information of the vasculature, not readily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims were to determine if human breast and prostate cancer xenografts preselected for differences in invasive and metastatic characteristics established correspondingly different vascular volume and permeability, quantified here with noninvasive MRI of the intravascular contrast agent albumin-GdDTPA. Tumor vascular volume and permeability of human breast and prostate cancer xenografts were characterized using MRI. Parallel studies confirmed the invasive behavior of these cell lines. Vascular endothelial growth factor (VEGF) expression in the cell lines was measured using ELISA and Western blots. Metastasis to the lungs was evaluated with spontaneous as well as experimental assay. Metastatic tumors formed vasculature with significantly higher permeability or vascular volume (P<.05, two-sided unpaired t test). The permeability profile matched VEGF expression. Within tumors, regions of high vascular volume usually exhibited low permeability whereas regions of low vascular volume exhibited high permeability. We observed that although invasion was necessary, without adequate vascularization it was not sufficient for metastasis to occur.

journal_name

Neoplasia

authors

Bhujwalla ZM,Artemov D,Natarajan K,Ackerstaff E,Solaiyappan M

doi

10.1038/sj.neo.7900129

keywords:

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

143-53

issue

2

eissn

1522-8002

issn

1476-5586

journal_volume

3

pub_type

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