ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells.

abstract：:Activation of the insulin-like growth factor-1 receptor (IGF-1R) by IGF-1 is associated with the risk and progression of many types of cancer, although despite this it remains unclear how activated IGF-1R contributes to cancer progression. In this study, gene expression changes elicited by IGF-1 were profiled in breas...

journal_title：Neoplasia (New York, N.Y.)

authors： Oh JS,Kucab JE,Bushel PR,Martin K,Bennett L,Collins J,DiAugustine RP,Barrett JC,Afshari CA,Dunn SE

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:This study was performed to evaluate the safety and efficacy of paclitaxel with cisplatin as salvage therapy in patients previously treated with gemcitabine and cisplatin (G/C) for advanced transitional cell carcinoma (TCC) of the urothelial tract. METHODS:Twenty-eight patients with metastatic or locally ad...

journal_title：Neoplasia (New York, N.Y.)

authors： Uhm JE,Lim HY,Kim WS,Choi HY,Lee HM,Park BB,Park K,Kang WK

更新日期：2007-01-01 00:00:00

abstract：:The expression of N-cadherin (NCAD) has been shown to correlate with increased tumor cell motility and metastasis. However, NCAD-mediated adhesion is a robust phenomenon and therefore seems to be inconsistent with the "release" from intercellular adhesion required for invasion. We show that in the most invasive melano...

journal_title：Neoplasia (New York, N.Y.)

authors： Maret D,Gruzglin E,Sadr MS,Siu V,Shan W,Koch AW,Seidah NG,Del Maestro RF,Colman DR

更新日期：2010-12-01 00:00:00

abstract：:We investigated the epigenetic silencing and genetic changes of the RAS-associated domain family 1A (RASSF1A) gene and the O6-methylguanine-DNA methyltransferase (MGMT) gene in retinoblastoma. We extracted DNA from microdissected tumor and normal retina tissues of the same patient in 68 retinoblastoma cases. Promoter ...

journal_title：Neoplasia (New York, N.Y.)

authors： Choy KW,Lee TC,Cheung KF,Fan DS,Lo KW,Beaverson KL,Abramson DH,Lam DS,Yu CB,Pang CP

更新日期：2005-03-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the major gastrointestinal mesenchymal tumors with a variable malignancy ranging from a curable disorder to highly malignant sarcomas. Metastasis and recurrence are the main causes of death in GIST patients. To further explore the mechanism of metastasis and to more accurate...

journal_title：Neoplasia (New York, N.Y.)

authors： Ma MZ,Zhuang C,Yang XM,Zhang ZZ,Ma H,Zhang WM,You H,Qin W,Gu J,Yang S,Cao H,Zhang ZG

更新日期：2014-03-01 00:00:00

abstract：:Lysophosphatidic acid (LPA), a blood-borne lipid mediator, is present in elevated concentrations in ascites of ovarian cancer patients and other malignant effusions. LPA is a potent mitogen in cancer cells. The mechanism linking LPA signal to cancer cell proliferation is not well understood. Little is known about whet...

journal_title：Neoplasia (New York, N.Y.)

authors： Mukherjee A,Ma Y,Yuan F,Gong Y,Fang Z,Mohamed EM,Berrios E,Shao H,Fang X

更新日期：2015-09-01 00:00:00

abstract：:Although it is well known that nasopharyngeal carcinoma (NPC) is closely related with Epstein-Barr virus (EBV), few data are available about which and how EBV-expressed gene is involved in the carcinogenesis of human nasopharyngeal epithelial cells. EBV-encoded BARF1 (BamH I-A right frame 1) gene has been shown to be ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jiang R,Cabras G,Sheng W,Zeng Y,Ooka T

更新日期：2009-09-01 00:00:00

abstract：:The Wilms tumor gene (WT1) is mutated or deleted in patients with heredofamilial syndromes associated with the development of Wilms tumors, but is infrequently mutated in sporadic Wilms tumors. By comparing the microarray profiles of syndromic versus sporadic Wilms tumors and WT1-inducible Saos-2 osteosarcoma cells, w...

journal_title：Neoplasia (New York, N.Y.)

authors： Kim MK,Mason JM,Li CM,Berkofsky-Fessler W,Jiang L,Choubey D,Grundy PE,Tycko B,Licht JD

更新日期：2008-01-01 00:00:00

abstract：:Approximately 50% of prostate cancers harbor the TMPRSS2:ERG fusion, resulting in elevated expression of the ERG transcription factor. Despite the identification of this subclass of prostate cancers, no personalized therapeutic strategies have achieved clinical implementation. Kinases are attractive therapeutic target...

journal_title：Neoplasia (New York, N.Y.)

authors： Lee RS,Zhang L,Berger A,Lawrence MG,Song J,Niranjan B,Davies RG,Lister NL,Sandhu SK,Rubin MA,Risbridger GP,Taylor RA,Rickman DS,Horvath LG,Daly RJ

更新日期：2019-04-01 00:00:00

abstract：:We have recently reported that elastin microfibril interface located protein 2 (EMILIN2), an extracellular matrix (ECM) glycoprotein, triggers cell death through a direct binding to death receptors. EMILIN2 thus influences cell viability through a mechanism that is unique for an ECM molecule. In the present work, we r...

journal_title：Neoplasia (New York, N.Y.)

authors： Mongiat M,Marastoni S,Ligresti G,Lorenzon E,Schiappacassi M,Perris R,Frustaci S,Colombatti A

更新日期：2010-04-01 00:00:00

abstract：:The long noncoding (lnc) RNA H19 was involved in the tumorigenesis of many types of cancer. However, the role of H19 in the tumorigenesis of colon cancer has not been fully illustrated. Recent studies suggested a potential relationship between H19 and vitamin D receptor (VDR) signaling. Considering the pivotal role of...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen S,Bu D,Ma Y,Zhu J,Chen G,Sun L,Zuo S,Li T,Pan Y,Wang X,Liu Y,Wang P

更新日期：2017-03-01 00:00:00

abstract：:We report that daurinol, a novel arylnaphthalene lignan, is a promising potential anticancer agent with adverse effects that are less severe than those of etoposide, a clinical anticancer agent. Despite its potent antitumor activity, clinical use of etoposide is limited because of its adverse effects, including myelos...

journal_title：Neoplasia (New York, N.Y.)

authors： Kang K,Oh SH,Yun JH,Jho EH,Kang JH,Batsuren D,Tunsag J,Park KH,Kim M,Nho CW

更新日期：2011-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) latent infection is a critical event in nasopharyngeal carcinoma (NPC) tumorigenesis. EBV-encoded genes have been shown to be involved in immune evasion and in the regulation of various cellular signaling cascades. To elucidate the roles of EBV in NPC development, stable infection of EBV in na...

journal_title：Neoplasia (New York, N.Y.)

authors： Lo AK,Lo KW,Tsao SW,Wong HL,Hui JW,To KF,Hayward DS,Chui YL,Lau YL,Takada K,Huang DP

更新日期：2006-03-01 00:00:00

abstract：:There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)-derived EVs on gastric organoids (gastroids) and elucidated molecular mechanisms underlying the...

journal_title：Neoplasia (New York, N.Y.)

authors： Ke X,Yan R,Sun Z,Cheng Y,Meltzer A,Lu N,Shu X,Wang Z,Huang B,Liu X,Wang Z,Song JH,Ng CK,Ibrahim S,Abraham JM,Shin EJ,He S,Meltzer SJ

更新日期：2017-11-01 00:00:00

abstract：:To survive and metastasize, tumors interact with surrounding tissues by secreting growth factors and cytokines. In return, surrounding host tissues respond by changing their secretome. Numerous factors theoretically function as therapeutic targets or biomarkers of cancer growth and metastatic risk. However, it is uncl...

journal_title：Neoplasia (New York, N.Y.)

authors： Kerr BA,Miocinovic R,Smith AK,Klein EA,Byzova TV

更新日期：2010-05-01 00:00:00

abstract：:Gastrin-releasing peptide receptor (GRPR) and the epidermal growth factor receptor (EGFR) are expressed in several cancers including non-small cell lung cancer (NSCLC). Here we demonstrate the activation of EGFR by the GRPR ligand, gastrin-releasing peptide (GRP), in NSCLC cells. GRP induced rapid activation of p44/42...

journal_title：Neoplasia (New York, N.Y.)

authors： Thomas SM,Grandis JR,Wentzel AL,Gooding WE,Lui VW,Siegfried JM

更新日期：2005-04-01 00:00:00

abstract：:Malignant gliomas are refractory to conventional therapies, including surgery, radiotherapy and chemotherapy. Thus, a variety of therapies such as the inhibition of angiogenesis and signal transduction pathways have been attempted. In the present study, we have evaluated the combined effect of endostatin, an inhibitor...

journal_title：Neoplasia (New York, N.Y.)

authors： Sorensen DR,Leirdal M,Iversen PO,Sioud M

更新日期：2002-11-01 00:00:00

abstract：:Identification of the cell types capable of initiating and sustaining growth of the neoplastic clone in vivo is a fundamental problem in cancer research. It is likely that tumor growth can be sustained both by rare cancer stem-like cells and selected aggressive clones and that the nature of the mutations, the cell of ...

journal_title：Neoplasia (New York, N.Y.)

authors： Tysnes BB

更新日期：2010-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. Despite progress in identifying risk factors, the incidence of HCC is increasing. Moreover, therapeutic options are limited and survival is poor. Therefore, alternative and innovative therapeutic strategies are urgently required. R-Tf-D-LP4, a c...

journal_title：Neoplasia (New York, N.Y.)

authors： Pittala S,Krelin Y,Shoshan-Barmatz V

更新日期：2018-06-01 00:00:00

abstract：:The cancer stem cell paradigm postulates that dysregulated tissue-specific stem cells or progenitor cells are precursors for cancer biogenesis. Consequently, identifying cancer stem cells is crucial to our understanding of cancer progression and for the development of novel therapeutic agents. In this study, we demons...

journal_title：Neoplasia (New York, N.Y.)

authors： Vesuna F,Lisok A,Kimble B,Raman V

更新日期：2009-12-01 00:00:00

abstract：:Chordoma is a rare tumor arising in the sacrum, clivus, or vertebrae. It is often not completely resectable and shows a high incidence of recurrence and progression with shortened patient survival and impaired quality of life. Chemotherapeutic options are limited to investigational therapies at present. Therefore, adj...

journal_title：Neoplasia (New York, N.Y.)

authors： Diaz RJ,Guduk M,Romagnuolo R,Smith CA,Northcott P,Shih D,Berisha F,Flanagan A,Munoz DG,Cusimano MD,Pamir MN,Rutka JT

更新日期：2012-09-01 00:00:00

abstract：:Neuroblastoma (NB) is the most commonly occurring solid tumor in children. The disease usually arises in the adrenal medulla, and it is characterized by a remarkable heterogeneity in its progression. Most NB patients with an advanced disease have massive bone marrow infiltration at diagnosis. Lung metastasis represent...

journal_title：Neoplasia (New York, N.Y.)

authors： Nevo I,Sagi-Assif O,Edry Botzer L,Amar D,Maman S,Kariv N,Leider-Trejo LE,Savelyeva L,Schwab M,Yron I,Witz IP

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND AIMS:BACKGROUND AND AIMSGemcitabine is the standard therapy for patients with pancreatic cancer with metastatic disease. Patients with metastatic pancreatic cancer presenting with increased values of C-reactive protein do not respond to gemcitabine. So far, no studies have evaluated the correlation betwe...

journal_title：Neoplasia (New York, N.Y.)

authors： Knoop RF,Sparn M,Waldmann J,Plassmeier L,Bartsch DK,Lauth M,Hudemann C,Fendrich V

更新日期：2014-06-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors that are rarely curable, even with aggressive therapy (surgery, chemotherapy, and radiation). Glioblastomas frequently display loss of PTEN and/or epidermal growth factor receptor activation, both of which activate the PI3K pathway. This pathway can increase vascular endothelia...

journal_title：Neoplasia (New York, N.Y.)

authors： Pore N,Gupta AK,Cerniglia GJ,Maity A

更新日期：2006-11-01 00:00:00

abstract：:PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1alpha, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanced (DCE) and diffusi...

journal_title：Neoplasia (New York, N.Y.)

authors： Jordan BF,Runquist M,Raghunand N,Baker A,Williams R,Kirkpatrick L,Powis G,Gillies RJ

更新日期：2005-05-01 00:00:00

abstract：:Several studies have linked vascular density, identified in histologic sections, to "metastatic risk." Functional information of the vasculature, not readily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims were to determine if hum...

journal_title：Neoplasia (New York, N.Y.)

authors： Bhujwalla ZM,Artemov D,Natarajan K,Ackerstaff E,Solaiyappan M

更新日期：2001-03-01 00:00:00

abstract：:Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG. Studies on the molecular mechanisms and functional consequences of this important chromosomal rea...

journal_title：Neoplasia (New York, N.Y.)

authors： Mertz KD,Setlur SR,Dhanasekaran SM,Demichelis F,Perner S,Tomlins S,Tchinda J,Laxman B,Vessella RL,Beroukhim R,Lee C,Chinnaiyan AM,Rubin MA

更新日期：2007-03-01 00:00:00

abstract：:Activation of the Wnt-signaling pathway is known to play a crucial role in carcinogenesis of various human organs including the colon, liver, prostate, and endometrium. To investigate the mechanisms underlying hepatocellular carcinogenesis, we attempted to identify genes regulated by beta-catenin/Tcf complex in a huma...

journal_title：Neoplasia (New York, N.Y.)

authors： Kato T,Satoh S,Okabe H,Kitahara O,Ono K,Kihara C,Tanaka T,Tsunoda T,Yamaoka Y,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00

abstract：:High microvascular density (MVD) in the primary tumor has been shown to be associated with increased incidence of lymph node metastases and poor clinical outcome. Other investigations have revealed that a large fraction of hypoxic tissue in the primary tumor is associated with metastatic disease and impaired survival....

journal_title：Neoplasia (New York, N.Y.)

authors： Rofstad EK,Galappathi K,Mathiesen BS

更新日期：2014-07-01 00:00:00

abstract：:NF-kappaB and the upstream kinase PKB/Akt are highly expressed in chemoresistance tumor cells and may hamper the apoptotic pathway. CF101, a specific agonist to the A3 adenosine receptor (A3AR), inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. Because CF101 has been show...

journal_title：Neoplasia (New York, N.Y.)

authors： Bar-Yehuda S,Madi L,Silberman D,Gery S,Shkapenuk M,Fishman P

更新日期：2005-01-01 00:00:00