Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma.

abstract：:Head and neck squamous cell carcinomas (HNSCC) are frequently characterized by chemotherapy and radiation resistance, and by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report we examined whether cell-permeable peptides derived from the BH3 domains of proapoptotic Bax, Bad, o...

journal_title：Neoplasia (New York, N.Y.)

authors： Li R,Boehm AL,Miranda MB,Shangary S,Grandis JR,Johnson DE

更新日期：2007-10-01 00:00:00

abstract：:We used the standard comet assay successfully to generate in vitro dose-response curves under oxic and hypoxic conditions. We then made mixtures of cells that had been irradiated with 3 and 9 Gy of X-rays to simulate two subpopulations in a tumor, but efforts to accurately detect and quantify the subpopulations using ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang J,Klem J,Wyrick JB,Ozawa T,Cunningham E,Golinveaux J,Allen MJ,Lamborn KR,Deen DF

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Inflammatory breast cancer (IBC) is arguably the deadliest form of breast cancer due to its rapid onset and highly invasive nature. IBC carries 5- and 10-year disease-free survival rates of ~45% and <20%, respectively. Multiple studies demonstrate that in comparison with conventional breast cancer, IBC has a un...

journal_title：Neoplasia (New York, N.Y.)

authors： Joglekar-Javadekar M,Van Laere S,Bourne M,Moalwi M,Finetti P,Vermeulen PB,Birnbaum D,Dirix LY,Ueno N,Carter M,Rains J,Ramachandran A,Bertucci F,van Golen KL

更新日期：2017-07-01 00:00:00

abstract：:ET-743 (trabectedin; Yondelis) is approved in Europe for the treatment of soft tissue sarcomas. Emerging phase 1 and 2 clinical data have shown high response rates in myxoid liposarcoma in part owing to the inhibition of the FUS-CHOP transcription factor. In this report, we show that modulation of specific oncogenic t...

journal_title：Neoplasia (New York, N.Y.)

authors： Grohar PJ,Griffin LB,Yeung C,Chen QR,Pommier Y,Khanna C,Khan J,Helman LJ

更新日期：2011-02-01 00:00:00

abstract：:Gemcitabine is widely used as first-line chemotherapeutic drug in the treatment of pancreatic cancer. Our previous experimental chemotherapy studies have shown that treatment of human pancreatic carcinoma cells with 5-fluorouracil (5-FU) alters the cellular transporter expression profile and that modulation of the exp...

journal_title：Neoplasia (New York, N.Y.)

authors： Hagmann W,Jesnowski R,Löhr JM

更新日期：2010-09-01 00:00:00

abstract：:TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer. Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo model systems. Transgenic mice expressing the ERG gene fusion product under androgen-regulation develop mouse prostatic intraepithelial neoplasia (...

journal_title：Neoplasia (New York, N.Y.)

authors： Tomlins SA,Laxman B,Varambally S,Cao X,Yu J,Helgeson BE,Cao Q,Prensner JR,Rubin MA,Shah RB,Mehra R,Chinnaiyan AM

更新日期：2008-02-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer. Clinical trials using the United States Food and Drug Administration (FDA)-approved, AMPK-activating, antidiabetic drug metformin a...

journal_title：Neoplasia (New York, N.Y.)

authors： Buac D,Kona FR,Seth AK,Dou QP

更新日期：2013-12-01 00:00:00

abstract：:The present study focuses on the influence of the tumor microenvironment on the expression of HLA-G in ovarian cancer and its impact on immune cells. We used carcinomatosis fluids (n = 16) collected from patients diagnosed with epithelial ovarian cancer, detected by an increase in CA125 levels. Our results indicate th...

journal_title：Neoplasia (New York, N.Y.)

authors： Ullah M,Azazzen D,Kaci R,Benabbou N,Pujade Lauraine E,Pocard M,Mirshahi M

更新日期：2019-03-01 00:00:00

abstract：:This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies, with a prevalence of <200,000 in the United States, which makes it an orphan disease (Basu et al., 2010).1 For functional purposes, NENs are divided into two grou...

journal_title：Neoplasia (New York, N.Y.)

authors： Oronsky B,Ma PC,Morgensztern D,Carter CA

更新日期：2017-12-01 00:00:00

abstract：:NF-kappaB and the upstream kinase PKB/Akt are highly expressed in chemoresistance tumor cells and may hamper the apoptotic pathway. CF101, a specific agonist to the A3 adenosine receptor (A3AR), inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. Because CF101 has been show...

journal_title：Neoplasia (New York, N.Y.)

authors： Bar-Yehuda S,Madi L,Silberman D,Gery S,Shkapenuk M,Fishman P

更新日期：2005-01-01 00:00:00

abstract：:Pancreatic carcinoma has an extremely bad prognosis due to lack of early diagnostic markers and lack of effective therapeutic strategies. Recently, we have established an in vitro model recapitulating the first steps in the carcinogenesis of the pancreas. SV40 large T antigen-immortalized bovine pancreatic duct cells ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jesnowski R,Zubakov D,Faissner R,Ringel J,Hoheisel JD,Lösel R,Schnölzer M,Löhr M

更新日期：2007-02-01 00:00:00

abstract：:It has been proposed that human colorectal tumors can be classified into two groups: one in which methylation is rare, and another with methylation of several loci associated with a "CpG island methylated phenotype (CIMP)," characterized by preferential proximal location in the colon, but otherwise poorly defined. The...

journal_title：Neoplasia (New York, N.Y.)

authors： Anacleto C,Leopoldino AM,Rossi B,Soares FA,Lopes A,Rocha JC,Caballero O,Camargo AA,Simpson AJ,Pena SD

更新日期：2005-04-01 00:00:00

abstract：:Direct tumor injections of (CpG ODN) into murine colon tumor 26 (CT-26) tumors can induce a potent antitumor response. Tumor size at the beginning of treatment determines the final therapeutic outcome, with smaller tumors responding favorably to CpG ODN therapy whereas large tumors do not. CpG ODN injections in small ...

journal_title：Neoplasia (New York, N.Y.)

authors： Sharma S,Karakousis CP,Takita H,Shin K,Brooks SP

更新日期：2004-09-01 00:00:00

abstract：:During normal sympathetic nervous system (SNS) development, cells of the ganglionic lineage can malignantly transform and develop into the childhood tumor neuroblastoma. Hypoxia-inducible transcription factors (HIFs) mediate cellular responses during normal development and are central in the adaptation to oxygen short...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohlin S,Hamidian A,Påhlman S

更新日期：2013-03-01 00:00:00

abstract：:Recent studies suggest that tumor-infiltrating immune cells can benefit the tumor by producing factors that promote angiogenesis and suppress immunity. Because the tumor microenvironment is characterized by high adenosine levels, we hypothesized that the low-affinity A(2B) adenosine receptor located on host immune cel...

journal_title：Neoplasia (New York, N.Y.)

authors： Ryzhov S,Novitskiy SV,Zaynagetdinov R,Goldstein AE,Carbone DP,Biaggioni I,Dikov MM,Feoktistov I

更新日期：2008-09-01 00:00:00

abstract：:We have recently reported that elastin microfibril interface located protein 2 (EMILIN2), an extracellular matrix (ECM) glycoprotein, triggers cell death through a direct binding to death receptors. EMILIN2 thus influences cell viability through a mechanism that is unique for an ECM molecule. In the present work, we r...

journal_title：Neoplasia (New York, N.Y.)

authors： Mongiat M,Marastoni S,Ligresti G,Lorenzon E,Schiappacassi M,Perris R,Frustaci S,Colombatti A

更新日期：2010-04-01 00:00:00

abstract：:Salmonella infection is a major public health concern, and colonization in humans can be chronic and increases the risk of cancers. Wnt signaling is a key pathway for intestinal renewal and development, inflammation, and tumorigenesis. In the current study, we report a novel role of Wnt1 in infection and colon cancer ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang J,Lu R,Fu X,Dan Z,Zhang YG,Chang X,Liu Q,Xia Y,Liu X,Sun J

更新日期：2018-05-01 00:00:00

abstract：:Mutations of the NF2 gene on chromosome 22q are thought to initiate tumorigenesis in nearly 50% of meningiomas, and 22q deletion is the earliest and most frequent large-scale chromosomal abnormality observed in these tumors. In aggressive meningiomas, 22q deletions are generally accompanied by the presence of large-sc...

journal_title：Neoplasia (New York, N.Y.)

authors： Yang HW,Kim TM,Song SS,Shrinath N,Park R,Kalamarides M,Park PJ,Black PM,Carroll RS,Johnson MD

更新日期：2012-01-01 00:00:00

abstract：:Substantial heterogeneity exists within cervical cancer that is generally infected by human papillomavirus (HPV). However, the most common histological subtype of cervical cancer, cervical squamous cell carcinoma (CSCC), is poorly characterized regarding the association between its heterogeneity and HPV oncoprotein ex...

journal_title：Neoplasia (New York, N.Y.)

authors： Lu X,Jiang L,Zhang L,Zhu Y,Hu W,Wang J,Ruan X,Xu Z,Meng X,Gao J,Su X,Yan F

更新日期：2019-06-01 00:00:00

abstract：:The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model to activate platelet derived growth factor receptor-alpha (PDGFRα) specifically in the stroma. Hyperactivati...

journal_title：Neoplasia (New York, N.Y.)

authors： Hammer AM,Sizemore GM,Shukla VC,Avendano A,Sizemore ST,Chang JJ,Kladney RD,Cuitiño MC,Thies KA,Verfurth Q,Chakravarti A,Yee LD,Leone G,Song JW,Ghadiali SN,Ostrowski MC

更新日期：2017-06-01 00:00:00

abstract：:Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts, plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal niche. Similarly, prostate cancer (PCa) cells express the annexin II receptor and seem to use the stem cell niche for homing to the bo...

journal_title：Neoplasia (New York, N.Y.)

authors： Shiozawa Y,Pedersen EA,Patel LR,Ziegler AM,Havens AM,Jung Y,Wang J,Zalucha S,Loberg RD,Pienta KJ,Taichman RS

更新日期：2010-02-01 00:00:00

abstract：:Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise to some doubts concerning the effectiveness of the senescence-induced anticancer therapy. Similarly, it is post...

journal_title：Neoplasia (New York, N.Y.)

authors： Mosieniak G,Sliwinska MA,Alster O,Strzeszewska A,Sunderland P,Piechota M,Was H,Sikora E

更新日期：2015-12-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors that are rarely curable, even with aggressive therapy (surgery, chemotherapy, and radiation). Glioblastomas frequently display loss of PTEN and/or epidermal growth factor receptor activation, both of which activate the PI3K pathway. This pathway can increase vascular endothelia...

journal_title：Neoplasia (New York, N.Y.)

authors： Pore N,Gupta AK,Cerniglia GJ,Maity A

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto-oncogene is based on several Pim-1 target proteins involved in pivotal cellular processes. Here, we explore the functional relevance of Pim...

journal_title：Neoplasia (New York, N.Y.)

authors： Weirauch U,Beckmann N,Thomas M,Grünweller A,Huber K,Bracher F,Hartmann RK,Aigner A

更新日期：2013-07-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand these critical cells in tumor progression, we screened a portfolio of rationally selected, injectable agents to image endogenous TAMs ubiquitously in three differen...

journal_title：Neoplasia (New York, N.Y.)

authors： Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ

更新日期：2009-05-01 00:00:00

abstract：:It has been proposed that the structural and numerical chromosome abnormalities recorded in breast cancer could be the result of telomere dysfunction and that telomerase is activated de novo to provide a survival mechanism curtailing further chromosomal aberrations. However, recent in vivo and in vitro data show that ...

journal_title：Neoplasia (New York, N.Y.)

authors： Papadopoulou A,Trangas T,Teixeira MR,Heim S,Dimitriadis E,Tsarouha H,Andersen JA,Evangelou E,Ioannidis P,Agnantis NJ,Pandis N

更新日期：2003-03-01 00:00:00

abstract：:Cancer, a proliferative disease hallmarked by abnormal cell growth and spread, is largely dependent on tumor neoangiogenesis, with evidence of vascular endothelial dysfunction. Novel ways to assess vascular function in cancer include measuring levels of circulating endothelial cells (CEC). Rare in healthy individuals,...

journal_title：Neoplasia (New York, N.Y.)

authors： Goon PK,Lip GY,Boos CJ,Stonelake PS,Blann AD

更新日期：2006-02-01 00:00:00

abstract：:Prostate cancer (PCa) patients receive androgen-deprivation therapy (ADT) to reduce tumor burden. However, complete eradication of PCa is unusual, and recurrent disease is evident within approximately 2 years in high-risk patients. Clinical evidence suggests that combining ADT with radiotherapy improves local control ...

journal_title：Neoplasia (New York, N.Y.)

authors： Røe K,Seierstad T,Kristian A,Mikalsen LT,Mælandsmo GM,van der Kogel AJ,Ree AH,Olsen DR

更新日期：2010-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths in America. Nearly two thirds of newly diagnosed CRC cases include lymph node (LN) involvement, and LN metastasis is one of the strongest negative prognostic factors for CRC. It is thought that CRC tumors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Margolin DA,Silinsky J,Grimes C,Spencer N,Aycock M,Green H,Cordova J,Davis NK,Driscoll T,Li L

更新日期：2011-09-01 00:00:00

abstract：:Monocytes/macrophages are an influential component of the glioma microenvironment. However, understanding their diversity and plasticity constitute one of the most challenging areas of research due to the paucity of models to study these cells' inherent complexity. Herein, we analyzed the role of monocytes/macrophages...

journal_title：Neoplasia (New York, N.Y.)

authors： Gabrusiewicz K,Hossain MB,Cortes-Santiago N,Fan X,Kaminska B,Marini FC,Fueyo J,Gomez-Manzano C

更新日期：2015-04-01 00:00:00