Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1α/CXCR4 paracrine signaling.

abstract：:Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rates of polyploidization. We now sho...

journal_title：Neoplasia (New York, N.Y.)

authors： Christodoulidou A,Raftopoulou C,Chiourea M,Papaioannou GK,Hoshiyama H,Wright WE,Shay JW,Gagos S

更新日期：2013-02-01 00:00:00

abstract：:Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase activity and immortal...

journal_title：Neoplasia (New York, N.Y.)

authors： Yi X,White DM,Aisner DL,Baur JA,Wright WE,Shay JW

更新日期：2000-09-01 00:00:00

abstract：:ET-743 (trabectedin; Yondelis) is approved in Europe for the treatment of soft tissue sarcomas. Emerging phase 1 and 2 clinical data have shown high response rates in myxoid liposarcoma in part owing to the inhibition of the FUS-CHOP transcription factor. In this report, we show that modulation of specific oncogenic t...

journal_title：Neoplasia (New York, N.Y.)

authors： Grohar PJ,Griffin LB,Yeung C,Chen QR,Pommier Y,Khanna C,Khan J,Helman LJ

更新日期：2011-02-01 00:00:00

abstract：:Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies demonstrating a cor...

journal_title：Neoplasia (New York, N.Y.)

authors： Chiu RK,Carpenito C,Dougherty ST,Hayes GM,Dougherty GJ

更新日期：1999-11-01 00:00:00

abstract：:We examined correlations between TGF-beta1, TbetaR-I and TbetaR-II, p12(CDK2-AP1), p21(WAF1), p27(KIP1), Smad2, and p-Smad2 in 125 cases of human oral squamous cell carcinoma (OSCC) to test the hypothesis that resistance to TGF-beta1-induced growth suppression is due to the disruption of its signaling pathway as a con...

journal_title：Neoplasia (New York, N.Y.)

authors： Peng H,Shintani S,Kim Y,Wong DT

更新日期：2006-12-01 00:00:00

abstract：:We previously reported that overexpression of an O-type glycosyltransferase, GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6) played critical roles in mammary carcinogenesis. To further investigate the biological function of GALNT6, we screened a substrate protein(s) of GALNT6 using a VVA (Vicia villosa agglut...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin J,Chung S,Ueda K,Matsuda K,Nakamura Y,Park JH

更新日期：2017-01-01 00:00:00

abstract：:Multidrug resistance (MDR) presents a major obstacle for the successful chemotherapy of cancer. Its emergence during chemotherapy is attributed to a selective process, which gives a growth advantage to MDR cells within the genetically unstable neoplastic cell population. The pleiotropic nature of clinical MDR poses a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Preise D,Mazor O,Koudinova N,Liscovitch M,Scherz A,Salomon Y

更新日期：2003-11-01 00:00:00

abstract：:Neurofibromatosis type 2 (NF2) is an inherited predisposition cancer syndrome characterized by the development of multiple benign tumors in the nervous system including schwannomas, meningiomas, and ependymomas. Using a disease model comprising primary human schwannoma cells, we previously demonstrated that adherens j...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhou L,Ercolano E,Ammoun S,Schmid MC,Barczyk MA,Hanemann CO

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate cancer. Inhibition of the antiapoptotic proteins Bcl-2 and Mcl-1 may delay the transition to androgen-independent growth. EXPERIMENTAL DESIGN:We have established a prostate cancer model with...

journal_title：Neoplasia (New York, N.Y.)

authors： Loberg RD,McGregor N,Ying C,Sargent E,Pienta KJ

更新日期：2007-12-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the major gastrointestinal mesenchymal tumors with a variable malignancy ranging from a curable disorder to highly malignant sarcomas. Metastasis and recurrence are the main causes of death in GIST patients. To further explore the mechanism of metastasis and to more accurate...

journal_title：Neoplasia (New York, N.Y.)

authors： Ma MZ,Zhuang C,Yang XM,Zhang ZZ,Ma H,Zhang WM,You H,Qin W,Gu J,Yang S,Cao H,Zhang ZG

更新日期：2014-03-01 00:00:00

abstract：:Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN). Microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) are important molecular classifiers in colorectal cancer. However, the relationship between ...

journal_title：Neoplasia (New York, N.Y.)

authors： Nosho K,Kawasaki T,Ohnishi M,Suemoto Y,Kirkner GJ,Zepf D,Yan L,Longtine JA,Fuchs CS,Ogino S

更新日期：2008-06-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is an important process of tumor progression associated with increased metastatic potential. EMT can be activated by external triggers such as cytokines or metabolic parameters (e.g. hypoxia). Since extracellular acidosis is a common finding in tumors, the aim of the study is...

journal_title：Neoplasia (New York, N.Y.)

authors： Riemann A,Rauschner M,Gießelmann M,Reime S,Haupt V,Thews O

更新日期：2019-05-01 00:00:00

abstract：:The high prevalence and long latency period of prostate cancer (PCa) provide a unique opportunity to control disease progression with dietary and nutraceutical approaches. We developed ProFine, a standardized composition of luteolin, quercetin, and kaempferol, and investigated its potential as a nutraceutical for PCa ...

journal_title：Neoplasia (New York, N.Y.)

authors： Mamouni K,Zhang S,Li X,Chen Y,Yang Y,Kim J,Bartlett MG,Coleman IM,Nelson PS,Kucuk O,Wu D

更新日期：2018-08-01 00:00:00

abstract：:The goal of oncology is the individualization of patient care to optimize therapeutic responses and minimize toxicities. Achieving this will require noninvasive, quantifiable, and early markers of tumor response. Preclinical data from xenografted tumors using a variety of antitumor therapies have shown that magnetic r...

journal_title：Neoplasia (New York, N.Y.)

authors： Theilmann RJ,Borders R,Trouard TP,Xia G,Outwater E,Ranger-Moore J,Gillies RJ,Stopeck A

更新日期：2004-11-01 00:00:00

abstract：:Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) incidence is increasing at a near epidemic rate. We investigated whether the mammalian (or mechanistic) target of rapamycin (mTOR) inhibitor, rapamycin, can be used as a concurrent agent to standard-of-care cisplatin/radiation therapy (CR...

journal_title：Neoplasia (New York, N.Y.)

authors： Coppock JD,Wieking BG,Molinolo AA,Gutkind JS,Miskimins WK,Lee JH

更新日期：2013-06-01 00:00:00

abstract：:NF-kappaB and the upstream kinase PKB/Akt are highly expressed in chemoresistance tumor cells and may hamper the apoptotic pathway. CF101, a specific agonist to the A3 adenosine receptor (A3AR), inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. Because CF101 has been show...

journal_title：Neoplasia (New York, N.Y.)

authors： Bar-Yehuda S,Madi L,Silberman D,Gery S,Shkapenuk M,Fishman P

更新日期：2005-01-01 00:00:00

abstract：:Gemcitabine is widely used as first-line chemotherapeutic drug in the treatment of pancreatic cancer. Our previous experimental chemotherapy studies have shown that treatment of human pancreatic carcinoma cells with 5-fluorouracil (5-FU) alters the cellular transporter expression profile and that modulation of the exp...

journal_title：Neoplasia (New York, N.Y.)

authors： Hagmann W,Jesnowski R,Löhr JM

更新日期：2010-09-01 00:00:00

abstract：:It is widely accepted that a deranged immune system plays a key role in the onset and evolution of classic Kaposi sarcoma (CKS). Nevertheless, the usage of the T-cell receptor (TCR) β-variable (BV) chain repertoire expressed by peripheral blood lymphocytes in patients with CKS is still unknown. With the aim of providi...

journal_title：Neoplasia (New York, N.Y.)

authors： Galleu A,Fozza C,Simula MP,Contini S,Virdis P,Corda G,Pardini S,Cottoni F,Pruneddu S,Angeloni A,Ceccarelli S,Longinotti M

更新日期：2012-06-01 00:00:00

abstract：:Chordoma is a rare tumor arising in the sacrum, clivus, or vertebrae. It is often not completely resectable and shows a high incidence of recurrence and progression with shortened patient survival and impaired quality of life. Chemotherapeutic options are limited to investigational therapies at present. Therefore, adj...

journal_title：Neoplasia (New York, N.Y.)

authors： Diaz RJ,Guduk M,Romagnuolo R,Smith CA,Northcott P,Shih D,Berisha F,Flanagan A,Munoz DG,Cusimano MD,Pamir MN,Rutka JT

更新日期：2012-09-01 00:00:00

abstract：:Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair. Dbait (which stands for DNA strand break bait) molecules mimic DSBs and trap DNA repair proteins, thereby inhibiting repair of DNA damage induced by radiation therapy (RT). First, the cytotoxic efficacy of Dbait i...

journal_title：Neoplasia (New York, N.Y.)

authors： Biau J,Devun F,Jdey W,Kotula E,Quanz M,Chautard E,Sayarath M,Sun JS,Verrelle P,Dutreix M

更新日期：2014-10-23 00:00:00

abstract：:In spite of intensive and increasingly successful attempts to determine the multiple steps involved in colorectal carcinogenesis, the mechanisms responsible for metastasis of colorectal tumors to the liver remain to be clarified. To identify genes that are candidates for involvement in the metastatic process, we analy...

journal_title：Neoplasia (New York, N.Y.)

authors： Yanagawa R,Furukawa Y,Tsunoda T,Kitahara O,Kameyama M,Murata K,Ishikawa O,Nakamura Y

更新日期：2001-09-01 00:00:00

abstract：:Cancers originating from epithelial cells are the most common malignancies. No common expression profile of solid tumors compared to normal tissues has been described so far. Therefore we were interested if genes differentially expressed in the majority of carcinomas could be identified using bioinformatic methods. Co...

journal_title：Neoplasia (New York, N.Y.)

authors： Pilarsky C,Wenzig M,Specht T,Saeger HD,Grützmann R

更新日期：2004-11-01 00:00:00

abstract：:A noninvasive method for molecular imaging of T-cell activity in vivo would be of considerable value. It would aid in understanding the role of specific genes and signal transduction pathways in the course of normal and pathologic immune responses, and could elucidate temporal dynamics and immune regulation at differe...

journal_title：Neoplasia (New York, N.Y.)

authors： Ponomarev V,Doubrovin M,Lyddane C,Beresten T,Balatoni J,Bornman W,Finn R,Akhurst T,Larson S,Blasberg R,Sadelain M,Tjuvajev JG

更新日期：2001-11-01 00:00:00

abstract：:Metastatic dissemination of primary tumors is responsible for 90% of colorectal cancer (CRC) deaths. The presence of positive lymph nodes, which separates stage I/II from stage III CRC, is a particularly key factor in patient management. Here, we describe results of a quantitative proteomic survey to identify molecula...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin Y,Buckhaults PJ,Lee JR,Xiong H,Farrell C,Podolsky RH,Schade RR,Dynan WS

更新日期：2009-09-01 00:00:00

abstract：:Chromobox 4 (CBX4) is a core component of polycomb-repressive complex 1 with important roles in cancer biology and tissue homeostasis. Aberrant expression of CBX4 has been implicated in several human malignancies. However, its role and underlying mechanisms in the tumorigenesis of lung adenocarcinoma (LUAD) have not b...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang Z,Fang Z,Chen G,Liu B,Xu J,Li F,Li F,Liu H,Zhang H,Sun Y,Tian G,Chen H,Xu G,Zhang L,Hu L,Ji H

更新日期：2021-02-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer. Clinical trials using the United States Food and Drug Administration (FDA)-approved, AMPK-activating, antidiabetic drug metformin a...

journal_title：Neoplasia (New York, N.Y.)

authors： Buac D,Kona FR,Seth AK,Dou QP

更新日期：2013-12-01 00:00:00

abstract：:Tumor necrosis factor (TNF) has been implicated in inflammation-associated tumor progression. Although multiple reports identified a role for TNF signaling in established cancers, few studies have assessed the impact of TNF blockade on early tumor formation promotion. We aimed at exploring the effects of TNF neutraliz...

journal_title：Neoplasia (New York, N.Y.)

authors： Karabela SP,Kairi CA,Magkouta S,Psallidas I,Moschos C,Stathopoulos I,Zakynthinos SG,Roussos C,Kalomenidis I,Stathopoulos GT

更新日期：2011-12-01 00:00:00

abstract：:The receptor tyrosine kinase MET is a major component controlling the invasive growth program in embryonic development and in invasive malignancies. The discovery of therapeutic antibodies against MET has been difficult, and antibodies that compete with hepatocyte growth factor (HGF) act as agonists. By applying phage...

journal_title：Neoplasia (New York, N.Y.)

authors： van der Horst EH,Chinn L,Wang M,Velilla T,Tran H,Madrona Y,Lam A,Ji M,Hoey TC,Sato AK

更新日期：2009-04-01 00:00:00

abstract：:The term mucositis is coined to describe the adverse effects of radiation and chemotherapy treatments. Mucositis is one of the most common adverse reactions encountered in radiation therapy for head and neck cancers, as well as in chemotherapy, in particular with drugs affecting DNA synthesis (S-phase-specific agents ...

journal_title：Neoplasia (New York, N.Y.)

authors： Naidu MU,Ramana GV,Rani PU,Mohan IK,Suman A,Roy P

更新日期：2004-09-01 00:00:00

abstract：:The most frequent site of metastasis in human prostate cancer (PCa) is the bone. Preferential adhesion of PCa cells to bone-specific factors may facilitate the selective metastasis of the skeleton. The most abundant protein within the skeleton is type I collagen. We previously demonstrated that PCa cells selected in v...

journal_title：Neoplasia (New York, N.Y.)

authors： Hall CL,Dubyk CW,Riesenberger TA,Shein D,Keller ET,van Golen KL

更新日期：2008-08-01 00:00:00