Generation and characterization of novel local and metastatic human neuroblastoma variants.

abstract：:We previously demonstrated the synergistic therapeutic effect of the cetuximab (anti-epidermal growth factor receptor [EGFR] monoclonal antibody, mAb)-trastuzumab (anti-HER2 mAb) combination (2mAbs therapy) in HER2(low) human pancreatic carcinoma xenografts. Here, we compared the 2mAbs therapy, the erlotinib (EGFR tyr...

journal_title：Neoplasia (New York, N.Y.)

authors： Larbouret C,Gaborit N,Chardès T,Coelho M,Campigna E,Bascoul-Mollevi C,Mach JP,Azria D,Robert B,Pèlegrin A

更新日期：2012-02-01 00:00:00

abstract：:The ZNF198- FGFR1 fusion gene arises as a result of the t(8;13)(p11;q12) in the 8p11 myeloproliferative syndrome. To determine the transforming properties of this chimeric protein we transfected ZNF198-FGFR1 into the interleukin (IL)-3 dependent cell line Ba/F3. Growth factor independent subclones were obtained in whi...

journal_title：Neoplasia (New York, N.Y.)

authors： Smedley D,Demiroglu A,Abdul-Rauf M,Heath C,Cooper C,Shipley J,Cross NC

更新日期：1999-10-01 00:00:00

abstract：:Glucose transport across glioblastoma membranes plays a crucial role in maintaining the enhanced glycolysis typical of high-grade gliomas and glioblastoma. We tested the ability of two inhibitors of the glucose transporters GLUT/SLC2A superfamily, indinavir (IDV) and ritonavir (RTV), and of one inhibitor of the Na/glu...

journal_title：Neoplasia (New York, N.Y.)

authors： Azzalin A,Nato G,Parmigiani E,Garello F,Buffo A,Magrassi L

更新日期：2017-04-01 00:00:00

abstract：:Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts, plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal niche. Similarly, prostate cancer (PCa) cells express the annexin II receptor and seem to use the stem cell niche for homing to the bo...

journal_title：Neoplasia (New York, N.Y.)

authors： Shiozawa Y,Pedersen EA,Patel LR,Ziegler AM,Havens AM,Jung Y,Wang J,Zalucha S,Loberg RD,Pienta KJ,Taichman RS

更新日期：2010-02-01 00:00:00

abstract：:It is widely accepted that a deranged immune system plays a key role in the onset and evolution of classic Kaposi sarcoma (CKS). Nevertheless, the usage of the T-cell receptor (TCR) β-variable (BV) chain repertoire expressed by peripheral blood lymphocytes in patients with CKS is still unknown. With the aim of providi...

journal_title：Neoplasia (New York, N.Y.)

authors： Galleu A,Fozza C,Simula MP,Contini S,Virdis P,Corda G,Pardini S,Cottoni F,Pruneddu S,Angeloni A,Ceccarelli S,Longinotti M

更新日期：2012-06-01 00:00:00

abstract：:We have recently reported that elastin microfibril interface located protein 2 (EMILIN2), an extracellular matrix (ECM) glycoprotein, triggers cell death through a direct binding to death receptors. EMILIN2 thus influences cell viability through a mechanism that is unique for an ECM molecule. In the present work, we r...

journal_title：Neoplasia (New York, N.Y.)

authors： Mongiat M,Marastoni S,Ligresti G,Lorenzon E,Schiappacassi M,Perris R,Frustaci S,Colombatti A

更新日期：2010-04-01 00:00:00

abstract：:Mouse models are powerful tools to study lung cancer initiation and progression in vivo and have contributed significantly to recent advances in therapy. Using micro-computed tomography to monitor and study parenchymal and extra-parenchymal metastases in existing murine models of lung cancer is challenging owing to a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Viswanath P,Peng S,Singh R,Kingsley C,Balter PA,Johnson FM

更新日期：2018-10-01 00:00:00

abstract：:Activation of the Wnt-signaling pathway is known to play a crucial role in carcinogenesis of various human organs including the colon, liver, prostate, and endometrium. To investigate the mechanisms underlying hepatocellular carcinogenesis, we attempted to identify genes regulated by beta-catenin/Tcf complex in a huma...

journal_title：Neoplasia (New York, N.Y.)

authors： Kato T,Satoh S,Okabe H,Kitahara O,Ono K,Kihara C,Tanaka T,Tsunoda T,Yamaoka Y,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00

abstract：:We investigated the epigenetic silencing and genetic changes of the RAS-associated domain family 1A (RASSF1A) gene and the O6-methylguanine-DNA methyltransferase (MGMT) gene in retinoblastoma. We extracted DNA from microdissected tumor and normal retina tissues of the same patient in 68 retinoblastoma cases. Promoter ...

journal_title：Neoplasia (New York, N.Y.)

authors： Choy KW,Lee TC,Cheung KF,Fan DS,Lo KW,Beaverson KL,Abramson DH,Lam DS,Yu CB,Pang CP

更新日期：2005-03-01 00:00:00

abstract：:A noninvasive method for molecular imaging of T-cell activity in vivo would be of considerable value. It would aid in understanding the role of specific genes and signal transduction pathways in the course of normal and pathologic immune responses, and could elucidate temporal dynamics and immune regulation at differe...

journal_title：Neoplasia (New York, N.Y.)

authors： Ponomarev V,Doubrovin M,Lyddane C,Beresten T,Balatoni J,Bornman W,Finn R,Akhurst T,Larson S,Blasberg R,Sadelain M,Tjuvajev JG

更新日期：2001-11-01 00:00:00

abstract：:Anoikis, a cell death mechanism triggered upon cell-matrix detachment, is regarded as a physiological suppressor of metastasis that can be regulated by a diverse array of signals. The protein encoded by GDF2 is BMP9 and is a member of the bone morphogenetic protein family and the transforming growth factor (TGF) β sup...

journal_title：Neoplasia (New York, N.Y.)

authors： Varadaraj A,Patel P,Serrao A,Bandyopadhay T,Lee NY,Jazaeri AA,Huang Z,Murphy SK,Mythreye K

更新日期：2015-11-01 00:00:00

abstract：:Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PanINs), the precursor lesions, are a potential target for chemoprevention. Targeting eicosanoid pathways is an obvious choice because 5-lipoxygenase (5-LOX) has been s...

journal_title：Neoplasia (New York, N.Y.)

authors： Hennig R,Kehl T,Noor S,Ding XZ,Rao SM,Bergmann F,Fürstenberger G,Büchler MW,Friess H,Krieg P,Adrian TE

更新日期：2007-11-01 00:00:00

abstract：:Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Concerning this, it h...

journal_title：Neoplasia (New York, N.Y.)

authors： Jung YS,Chun HY,Yoon MH,Park BJ

更新日期：2014-12-01 00:00:00

abstract：:It has long been a puzzle in cancer treatment that despite the initial appearance of apoptosis, the process could be reversed in some cancer cells and often results in more aggressive tumors and metastasis. The mechanism for this recurrence is yet unknown. Here we report that human mammary carcinoma cells induced to u...

journal_title：Neoplasia (New York, N.Y.)

authors： Xu Y,So C,Lam HM,Fung MC,Tsang SY

更新日期：2018-03-01 00:00:00

abstract：:Numerous human tumor types, including ovarian cancer, display a significant expression of the CD44 family of cell surface proteoglycans. To develop tumor-targeted drugs, we have initially evaluated whether the CD44 ligand hyaluronic acid (HA) could serve as a backbone for paclitaxel (TXL) prodrugs. HA-TXL was prepared...

journal_title：Neoplasia (New York, N.Y.)

authors： Auzenne E,Ghosh SC,Khodadadian M,Rivera B,Farquhar D,Price RE,Ravoori M,Kundra V,Freedman RS,Klostergaard J

更新日期：2007-06-01 00:00:00

abstract：:We report that daurinol, a novel arylnaphthalene lignan, is a promising potential anticancer agent with adverse effects that are less severe than those of etoposide, a clinical anticancer agent. Despite its potent antitumor activity, clinical use of etoposide is limited because of its adverse effects, including myelos...

journal_title：Neoplasia (New York, N.Y.)

authors： Kang K,Oh SH,Yun JH,Jho EH,Kang JH,Batsuren D,Tunsag J,Park KH,Kim M,Nho CW

更新日期：2011-11-01 00:00:00

abstract：:A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG. The TMPRSS2-ERG fusion is observed in around 90% of tumors that overexpress the oncogene ERG. The goal o...

journal_title：Neoplasia (New York, N.Y.)

authors： Pflueger D,Rickman DS,Sboner A,Perner S,LaFargue CJ,Svensson MA,Moss BJ,Kitabayashi N,Pan Y,de la Taille A,Kuefer R,Tewari AK,Demichelis F,Chee MS,Gerstein MB,Rubin MA

更新日期：2009-08-01 00:00:00

abstract：:Two genetically engineered, conditional mouse models of lung tumor formation, K-ras(LSL-G12D) and K-ras(LSL-G12D)/p53(LSL-R270H), are commonly used to model human lung cancer. Developed by Tyler Jacks and colleagues, these models have been invaluable to study in vivo lung cancer initiation and progression in a genetic...

journal_title：Neoplasia (New York, N.Y.)

authors： Haines BB,Bettano KA,Chenard M,Sevilla RS,Ware C,Angagaw MH,Winkelmann CT,Tong C,Reilly JF,Sur C,Zhang W

更新日期：2009-01-01 00:00:00

abstract：:Global molecular profiling of cancers has shown broad utility in delineating pathways and processes underlying disease, in predicting prognosis and response to therapy, and in suggesting novel treatments. To gain further insights from such data, we have integrated and analyzed a comprehensive collection of "molecular ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rhodes DR,Kalyana-Sundaram S,Tomlins SA,Mahavisno V,Kasper N,Varambally R,Barrette TR,Ghosh D,Varambally S,Chinnaiyan AM

更新日期：2007-05-01 00:00:00

abstract：:The biologic plausibility of an association between type 2 diabetes mellitus (T2D) and lung cancer has received increasing attention, but the results of investigations remain largely inconclusive. In the present study we investigated the influence of the anti-diabetic drug metformin on the cytotoxic effects of EGFR ta...

journal_title：Neoplasia (New York, N.Y.)

authors： Xiao Z,Gaertner S,Morresi-Hauf A,Genzel R,Duell T,Ullrich A,Knyazev PG

更新日期：2017-05-01 00:00:00

abstract：:Pro-inflammatory conditions have long been associated with mammary carcinogenesis and breast cancer progression. The underlying mechanisms are incompletely understood but signaling of pro-inflammatory cytokine TNFα through its receptors TNFR1 and TNFR2 is a major mediator of inflammation in both obesity and in the res...

journal_title：Neoplasia (New York, N.Y.)

authors： He L,Bhat K,Duhacheck-Muggy S,Ioannidis A,Zhang L,Nguyen NT,Moatamed NA,Pajonk F

更新日期：2021-02-01 00:00:00

abstract：:The WNT/beta-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested. The relationship between beta-catenin activation and microsatellite instability (MSI) in colorectal cancer has been cont...

journal_title：Neoplasia (New York, N.Y.)

authors： Kawasaki T,Nosho K,Ohnishi M,Suemoto Y,Kirkner GJ,Dehari R,Meyerhardt JA,Fuchs CS,Ogino S

更新日期：2007-07-01 00:00:00

abstract：:Malignant gliomas are refractory to conventional therapies, including surgery, radiotherapy and chemotherapy. Thus, a variety of therapies such as the inhibition of angiogenesis and signal transduction pathways have been attempted. In the present study, we have evaluated the combined effect of endostatin, an inhibitor...

journal_title：Neoplasia (New York, N.Y.)

authors： Sorensen DR,Leirdal M,Iversen PO,Sioud M

更新日期：2002-11-01 00:00:00

abstract：:We previously discovered that a fat-metabolizing enzyme, 15-lipoxygenase-1 (15-LO-1), is high in human prostate cancer (PCa) and correlates with disease progression. The biologic link between the aberrant 15-LO-1/linoleic acid (LA) metabolism and fat (which is a rich source of growth factors) in PCa is unknown. Theref...

journal_title：Neoplasia (New York, N.Y.)

authors： Kelavkar UP,Cohen C

更新日期：2004-01-01 00:00:00

abstract：:Type I cells have been defined to be independent of mitochondria for the induction of Fas death receptor-mediated apoptosis, whereas Type II cells are mitochondria-dependent. Knock-out studies in mice show that thymocytes are Type I and liver cells are Type II. We have previously shown that primary human hepatocytes a...

journal_title：Neoplasia (New York, N.Y.)

authors： Ozören N,El-Deiry WS

更新日期：2002-11-01 00:00:00

abstract：:About 10% to 30% of patients with ataxia-telangiectasia (A-T) develop leukemias or lymphomas. There is considerable interpatient variation in the age of onset and leukemia/lymphoma type. The incomplete penetrance and variable age of onset may be attributable to several factors. These include competing mortality from o...

journal_title：Neoplasia (New York, N.Y.)

authors： Genik PC,Bielefeldt-Ohmann H,Liu X,Story MD,Ding L,Bush JM,Fallgren CM,Weil MM

更新日期：2014-02-01 00:00:00

abstract：:The transforming growth factorbeta (TGFbeta) superfamily regulates a broad spectrum of biological responses throughout embryonic development and adult life, including cell proliferation and differentiation, epithelial-to-mesenchymal transition, apoptosis, and angiogenesis. TGFbeta members initiate signaling by bringin...

journal_title：Neoplasia (New York, N.Y.)

authors： Izzi L,Attisano L

更新日期：2006-08-01 00:00:00

abstract：:It is known that total telomere length is shorter in invasive breast cancer than in normal breast tissue but the status of individual telomere lengths has not been studied. Part of the difficulty is that usually telomere length in interphase cells is measured on all chromosomes together. In this study we compared norm...

journal_title：Neoplasia (New York, N.Y.)

authors： Rashid-Kolvear F,Pintilie M,Done SJ

更新日期：2007-04-01 00:00:00

abstract：:The genetic mechanisms underlying adrenocortical tumor development are still largely unknown. We used high-resolution single nucleotide polymorphism microarrays (Affymetrix SNP 6.0) to detect copy number alterations (CNAs) and copy-neutral losses of heterozygosity (cnLOH) in 15 cortisol-secreting adrenocortical adenom...

journal_title：Neoplasia (New York, N.Y.)

authors： Ronchi CL,Leich E,Sbiera S,Weismann D,Rosenwald A,Allolio B,Fassnacht M

更新日期：2012-03-01 00:00:00

abstract：:Metastatic dissemination of primary tumors is responsible for 90% of colorectal cancer (CRC) deaths. The presence of positive lymph nodes, which separates stage I/II from stage III CRC, is a particularly key factor in patient management. Here, we describe results of a quantitative proteomic survey to identify molecula...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin Y,Buckhaults PJ,Lee JR,Xiong H,Farrell C,Podolsky RH,Schade RR,Dynan WS

更新日期：2009-09-01 00:00:00