Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.

abstract：:The maspin gene is not expressed in normal human pancreas, but its expression is acquired during human pancreatic carcinogenesis. In other normal human cells and their malignant counterparts, maspin expression is controlled through the epigenetic state of its promoter. In studies presented herein, we used bisulfite ge...

journal_title：Neoplasia (New York, N.Y.)

authors： Fitzgerald M,Oshiro M,Holtan N,Krager K,Cullen JJ,Futscher BW,Domann FE

更新日期：2003-09-01 00:00:00

abstract：:The maspin gene functions as a tumor suppressor in human breasts, and its expression is frequently lost during breast cancer progression. In vitro models of human breast cancer indicate that the loss of maspin expression is closely linked to aberrant methylation of the maspin promoter. We conducted a study on 30 archi...

journal_title：Neoplasia (New York, N.Y.)

authors： Futscher BW,O'Meara MM,Kim CJ,Rennels MA,Lu D,Gruman LM,Seftor RE,Hendrix MJ,Domann FE

更新日期：2004-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths in America. Nearly two thirds of newly diagnosed CRC cases include lymph node (LN) involvement, and LN metastasis is one of the strongest negative prognostic factors for CRC. It is thought that CRC tumors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Margolin DA,Silinsky J,Grimes C,Spencer N,Aycock M,Green H,Cordova J,Davis NK,Driscoll T,Li L

更新日期：2011-09-01 00:00:00

abstract：:It has been proposed that the structural and numerical chromosome abnormalities recorded in breast cancer could be the result of telomere dysfunction and that telomerase is activated de novo to provide a survival mechanism curtailing further chromosomal aberrations. However, recent in vivo and in vitro data show that ...

journal_title：Neoplasia (New York, N.Y.)

authors： Papadopoulou A,Trangas T,Teixeira MR,Heim S,Dimitriadis E,Tsarouha H,Andersen JA,Evangelou E,Ioannidis P,Agnantis NJ,Pandis N

更新日期：2003-03-01 00:00:00

abstract：:Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies demonstrating a cor...

journal_title：Neoplasia (New York, N.Y.)

authors： Chiu RK,Carpenito C,Dougherty ST,Hayes GM,Dougherty GJ

更新日期：1999-11-01 00:00:00

abstract：:Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise to some doubts concerning the effectiveness of the senescence-induced anticancer therapy. Similarly, it is post...

journal_title：Neoplasia (New York, N.Y.)

authors： Mosieniak G,Sliwinska MA,Alster O,Strzeszewska A,Sunderland P,Piechota M,Was H,Sikora E

更新日期：2015-12-01 00:00:00

abstract：:Treatment decisions in oncology are increasingly guided by information on the biologic characteristics of tumors. Currently, patient-specific information on tumor biology is obtained from the analysis of biopsy material. Positron emission tomography (PET) provides quantitative estimates of regional biochemistry and re...

journal_title：Neoplasia (New York, N.Y.)

authors： Mankoff DA,Dehdashti F,Shields AF

更新日期：2000-01-01 00:00:00

abstract：:Chordoma is a rare tumor arising in the sacrum, clivus, or vertebrae. It is often not completely resectable and shows a high incidence of recurrence and progression with shortened patient survival and impaired quality of life. Chemotherapeutic options are limited to investigational therapies at present. Therefore, adj...

journal_title：Neoplasia (New York, N.Y.)

authors： Diaz RJ,Guduk M,Romagnuolo R,Smith CA,Northcott P,Shih D,Berisha F,Flanagan A,Munoz DG,Cusimano MD,Pamir MN,Rutka JT

更新日期：2012-09-01 00:00:00

abstract：:Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts, plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal niche. Similarly, prostate cancer (PCa) cells express the annexin II receptor and seem to use the stem cell niche for homing to the bo...

journal_title：Neoplasia (New York, N.Y.)

authors： Shiozawa Y,Pedersen EA,Patel LR,Ziegler AM,Havens AM,Jung Y,Wang J,Zalucha S,Loberg RD,Pienta KJ,Taichman RS

更新日期：2010-02-01 00:00:00

abstract：:BUB1 (budding uninhibited by benzimidazoles-1) is required for efficient TGF-β signaling, through its role in stabilizing the TGFBR1 and TGFBR2 complex. Here we demonstrate that TGFBR2 phosphorylates BUB1 at Serine-318, which is conserved in primates. S318 phosphorylation abrogates the interaction of BUB1 with TGFBR1 ...

journal_title：Neoplasia (New York, N.Y.)

authors： Nyati S,Gregg BS,Xu J,Young G,Kimmel L,Nyati MK,Ray D,Speers C,Rehemtulla A

更新日期：2020-04-01 00:00:00

abstract：:Bcl-2 is commonly overexpressed in tumors, where it is often associated with unfavorable outcome. However, it has also been linked to a favorable sensitivity to microtubule-targeting agents (MTAs). We show that Bcl-2-overexpressing lung and breast cancer cells were more sensitive to both paclitaxel and vinorelbine. Bc...

journal_title：Neoplasia (New York, N.Y.)

authors： Savry A,Carre M,Berges R,Rovini A,Pobel I,Chacon C,Braguer D,Bourgarel-Rey V

更新日期：2013-01-01 00:00:00

abstract：:ET-743 (trabectedin; Yondelis) is approved in Europe for the treatment of soft tissue sarcomas. Emerging phase 1 and 2 clinical data have shown high response rates in myxoid liposarcoma in part owing to the inhibition of the FUS-CHOP transcription factor. In this report, we show that modulation of specific oncogenic t...

journal_title：Neoplasia (New York, N.Y.)

authors： Grohar PJ,Griffin LB,Yeung C,Chen QR,Pommier Y,Khanna C,Khan J,Helman LJ

更新日期：2011-02-01 00:00:00

abstract：:The infection of hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC), in which HBV X protein (HBx) plays crucial roles. MicroRNAs are involved in diverse biologic functions and in carcinogenesis by regulating gene expression. In the present study, we aim to investigate ...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang T,Zhang J,Cui M,Liu F,You X,Du Y,Gao Y,Zhang S,Lu Z,Ye L,Zhang X

更新日期：2013-11-01 00:00:00

abstract：:The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R. In human U87MG glioblastoma cells, AChE-R formed a triple complex wit...

journal_title：Neoplasia (New York, N.Y.)

authors： Perry C,Sklan EH,Soreq H

更新日期：2004-05-01 00:00:00

abstract：:Several observations suggest a potential role of T-cell-mediated immunity in the control of neuroblastoma (NB). However, the generation of NB-specific cytotoxic T lymphocytes (CTL) on T-cell priming with tumor mRNA-transfected dendritic cells (DC) has never been investigated before. In the present study, the feasibili...

journal_title：Neoplasia (New York, N.Y.)

authors： Morandi F,Chiesa S,Bocca P,Millo E,Salis A,Solari M,Pistoia V,Prigione I

更新日期：2006-10-01 00:00:00

abstract：:Research efforts in the area of palaeopathology have been seen as an avenue to improve our understanding of the pathogenesis of cancer. Answers to questions of whether dinosaurs had cancer, or if cancer plagued ancient civilizations, have captured the imagination as well as the popular media. Evidence for dinosaurian ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rehemtulla A

更新日期：2010-12-01 00:00:00

abstract：:Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1 expression. Reverse transcription-polymerase chain reaction analysis...

journal_title：Neoplasia (New York, N.Y.)

authors： Rao G,Liu D,Xing M,Tauler J,Prinz RA,Xu X

更新日期：2010-11-01 00:00:00

abstract：:We characterized the molecular genetic consequences of a balanced chromosome translocation t(8;22)(p21;q12), which occurred as the sole cytogenetic aberration in short-term cultured cells from an intrathoracic mature teratoma in a 15-year-old girl. Fluorescence in situ hybridization and reverse transcription-polymeras...

journal_title：Neoplasia (New York, N.Y.)

authors： Jin Y,Mertens F,Kullendorff CM,Panagopoulos I

更新日期：2006-05-01 00:00:00

abstract：:We determined whether the implantation of human pancreatic cancer cells into the pancreas of nude mice can be used to select variants with increasing metastatic potential. COLO 357 line fast-growing cells were injected into the spleen or pancreas of nude mice. Hepatic metastases were harvested, and tumor cells were re...

journal_title：Neoplasia (New York, N.Y.)

authors： Bruns CJ,Harbison MT,Kuniyasu H,Eue I,Fidler IJ

更新日期：1999-04-01 00:00:00

abstract：:Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity and might influence the prognosis of UUT-TCC. We examined the as...

journal_title：Neoplasia (New York, N.Y.)

authors： Sasaki M,Sakano S,Okayama N,Akao J,Hara T,Kawai Y,Ohmi C,Hinoda Y,Naito K

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate cancer. Inhibition of the antiapoptotic proteins Bcl-2 and Mcl-1 may delay the transition to androgen-independent growth. EXPERIMENTAL DESIGN:We have established a prostate cancer model with...

journal_title：Neoplasia (New York, N.Y.)

authors： Loberg RD,McGregor N,Ying C,Sargent E,Pienta KJ

更新日期：2007-12-01 00:00:00

abstract：:The bcl-2 and c-myc oncogenes cooperate to transform multiple cell types. In the pediatric malignancy NB(2), Bcl-2 is highly expressed. In tumors with a poor prognosis, N-Myc, a protein homologous to c-Myc, is overexpressed as a result of gene amplification. The present study was designed to determine whether Bcl-2 co...

journal_title：Neoplasia (New York, N.Y.)

authors： Jasty R,van Golen C,Lin HJ,Solomon G,Heidelberger K,Polverini P,Opipari A,Feldman E,Castle VP

更新日期：2001-07-01 00:00:00

abstract：:SEMA3F is a secreted semaphorin with potent antitumor activity, which is frequently downregulated in lung cancer. In cancer cell lines, SEMA3F overexpression decreases hypoxia-induced factor 1alpha protein and vascular endothelial growth factor mRNA, and inhibits multiple signaling components. Therefore, understanding...

journal_title：Neoplasia (New York, N.Y.)

authors： Clarhaut J,Gemmill RM,Potiron VA,Ait-Si-Ali S,Imbert J,Drabkin HA,Roche J

更新日期：2009-02-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors that are rarely curable, even with aggressive therapy (surgery, chemotherapy, and radiation). Glioblastomas frequently display loss of PTEN and/or epidermal growth factor receptor activation, both of which activate the PI3K pathway. This pathway can increase vascular endothelia...

journal_title：Neoplasia (New York, N.Y.)

authors： Pore N,Gupta AK,Cerniglia GJ,Maity A

更新日期：2006-11-01 00:00:00

abstract：:There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)-derived EVs on gastric organoids (gastroids) and elucidated molecular mechanisms underlying the...

journal_title：Neoplasia (New York, N.Y.)

authors： Ke X,Yan R,Sun Z,Cheng Y,Meltzer A,Lu N,Shu X,Wang Z,Huang B,Liu X,Wang Z,Song JH,Ng CK,Ibrahim S,Abraham JM,Shin EJ,He S,Meltzer SJ

更新日期：2017-11-01 00:00:00

abstract：:Modulation of the antitumor immune response through the engagement of NKG2D receptors with their ligands (L) on targets represents a promising therapeutic approach against cancer. In this study, we tested the effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, on the expression of NKG2D ligands in m...

journal_title：Neoplasia (New York, N.Y.)

authors： Wu X,Tao Y,Hou J,Meng X,Shi J

更新日期：2012-12-01 00:00:00

abstract：:The expression of N-cadherin (NCAD) has been shown to correlate with increased tumor cell motility and metastasis. However, NCAD-mediated adhesion is a robust phenomenon and therefore seems to be inconsistent with the "release" from intercellular adhesion required for invasion. We show that in the most invasive melano...

journal_title：Neoplasia (New York, N.Y.)

authors： Maret D,Gruzglin E,Sadr MS,Siu V,Shan W,Koch AW,Seidah NG,Del Maestro RF,Colman DR

更新日期：2010-12-01 00:00:00

abstract：:Recent studies suggest that tumor-infiltrating immune cells can benefit the tumor by producing factors that promote angiogenesis and suppress immunity. Because the tumor microenvironment is characterized by high adenosine levels, we hypothesized that the low-affinity A(2B) adenosine receptor located on host immune cel...

journal_title：Neoplasia (New York, N.Y.)

authors： Ryzhov S,Novitskiy SV,Zaynagetdinov R,Goldstein AE,Carbone DP,Biaggioni I,Dikov MM,Feoktistov I

更新日期：2008-09-01 00:00:00

abstract：:One of the challenges of tailored antiangiogenic therapy is the ability to adequately monitor the angiogenic activity of a malignancy in response to treatment. The α(v)β(3) integrin, highly overexpressed on newly formed tumor vessels, has been successfully used as a target for Arg-Gly-Asp (RGD)-functionalized nanopart...

journal_title：Neoplasia (New York, N.Y.)

authors： Jarzyna PA,Deddens LH,Kann BH,Ramachandran S,Calcagno C,Chen W,Gianella A,Dijkhuizen RM,Griffioen AW,Fayad ZA,Mulder WJ

更新日期：2012-10-01 00:00:00

abstract：:We present an in vivo fluorescence microscopic evaluation of intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6 (NPe6) in an intradermal mouse EMT6 tumor model. Although the identification of favorable photophysical and pharmacological properties has led to the development of new photosensitizers...

journal_title：Neoplasia (New York, N.Y.)

authors： Mitra S,Foster TH

更新日期：2008-05-01 00:00:00