Chronic pancreatitis and systemic inflammatory response syndrome prevent impact of chemotherapy with gemcitabine in a genetically engineered mouse model of pancreatic cancer.

abstract：:Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PanINs), the precursor lesions, are a potential target for chemoprevention. Targeting eicosanoid pathways is an obvious choice because 5-lipoxygenase (5-LOX) has been s...

journal_title：Neoplasia (New York, N.Y.)

authors： Hennig R,Kehl T,Noor S,Ding XZ,Rao SM,Bergmann F,Fürstenberger G,Büchler MW,Friess H,Krieg P,Adrian TE

更新日期：2007-11-01 00:00:00

abstract：:While normal cells in the human breast are organized into acinar structures, disruption of the acinar architecture is a hallmark of cancer. In a three-dimensional model of morphogenesis, we show that down-regulation of the matrix-associated tumor suppressor protein CCN6 (WNT1-inducible-signaling pathway protein 3) dis...

journal_title：Neoplasia (New York, N.Y.)

authors： Pal A,Huang W,Toy KA,Kleer CG

更新日期：2012-11-01 00:00:00

abstract：:We investigated the epigenetic silencing and genetic changes of the RAS-associated domain family 1A (RASSF1A) gene and the O6-methylguanine-DNA methyltransferase (MGMT) gene in retinoblastoma. We extracted DNA from microdissected tumor and normal retina tissues of the same patient in 68 retinoblastoma cases. Promoter ...

journal_title：Neoplasia (New York, N.Y.)

authors： Choy KW,Lee TC,Cheung KF,Fan DS,Lo KW,Beaverson KL,Abramson DH,Lam DS,Yu CB,Pang CP

更新日期：2005-03-01 00:00:00

abstract：:Modulation of the antitumor immune response through the engagement of NKG2D receptors with their ligands (L) on targets represents a promising therapeutic approach against cancer. In this study, we tested the effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, on the expression of NKG2D ligands in m...

journal_title：Neoplasia (New York, N.Y.)

authors： Wu X,Tao Y,Hou J,Meng X,Shi J

更新日期：2012-12-01 00:00:00

abstract：:Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Concerning this, it h...

journal_title：Neoplasia (New York, N.Y.)

authors： Jung YS,Chun HY,Yoon MH,Park BJ

更新日期：2014-12-01 00:00:00

abstract：:Salmonella infection is a major public health concern, and colonization in humans can be chronic and increases the risk of cancers. Wnt signaling is a key pathway for intestinal renewal and development, inflammation, and tumorigenesis. In the current study, we report a novel role of Wnt1 in infection and colon cancer ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang J,Lu R,Fu X,Dan Z,Zhang YG,Chang X,Liu Q,Xia Y,Liu X,Sun J

更新日期：2018-05-01 00:00:00

abstract：:Previous studies have suggested that tumor hypoxia could be exploited for cancer gene therapy. Using hypoxia-responsive elements derived from the human vascular endothelial growth factor gene, we have generated vectors expressing a bacterial nitroreductase (NTR) gene that can activate the anticancer prodrug CB1954. St...

journal_title：Neoplasia (New York, N.Y.)

authors： Shibata T,Giaccia AJ,Brown JM

更新日期：2002-01-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is an important process of tumor progression associated with increased metastatic potential. EMT can be activated by external triggers such as cytokines or metabolic parameters (e.g. hypoxia). Since extracellular acidosis is a common finding in tumors, the aim of the study is...

journal_title：Neoplasia (New York, N.Y.)

authors： Riemann A,Rauschner M,Gießelmann M,Reime S,Haupt V,Thews O

更新日期：2019-05-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer. Clinical trials using the United States Food and Drug Administration (FDA)-approved, AMPK-activating, antidiabetic drug metformin a...

journal_title：Neoplasia (New York, N.Y.)

authors： Buac D,Kona FR,Seth AK,Dou QP

更新日期：2013-12-01 00:00:00

abstract：:We determined whether the implantation of human pancreatic cancer cells into the pancreas of nude mice can be used to select variants with increasing metastatic potential. COLO 357 line fast-growing cells were injected into the spleen or pancreas of nude mice. Hepatic metastases were harvested, and tumor cells were re...

journal_title：Neoplasia (New York, N.Y.)

authors： Bruns CJ,Harbison MT,Kuniyasu H,Eue I,Fidler IJ

更新日期：1999-04-01 00:00:00

abstract：:Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG. Studies on the molecular mechanisms and functional consequences of this important chromosomal rea...

journal_title：Neoplasia (New York, N.Y.)

authors： Mertz KD,Setlur SR,Dhanasekaran SM,Demichelis F,Perner S,Tomlins S,Tchinda J,Laxman B,Vessella RL,Beroukhim R,Lee C,Chinnaiyan AM,Rubin MA

更新日期：2007-03-01 00:00:00

abstract：:The bcl-2 and c-myc oncogenes cooperate to transform multiple cell types. In the pediatric malignancy NB(2), Bcl-2 is highly expressed. In tumors with a poor prognosis, N-Myc, a protein homologous to c-Myc, is overexpressed as a result of gene amplification. The present study was designed to determine whether Bcl-2 co...

journal_title：Neoplasia (New York, N.Y.)

authors： Jasty R,van Golen C,Lin HJ,Solomon G,Heidelberger K,Polverini P,Opipari A,Feldman E,Castle VP

更新日期：2001-07-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand these critical cells in tumor progression, we screened a portfolio of rationally selected, injectable agents to image endogenous TAMs ubiquitously in three differen...

journal_title：Neoplasia (New York, N.Y.)

authors： Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ

更新日期：2009-05-01 00:00:00

abstract：:Glucose transport across glioblastoma membranes plays a crucial role in maintaining the enhanced glycolysis typical of high-grade gliomas and glioblastoma. We tested the ability of two inhibitors of the glucose transporters GLUT/SLC2A superfamily, indinavir (IDV) and ritonavir (RTV), and of one inhibitor of the Na/glu...

journal_title：Neoplasia (New York, N.Y.)

authors： Azzalin A,Nato G,Parmigiani E,Garello F,Buffo A,Magrassi L

更新日期：2017-04-01 00:00:00

abstract：:Glioblastoma (GBM) represents the most aggressive malignancy of the central nervous system. Increased expression of Angiotensin II Receptor Type 1 (AGTR1) has been associated with proliferative and infiltrative properties of glioma cells. However, the underlying mechanism of AGTR1 upregulation in GBM is still unexplor...

journal_title：Neoplasia (New York, N.Y.)

authors： Singh A,Srivastava N,Yadav A,Ateeq B

更新日期：2020-10-01 00:00:00

abstract：:The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R. In human U87MG glioblastoma cells, AChE-R formed a triple complex wit...

journal_title：Neoplasia (New York, N.Y.)

authors： Perry C,Sklan EH,Soreq H

更新日期：2004-05-01 00:00:00

abstract：:Type I cells have been defined to be independent of mitochondria for the induction of Fas death receptor-mediated apoptosis, whereas Type II cells are mitochondria-dependent. Knock-out studies in mice show that thymocytes are Type I and liver cells are Type II. We have previously shown that primary human hepatocytes a...

journal_title：Neoplasia (New York, N.Y.)

authors： Ozören N,El-Deiry WS

更新日期：2002-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) latent infection is a critical event in nasopharyngeal carcinoma (NPC) tumorigenesis. EBV-encoded genes have been shown to be involved in immune evasion and in the regulation of various cellular signaling cascades. To elucidate the roles of EBV in NPC development, stable infection of EBV in na...

journal_title：Neoplasia (New York, N.Y.)

authors： Lo AK,Lo KW,Tsao SW,Wong HL,Hui JW,To KF,Hayward DS,Chui YL,Lau YL,Takada K,Huang DP

更新日期：2006-03-01 00:00:00

abstract：:It has been proposed that human colorectal tumors can be classified into two groups: one in which methylation is rare, and another with methylation of several loci associated with a "CpG island methylated phenotype (CIMP)," characterized by preferential proximal location in the colon, but otherwise poorly defined. The...

journal_title：Neoplasia (New York, N.Y.)

authors： Anacleto C,Leopoldino AM,Rossi B,Soares FA,Lopes A,Rocha JC,Caballero O,Camargo AA,Simpson AJ,Pena SD

更新日期：2005-04-01 00:00:00

abstract：:Treatment decisions in oncology are increasingly guided by information on the biologic characteristics of tumors. Currently, patient-specific information on tumor biology is obtained from the analysis of biopsy material. Positron emission tomography (PET) provides quantitative estimates of regional biochemistry and re...

journal_title：Neoplasia (New York, N.Y.)

authors： Mankoff DA,Dehdashti F,Shields AF

更新日期：2000-01-01 00:00:00

abstract：:We used the standard comet assay successfully to generate in vitro dose-response curves under oxic and hypoxic conditions. We then made mixtures of cells that had been irradiated with 3 and 9 Gy of X-rays to simulate two subpopulations in a tumor, but efforts to accurately detect and quantify the subpopulations using ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang J,Klem J,Wyrick JB,Ozawa T,Cunningham E,Golinveaux J,Allen MJ,Lamborn KR,Deen DF

更新日期：2003-07-01 00:00:00

abstract：:Bcl-2 is commonly overexpressed in tumors, where it is often associated with unfavorable outcome. However, it has also been linked to a favorable sensitivity to microtubule-targeting agents (MTAs). We show that Bcl-2-overexpressing lung and breast cancer cells were more sensitive to both paclitaxel and vinorelbine. Bc...

journal_title：Neoplasia (New York, N.Y.)

authors： Savry A,Carre M,Berges R,Rovini A,Pobel I,Chacon C,Braguer D,Bourgarel-Rey V

更新日期：2013-01-01 00:00:00

abstract：:The infection of hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC), in which HBV X protein (HBx) plays crucial roles. MicroRNAs are involved in diverse biologic functions and in carcinogenesis by regulating gene expression. In the present study, we aim to investigate ...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang T,Zhang J,Cui M,Liu F,You X,Du Y,Gao Y,Zhang S,Lu Z,Ye L,Zhang X

更新日期：2013-11-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)-targeted therapies predominantly affect nascent, immature tumor vessels. Since platelet-derived growth factor receptor (PDGFR) blockade inhibits vessel maturation and thus increases the amount of immature tumor vessels, we evaluated whether the combined P...

journal_title：Neoplasia (New York, N.Y.)

authors： Zafarnia S,Bzyl-Ibach J,Spivak I,Li Y,Koletnik S,Doleschel D,Rix A,Pochon S,Tardy I,Koyadan S,van Zandvoort M,Palmowski M,Kiessling F,Lederle W

更新日期：2017-11-01 00:00:00

abstract：:Research efforts in the area of palaeopathology have been seen as an avenue to improve our understanding of the pathogenesis of cancer. Answers to questions of whether dinosaurs had cancer, or if cancer plagued ancient civilizations, have captured the imagination as well as the popular media. Evidence for dinosaurian ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rehemtulla A

更新日期：2010-12-01 00:00:00

abstract：:Originally identified as an oncogene activated by amplification in squamous cell carcinomas, several lines of evidence now suggest that squamous cell carcinoma-related oncogene (SCCRO; aka DCUN1D1) may play a role in the pathogenesis of a wide range of human cancers including gliomas. SCCRO's oncogenic function is sub...

journal_title：Neoplasia (New York, N.Y.)

authors： Broderick SR,Golas BJ,Pham D,Towe CW,Talbot SG,Kaufman A,Bains S,Huryn LA,Yonekawa Y,Carlson D,Hambardzumyan D,Ramanathan Y,Singh B

更新日期：2010-06-01 00:00:00

abstract：:Using bioinformatics, we have identified a novel tumor-specific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (...

journal_title：Neoplasia (New York, N.Y.)

authors： Li Y,Dong X,Yin Y,Su Y,Xu Q,Zhang Y,Pang X,Zhang Y,Chen W

更新日期：2005-12-01 00:00:00

abstract：:Interstitial fluid pressure (IFP) has been shown to be an independent prognostic parameter for disease-free survival in cervical carcinoma patients treated with radiation therapy. However, the underlying mechanisms are not fully understood. The main aims of this study were to investigate whether tumor radiocurability ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rofstad EK,Gaustad JV,Brurberg KG,Mathiesen B,Galappathi K,Simonsen TG

更新日期：2009-11-01 00:00:00

abstract：:The MEK-ERK growth signaling pathway is important in human hepatocellular carcinoma (HCC). To evaluate the targeting of this pathway in HCC, we characterized a novel, orally-active MEK inhibitor, PD184161, using human HCC cells (HepG2, Hep3B, PLC, and SKHep) and in vivo human tumor xenografts. PD184161 inhibited MEK a...

journal_title：Neoplasia (New York, N.Y.)

authors： Klein PJ,Schmidt CM,Wiesenauer CA,Choi JN,Gage EA,Yip-Schneider MT,Wiebke EA,Wang Y,Omer C,Sebolt-Leopold JS

更新日期：2006-01-01 00:00:00

abstract：:Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PRKAR1A causes enhance...

journal_title：Neoplasia (New York, N.Y.)

authors： Jones GN,Tep C,Towns WH 2nd,Mihai G,Tonks ID,Kay GF,Schmalbrock PM,Stemmer-Rachamimov AO,Yoon SO,Kirschner LS

更新日期：2008-11-01 00:00:00