An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.

abstract：:Chordoma is a rare tumor arising in the sacrum, clivus, or vertebrae. It is often not completely resectable and shows a high incidence of recurrence and progression with shortened patient survival and impaired quality of life. Chemotherapeutic options are limited to investigational therapies at present. Therefore, adj...

journal_title：Neoplasia (New York, N.Y.)

authors： Diaz RJ,Guduk M,Romagnuolo R,Smith CA,Northcott P,Shih D,Berisha F,Flanagan A,Munoz DG,Cusimano MD,Pamir MN,Rutka JT

更新日期：2012-09-01 00:00:00

abstract：:This white paper discusses prospects for advancing hyperpolarization technology to better understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13C magnetic resonance imaging's (MRI's) widespread clinical use, and provide recommendations for overcoming them. Since the publication of the first...

journal_title：Neoplasia (New York, N.Y.)

authors： Kurhanewicz J,Vigneron DB,Ardenkjaer-Larsen JH,Bankson JA,Brindle K,Cunningham CH,Gallagher FA,Keshari KR,Kjaer A,Laustsen C,Mankoff DA,Merritt ME,Nelson SJ,Pauly JM,Lee P,Ronen S,Tyler DJ,Rajan SS,Spielman DM,Wald

更新日期：2019-01-01 00:00:00

abstract：:Previously, we identified the transcription factor CUX1 as an important modulator of invasion and resistance to apoptosis. Expression profiles suggested that CUX1 regulates a complex transcriptional program mediating tumor progression. We aimed to identify functionally relevant targets of CUX1 by using RNA interferenc...

journal_title：Neoplasia (New York, N.Y.)

authors： Ripka S,Riedel J,Neesse A,Griesmann H,Buchholz M,Ellenrieder V,Moeller F,Barth P,Gress TM,Michl P

更新日期：2010-08-01 00:00:00

abstract：:Identification of the cell types capable of initiating and sustaining growth of the neoplastic clone in vivo is a fundamental problem in cancer research. It is likely that tumor growth can be sustained both by rare cancer stem-like cells and selected aggressive clones and that the nature of the mutations, the cell of ...

journal_title：Neoplasia (New York, N.Y.)

authors： Tysnes BB

更新日期：2010-07-01 00:00:00

abstract：:Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate. Pyruvate is a main glycolytic metabolite that could be mainly converted into either lactate by Lactate Dehydrogenase A (L...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen TY,Hsieh YT,Huang JM,Liu CJ,Chuang LT,Huang PC,Kuo TY,Chia HY,Chou CY,Chang CW,Chen YF,Chen HM,Lo JF,Li WC

更新日期：2019-07-01 00:00:00

abstract：:Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PRKAR1A causes enhance...

journal_title：Neoplasia (New York, N.Y.)

authors： Jones GN,Tep C,Towns WH 2nd,Mihai G,Tonks ID,Kay GF,Schmalbrock PM,Stemmer-Rachamimov AO,Yoon SO,Kirschner LS

更新日期：2008-11-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand these critical cells in tumor progression, we screened a portfolio of rationally selected, injectable agents to image endogenous TAMs ubiquitously in three differen...

journal_title：Neoplasia (New York, N.Y.)

authors： Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ

更新日期：2009-05-01 00:00:00

abstract：:Wnt/beta-catenin signaling plays an important role in normal development. However, its aberrant activation is associated with several cancers. The aim of this study is to examine the Wnt/beta-catenin pathway in patients with advanced pancreatic adenocarcinoma (n = 31). Paraffin sections from tumors (n = 16) and normal...

journal_title：Neoplasia (New York, N.Y.)

authors： Zeng G,Germinaro M,Micsenyi A,Monga NK,Bell A,Sood A,Malhotra V,Sood N,Midda V,Monga DK,Kokkinakis DM,Monga SP

更新日期：2006-04-01 00:00:00

abstract：:Gemcitabine is widely used as first-line chemotherapeutic drug in the treatment of pancreatic cancer. Our previous experimental chemotherapy studies have shown that treatment of human pancreatic carcinoma cells with 5-fluorouracil (5-FU) alters the cellular transporter expression profile and that modulation of the exp...

journal_title：Neoplasia (New York, N.Y.)

authors： Hagmann W,Jesnowski R,Löhr JM

更新日期：2010-09-01 00:00:00

abstract：:Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduce the risk and mortality from colorectal cancer, in part by inhibiting prostaglandin (PG) synthesis. Cyclooxygenase (COX), the rate-limiting enzyme in PG biosynthesis, exists in two isoforms, COX-1 and COX-2. Genetic...

journal_title：Neoplasia (New York, N.Y.)

authors： Tong BJ,Tan J,Tajeda L,Das SK,Chapman JA,DuBois RN,Dey SK

更新日期：2000-11-01 00:00:00

abstract：:Glioblastoma (GBM) represents the most aggressive malignancy of the central nervous system. Increased expression of Angiotensin II Receptor Type 1 (AGTR1) has been associated with proliferative and infiltrative properties of glioma cells. However, the underlying mechanism of AGTR1 upregulation in GBM is still unexplor...

journal_title：Neoplasia (New York, N.Y.)

authors： Singh A,Srivastava N,Yadav A,Ateeq B

更新日期：2020-10-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity ...

journal_title：Neoplasia (New York, N.Y.)

authors： Muñoz-Hidalgo L,San-Miguel T,Megías J,Monleón D,Navarro L,Roldán P,Cerdá-Nicolás M,López-Ginés C

更新日期：2020-01-01 00:00:00

abstract：:We previously reported that overexpression of an O-type glycosyltransferase, GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6) played critical roles in mammary carcinogenesis. To further investigate the biological function of GALNT6, we screened a substrate protein(s) of GALNT6 using a VVA (Vicia villosa agglut...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin J,Chung S,Ueda K,Matsuda K,Nakamura Y,Park JH

更新日期：2017-01-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the major gastrointestinal mesenchymal tumors with a variable malignancy ranging from a curable disorder to highly malignant sarcomas. Metastasis and recurrence are the main causes of death in GIST patients. To further explore the mechanism of metastasis and to more accurate...

journal_title：Neoplasia (New York, N.Y.)

authors： Ma MZ,Zhuang C,Yang XM,Zhang ZZ,Ma H,Zhang WM,You H,Qin W,Gu J,Yang S,Cao H,Zhang ZG

更新日期：2014-03-01 00:00:00

abstract：:Gastrin-releasing peptide receptor (GRPR) and the epidermal growth factor receptor (EGFR) are expressed in several cancers including non-small cell lung cancer (NSCLC). Here we demonstrate the activation of EGFR by the GRPR ligand, gastrin-releasing peptide (GRP), in NSCLC cells. GRP induced rapid activation of p44/42...

journal_title：Neoplasia (New York, N.Y.)

authors： Thomas SM,Grandis JR,Wentzel AL,Gooding WE,Lui VW,Siegfried JM

更新日期：2005-04-01 00:00:00

abstract：:Anoikis, a cell death mechanism triggered upon cell-matrix detachment, is regarded as a physiological suppressor of metastasis that can be regulated by a diverse array of signals. The protein encoded by GDF2 is BMP9 and is a member of the bone morphogenetic protein family and the transforming growth factor (TGF) β sup...

journal_title：Neoplasia (New York, N.Y.)

authors： Varadaraj A,Patel P,Serrao A,Bandyopadhay T,Lee NY,Jazaeri AA,Huang Z,Murphy SK,Mythreye K

更新日期：2015-11-01 00:00:00

abstract：:Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies demonstrating a cor...

journal_title：Neoplasia (New York, N.Y.)

authors： Chiu RK,Carpenito C,Dougherty ST,Hayes GM,Dougherty GJ

更新日期：1999-11-01 00:00:00

abstract：:Conventional comparative genomic hybridization (CGH) profiling of neuroblastomas has identified many genomic aberrations, although the limited resolution has precluded a precise localization of sequences of interest within amplicons. To map high copy number genomic gains in clinically matched stage IV neuroblastomas, ...

journal_title：Neoplasia (New York, N.Y.)

authors： Beheshti B,Braude I,Marrano P,Thorner P,Zielenska M,Squire JA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Inflammatory breast cancer (IBC) is arguably the deadliest form of breast cancer due to its rapid onset and highly invasive nature. IBC carries 5- and 10-year disease-free survival rates of ~45% and <20%, respectively. Multiple studies demonstrate that in comparison with conventional breast cancer, IBC has a un...

journal_title：Neoplasia (New York, N.Y.)

authors： Joglekar-Javadekar M,Van Laere S,Bourne M,Moalwi M,Finetti P,Vermeulen PB,Birnbaum D,Dirix LY,Ueno N,Carter M,Rains J,Ramachandran A,Bertucci F,van Golen KL

更新日期：2017-07-01 00:00:00

abstract：:Mutation of the PARK2 gene can promote both Parkinson's Disease and cancer, yet the underlying mechanisms of how PARK2 controls cellular physiology is incompletely understood. Here, we show that the PARK2 tumor suppressor controls the apoptotic regulator BCL-XL and modulates programmed cell death. Analysis of approxim...

journal_title：Neoplasia (New York, N.Y.)

authors： Gong Y,Schumacher SE,Wu WH,Tang F,Beroukhim R,Chan TA

更新日期：2017-02-01 00:00:00

abstract：:The human gyrovirus derived protein Apoptin (HGV-Apoptin) a homologue of the chicken anemia virus Apoptin (CAV-Apoptin), a protein with high cancer cells selective toxicity, triggers apoptosis selectively in cancer cells. In this paper, we show that HGV-Apoptin acts independently from the death receptor pathway as it ...

journal_title：Neoplasia (New York, N.Y.)

authors： Chaabane W,Cieślar-Pobuda A,El-Gazzah M,Jain MV,Rzeszowska-Wolny J,Rafat M,Stetefeld J,Ghavami S,Los MJ

更新日期：2014-09-01 00:00:00

abstract：:A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG. The TMPRSS2-ERG fusion is observed in around 90% of tumors that overexpress the oncogene ERG. The goal o...

journal_title：Neoplasia (New York, N.Y.)

authors： Pflueger D,Rickman DS,Sboner A,Perner S,LaFargue CJ,Svensson MA,Moss BJ,Kitabayashi N,Pan Y,de la Taille A,Kuefer R,Tewari AK,Demichelis F,Chee MS,Gerstein MB,Rubin MA

更新日期：2009-08-01 00:00:00

abstract：:The biologic plausibility of an association between type 2 diabetes mellitus (T2D) and lung cancer has received increasing attention, but the results of investigations remain largely inconclusive. In the present study we investigated the influence of the anti-diabetic drug metformin on the cytotoxic effects of EGFR ta...

journal_title：Neoplasia (New York, N.Y.)

authors： Xiao Z,Gaertner S,Morresi-Hauf A,Genzel R,Duell T,Ullrich A,Knyazev PG

更新日期：2017-05-01 00:00:00

abstract：:Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair. Dbait (which stands for DNA strand break bait) molecules mimic DSBs and trap DNA repair proteins, thereby inhibiting repair of DNA damage induced by radiation therapy (RT). First, the cytotoxic efficacy of Dbait i...

journal_title：Neoplasia (New York, N.Y.)

authors： Biau J,Devun F,Jdey W,Kotula E,Quanz M,Chautard E,Sayarath M,Sun JS,Verrelle P,Dutreix M

更新日期：2014-10-23 00:00:00

abstract：:Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase activity and immortal...

journal_title：Neoplasia (New York, N.Y.)

authors： Yi X,White DM,Aisner DL,Baur JA,Wright WE,Shay JW

更新日期：2000-09-01 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCC) are frequently characterized by chemotherapy and radiation resistance, and by overexpression of Bcl-XL, an antiapoptotic member of the Bcl-2 protein family. In this report we examined whether cell-permeable peptides derived from the BH3 domains of proapoptotic Bax, Bad, o...

journal_title：Neoplasia (New York, N.Y.)

authors： Li R,Boehm AL,Miranda MB,Shangary S,Grandis JR,Johnson DE

更新日期：2007-10-01 00:00:00

abstract：:Human carcinoembryonic antigen (CEA) and the CEA family member CEACAM6 (formerly nonspecific cross-reacting antigen [NCA]) function in vitro, at least, as homotypic intercellular adhesion molecules and, in model systems, can block the terminal differentiation and anoikis of several different cell types. We have recent...

journal_title：Neoplasia (New York, N.Y.)

authors： Ilantzis C,DeMarte L,Screaton RA,Stanners CP

更新日期：2002-03-01 00:00:00

abstract：:Preclinical studies have shown that gefitinib, licofelone, atorvastatin, and α-difluoromethylornithine (GLAD) are promising colon cancer chemopreventive agents. Because low-dose combination regimens can offer potential additive or synergistic effects without toxicity, GLAD combination was tested for toxicity and chemo...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohammed A,Janakiram NB,Brewer M,Vedala K,Steele VE,Rao CV

更新日期：2013-05-01 00:00:00

abstract：:Although it is well known that nasopharyngeal carcinoma (NPC) is closely related with Epstein-Barr virus (EBV), few data are available about which and how EBV-expressed gene is involved in the carcinogenesis of human nasopharyngeal epithelial cells. EBV-encoded BARF1 (BamH I-A right frame 1) gene has been shown to be ...

journal_title：Neoplasia (New York, N.Y.)

authors： Jiang R,Cabras G,Sheng W,Zeng Y,Ooka T

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) kinase is overexpressed in various tumors and has been linked to poor prognosis. Its role as proto-oncogene is based on several Pim-1 target proteins involved in pivotal cellular processes. Here, we explore the functional relevance of Pim...

journal_title：Neoplasia (New York, N.Y.)

authors： Weirauch U,Beckmann N,Thomas M,Grünweller A,Huber K,Bracher F,Hartmann RK,Aigner A

更新日期：2013-07-01 00:00:00