Pushing the optical imaging limits of cancer with multi-frequency-band raster-scan optoacoustic mesoscopy (RSOM).

abstract：:This white paper discusses prospects for advancing hyperpolarization technology to better understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13C magnetic resonance imaging's (MRI's) widespread clinical use, and provide recommendations for overcoming them. Since the publication of the first...

journal_title：Neoplasia (New York, N.Y.)

authors： Kurhanewicz J,Vigneron DB,Ardenkjaer-Larsen JH,Bankson JA,Brindle K,Cunningham CH,Gallagher FA,Keshari KR,Kjaer A,Laustsen C,Mankoff DA,Merritt ME,Nelson SJ,Pauly JM,Lee P,Ronen S,Tyler DJ,Rajan SS,Spielman DM,Wald

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIMS:BACKGROUND AND AIMSGemcitabine is the standard therapy for patients with pancreatic cancer with metastatic disease. Patients with metastatic pancreatic cancer presenting with increased values of C-reactive protein do not respond to gemcitabine. So far, no studies have evaluated the correlation betwe...

journal_title：Neoplasia (New York, N.Y.)

authors： Knoop RF,Sparn M,Waldmann J,Plassmeier L,Bartsch DK,Lauth M,Hudemann C,Fendrich V

更新日期：2014-06-01 00:00:00

abstract：:Activation of the insulin-like growth factor-1 receptor (IGF-1R) by IGF-1 is associated with the risk and progression of many types of cancer, although despite this it remains unclear how activated IGF-1R contributes to cancer progression. In this study, gene expression changes elicited by IGF-1 were profiled in breas...

journal_title：Neoplasia (New York, N.Y.)

authors： Oh JS,Kucab JE,Bushel PR,Martin K,Bennett L,Collins J,DiAugustine RP,Barrett JC,Afshari CA,Dunn SE

更新日期：2002-05-01 00:00:00

abstract：:The progression of ovarian cancer, from cell transformation through invasion of normal tissue, relies on communication between tumor cells and their adjacent stromal microenvironment. Through a natural selection process, an autocrine-paracrine communication loop establishes reciprocal reinforcement of growth and migra...

journal_title：Neoplasia (New York, N.Y.)

authors： Schauer IG,Sood AK,Mok S,Liu J

更新日期：2011-05-01 00:00:00

abstract：:Increases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in c...

journal_title：Neoplasia (New York, N.Y.)

authors： Barraclough J,Hodgkinson C,Hogg A,Dive C,Welman A

更新日期：2007-09-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is an important process of tumor progression associated with increased metastatic potential. EMT can be activated by external triggers such as cytokines or metabolic parameters (e.g. hypoxia). Since extracellular acidosis is a common finding in tumors, the aim of the study is...

journal_title：Neoplasia (New York, N.Y.)

authors： Riemann A,Rauschner M,Gießelmann M,Reime S,Haupt V,Thews O

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Foxhead box M1 (FOXM1) expression has been shown to be linked with human papillomavirus (HPV) 16/18-infected cervical cancer. However, the mechanism underlying the induction of FOXM1 in HPV 16/18-infected cancers remains elusive. EXPERIMENTAL DESIGN:The mechanistic actions of FOXM1 induced by the E6/NKX2-1 axi...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen PM,Cheng YW,Wang YC,Wu TC,Chen CY,Lee H

更新日期：2014-11-20 00:00:00

abstract：:We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine, i.e., fms-like tyrosine kinase 3 ligand (Flt3L) leads to T-cell-dependent tumor regression in rod...

journal_title：Neoplasia (New York, N.Y.)

authors： Candolfi M,Curtin JF,Yagiz K,Assi H,Wibowo MK,Alzadeh GE,Foulad D,Muhammad AK,Salehi S,Keech N,Puntel M,Liu C,Sanderson NR,Kroeger KM,Dunn R,Martins G,Lowenstein PR,Castro MG

更新日期：2011-10-01 00:00:00

abstract：:It is known that total telomere length is shorter in invasive breast cancer than in normal breast tissue but the status of individual telomere lengths has not been studied. Part of the difficulty is that usually telomere length in interphase cells is measured on all chromosomes together. In this study we compared norm...

journal_title：Neoplasia (New York, N.Y.)

authors： Rashid-Kolvear F,Pintilie M,Done SJ

更新日期：2007-04-01 00:00:00

abstract：:The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth fac...

journal_title：Neoplasia (New York, N.Y.)

authors： Duignan IJ,Corcoran E,Pennello A,Plym MJ,Amatulli M,Claros N,Iacolina M,Youssoufian H,Witte L,Samakoglu S,Schwartz J,Surguladze D,Tonra JR

更新日期：2011-01-01 00:00:00

abstract：:Salmonella infection is a major public health concern, and colonization in humans can be chronic and increases the risk of cancers. Wnt signaling is a key pathway for intestinal renewal and development, inflammation, and tumorigenesis. In the current study, we report a novel role of Wnt1 in infection and colon cancer ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang J,Lu R,Fu X,Dan Z,Zhang YG,Chang X,Liu Q,Xia Y,Liu X,Sun J

更新日期：2018-05-01 00:00:00

abstract：:The genetic mechanisms underlying adrenocortical tumor development are still largely unknown. We used high-resolution single nucleotide polymorphism microarrays (Affymetrix SNP 6.0) to detect copy number alterations (CNAs) and copy-neutral losses of heterozygosity (cnLOH) in 15 cortisol-secreting adrenocortical adenom...

journal_title：Neoplasia (New York, N.Y.)

authors： Ronchi CL,Leich E,Sbiera S,Weismann D,Rosenwald A,Allolio B,Fassnacht M

更新日期：2012-03-01 00:00:00

abstract：:p21-activated kinase 2 (PAK-2) seems to be a regulatory switch between cell survival and cell death signaling. We have shown previously that activation of full-length PAK-2 by Rac or Cdc42 stimulates cell survival, whereas caspase activation of PAK-2 to the proapoptotic PAK-2p34 fragment is involved in the cell death ...

journal_title：Neoplasia (New York, N.Y.)

authors： Marlin JW,Eaton A,Montano GT,Chang YW,Jakobi R

更新日期：2009-03-01 00:00:00

abstract：:The maspin gene is not expressed in normal human pancreas, but its expression is acquired during human pancreatic carcinogenesis. In other normal human cells and their malignant counterparts, maspin expression is controlled through the epigenetic state of its promoter. In studies presented herein, we used bisulfite ge...

journal_title：Neoplasia (New York, N.Y.)

authors： Fitzgerald M,Oshiro M,Holtan N,Krager K,Cullen JJ,Futscher BW,Domann FE

更新日期：2003-09-01 00:00:00

abstract：:High microvascular density (MVD) in the primary tumor has been shown to be associated with increased incidence of lymph node metastases and poor clinical outcome. Other investigations have revealed that a large fraction of hypoxic tissue in the primary tumor is associated with metastatic disease and impaired survival....

journal_title：Neoplasia (New York, N.Y.)

authors： Rofstad EK,Galappathi K,Mathiesen BS

更新日期：2014-07-01 00:00:00

abstract：:The receptor tyrosine kinase MET is a major component controlling the invasive growth program in embryonic development and in invasive malignancies. The discovery of therapeutic antibodies against MET has been difficult, and antibodies that compete with hepatocyte growth factor (HGF) act as agonists. By applying phage...

journal_title：Neoplasia (New York, N.Y.)

authors： van der Horst EH,Chinn L,Wang M,Velilla T,Tran H,Madrona Y,Lam A,Ji M,Hoey TC,Sato AK

更新日期：2009-04-01 00:00:00

abstract：:The tumor-selective cytotoxic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) makes TRAIL an attractive candidate as an anticancer agent. However, resistance to TRAIL poses a challenge in anticancer therapy with TRAIL. Therefore, characterizing the mechanisms of resistance and developing stra...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang L,Zhu H,Teraishi F,Davis JJ,Guo W,Fan Z,Fang B

更新日期：2005-06-01 00:00:00

abstract：:In this study, a new compound, 4-(N)-docosahexaenoyl 2', 2'-difluorodeoxycytidine (DHA-dFdC), was synthesized and characterized. Its antitumor activity was evaluated in cell culture and in mouse models of pancreatic cancer. DHA-dFdC is a poorly soluble, pale yellow waxy solid, with a molecular mass of 573.3Da and a me...

journal_title：Neoplasia (New York, N.Y.)

authors： Naguib YW,Lansakara-P D,Lashinger LM,Rodriguez BL,Valdes S,Niu M,Aldayel AM,Peng L,Hursting SD,Cui Z

更新日期：2016-01-01 00:00:00

abstract：:Cancer, a proliferative disease hallmarked by abnormal cell growth and spread, is largely dependent on tumor neoangiogenesis, with evidence of vascular endothelial dysfunction. Novel ways to assess vascular function in cancer include measuring levels of circulating endothelial cells (CEC). Rare in healthy individuals,...

journal_title：Neoplasia (New York, N.Y.)

authors： Goon PK,Lip GY,Boos CJ,Stonelake PS,Blann AD

更新日期：2006-02-01 00:00:00

abstract：:SEMA3F is a secreted semaphorin with potent antitumor activity, which is frequently downregulated in lung cancer. In cancer cell lines, SEMA3F overexpression decreases hypoxia-induced factor 1alpha protein and vascular endothelial growth factor mRNA, and inhibits multiple signaling components. Therefore, understanding...

journal_title：Neoplasia (New York, N.Y.)

authors： Clarhaut J,Gemmill RM,Potiron VA,Ait-Si-Ali S,Imbert J,Drabkin HA,Roche J

更新日期：2009-02-01 00:00:00

abstract：:We report herein a method to track the migration of dendritic cells (DCs) using optical imaging. With the assistance of the delivery module, fluorescein isothiocyanate (FITC) could internalize inside DCs within 15 minutes of incubation. The fluorescent signal was mostly cytoplasmic and could be detected using in vivo ...

journal_title：Neoplasia (New York, N.Y.)

authors： Pham W,Xie J,Gore JC

更新日期：2007-12-01 00:00:00

abstract：:Several observations suggest a potential role of T-cell-mediated immunity in the control of neuroblastoma (NB). However, the generation of NB-specific cytotoxic T lymphocytes (CTL) on T-cell priming with tumor mRNA-transfected dendritic cells (DC) has never been investigated before. In the present study, the feasibili...

journal_title：Neoplasia (New York, N.Y.)

authors： Morandi F,Chiesa S,Bocca P,Millo E,Salis A,Solari M,Pistoia V,Prigione I

更新日期：2006-10-01 00:00:00

abstract：:We previously reported that overexpression of an O-type glycosyltransferase, GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6) played critical roles in mammary carcinogenesis. To further investigate the biological function of GALNT6, we screened a substrate protein(s) of GALNT6 using a VVA (Vicia villosa agglut...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin J,Chung S,Ueda K,Matsuda K,Nakamura Y,Park JH

更新日期：2017-01-01 00:00:00

abstract：:We have recently reported that elastin microfibril interface located protein 2 (EMILIN2), an extracellular matrix (ECM) glycoprotein, triggers cell death through a direct binding to death receptors. EMILIN2 thus influences cell viability through a mechanism that is unique for an ECM molecule. In the present work, we r...

journal_title：Neoplasia (New York, N.Y.)

authors： Mongiat M,Marastoni S,Ligresti G,Lorenzon E,Schiappacassi M,Perris R,Frustaci S,Colombatti A

更新日期：2010-04-01 00:00:00

abstract：:Using bioinformatics, we have identified a novel tumor-specific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (...

journal_title：Neoplasia (New York, N.Y.)

authors： Li Y,Dong X,Yin Y,Su Y,Xu Q,Zhang Y,Pang X,Zhang Y,Chen W

更新日期：2005-12-01 00:00:00

abstract：:Glucose transport across glioblastoma membranes plays a crucial role in maintaining the enhanced glycolysis typical of high-grade gliomas and glioblastoma. We tested the ability of two inhibitors of the glucose transporters GLUT/SLC2A superfamily, indinavir (IDV) and ritonavir (RTV), and of one inhibitor of the Na/glu...

journal_title：Neoplasia (New York, N.Y.)

authors： Azzalin A,Nato G,Parmigiani E,Garello F,Buffo A,Magrassi L

更新日期：2017-04-01 00:00:00

abstract：:Cancers originating from epithelial cells are the most common malignancies. No common expression profile of solid tumors compared to normal tissues has been described so far. Therefore we were interested if genes differentially expressed in the majority of carcinomas could be identified using bioinformatic methods. Co...

journal_title：Neoplasia (New York, N.Y.)

authors： Pilarsky C,Wenzig M,Specht T,Saeger HD,Grützmann R

更新日期：2004-11-01 00:00:00

abstract：:Tumor cells in the bone interact with the microenvironment to promote tumor cell survival and proliferation, resulting in a lethal phenotype for patients with advanced prostate cancer. Monocyte chemoattractant protein 1 (CCL2) is a member of the CC chemokine family and is known to promote monocyte chemotaxis to sites ...

journal_title：Neoplasia (New York, N.Y.)

authors： Loberg RD,Day LL,Harwood J,Ying C,St John LN,Giles R,Neeley CK,Pienta KJ

更新日期：2006-07-01 00:00:00

abstract：:Treatment decisions in oncology are increasingly guided by information on the biologic characteristics of tumors. Currently, patient-specific information on tumor biology is obtained from the analysis of biopsy material. Positron emission tomography (PET) provides quantitative estimates of regional biochemistry and re...

journal_title：Neoplasia (New York, N.Y.)

authors： Mankoff DA,Dehdashti F,Shields AF

更新日期：2000-01-01 00:00:00

abstract：:During normal sympathetic nervous system (SNS) development, cells of the ganglionic lineage can malignantly transform and develop into the childhood tumor neuroblastoma. Hypoxia-inducible transcription factors (HIFs) mediate cellular responses during normal development and are central in the adaptation to oxygen short...

journal_title：Neoplasia (New York, N.Y.)

authors： Mohlin S,Hamidian A,Påhlman S

更新日期：2013-03-01 00:00:00