Pushing the optical imaging limits of cancer with multi-frequency-band raster-scan optoacoustic mesoscopy (RSOM).

Abstract:

:Angiogenesis is a central cancer hallmark, necessary for supporting tumor growth and metastasis. In vivo imaging of angiogenesis is commonly applied, to understand dynamic processes in cancer development and treatment strategies. However, most radiological modalities today assess angiogenesis based on indirect mechanisms, such as the rate of contrast enhancement after contrast agent administration. We studied the performance of raster-scan optoacoustic mesoscopy (RSOM), to directly reveal the vascular network supporting melanoma growth in vivo, at 50 MHz and 100 MHz, through several millimeters of tumor depth. After comparing the performance at each frequency, we recorded, for the first time, high-resolution images of melanin tumor vasculature development in vivo, over a period of several days. Image validation was provided by means of cryo-slice sections of the same tumor after sacrificing the mice. We show how optoacoustic (photoacoustic) mesoscopy reveals a potentially powerful look into tumor angiogenesis, with properties and features that are markedly different than other radiological modalities. This will facilitate a better understanding of tumor's angiogenesis, and the evaluation of treatment strategies.

journal_name

Neoplasia

authors

Omar M,Schwarz M,Soliman D,Symvoulidis P,Ntziachristos V

doi

10.1016/j.neo.2014.12.010

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

208-14

issue

2

eissn

1522-8002

issn

1476-5586

pii

S1476-5586(14)00200-0

journal_volume

17

pub_type

杂志文章
  • Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment.

    abstract::Hu-antigen R (HuR) is an RNA-binding posttranscriptional regulator that belongs to the Hu/ELAV family. HuR expression levels are modulated by a variety of proteins, microRNAs, chemical compounds, or the microenvironment, and in turn, HuR affects mRNA stability and translation of various genes implicated in breast canc...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章,评审

    doi:10.1016/j.neo.2016.09.002

    authors: Kotta-Loizou I,Vasilopoulos SN,Coutts RH,Theocharis S

    更新日期:2016-11-01 00:00:00

  • Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation.

    abstract::Inhibitors of histone deacetylases have been shown to enhance the sensitivity of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand TRAIL-mediated cytotoxicity. Valproic acid (VA), a commonly used antiepileptic agent whose pharmacokinetics and toxicity profiles are well described, is a histone dea...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.05823

    authors: Ziauddin MF,Yeow WS,Maxhimer JB,Baras A,Chua A,Reddy RM,Tsai W,Cole GW Jr,Schrump DS,Nguyen DM

    更新日期:2006-06-01 00:00:00

  • Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma.

    abstract::Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduce the risk and mortality from colorectal cancer, in part by inhibiting prostaglandin (PG) synthesis. Cyclooxygenase (COX), the rate-limiting enzyme in PG biosynthesis, exists in two isoforms, COX-1 and COX-2. Genetic...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1038/sj.neo.7900119

    authors: Tong BJ,Tan J,Tajeda L,Das SK,Chapman JA,DuBois RN,Dey SK

    更新日期:2000-11-01 00:00:00

  • Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.

    abstract::Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a variety of malignancies. Our present study sought to determine whether oncogene BRAF and RAS mutations lead to increased HPR1 expression. Reverse transcription-polymerase chain reaction analysis...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.10790

    authors: Rao G,Liu D,Xing M,Tauler J,Prinz RA,Xu X

    更新日期:2010-11-01 00:00:00

  • Pleiotropic stromal effects of vascular endothelial growth factor receptor 2 antibody therapy in renal cell carcinoma models.

    abstract::The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth fac...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.101162

    authors: Duignan IJ,Corcoran E,Pennello A,Plym MJ,Amatulli M,Claros N,Iacolina M,Youssoufian H,Witte L,Samakoglu S,Schwartz J,Surguladze D,Tonra JR

    更新日期:2011-01-01 00:00:00

  • Tumor interstitial fluid pressure-a link between tumor hypoxia, microvascular density, and lymph node metastasis.

    abstract::High microvascular density (MVD) in the primary tumor has been shown to be associated with increased incidence of lymph node metastases and poor clinical outcome. Other investigations have revealed that a large fraction of hypoxic tissue in the primary tumor is associated with metastatic disease and impaired survival....

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2014.07.003

    authors: Rofstad EK,Galappathi K,Mathiesen BS

    更新日期:2014-07-01 00:00:00

  • An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity.

    abstract::Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase activity and immortal...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1038/sj.neo.7900113

    authors: Yi X,White DM,Aisner DL,Baur JA,Wright WE,Shay JW

    更新日期:2000-09-01 00:00:00

  • VEGFR3 inhibition chemosensitizes ovarian cancer stemlike cells through down-regulation of BRCA1 and BRCA2.

    abstract::In ovarian cancer, loss of BRCA gene expression in tumors is associated with improved response to chemotherapy and increased survival. A means to pharmacologically downregulate BRCA gene expression could improve the outcomes of patients with BRCA wild-type tumors. We report that vascular endothelial growth factor rece...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2014.04.003

    authors: Lim JJ,Yang K,Taylor-Harding B,Wiedemeyer WR,Buckanovich RJ

    更新日期:2014-04-01 00:00:00

  • Bypass of tumor drug resistance by antivascular therapy.

    abstract::Multidrug resistance (MDR) presents a major obstacle for the successful chemotherapy of cancer. Its emergence during chemotherapy is attributed to a selective process, which gives a growth advantage to MDR cells within the genetically unstable neoplastic cell population. The pleiotropic nature of clinical MDR poses a ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/s1476-5586(03)80031-3

    authors: Preise D,Mazor O,Koudinova N,Liscovitch M,Scherz A,Salomon Y

    更新日期:2003-11-01 00:00:00

  • CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model.

    abstract::NF-kappaB and the upstream kinase PKB/Akt are highly expressed in chemoresistance tumor cells and may hamper the apoptotic pathway. CF101, a specific agonist to the A3 adenosine receptor (A3AR), inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. Because CF101 has been show...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.04364

    authors: Bar-Yehuda S,Madi L,Silberman D,Gery S,Shkapenuk M,Fishman P

    更新日期:2005-01-01 00:00:00

  • BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1.

    abstract::We report that Binder of Arl Two (BART) plays a role in inhibiting cell invasion by regulating the activity of the Rho small guanosine triphosphatase protein Rac1 in pancreatic cancer cells. BART was originally identified as a binding partner of ADP-ribosylation factor-like 2, a small G protein implicated as a regulat...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.12352

    authors: Taniuchi K,Yokotani K,Saibara T

    更新日期:2012-05-01 00:00:00

  • Neoplasia: the second decade.

    abstract::This issue marks the end of the 10-year anniversary of Neoplasia where we have seen exciting growth in both number of submitted and published articles in Neoplasia. Neoplasia was first published in 1999. During the past 10 years, Neoplasia has dynamically adapted to the needs of the cancer research community as techno...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.81372

    authors: Rehemtulla A

    更新日期:2008-12-01 00:00:00

  • The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.

    abstract::The p53 gene is rarely mutated in neuroblastoma, but codon 72 polymorphism that modulates its proapoptotic activity might influence cancer risk and clinical outcome. We investigated whether this polymorphism affects neuroblastoma risk and disease outcome and assessed the biologic effects of the p53-72R and p53-72P iso...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.12594

    authors: Cattelani S,Ferrari-Amorotti G,Galavotti S,Defferrari R,Tanno B,Cialfi S,Vergalli J,Fragliasso V,Guerzoni C,Manzotti G,Soliera AR,Menin C,Bertorelle R,McDowell HP,Inserra A,Belli ML,Varesio L,Tweddle D,Tonini GP,Alt

    更新日期:2012-07-01 00:00:00

  • Radiocurability is associated with interstitial fluid pressure in human tumor xenografts.

    abstract::Interstitial fluid pressure (IFP) has been shown to be an independent prognostic parameter for disease-free survival in cervical carcinoma patients treated with radiation therapy. However, the underlying mechanisms are not fully understood. The main aims of this study were to investigate whether tumor radiocurability ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.91152

    authors: Rofstad EK,Gaustad JV,Brurberg KG,Mathiesen B,Galappathi K,Simonsen TG

    更新日期:2009-11-01 00:00:00

  • Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling.

    abstract::Ras-transformed intestinal epithelial cells are resistant to the growth inhibitory actions of TGFbeta and have a marked decrease in expression of the TGFbeta type II receptor (TGFbetaRII). Rat intestinal epithelial cells (RIE) were stably transfected with activated Ras, Sos and Raf constructs and tested for expression...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1038/sj.neo.7900099

    authors: Bulus NM,Sheng HM,Sizemore N,Oldham SM,Barnett JV,Coffey RJ,Beauchamp DR,Barnard JA

    更新日期:2000-07-01 00:00:00

  • Tracking the migration of dendritic cells by in vivo optical imaging.

    abstract::We report herein a method to track the migration of dendritic cells (DCs) using optical imaging. With the assistance of the delivery module, fluorescein isothiocyanate (FITC) could internalize inside DCs within 15 minutes of incubation. The fluorescent signal was mostly cytoplasmic and could be detected using in vivo ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.07586

    authors: Pham W,Xie J,Gore JC

    更新日期:2007-12-01 00:00:00

  • In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice.

    abstract::We determined whether the implantation of human pancreatic cancer cells into the pancreas of nude mice can be used to select variants with increasing metastatic potential. COLO 357 line fast-growing cells were injected into the spleen or pancreas of nude mice. Hepatic metastases were harvested, and tumor cells were re...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1038/sj.neo.7900005

    authors: Bruns CJ,Harbison MT,Kuniyasu H,Eue I,Fidler IJ

    更新日期:1999-04-01 00:00:00

  • PIAS1-FAK Interaction Promotes the Survival and Progression of Non-Small Cell Lung Cancer.

    abstract::The sequence of genomic alterations acquired by cancer cells during tumor progression and metastasis is poorly understood. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that integrates cytoskeleton remodeling, mitogenic signaling and cell survival. FAK has previously been reported to undergo nuclear lo...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2016.03.003

    authors: Constanzo JD,Tang KJ,Rindhe S,Melegari M,Liu H,Tang X,Rodriguez-Canales J,Wistuba I,Scaglioni PP

    更新日期:2016-05-01 00:00:00

  • Paclitaxel with cisplatin as salvage treatment for patients with previously treated advanced transitional cell carcinoma of the urothelial tract.

    abstract:BACKGROUND:This study was performed to evaluate the safety and efficacy of paclitaxel with cisplatin as salvage therapy in patients previously treated with gemcitabine and cisplatin (G/C) for advanced transitional cell carcinoma (TCC) of the urothelial tract. METHODS:Twenty-eight patients with metastatic or locally ad...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.06661

    authors: Uhm JE,Lim HY,Kim WS,Choi HY,Lee HM,Park BB,Park K,Kang WK

    更新日期:2007-01-01 00:00:00

  • Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma.

    abstract::Wnt/beta-catenin signaling plays an important role in normal development. However, its aberrant activation is associated with several cancers. The aim of this study is to examine the Wnt/beta-catenin pathway in patients with advanced pancreatic adenocarcinoma (n = 31). Paraffin sections from tumors (n = 16) and normal...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.05607

    authors: Zeng G,Germinaro M,Micsenyi A,Monga NK,Bell A,Sood A,Malhotra V,Sood N,Midda V,Monga DK,Kokkinakis DM,Monga SP

    更新日期:2006-04-01 00:00:00

  • BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer.

    abstract::Using bioinformatics, we have identified a novel tumor-specific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.05406

    authors: Li Y,Dong X,Yin Y,Su Y,Xu Q,Zhang Y,Pang X,Zhang Y,Chen W

    更新日期:2005-12-01 00:00:00

  • Cancer: A turbulence problem.

    abstract::Cancers are complex, adaptive ecosystems. They remain the leading cause of disease-related death among children in North America. As we approach computational oncology and Deep Learning Healthcare, our mathematical models of cancer dynamics must be revised. Recent findings support the perspective that cancer-microenvi...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章,评审

    doi:10.1016/j.neo.2020.09.008

    authors: Uthamacumaran A

    更新日期:2020-12-01 00:00:00

  • Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis.

    abstract::Mutation of the PARK2 gene can promote both Parkinson's Disease and cancer, yet the underlying mechanisms of how PARK2 controls cellular physiology is incompletely understood. Here, we show that the PARK2 tumor suppressor controls the apoptotic regulator BCL-XL and modulates programmed cell death. Analysis of approxim...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2016.12.006

    authors: Gong Y,Schumacher SE,Wu WH,Tang F,Beroukhim R,Chan TA

    更新日期:2017-02-01 00:00:00

  • Up-regulation of FOXM1 by E6 oncoprotein through the MZF1/NKX2-1 axis is required for human papillomavirus-associated tumorigenesis.

    abstract:PURPOSE:Foxhead box M1 (FOXM1) expression has been shown to be linked with human papillomavirus (HPV) 16/18-infected cervical cancer. However, the mechanism underlying the induction of FOXM1 in HPV 16/18-infected cancers remains elusive. EXPERIMENTAL DESIGN:The mechanistic actions of FOXM1 induced by the E6/NKX2-1 axi...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2014.09.010

    authors: Chen PM,Cheng YW,Wang YC,Wu TC,Chen CY,Lee H

    更新日期:2014-11-20 00:00:00

  • Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control.

    abstract::The maspin gene is not expressed in normal human pancreas, but its expression is acquired during human pancreatic carcinogenesis. In other normal human cells and their malignant counterparts, maspin expression is controlled through the epigenetic state of its promoter. In studies presented herein, we used bisulfite ge...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/s1476-5586(03)80045-3

    authors: Fitzgerald M,Oshiro M,Holtan N,Krager K,Cullen JJ,Futscher BW,Domann FE

    更新日期:2003-09-01 00:00:00

  • SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.

    abstract::SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported. Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomita...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2019.04.008

    authors: Chen S,Yang X,Yu M,Wang Z,Liu B,Liu M,Liu L,Ren M,Qi H,Zou J,Vucenik I,Zhu WG,Luo J

    更新日期:2019-07-01 00:00:00

  • Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin.

    abstract::A mathematical model is presented for the cellular uptake and cytotoxicity of the anticancer drug doxorubicin. The model assumes sigmoidal, Hill-type dependence of cell survival on drug-induced damage. Experimental evidence indicates distinct intracellular and extracellular mechanisms of doxorubicin cytotoxicity. Drug...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.05118

    authors: El-Kareh AW,Secomb TW

    更新日期:2005-07-01 00:00:00

  • Imbalance between genomic gain and loss identifies high-risk neuroblastoma patients with worse outcomes.

    abstract::Survival in high-risk neuroblastoma (HR-NB) patients remains poor despite multimodal treatment. We aimed to identify HR-NB patients with worse outcomes by analyzing the genomic instability derived from segmental chromosomal aberrations. We calculated 3 genomic instability indexes for primary tumor SNP array profiles f...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2020.11.001

    authors: Fernández-Blanco B,Berbegall AP,Martin-Vañó S,Castel V,Navarro S,Noguera R

    更新日期:2021-01-01 00:00:00

  • Esophageal Adenocarcinoma-Derived Extracellular Vesicle MicroRNAs Induce a Neoplastic Phenotype in Gastric Organoids.

    abstract::There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)-derived EVs on gastric organoids (gastroids) and elucidated molecular mechanisms underlying the...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1016/j.neo.2017.06.007

    authors: Ke X,Yan R,Sun Z,Cheng Y,Meltzer A,Lu N,Shu X,Wang Z,Huang B,Liu X,Wang Z,Song JH,Ng CK,Ibrahim S,Abraham JM,Shin EJ,He S,Meltzer SJ

    更新日期:2017-11-01 00:00:00

  • Synergism of BARF1 with Ras induces malignant transformation in primary primate epithelial cells and human nasopharyngeal epithelial cells.

    abstract::Although it is well known that nasopharyngeal carcinoma (NPC) is closely related with Epstein-Barr virus (EBV), few data are available about which and how EBV-expressed gene is involved in the carcinogenesis of human nasopharyngeal epithelial cells. EBV-encoded BARF1 (BamH I-A right frame 1) gene has been shown to be ...

    journal_title:Neoplasia (New York, N.Y.)

    pub_type: 杂志文章

    doi:10.1593/neo.09706

    authors: Jiang R,Cabras G,Sheng W,Zeng Y,Ooka T

    更新日期:2009-09-01 00:00:00