Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line.

abstract：:Monocytes/macrophages are an influential component of the glioma microenvironment. However, understanding their diversity and plasticity constitute one of the most challenging areas of research due to the paucity of models to study these cells' inherent complexity. Herein, we analyzed the role of monocytes/macrophages...

journal_title：Neoplasia (New York, N.Y.)

authors： Gabrusiewicz K,Hossain MB,Cortes-Santiago N,Fan X,Kaminska B,Marini FC,Fueyo J,Gomez-Manzano C

更新日期：2015-04-01 00:00:00

abstract：:In order to find common genetic abnormalities that may identify loci of genes involved in the development of adenoid cystic carcinoma (ACC), we investigated DNA copy number changes in 24 of these tumors by comparative genomic hybridization (CGH). Our results indicate that unlike many carcinomas, ACCs have relatively f...

journal_title：Neoplasia (New York, N.Y.)

authors： El-Rifai W,Rutherford S,Knuutila S,Frierson HF Jr,Moskaluk CA

更新日期：2001-05-01 00:00:00

abstract：:It has been proposed that the structural and numerical chromosome abnormalities recorded in breast cancer could be the result of telomere dysfunction and that telomerase is activated de novo to provide a survival mechanism curtailing further chromosomal aberrations. However, recent in vivo and in vitro data show that ...

journal_title：Neoplasia (New York, N.Y.)

authors： Papadopoulou A,Trangas T,Teixeira MR,Heim S,Dimitriadis E,Tsarouha H,Andersen JA,Evangelou E,Ioannidis P,Agnantis NJ,Pandis N

更新日期：2003-03-01 00:00:00

abstract：:Multidrug resistance (MDR) presents a major obstacle for the successful chemotherapy of cancer. Its emergence during chemotherapy is attributed to a selective process, which gives a growth advantage to MDR cells within the genetically unstable neoplastic cell population. The pleiotropic nature of clinical MDR poses a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Preise D,Mazor O,Koudinova N,Liscovitch M,Scherz A,Salomon Y

更新日期：2003-11-01 00:00:00

abstract：:Tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) is an important adaptor in TNFR1 signaling and has an essential role in nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation and survival signaling. Increased expression of TRADD is sufficient to activate NF-κ...

journal_title：Neoplasia (New York, N.Y.)

authors： Chakraborty S,Li L,Tang H,Xie Y,Puliyappadamba VT,Raisanen J,Burma S,Boothman DA,Cochran B,Wu J,Habib AA

更新日期：2013-08-01 00:00:00

abstract：:Adenomatous polyposis coli (APC) is a multifunctional protein having diverse cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation, and apoptosis. Recently, we found a new role of APC in base excision repair (BER) and showed that it interacts with DNA polymerase β...

journal_title：Neoplasia (New York, N.Y.)

authors： Jaiswal AS,Panda H,Pampo CA,Siemann DW,Gairola CG,Hromas R,Narayan S

更新日期：2013-04-01 00:00:00

abstract：:One of the challenges of tailored antiangiogenic therapy is the ability to adequately monitor the angiogenic activity of a malignancy in response to treatment. The α(v)β(3) integrin, highly overexpressed on newly formed tumor vessels, has been successfully used as a target for Arg-Gly-Asp (RGD)-functionalized nanopart...

journal_title：Neoplasia (New York, N.Y.)

authors： Jarzyna PA,Deddens LH,Kann BH,Ramachandran S,Calcagno C,Chen W,Gianella A,Dijkhuizen RM,Griffioen AW,Fayad ZA,Mulder WJ

更新日期：2012-10-01 00:00:00

abstract：:Several studies have linked vascular density, identified in histologic sections, to "metastatic risk." Functional information of the vasculature, not readily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims were to determine if hum...

journal_title：Neoplasia (New York, N.Y.)

authors： Bhujwalla ZM,Artemov D,Natarajan K,Ackerstaff E,Solaiyappan M

更新日期：2001-03-01 00:00:00

abstract：:A significant proportion of colorectal adenomas, in particular those that lack an elevated growth component, continue to escape detection during endoscopic surveillance. Elevation of the activity of matrix metalloproteinases (MMPs), a large family of zinc endopeptidases, in adenomas serves as a biomarker of early tumo...

journal_title：Neoplasia (New York, N.Y.)

authors： Clapper ML,Hensley HH,Chang WC,Devarajan K,Nguyen MT,Cooper HS

更新日期：2011-08-01 00:00:00

abstract：:Pancreatic invasive ductal adenocarcinoma (PDAC) is a representative intractable malignancy under the current cancer therapies, and is considered a scirrhous carcinoma because it develops dense stroma. Both PODXL1, a member of CD34 family molecules, and C5aR, a critical cell motility inducer, have gained recent attent...

journal_title：Neoplasia (New York, N.Y.)

authors： Saito K,Iioka H,Maruyama S,Sumardika IW,Sakaguchi M,Kondo E

更新日期：2019-12-01 00:00:00

abstract：:Wnt/beta-catenin signaling plays an important role in normal development. However, its aberrant activation is associated with several cancers. The aim of this study is to examine the Wnt/beta-catenin pathway in patients with advanced pancreatic adenocarcinoma (n = 31). Paraffin sections from tumors (n = 16) and normal...

journal_title：Neoplasia (New York, N.Y.)

authors： Zeng G,Germinaro M,Micsenyi A,Monga NK,Bell A,Sood A,Malhotra V,Sood N,Midda V,Monga DK,Kokkinakis DM,Monga SP

更新日期：2006-04-01 00:00:00

abstract：:The goal of oncology is the individualization of patient care to optimize therapeutic responses and minimize toxicities. Achieving this will require noninvasive, quantifiable, and early markers of tumor response. Preclinical data from xenografted tumors using a variety of antitumor therapies have shown that magnetic r...

journal_title：Neoplasia (New York, N.Y.)

authors： Theilmann RJ,Borders R,Trouard TP,Xia G,Outwater E,Ranger-Moore J,Gillies RJ,Stopeck A

更新日期：2004-11-01 00:00:00

abstract：:TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer. Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo model systems. Transgenic mice expressing the ERG gene fusion product under androgen-regulation develop mouse prostatic intraepithelial neoplasia (...

journal_title：Neoplasia (New York, N.Y.)

authors： Tomlins SA,Laxman B,Varambally S,Cao X,Yu J,Helgeson BE,Cao Q,Prensner JR,Rubin MA,Shah RB,Mehra R,Chinnaiyan AM

更新日期：2008-02-01 00:00:00

abstract：:To survive and metastasize, tumors interact with surrounding tissues by secreting growth factors and cytokines. In return, surrounding host tissues respond by changing their secretome. Numerous factors theoretically function as therapeutic targets or biomarkers of cancer growth and metastatic risk. However, it is uncl...

journal_title：Neoplasia (New York, N.Y.)

authors： Kerr BA,Miocinovic R,Smith AK,Klein EA,Byzova TV

更新日期：2010-05-01 00:00:00

abstract：:Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate. Pyruvate is a main glycolytic metabolite that could be mainly converted into either lactate by Lactate Dehydrogenase A (L...

journal_title：Neoplasia (New York, N.Y.)

authors： Chen TY,Hsieh YT,Huang JM,Liu CJ,Chuang LT,Huang PC,Kuo TY,Chia HY,Chou CY,Chang CW,Chen YF,Chen HM,Lo JF,Li WC

更新日期：2019-07-01 00:00:00

abstract：:c-Cbl, a RING-type ubiquitin E3 ligase, downregulates various receptor tyrosine kinases (e.g., epidermal growth factor receptor (EGFR)), leading to inhibition of cell proliferation. Moreover, patients with myeloid neoplasm frequently harbor c-Cbl mutations, implicating the role of c-Cbl as a tumor suppressor. Recently...

journal_title：Neoplasia (New York, N.Y.)

authors： Seong MW,Ka SH,Park JH,Park JH,Yoo HM,Yang SW,Park JM,Park D,Lee ST,Seol JH,Chung CH

更新日期：2015-06-01 00:00:00

abstract：:DBD* is a novel gene encoding an 89 amino acid peptide that is constitutively lethal to leukemic cells. DBD* was derived from the DNA binding domain of the human glucocorticoid receptor by a frameshift that replaces the final 21 C-terminal amino acids of the domain. Previous studies suggested that DBD* no longer acted...

journal_title：Neoplasia (New York, N.Y.)

authors： Ji YS,Johnson BH,Webb MS,Thompson EB

更新日期：2002-09-01 00:00:00

abstract：:Recent studies have demonstrated that the chemokine receptor CXCR4 plays a crucial role in organ-specific metastasis formation. Although a variety of studies showed the expression of chemokine receptors, in particular, CXCR4, by gastrointestinal tumors, the precise mechanisms of chemokine receptor-mediated homing of c...

journal_title：Neoplasia (New York, N.Y.)

authors： Gassmann P,Haier J,Schlüter K,Domikowsky B,Wendel C,Wiesner U,Kubitza R,Engers R,Schneider SW,Homey B,Müller A

更新日期：2009-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV) latent infection is a critical event in nasopharyngeal carcinoma (NPC) tumorigenesis. EBV-encoded genes have been shown to be involved in immune evasion and in the regulation of various cellular signaling cascades. To elucidate the roles of EBV in NPC development, stable infection of EBV in na...

journal_title：Neoplasia (New York, N.Y.)

authors： Lo AK,Lo KW,Tsao SW,Wong HL,Hui JW,To KF,Hayward DS,Chui YL,Lau YL,Takada K,Huang DP

更新日期：2006-03-01 00:00:00

abstract：:Neuroblastoma (NB) is the most commonly occurring solid tumor in children. The disease usually arises in the adrenal medulla, and it is characterized by a remarkable heterogeneity in its progression. Most NB patients with an advanced disease have massive bone marrow infiltration at diagnosis. Lung metastasis represent...

journal_title：Neoplasia (New York, N.Y.)

authors： Nevo I,Sagi-Assif O,Edry Botzer L,Amar D,Maman S,Kariv N,Leider-Trejo LE,Savelyeva L,Schwab M,Yron I,Witz IP

更新日期：2008-08-01 00:00:00

abstract：:It has been proposed that human colorectal tumors can be classified into two groups: one in which methylation is rare, and another with methylation of several loci associated with a "CpG island methylated phenotype (CIMP)," characterized by preferential proximal location in the colon, but otherwise poorly defined. The...

journal_title：Neoplasia (New York, N.Y.)

authors： Anacleto C,Leopoldino AM,Rossi B,Soares FA,Lopes A,Rocha JC,Caballero O,Camargo AA,Simpson AJ,Pena SD

更新日期：2005-04-01 00:00:00

abstract：:Mouse models are powerful tools to study lung cancer initiation and progression in vivo and have contributed significantly to recent advances in therapy. Using micro-computed tomography to monitor and study parenchymal and extra-parenchymal metastases in existing murine models of lung cancer is challenging owing to a ...

journal_title：Neoplasia (New York, N.Y.)

authors： Viswanath P,Peng S,Singh R,Kingsley C,Balter PA,Johnson FM

更新日期：2018-10-01 00:00:00

abstract：:We used the standard comet assay successfully to generate in vitro dose-response curves under oxic and hypoxic conditions. We then made mixtures of cells that had been irradiated with 3 and 9 Gy of X-rays to simulate two subpopulations in a tumor, but efforts to accurately detect and quantify the subpopulations using ...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang J,Klem J,Wyrick JB,Ozawa T,Cunningham E,Golinveaux J,Allen MJ,Lamborn KR,Deen DF

更新日期：2003-07-01 00:00:00

abstract：:About 10% to 30% of patients with ataxia-telangiectasia (A-T) develop leukemias or lymphomas. There is considerable interpatient variation in the age of onset and leukemia/lymphoma type. The incomplete penetrance and variable age of onset may be attributable to several factors. These include competing mortality from o...

journal_title：Neoplasia (New York, N.Y.)

authors： Genik PC,Bielefeldt-Ohmann H,Liu X,Story MD,Ding L,Bush JM,Fallgren CM,Weil MM

更新日期：2014-02-01 00:00:00

abstract：:Methyl jasmonate (MJ) acts both in vitro and in vivo against various cancer cell lines. Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway results in decreased susceptibility to cytotoxic agents in many types of cancer cells. We found a strong inverse correlation between the basal level of phospho-Akt ...

journal_title：Neoplasia (New York, N.Y.)

authors： Elia U,Flescher E

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:Inflammatory breast cancer (IBC) is arguably the deadliest form of breast cancer due to its rapid onset and highly invasive nature. IBC carries 5- and 10-year disease-free survival rates of ~45% and <20%, respectively. Multiple studies demonstrate that in comparison with conventional breast cancer, IBC has a un...

journal_title：Neoplasia (New York, N.Y.)

authors： Joglekar-Javadekar M,Van Laere S,Bourne M,Moalwi M,Finetti P,Vermeulen PB,Birnbaum D,Dirix LY,Ueno N,Carter M,Rains J,Ramachandran A,Bertucci F,van Golen KL

更新日期：2017-07-01 00:00:00

abstract：:We report herein a method to track the migration of dendritic cells (DCs) using optical imaging. With the assistance of the delivery module, fluorescein isothiocyanate (FITC) could internalize inside DCs within 15 minutes of incubation. The fluorescent signal was mostly cytoplasmic and could be detected using in vivo ...

journal_title：Neoplasia (New York, N.Y.)

authors： Pham W,Xie J,Gore JC

更新日期：2007-12-01 00:00:00

abstract：:Cancers originating from epithelial cells are the most common malignancies. No common expression profile of solid tumors compared to normal tissues has been described so far. Therefore we were interested if genes differentially expressed in the majority of carcinomas could be identified using bioinformatic methods. Co...

journal_title：Neoplasia (New York, N.Y.)

authors： Pilarsky C,Wenzig M,Specht T,Saeger HD,Grützmann R

更新日期：2004-11-01 00:00:00

abstract：:BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with improved survival compared with chemotherapy. Unfortunately, reactiva...

journal_title：Neoplasia (New York, N.Y.)

authors： Mologni L,Costanza M,Sharma GG,Viltadi M,Massimino L,Citterio S,Purgante S,Raman H,Pirola A,Zucchetti M,Piazza R,Gambacorti-Passerini C

更新日期：2018-05-01 00:00:00

abstract：:The noninvasive assessment of anticancer treatment efficacy is very important for the improvement of therapeutic window. The purpose of the present study was to evaluate the antitumoral effects of the vascular targeting agent, combretastatin A-4 phosphate (CA-4-P), at selected time points after repeated intraperitonea...

journal_title：Neoplasia (New York, N.Y.)

authors： Thoeny HC,De Keyzer F,Chen F,Vandecaveye V,Verbeken EK,Ahmed B,Sun X,Ni Y,Bosmans H,Hermans R,van Oosterom A,Marchal G,Landuyt W

更新日期：2005-08-01 00:00:00