Abstract:
OBJECTIVES:Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD. RESEARCH DESIGN AND METHODS:Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD). Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea. RESULTS:Patients with DKD, as compared with those without the disease, were mostly men (52%vs38% for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia. Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=0.02, OR=3.12, 95% CI 1.21 to 8.02). Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (Padjusted=0.04, OR=1.46); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels. CONCLUSIONS:Associations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry.
journal_name
BMJ Openjournal_title
BMJ openauthors
Osman WM,Jelinek HF,Tay GK,Khandoker AH,Khalaf K,Almahmeed W,Hassan MH,Alsafar HSdoi
10.1136/bmjopen-2017-020759subject
Has Abstractpub_date
2018-12-14 00:00:00pages
e020759issue
12issn
2044-6055pii
bmjopen-2017-020759journal_volume
8pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVE:Recent studies have suggested that stress in a pregnant mother may affect the future health of the unborn child negatively. An excellent proxy for health problems is the use of healthcare resources. Using nationwide data, we examined whether persons born to mothers who lost a close relative during pregnancy h...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005657
更新日期:2015-01-08 00:00:00
abstract::Objectives (1) To assess endorsement of trial registration in author instructions of urology-related journals and (2) to assess whether randomised controlled trials (RCTs) in the field of urology were effectively registered. Design Cross-sectional study of author instructions and published trials. Setting Journals p...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000430
更新日期:2011-12-06 00:00:00
abstract:INTRODUCTION:Recreational drug use in the nightlife setting carries the risk of many negative consequences, such as violence, injuries, aberrant driving and sexual risk-taking. The aim of this study is to investigate recreational drug use and user characteristics among people visiting licensed premises, for example, ni...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009306
更新日期:2016-04-22 00:00:00
abstract:OBJECTIVE:Cancer of the oral cavity is the leading malignancy among males in Sri Lanka, and sixth among women. This study aimed to estimate costs of managing patients with oral cancer (OCA) in Sri Lanka for a 12 month period from diagnosis. DESIGN:Hospital based costing study. SETTINGS:Four selected cancer treatment ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-027661
更新日期:2019-07-19 00:00:00
abstract:OBJECTIVE:To investigate the length of time taken to open UK research sites in multicentre clinical trials and to identify reasons for any delays. DESIGN:A case study, recording key milestone dates from the time a site receives ethical approval through to opening to recruitment. Delay reasons were prospectively logged...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005874
更新日期:2014-09-16 00:00:00
abstract:OBJECTIVES:We conducted a systematic survey of the methodological literature to identify recommended approaches for how and what randomised clinical trial (RCT) authors should report on missing participant data and, on the basis of these approaches, to propose guidance for RCT authors. METHODS:We defined missing parti...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2015-008431
更新日期:2015-12-30 00:00:00
abstract:PURPOSE:The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study is a prospective cohort study focused on the relationship between the microbiome and oral and systemic health outcomes in postmenopausal women. The cohort was established to examine how the oral microbiome is affected by (and how it affects) pe...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024263
更新日期:2018-12-04 00:00:00
abstract:OBJECTIVES:To examine whether patient satisfaction with nursing care in National Health Service (NHS) hospitals in England is associated with the proportion of non-UK educated nurses providing care. DESIGN:Cross-sectional analysis using data from the 2010 NHS Adult Inpatient Survey merged with data from nurse and hosp...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2015-009483
更新日期:2015-12-02 00:00:00
abstract:OBJECTIVES:To develop an algorithm that aims to provide guidance and awareness for choosing multiple study designs in systematic reviews of healthcare interventions. DESIGN:Method study: (1) To summarise the literature base on the topic. (2) To apply the integration of various study types in systematic reviews. (3) To...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-007540
更新日期:2015-08-19 00:00:00
abstract:OBJECTIVES:Cost-efficient active case finding (ACF) approaches are needed for their large-scale adoption in national tuberculosis (TB) programmes. Our aim was to assess if community health workers' (CHW) knowledge about families' health status can improve the cost efficiency of the ACF programme without adversely affec...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036625
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether the daily workload per nurse (Oulu Patient Classification (OPCq)/nurse) as measured by the RAFAELA system correlates with different types of patient safety incidents and with patient mortality, and to compare the results with regressions based on the standard patients/nurse measure. SE...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016367
更新日期:2018-04-24 00:00:00
abstract:OBJECTIVES:Regular physical exercise may preserve β cell function in newly diagnosed adults with type 1 diabetes (T1D). However, clinical trials to test this theory require the recruitment and retention of adults with new-onset T1D, which can be challenging. We sought to determine the overall experiences of newly diagn...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022353
更新日期:2018-07-17 00:00:00
abstract:OBJECTIVE:To identify components of a proposed blood-borne virus (BBV) population screening programme and its associated consent procedure that both the public and health practitioners (HPs) would find acceptable. The proposed BBV screening system would aim to reduce late diagnosis of BBVs and be used in patients under...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015373
更新日期:2017-05-29 00:00:00
abstract:OBJECTIVE:To assess the representativeness of the Heart Protection Study (HPS) and the Collaborative Atorvastatin Diabetes Study (CARDS) for incident statin users. DESIGN:A population-based analysis with linked register data. SETTING:Finland. POPULATION:56 963 patients with diabetes initiating statin use from 2005 t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005402
更新日期:2014-06-19 00:00:00
abstract:OBJECTIVES:To comprehensively survey the sugar and nutrient contents of yogurt products available in UK supermarkets, in particular those marketed to children. DESIGN:A cross-sectional survey of yogurt products available in the UK's supermarkets in November 2016. METHODS:Data were collected from five major online UK ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-021387
更新日期:2018-09-18 00:00:00
abstract::Background Although recent genome-wide association studies have identified several genetic variants contributing to the complex aetiology of multiple sclerosis (MS), expression and functional studies are required to further understand its molecular basis. Objectives To identify genes and pathways with differential ex...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000053
更新日期:2011-07-18 00:00:00
abstract:OBJECTIVES:Novel therapeutics are an important part of ophthalmologists' armamentarium, and the risks and benefits of these therapies must be carefully evaluated. We sought to quantify the characteristics of the pivotal clinical trials supporting the regulatory approval of new ophthalmic drugs and medical devices. DES...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-007987
更新日期:2015-06-04 00:00:00
abstract:OBJECTIVES:The aim of this study was to quantify sex differences in diagnostic and revascularisation coronary procedures within 1 year of hospitalisation for acute myocardial infarction (AMI) or angina. DESIGN:This is a prospective cohort study. Baseline questionnaire (January 2006-April 2009) data from the Sax Instit...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026507
更新日期:2019-07-23 00:00:00
abstract:OBJECTIVES:To investigate the accuracy, reproducibility and costs of different laboratory assays for the monitoring of unfractionated heparin (UFH) in clinical practice and to study test utilisation in Switzerland. DESIGN:Prospective evaluation study and survey among Swiss hospitals and laboratories. SETTING:Secondar...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022943
更新日期:2018-06-09 00:00:00
abstract:INTRODUCTION:The Australian Council on Healthcare Standards (ACHS) set criteria for the delivery of healthcare services in Australia. While a voluntary process, continual accreditation with ACHS is an expectation of, and for, Australian healthcare providers. Juxtapositioned with the ACHS, the Nursing and Midwifery Boar...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031499
更新日期:2019-08-24 00:00:00
abstract:OBJECTIVES:Socioeconomically deprived individuals with renal disease are less likely to receive a live-donor kidney transplant than less-deprived individuals. This qualitative study aimed to identify reasons for the observed socioeconomic disparity in live-donor kidney transplantation. DESIGN:A qualitative study using...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010605
更新日期:2016-03-02 00:00:00
abstract:OBJECTIVES:To further identify the single-nucleotide polymorphisms (SNPs) that contribute to the genetic susceptibility to sarcoidosis, we examined the potential association between sarcoidosis and 15 SNPs of the ANXA11 gene. DESIGN:A case-control study. SETTING:A tuberculosis unit in a hospital of the university in ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004466
更新日期:2014-07-23 00:00:00
abstract:OBJECTIVES:In May 2018, the British Health Secretary announced the 'serious failure' that 450 000 women had missed out on invitations to breast screening in England, leading to extensive media coverage. This study measured public awareness of the story and tested for associated factors (eg, educational level and trust ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028040
更新日期:2019-09-06 00:00:00
abstract:OBJECTIVE:To determine the feasibility of a randomised controlled trial (RCT) assessing the effects of an experience-based website as a resource for the self-management of chronic asthma. DESIGN AND SETTING:Feasibility, single-blind RCT in 2 regions of England. Randomisation used computer-generated random number seque...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-013401
更新日期:2016-12-28 00:00:00
abstract:INTRODUCTION:Hepatitis C is a blood-borne virus (HCV) that can seriously damage the liver and is spread mainly through blood-to-blood contact with an infected person. Over 85% of individuals who have HCV in Scotland became infected following injecting drug use. Since people who inject drugs (PWID) are the main source o...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029516
更新日期:2019-08-08 00:00:00
abstract:OBJECTIVES:To analyse the parental understanding of informed consent information in first-line randomised clinical trials (RCTs) including children with malignant solid tumours and to assess parents' needs for decision-making. DESIGN:Observational prospective study. SETTING:3 paediatric oncology centres in the Parisi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002733
更新日期:2013-05-28 00:00:00
abstract:INTRODUCTION:Families in low-income and middle-income countries (LMICs) face multiple challenges (eg, poverty and adverse childhood experiences) that increase the risk for child mental health problems, while the context may provide them with few resources. Existing prevention-oriented parenting programmes have been sho...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026684
更新日期:2019-01-25 00:00:00
abstract:INTRODUCTION:Person-centredness is a philosophy for organising and delivering healthcare based on patients' needs, preferences and experiences. Although widely endorsed, the concept suffers from a lack of detail and clarification, in turn accounting for ambiguous implementation and outcomes. While a conceptual framewor...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011959
更新日期:2016-07-19 00:00:00
abstract:OBJECTIVES:Childhood asthma is a complex condition where many environmental factors are implicated in causation. The aim of this study was to complete a systematic review of the literature describing associations between environmental exposures and the development of asthma in young children. SETTING:A systematic revi...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2014-006554
更新日期:2014-11-24 00:00:00
abstract:OBJECTIVES:Anxiety disorders (ADs) are common after traumatic brain injury (TBI). However, the risk factors of new-onset ADs remain unclear. This study was aimed at evaluating the incidence and risk factors for new-onset ADs, including pre-existing hyperlipidaemia and three major comorbidities (diabetes mellitus, hyper...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005269
更新日期:2014-07-17 00:00:00