Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays.

abstract：OBJECTIVES:To investigate the feasibility of manual segmentation by users of different backgrounds in a previously developed multifeature computer-aided diagnosis (CADx) system to classify melanocytic and non-melanocytic skin lesions based on conventional digital photographic images. METHODS:In total, 347 conventional...

journal_title：BMJ open

authors： Chang WY,Huang A,Chen YC,Lin CW,Tsai J,Yang CK,Huang YT,Wu YF,Chen GS

更新日期：2015-05-03 00:00:00

abstract：INTRODUCTION:Type 2 diabetes (T2D) is a significant problem, and lifestyle modifications including self-management are important. We have developed a structured individual-based lifestyle education (SILE) programme for T2D. With attention now being paid to techniques to change behaviour, we recently developed a behavio...

journal_title：BMJ open

authors： Adachi M,Yamaoka K,Watanabe M,Nemoto A,Tango T

更新日期：2017-10-24 00:00:00

abstract：OBJECTIVE:Kangaroo care (KC), a well-established parent-based intervention in neonatal intensive care units (NICUs), with documented benefits for infants and their parents. However, in China there remains a lack of knowledge and a reluctance to implement KC in hospitals. Therefore, our aim was to investigate the curren...

journal_title：BMJ open

authors： Zhang Y,Deng Q,Zhu B,Li Q,Wang F,Wang H,Xu X,Johnston L

更新日期：2018-08-30 00:00:00

abstract：OBJECTIVE:To complete a systematic review of the literature describing associations between all environmental exposures and asthma symptoms and exacerbations in children up to mean age of 9 years. DESIGN:Systematic review. SETTING:Reference lists of identified studies and reviews were searched for all articles publis...

journal_title：BMJ open

authors： Dick S,Doust E,Cowie H,Ayres JG,Turner S

更新日期：2014-02-12 00:00:00

abstract：OBJECTIVES:Bariatric surgery is the most clinically effective treatment for people with severe and complex obesity, however, the psychosocial outcomes are less clear. Follow-up care after bariatric surgery is known to be important, but limited guidance exists on what this should entail, particularly related to psycholo...

journal_title：BMJ open

authors： Coulman KD,MacKichan F,Blazeby JM,Donovan JL,Owen-Smith A

更新日期：2020-02-06 00:00:00

abstract：INTRODUCTION:In the context of a population that is growing older, and a number of high-profile scandals about care standards in hospital and community settings, having a skilled and knowledgeable workforce caring for older people is an ethical and policy imperative. Support workers make up the majority of the workforc...

journal_title：BMJ open

authors： Rycroft-Malone J,Burton C,Hall B,McCormack B,Nutley S,Seddon D,Williams L

更新日期：2014-05-30 00:00:00

abstract：OBJECTIVES:The objectives of this study were to describe the methods used to assess the quality of linkage between records of babies' birth registration and hospital birth records, and to evaluate the potential bias that may be introduced because of these methods. DESIGN/SETTING:Data from the civil registration and th...

journal_title：BMJ open

authors： Coathup V,Macfarlane A,Quigley M

更新日期：2020-10-26 00:00:00

abstract：OBJECTIVE:The purpose of this study was to analyse the rate of knee arthroplasty in the population of patients with a history of arthroscopic chondroplasty of the knee, in England, over 10 years, with comparison to general population data for patients without a history of chondroplasty. DESIGN:Retrospective cohort stu...

journal_title：BMJ open

authors： Abram SGF,Palmer AJR,Judge A,Beard DJ,Price AJ

更新日期：2020-04-16 00:00:00

abstract：INTRODUCTION:Trabeculotomy and combined trabeculotomy-trabeculectomy (CTT) are major surgical options for primary congenital glaucoma (PCG). However, it is unclear which of these two surgical procedures should be recommended as the optimum first-line treatment for PCG. This trial aims to determine whether the outcomes ...

journal_title：BMJ open

authors： Fang L,Guo X,Yang Y,Zhang J,Chen X,Zhu Y,Huang J,Huang J,Zhong Y,Xu X,Liu X

更新日期：2020-02-25 00:00:00

abstract：INTRODUCTION:Cancer-related cognitive impairment (CRCI) can have detrimental effects on quality of life, even among patients with non-central nervous system (CNS) cancers. Several studies have been conducted to explore different markers associated with CRCI to understand its pathobiology. It is proposed that the underl...

journal_title：BMJ open

authors： Mayo SJ,Kuruvilla J,Laister RC,Ayala AP,Alm M,Byker W,Kelly DL,Saligan L

更新日期：2018-01-27 00:00:00

abstract：AIM:To estimate the population attributable risk (PAR) for Chlamydia trachomatis infection in young men and women in Sydney, Australia. METHOD:Multivariate logistic regression was used to examine the association between demographic, sexual behaviour and other potential risk factors and chlamydia positivity in young (≤...

journal_title：BMJ open

authors： Wand H,Guy R,Donovan B,McNulty A

更新日期：2011-02-23 00:00:00

abstract：INTRODUCTION:Expectant mothers in low-income and middle-income countries often lack access to vital information about pregnancy, preparation for birth and best practices when caring for their newborn. Innovative solutions are needed to bridge this knowledge gap and dramatically improve maternal and neonatal health in t...

journal_title：BMJ open

authors： Su Y,Yuan C,Zhou Z,Heitner J,Campbell B

更新日期：2016-08-10 00:00:00

abstract：INTRODUCTION:Regular toothbrushing with fluoride toothpaste is a fundamental intervention for caries prevention. Professional fluoride application (PFA) is widely considered a beneficial supplement to the routine use of fluoride toothpaste. However, some recent studies have failed to demonstrate the preventive effect o...

journal_title：BMJ open

authors： Yu L,Yu X,Li Y,Li J,Hua F,Song G

更新日期：2020-09-21 00:00:00

abstract：INTRODUCTION:Nursing bedside handover in hospital has been identified as an opportunity to involve patients and promote patient-centred care. It is important to consider the preferences of both patients and nurses when implementing bedside handover to maximise the successful uptake of this policy. We outline a study wh...

journal_title：BMJ open

authors： Spinks J,Chaboyer W,Bucknall T,Tobiano G,Whitty JA

更新日期：2015-11-11 00:00:00

abstract：OBJECTIVES:It remains unclear if geriatric patients with different delirium motor subtypes express different levels of motor activity. Thus, we used two accelerometer-based devices to simultaneously measure upright activity and wrist activity across delirium motor subtypes in geriatric patients. DESIGN:Cross-sectional...

journal_title：BMJ open

authors： Evensen S,Bourke AK,Lydersen S,Sletvold O,Saltvedt I,Wyller TB,Taraldsen K

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:To evaluate glycaemic durability with dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes. DESIGN:A systematic review and meta-analysis of long-term randomised trials of DPP-4 inhibitors on haemoglobin A1c (HbA1c) was conducted. Electronic searches were carried out on the following databases: MEDLI...

journal_title：BMJ open

authors： Esposito K,Chiodini P,Maiorino MI,Bellastella G,Capuano A,Giugliano D

更新日期：2014-06-10 00:00:00

abstract：INTRODUCTION:Pharmacotherapy plays an important role in the treatment of major depression. At the initiation of antidepressant treatment, both improvement of symptoms in the short term and relapse prevention in the long term should be taken into account. However, there is insufficient evidence regarding the efficacy an...

journal_title：BMJ open

authors： Shinohara K,Efthimiou O,Ostinelli EG,Tomlinson A,Geddes JR,Nierenberg AA,Ruhe HG,Furukawa TA,Cipriani A

更新日期：2019-05-19 00:00:00

abstract：OBJECTIVES:To investigate the prevalence of mild cognitive impairment and the relationship with plasma aluminium among aluminium workers. DESIGN:This was a cross-sectional case-control study in the SH Aluminium Factory, China. SETTING:The university and affiliated hospital cooperated in the study. PARTICIPANTS:There...

journal_title：BMJ open

authors： Meng H,Wang S,Guo J,Zhao Y,Zhang S,Zhao Y,Niu Q

更新日期：2019-06-16 00:00:00

abstract：INTRODUCTION:Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking lysine-binding sites on plasminogen, which contribute to reduced bleeding, the need for transfusion and mortality. Although there is reliable evidence of the efficacy of TXA, its effects on other...

journal_title：BMJ open

authors： Murao S,Nakata H,Yamakawa K

更新日期：2020-06-22 00:00:00

abstract：OBJECTIVE:Independent living ability is crucial for the elderly; however, its assessment performed in China employs various scales and lacks risk factors, especially behavioural and social-psychological factors, which could be improved through health education. This study aimed to assess the independent living ability ...

journal_title：BMJ open

authors： Wang B,Wu Y,Zhang T,Han J,Yu L,Sun W

更新日期：2019-10-16 00:00:00

abstract：OBJECTIVE:To investigate the relationship between short sleep and obesity among Thai adults. DESIGN:Both 4-year longitudinal and cross-sectional analyses of a large national cohort. SETTING:Thai adults residing nationwide from 2005 to 2009. PARTICIPANTS:Cohort members were enrolled as distance learners at Sukhothai ...

journal_title：BMJ open

authors： Yiengprugsawan V,Banwell C,Seubsman SA,Sleigh AC,Thai Cohort Study Team.

更新日期：2012-02-03 00:00:00

abstract：PURPOSE:Chagas disease (CD) has become a global health issue mainly due to migration. Germany lacks surveillance data and is home to a large Latin American immigrant population. Recognising that Bolivia is the country with the highest CD prevalence in Latin America, this cross-sectional, descriptive pilot study investi...

journal_title：BMJ open

authors： Navarro M,Berens-Riha N,Hohnerlein S,Seiringer P,von Saldern C,Garcia S,Blasco-Hernández T,Navaza B,Shock J,Bretzel G,Hoelscher M,Löscher T,Albajar-Viñas P,Pritsch M

更新日期：2017-01-16 00:00:00

abstract：INTRODUCTION:The aim of this study, which will include randomised controlled trials (RCTs), is to assess the efficacy and safety of acupuncture for patients with stroke and urinary incontinence. METHODS AND ANALYSIS:RCTs will be searched electronically in the MEDLINE, EMBASE, Cochrane CENTRAL, CINAHL and four Chinese ...

journal_title：BMJ open

authors： Sun Z,Yu N,Yue J,Zhang Q

更新日期：2016-02-23 00:00:00

abstract：PURPOSE:Progression of stable coronary artery disease (CAD) towards acute coronary syndrome (ACS) is a dynamic and heterogeneous process with many intertwined constituents, in which a plaque destabilising sequence could lead to ACS within short time frames. Current CAD risk assessment models, however, are not designed ...

journal_title：BMJ open

authors： Oemrawsingh RM,Akkerhuis KM,Umans VA,Kietselaer B,Schotborgh C,Ronner E,Lenderink T,Liem A,Haitsma D,van der Harst P,Asselbergs FW,Maas A,Oude Ophuis AJ,Ilmer B,Dijkgraaf R,de Winter RJ,The SH,Wardeh AJ,Hermans W,Cr

更新日期：2016-12-23 00:00:00

abstract：OBJECTIVE:To examine whether confidence in primary healthcare (PHC) differs among ethnic-linguistic groups and which PHC experiences are associated with confidence. DESIGN:A cross-sectional study where patient surveys were administered using random digit dialling. Regression models identify whether ethnic-linguistic g...

journal_title：BMJ open

authors： Wong ST,Black C,Cutler F,Brooke R,Haggerty JL,Levesque JF

更新日期：2014-02-25 00:00:00

abstract：OBJECTIVE:To assess the effect of the Pregnant+ app on the 2-hour glucose level of the routine postpartum oral glucose tolerance test (OGTT) among women with gestational diabetes mellitus (GDM). The Pregnant+ app was designed to provide information about GDM, and promote physical activity and a healthy diet. DESIGN:A ...

journal_title：BMJ open

authors： Borgen I,Småstuen MC,Jacobsen AF,Garnweidner-Holme LM,Fayyad S,Noll J,Lukasse M

更新日期：2019-11-11 00:00:00

abstract：OBJECTIVE:In the field of palliative care (PC) as it is integrated into heart failure (HF) treatment, it is essential to explore the patient experience and build on this knowledge for the further development of PC practice and policy. Based on an intervention study, this paper explores what patients with HF find signif...

journal_title：BMJ open

authors： Roikjær SG,Simonÿ CP,Timm HU

更新日期：2020-12-31 00:00:00

abstract：OBJECTIVES:To compare the short-term and long-term effectiveness of human papillomavirus (HPV) tests in Norwegian Cervical Cancer Screening Programme (NCCSP). DESIGN:Nationwide register-based prospective follow-up study. SETTING:In 2005, the NCCSP implemented HPV testing in follow-up of unsatisfactory, atypical squam...

journal_title：BMJ open

authors： Nygård M,Røysland K,Campbell S,Dillner J

更新日期：2014-01-08 00:00:00

abstract：INTRODUCTION:Electronic prescribing (ePrescribing) systems are rapidly being introduced into National Health Systems (NHS) hospitals in England following their widespread earlier adoption into primary care settings. Such systems require substantial changes in the way pharmacists organise their work and perform their ro...

journal_title：BMJ open

authors： Schofield B,Cresswel K,Westbrook J,Slee A,Girling A,Shah S,Coleman J,Sheikh A

更新日期：2015-10-26 00:00:00

abstract：:Objective To investigate the views and practices of UK medical schools regarding the inclusion (or exclusion) of complementary and alternative medicine (CAM) in undergraduate medical curricula. Design Survey (by email) of UK medical schools offering MBBS (or equivalent) degrees. Results The overall response rate was...

journal_title：BMJ open

authors： Smith KR

更新日期：2011-06-08 00:00:00