Trabeculotomy versus combined trabeculotomy-trabeculectomy for primary congenital glaucoma: study protocol of a randomised controlled trial.

Abstract:

INTRODUCTION:Trabeculotomy and combined trabeculotomy-trabeculectomy (CTT) are major surgical options for primary congenital glaucoma (PCG). However, it is unclear which of these two surgical procedures should be recommended as the optimum first-line treatment for PCG. This trial aims to determine whether the outcomes of trabeculotomy are non-inferior to those of CTT in moderate PCG with a horizontal corneal diameter (HCD) of 12-14 mm. METHODS AND ANALYSIS:This is a 3-year, non-inferiority, prospective, randomised controlled trial. We plan to recruite 248 participants (aged ≤3 years) with PCG with an HCD of 12-14 mm from the Department of Glaucoma, Zhongshan Ophthalmic Center, Guangzhou, China. One eye per participant will be randomly (1:1) assigned to receive trabeculotomy or CTT. The primary outcome is the 3-year postoperative success rate in lowering intraocular pressure (IOP), and the secondary clinical outcomes will include IOP reduction, visual acuity, HCD, central corneal thickness, axial length, cup-disc ratio, refractive error and postoperative complications. Data will be analysed by the intention-to-treat principle. ETHICAL APPROVAL AND DISSEMINATION:The study protocol has been approved by the ethics committee of Zhongshan Ophthalmic Center (2014MEKY023) and the '5010 Plan' evaluation committee at Sun Yat-Sen University, Guangzhou, China. The results will be disseminated in international academic meetings and published in peer-reviewed journals. TRIAL REGISTRATION NUMBER:Chinese Clinical Trial Registry, ChiCTR-IOR-14005588; Date registered: 20 November 2014.

journal_name

BMJ Open

journal_title

BMJ open

authors

Fang L,Guo X,Yang Y,Zhang J,Chen X,Zhu Y,Huang J,Huang J,Zhong Y,Xu X,Liu X

doi

10.1136/bmjopen-2019-032957

subject

Has Abstract

pub_date

2020-02-25 00:00:00

pages

e032957

issue

2

issn

2044-6055

pii

bmjopen-2019-032957

journal_volume

10

pub_type

杂志文章

相关文献

BMJ Open文献大全
  • Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study.

    abstract:OBJECTIVES:To estimate the impact of the COVID-19 pandemic on cancer care services and overall (direct and indirect) excess deaths in people with cancer. METHODS:We employed near real-time weekly data on cancer care to determine the adverse effect of the pandemic on cancer services. We also used these data, together w...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmjopen-2020-043828

    authors: Lai AG,Pasea L,Banerjee A,Hall G,Denaxas S,Chang WH,Katsoulis M,Williams B,Pillay D,Noursadeghi M,Linch D,Hughes D,Forster MD,Turnbull C,Fitzpatrick NK,Boyd K,Foster GR,Enver T,Nafilyan V,Humberstone B,Neal RD,C

    更新日期:2020-11-17 00:00:00

  • Use of the SONET score to evaluate Urgent Care Center overcrowding: a prospective pilot study.

    abstract:OBJECTIVES:To derive a tool to determine Urgent Care Center (UCC) crowding and investigate the association between different levels of UCC overcrowding and negative patient care outcomes. DESIGN:Prospective pilot study. SETTING:Single centre study in the USA. PARTICIPANTS:3565 patients who registered at UCC during t...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2014-006860

    authors: Wang H,Robinson RD,Cowden CD,Gorman VA,Cook CD,Gicheru EK,Schrader CD,Jayswal RD,Zenarosa NR

    更新日期:2015-04-14 00:00:00

  • Characteristics of randomised trials on diseases in the digestive system registered in ClinicalTrials.gov: a retrospective analysis.

    abstract::Objectives To evaluate the adequacy of reporting of protocols for randomised trials on diseases of the digestive system registered in http://ClinicalTrials.gov and the consistency between primary outcomes, secondary outcomes and sample size specified in http://ClinicalTrials.gov and published trials. Methods Randomis...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2011-000309

    authors: Wildt S,Krag A,Gluud L

    更新日期:2011-01-01 00:00:00

  • Neighbourhood urban form and individual-level correlates of leisure-based screen time in Canadian adults.

    abstract:OBJECTIVES:Despite evidence for an association between the built environment and physical activity, less evidence exists regarding relations between the built environment and sedentary behaviour. This study investigated the extent to which objectively assessed and self-reported neighbourhood walkability, in addition to...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2015-009418

    authors: McCormack GR,Mardinger C

    更新日期:2015-11-25 00:00:00

  • Retrospective study of prognosis and relating factors of cardiac complications associated with electrical injuries at a single centre in Korea.

    abstract:OBJECTIVES:To date, no research has investigated the association between cardiac complication and electrical injury; hence, we aimed to assess the consequences and relating factors of cardiac complications from electrical injuries in South Korea. DESIGN:Retrospective single-centre study. PARTICIPANTS:721 patients who...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-028741

    authors: Choi JH,Han D,Kang SH,Yoon CH,Cho JR,Kym D

    更新日期:2019-07-10 00:00:00

  • Cross-sectional study of the provision of interventional oncology services in the UK.

    abstract:OBJECTIVE:To map out the current provision of interventional oncology (IO) services in the UK. DESIGN:Cross-sectional multicentre study. SETTING:All National Health Service (NHS) trusts in England and Scottish, Welsh and Northern Ireland health boards. PARTICIPANTS:Interventional radiology (IR) departments in all NH...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-016631

    authors: Zhong J,Atiiga P,Alcorn DJ,Kay D,Illing R,Breen DJ,Railton N,McCafferty IJ,Haslam PJ,Wah TM

    更新日期:2017-10-22 00:00:00

  • Influence of alcohol use on mortality and expenditure during hospital admission: a cross-sectional study.

    abstract:OBJECTIVES:This study was designed to investigate the effect of alcohol intoxication on clinical presentation of hospitalised adult trauma patients at a Level I trauma centre using propensity score matching. DESIGN:Cross-sectional study. SETTING:Taiwan. PARTICIPANTS:Detailed data of 929 hospitalised adult trauma pat...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-013176

    authors: Peng SH,Hsu SY,Kuo PJ,Rau CS,Cheng YA,Hsieh CH

    更新日期:2016-11-01 00:00:00

  • Predicting risk of emergency admission to hospital using primary care data: derivation and validation of QAdmissions score.

    abstract:OBJECTIVE:To develop and externally validate a risk algorithm (QAdmissions) to estimate the risk of emergency hospital admission for patients aged 18-100 years in primary care. DESIGN:Prospective open cohort study using routinely collected data from general practice linked to hospital episode data during the 2-year st...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-003482

    authors: Hippisley-Cox J,Coupland C

    更新日期:2013-08-19 00:00:00

  • Maltreatment or violence-related injury in children and adolescents admitted to the NHS: comparison of trends in England and Scotland between 2005 and 2011.

    abstract:OBJECTIVE:Legislation to safeguard children from maltreatment by carers or violence by others was advanced in England and Scotland around 2004-2005 and resulted in different policies and services. We examined whether subsequent trends in injury admissions to hospital related to maltreatment or violence varied between t...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-004474

    authors: Gonzalez-Izquierdo A,Cortina-Borja M,Woodman J,Mok J,McGhee J,Taylor J,Parkin C,Gilbert R

    更新日期:2014-04-22 00:00:00

  • Examining the relationship between neighbourhood deprivation and mental health service use of immigrants in Ontario, Canada: a cross-sectional study.

    abstract:OBJECTIVE:While newcomers are often disproportionately concentrated in disadvantaged areas, little attention is given to the effects of immigrants' postimmigration context on their mental health and care use. Intersectionality theory suggests that understanding the full impact of disadvantage requires considering the e...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2014-006690

    authors: Durbin A,Moineddin R,Lin E,Steele LS,Glazier RH

    更新日期:2015-03-13 00:00:00

  • The performance of seven QPrediction risk scores in an independent external sample of patients from general practice: a validation study.

    abstract:OBJECTIVES:To validate the performance of a set of risk prediction algorithms developed using the QResearch database, in an independent sample from general practices contributing to the Clinical Research Data Link (CPRD). SETTING:Prospective open cohort study using practices contributing to the CPRD database and pract...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2014-005809

    authors: Hippisley-Cox J,Coupland C,Brindle P

    更新日期:2014-08-28 00:00:00

  • Lifestyle risk factors for invasive pneumococcal disease: a systematic review.

    abstract:OBJECTIVE:To systematically review the literature for evidence of smoking and alcohol intake as independent risk factors for invasive pneumococcal disease (IPD). DESIGN:Systematic review. METHODS:MEDLINE (1946-May 2012) and EMBASE (1947-May 2012) were searched for studies investigating alcohol or smoking as risk fact...

    journal_title:BMJ open

    pub_type: 杂志文章,评审

    doi:10.1136/bmjopen-2014-005224

    authors: Cruickshank HC,Jefferies JM,Clarke SC

    更新日期:2014-06-20 00:00:00

  • Characterising the patient experience of diagnostic lumbar puncture in idiopathic intracranial hypertension: a cross-sectional online survey.

    abstract:OBJECTIVES:Patients with idiopathic intracranial hypertension (IIH) usually require multiple lumbar punctures (LPs) during the course of their disease, and often report significant morbidity associated with the procedure. The aim of this study was to assess the patient's experience of diagnostic LP in IIH. DESIGN, MET...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-020445

    authors: Scotton WJ,Mollan SP,Walters T,Doughty S,Botfield H,Markey K,Yiangou A,Williamson S,Sinclair AJ

    更新日期:2018-05-30 00:00:00

  • Case for hospital nurse-to-patient ratio legislation in Queensland, Australia, hospitals: an observational study.

    abstract:OBJECTIVES:To determine whether there was variation in nurse staffing across hospitals in Queensland prior to implementation of nurse-to-patient ratio legislation targeting medical-surgical wards, and if so, the extent to which nurse staffing variation was associated with poor outcomes for patients and nurses. DESIGN:...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-036264

    authors: McHugh MD,Aiken LH,Windsor C,Douglas C,Yates P

    更新日期:2020-09-06 00:00:00

  • Dietary intake, physical activity and muscle strength among adolescents: the Malaysian Health and Adolescents Longitudinal Research Team (MyHeART) study.

    abstract:OBJECTIVE:To examine the role of dietary intake and physical activity in muscle strength among adolescents. DESIGN:Cross-sectional analysis. SETTING:The Malaysian Health and Adolescents Longitudinal Research Team (MyHeART) study. PARTICIPANTS:Fifteen-year-old secondary school children who have given consent and who ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-026275

    authors: Ng AK,Hairi NN,Jalaludin MY,Majid HA

    更新日期:2019-06-27 00:00:00

  • A UK survey of driving behaviour, fatigue, risk taking and road traffic accidents.

    abstract:OBJECTIVE:The aim of the present research was to examine associations between poor driving behaviour (DB), driving when fatigued (DF), risk taking (RT) and road traffic accidents (RTAs). DESIGN:The study involved a cross-sectional online survey of clients of an insurance company. The survey measured DB (speeding, dist...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-011461

    authors: Smith AP

    更新日期:2016-08-18 00:00:00

  • Risk factors for bone metastasis in patients with primary lung cancer: study protocol for a systematic review.

    abstract:INTRODUCTION:Bone metastasis (BM) in patients with primary lung cancer poses a serious health problem. Numerous risk factors have been hypothesised to predict BM in these patients, but research studies are of mutable quality, and may not be of value in clinical evaluation. METHODS AND ANALYSIS:We will search a number ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2014-005202

    authors: Niu YJ,Wen YT,Shen WW,Deng L,Liu LL,Zhang HL

    更新日期:2014-07-24 00:00:00

  • Digital and online symptom checkers and health assessment/triage services for urgent health problems: systematic review.

    abstract:OBJECTIVES:In England, the NHS111 service provides assessment and triage by telephone for urgent health problems. A digital version of this service has recently been introduced. We aimed to systematically review the evidence on digital and online symptom checkers and similar services. DESIGN:Systematic review. DATA S...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-027743

    authors: Chambers D,Cantrell AJ,Johnson M,Preston L,Baxter SK,Booth A,Turner J

    更新日期:2019-08-01 00:00:00

  • Cohort profile: the Nordic Antireflux Surgery Cohort (NordASCo).

    abstract:PURPOSE:To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-016505

    authors: Maret-Ouda J,Wahlin K,Artama M,Brusselaers N,Färkkilä M,Lynge E,Mattsson F,Pukkala E,Romundstad P,Tryggvadóttir L,Euler-Chelpin MV,Lagergren J

    更新日期:2017-06-08 00:00:00

  • Impact of an SMS advice programme on maternal and newborn health in rural China: study protocol for a quasi-randomised controlled trial.

    abstract:INTRODUCTION:Expectant mothers in low-income and middle-income countries often lack access to vital information about pregnancy, preparation for birth and best practices when caring for their newborn. Innovative solutions are needed to bridge this knowledge gap and dramatically improve maternal and neonatal health in t...

    journal_title:BMJ open

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmjopen-2015-011016

    authors: Su Y,Yuan C,Zhou Z,Heitner J,Campbell B

    更新日期:2016-08-10 00:00:00

  • Association between platelet count and hepatocellular carcinoma overall survival: a large retrospective cohort study.

    abstract:OBJECTIVES:To explore the non-linear relationship between platelet count (PLT) and hepatocellular carcinoma (HCC) overall survival (OS). SETTING:The study was done in Sun Yat-sen University Cancer Center (SYSUCC) from January 2007 to May 2012, a total of 5005 consecutive participants at SYSUCC were retrospectively rev...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-038172

    authors: Lu L,Su Z,Zheng P,Wu Z,Zhang Y,He H,Liu J,Lin S,Chen X

    更新日期:2020-11-06 00:00:00

  • Increased planned delivery contributes to declining rates of pregnancy hypertension in Australia: a population-based record linkage study.

    abstract:OBJECTIVE:Since the 1990s, pregnancy hypertension rates have declined in some countries, but not all. Increasing rates of early planned delivery (before the due date) have been hypothesised as the reason for the decline. The aim of this study was to explore whether early planned delivery can partly explain the declinin...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2015-009313

    authors: Roberts CL,Algert CS,Morris JM,Ford JB

    更新日期:2015-10-05 00:00:00

  • Diagnostic markers of acute infections in infants aged 1 week to 3 months: a retrospective cohort study.

    abstract:OBJECTIVE:History and physical examination do not reliably exclude serious bacterial infections (SBIs) in infants. We examined potential markers of SBI in young febrile infants. DESIGN:We reviewed white cell count (WBC), absolute neutrophil count (ANC), neutrophil to lymphocyte count ratio (NLR) and C reactive protein...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-018092

    authors: Hamiel U,Bahat H,Kozer E,Hamiel Y,Ziv-Baran T,Goldman M

    更新日期:2018-01-24 00:00:00

  • Recruitment and retention of participants in randomised controlled trials: a review of trials funded and published by the United Kingdom Health Technology Assessment Programme.

    abstract:BACKGROUND:Substantial amounts of public funds are invested in health research worldwide. Publicly funded randomised controlled trials (RCTs) often recruit participants at a slower than anticipated rate. Many trials fail to reach their planned sample size within the envisaged trial timescale and trial funding envelope....

    journal_title:BMJ open

    pub_type: 杂志文章,评审

    doi:10.1136/bmjopen-2016-015276

    authors: Walters SJ,Bonacho Dos Anjos Henriques-Cadby I,Bortolami O,Flight L,Hind D,Jacques RM,Knox C,Nadin B,Rothwell J,Surtees M,Julious SA

    更新日期:2017-03-20 00:00:00

  • Evaluation of actigraphy-measured sleep patterns among children with disabilities and associations with caregivers' educational attainment: results from a cross-sectional study.

    abstract:OBJECTIVES:To use wrist-actrigrphy to collect objective measures of sleep and to characterise actigraphy-measured sleep patterns among children with disabilities. We also assessed the extent to which, if at all, caregivers' education is associated with children's sleep disturbances. DESIGN:Cross-sectional study. SETT...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2015-008589

    authors: Chen X,Velez JC,Barbosa C,Pepper M,Gelaye B,Redline S,Williams MA

    更新日期:2015-12-07 00:00:00

  • Prenatal exposure to antiepileptic drugs and use of primary healthcare during childhood: a population-based cohort study in Denmark.

    abstract:OBJECTIVE:Prenatal exposure to antiepileptic drugs (AEDs) has been associated with adverse outcomes in the offspring such as congenital malformations and neuropsychiatric disorders. The objective of this study was to investigate whether prenatal exposure to AEDs is also associated with more frequent use of primary heal...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-012836

    authors: Würtz AM,Rytter D,Vestergaard CH,Christensen J,Vestergaard M,Bech BH

    更新日期:2017-01-05 00:00:00

  • Preferences of people with type 2 diabetes for telemedical lifestyle programmes in Germany: protocol of a discrete choice experiment.

    abstract:INTRODUCTION:Telemedical lifestyle programmes for people with type 2 diabetes mellitus (T2DM) provide an opportunity to develop a healthier lifestyle and consequently to improve health outcomes. When implementing new programmes into standard care, considering patients' preferences may increase the success of the partic...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-036995

    authors: Sommer J,Dyczmons J,Grobosch S,Gontscharuk V,Vomhof M,Roden M,Icks A

    更新日期:2020-09-09 00:00:00

  • Is the admission test for a course in medicine a good predictor of academic performance? A case-control experience at the school of medicine of Turin.

    abstract:OBJECTIVES:The usefulness of university admission tests to medical schools has been discussed in recent years. In the academic year 2014-15 in Italy, several students who failed the admission test appealed to the regional administrative court ('Tribunale Amministrativo Regionale'-TAR) requesting to be included, despite...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-017417

    authors: Migliaretti G,Bozzaro S,Siliquini R,Stura I,Costa G,Cavallo F

    更新日期:2017-12-01 00:00:00

  • What factors contribute to positive early childhood health and development in Australian Aboriginal children? Protocol for a population-based cohort study using linked administrative data (The Seeding Success Study).

    abstract:INTRODUCTION:Australian Aboriginal children are more likely than non-Aboriginal children to have developmental vulnerability at school entry that tracks through to poorer literacy and numeracy outcomes and multiple social and health disadvantages in later life. Empirical evidence identifying the key drivers of positive...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2015-007898

    authors: Falster K,Jorm L,Eades S,Lynch J,Banks E,Brownell M,Craven R,Einarsdóttir K,Randall D,Seeding Success Investigators.

    更新日期:2015-05-18 00:00:00

  • Knowledge and attitudes of UK university students in relation to ultraviolet radiation (UVR) exposure and their sun-related behaviours: a qualitative study.

    abstract:OBJECTIVES:To explore whether knowledge about the harms of ultraviolet radiation (UVR) influences UK university students' sun-related behaviours and examine in depth their attitudes towards: sun protection, natural and artificial tanning behaviours. DESIGN:Qualitative methodology with 15 semistructured, individual int...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-014388

    authors: Kirk L,Greenfield S

    更新日期:2017-03-13 00:00:00