Systematic review of genome-wide expression studies in multiple sclerosis.

abstract：OBJECTIVES:Overweight and obesity remain at historically high levels, cluster within families and are established risk factors for multiple diseases. We describe the epidemiology and cross-generational concordance of body composition among Australian children aged 11-12 years and their parents. DESIGN:The population-b...

journal_title：BMJ open

authors： Clifford SA,Gillespie AN,Olds T,Grobler AC,Wake M

更新日期：2019-07-04 00:00:00

abstract：OBJECTIVE:To evaluate the cost-utility of 100 days of antibiotics in patients with chronic low back pain (LBP) and type I or II Modic changes included in the Antibiotic treatment In patients with chronic low back pain and Modic changes (AIM) study. DESIGN:A cost-utility analysis from a societal and healthcare perspect...

journal_title：BMJ open

authors： Grotle M,Bråten LC,Brox JI,Espeland A,Zolic-Karlsson Z,Munk Killingmo R,Tingulstad A,Grøvle L,Froholdt A,Kristoffersen PM,Wigemyr M,van Tulder MW,Storheim K,Zwart JA,AIM-study group.

更新日期：2020-06-15 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic, systemic, inflammatory diseases, primarily in the musculoskeletal system. Pain and fatigue are key symptoms of RA and AS. Treatment presents a clinical challenge for several reasons, including the progressive nature of the diseases and ...

journal_title：BMJ open

authors： Hendricks O,Andersen TE,Christiansen AA,Primdahl J,Hauge EM,Ellingsen T,Horsted TI,Bachmann AG,Loft AG,Bojesen AB,Østergaard M,Lund Hetland M,Krogh NS,Roessler KK,Petersen KH

更新日期：2019-06-04 00:00:00

abstract：OBJECTIVES:Ophthalmology units across the UK vary widely in their adoption of electronic medical records (EMR). There is a lack of evidence to show the extent and progress of EMR adoption. The aim of this study was to capture a snapshot of the current landscape of EMR use, as a baseline for comparison in future studies...

journal_title：BMJ open

authors： Lim SB,Shahid H

更新日期：2017-05-17 00:00:00

abstract：OBJECTIVE:To pilot and feasibility-test supervised final year undergraduate pharmacy student-led medication reviews for patients with diabetes to enable definitive trial design. METHOD:Third year pharmacy students were recruited from one UK School of Pharmacy and trained to review patient's medical records and provide...

journal_title：BMJ open

authors： Adams RP,Barton G,Bhattacharya D,Grassby PF,Holland R,Howe A,Norris N,Shepstone L,Wright DJ

更新日期：2015-11-04 00:00:00

abstract：OBJECTIVE:Evidence-based performance measures have been increasingly used to evaluate hospital quality of stroke care, but their impact on stroke outcomes has not been verified. We aimed to evaluate the correlations between hospital performance measures and outcomes among patients with acute ischaemic stroke in a Chine...

journal_title：BMJ open

authors： Zhang X,Li Z,Zhao X,Xian Y,Liu L,Wang C,Wang C,Li H,Prvu Bettger J,Yang Q,Wang D,Jiang Y,Bao X,Yang X,Wang Y,Wang Y

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Most studies reporting evidence of adverse effects of lead and cadmium on the ability to balance have been conducted in high-exposure groups or have included adults. The effects of prenatal exposure have not been well studied, nor have the effects in children been directly studied. The aim of the study was t...

journal_title：BMJ open

authors： Taylor CM,Humphriss R,Hall A,Golding J,Emond AM

更新日期：2015-12-30 00:00:00

abstract：INTRODUCTION:Understanding what enhances the motivation and performance of community health workers (CHWs) in humanitarian emergencies represents a key research gap within the field of human resources for health. This paper presents the research protocol for the Performance ImprovEment of CHWs in Emergency Settings (PI...

journal_title：BMJ open

authors： Gilmore B,Adams BJ,Bartoloni A,Alhaydar B,McAuliffe E,Raven J,Taegtmeyer M,Vallières F

更新日期：2016-08-16 00:00:00

abstract：OBJECTIVE:The risk of fetal death increases steeply after 42 gestational weeks. Since 2009, Denmark has had a more proactive policy including prevention of prolonged pregnancy, and early intervention in women with diabetes, preeclampsia, high body mass index and of a higher age group. The aim of this study was to descr...

journal_title：BMJ open

authors： Hedegaard M,Lidegaard Ø,Skovlund CW,Mørch LS,Hedegaard M

更新日期：2014-08-14 00:00:00

abstract：INTRODUCTION:Community-based interventions have been found to effectively increase the implementation of alcohol management practices and reduce excessive alcohol use and alcohol-related harm at sports clubs. However, once implementation support ceases there may be a reduction in such intervention effects. Thus, ongoin...

journal_title：BMJ open

authors： McFadyen T,Wolfenden L,Kingsland M,Tindall J,Rowland B,Sherker S,Gillham K,Heaton R,Clinton-McHarg T,Lecathelinais C,Brooke D,Wiggers J

更新日期：2018-01-23 00:00:00

abstract：OBJECTIVES:To simplify our previous risk score for predicting the in-hospital mortality risk in patients with non-ST-segment elevation myocardial infarction (NSTEMI) by dropping laboratory data. DESIGN:Prospective cohort. SETTING:Multicentre, 108 hospitals across three levels in China. PARTICIPANTS:A total of 5775 p...

journal_title：BMJ open

authors： Song C,Fu R,Li S,Yang J,Wang Y,Xu H,Gao X,Liu J,Liu Q,Wang C,Dou K,Yang Y

更新日期：2019-09-12 00:00:00

abstract：OBJECTIVES:Healthcare professionals are expected to firmly ground their practice in sound evidence. That implies that they know and use evidence-based medicine (EBM). In this study, our aim was to know how often health professionals actually made use of EBM in their daily practice. DESIGN:A questionnaire survey of hea...

journal_title：BMJ open

authors： Lafuente-Lafuente C,Leitao C,Kilani I,Kacher Z,Engels C,Canouï-Poitrine F,Belmin J

更新日期：2019-03-30 00:00:00

abstract：OBJECTIVES:Head injury is a common reason for emergency department (ED) attendance. Around 1% of patients have life-threatening injuries, while 80% of patients are discharged. National guidelines (Scottish Intercollegiate Guidelines Network (SIGN)) were introduced in Scotland with the aim of achieving early identificat...

journal_title：BMJ open

authors： Marincowitz C,Lecky FE,Morris E,Allgar V,Sheldon TA

更新日期：2018-12-22 00:00:00

abstract：OBJECTIVE:To map out the current provision of interventional oncology (IO) services in the UK. DESIGN:Cross-sectional multicentre study. SETTING:All National Health Service (NHS) trusts in England and Scottish, Welsh and Northern Ireland health boards. PARTICIPANTS:Interventional radiology (IR) departments in all NH...

journal_title：BMJ open

authors： Zhong J,Atiiga P,Alcorn DJ,Kay D,Illing R,Breen DJ,Railton N,McCafferty IJ,Haslam PJ,Wah TM

更新日期：2017-10-22 00:00:00

abstract：OBJECTIVES:Approximately one in eight practices in primary care in England are 'dispensing practices' with an in-house dispensary providing medication directly to patients. These practices can generate additional income by negotiating lower prices on higher cost drugs, while being reimbursed at a standard rate. They, t...

journal_title：BMJ open

authors： Goldacre B,Reynolds C,Powell-Smith A,Walker AJ,Yates TA,Croker R,Smeeth L

更新日期：2019-02-05 00:00:00

abstract：OBJECTIVES:To evaluate the prevalence of depressive symptoms and its influencing factors in late pregnancy. DESIGN:Cross-sectional study. SETTING:Fourteen community in urban areas of Hengyang City. PARTICIPANTS:The study conducted from July to October 2019, and surveyed 813 women in late pregnancy who lived in urban...

journal_title：BMJ open

authors： Yu Y,Zhu X,Xu H,Hu Z,Zhou W,Zheng B,Yin S

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To appraise and synthesise research on the impact of physician assistants/associates (PA) in secondary care, specifically acute internal medicine, care of the elderly, emergency medicine, trauma and orthopaedics, and mental health. DESIGN:Systematic review. SETTING:Electronic databases (Medline, Embase, ASS...

journal_title：BMJ open

authors： Halter M,Wheeler C,Pelone F,Gage H,de Lusignan S,Parle J,Grant R,Gabe J,Nice L,Drennan VM

更新日期：2018-06-19 00:00:00

abstract：INTRODUCTION:The development of malignant pleural effusion (MPE) results in disabling breathlessness, pain and reduced physical capability with treatment a palliative strategy. Ambulatory management of MPE has the potential to improve quality of life (QoL). The OPTIMUM trial is designed to determine whether full outpat...

journal_title：BMJ open

authors： Sivakumar P,Douiri A,West A,Rao D,Warwick G,Chen T,Ahmed L

更新日期：2016-10-18 00:00:00

abstract：OBJECTIVES:The Stretching And strengthening for Rheumatoid Arthritis of the Hand (SARAH) randomised controlled trial evaluated the effectiveness of a hand exercise programme and demonstrated it was clinically effective and cost-effective at 12 months. The aim of this extended follow-up was to evaluate the effects of th...

journal_title：BMJ open

authors： Williamson E,McConkey C,Heine P,Dosanjh S,Williams M,Lamb SE

更新日期：2017-04-12 00:00:00

abstract：OBJECTIVES:To establish if emergency medicine and neuroscience specialist consultants have different risk tolerances for investigation of suspected spontaneous subarachnoid haemorrhage (SAH), and to establish if their risk-benefit appraisals concur with current guidelines. SETTING:4 major neuroscience centres in Londo...

journal_title：BMJ open

authors： Lansley J,Selai C,Krishnan AS,Lobotesis K,Jäger HR

更新日期：2016-09-15 00:00:00

abstract：OBJECTIVES:In England, the NHS111 service provides assessment and triage by telephone for urgent health problems. A digital version of this service has recently been introduced. We aimed to systematically review the evidence on digital and online symptom checkers and similar services. DESIGN:Systematic review. DATA S...

journal_title：BMJ open

authors： Chambers D,Cantrell AJ,Johnson M,Preston L,Baxter SK,Booth A,Turner J

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Community health workers (CHWs)-shown to improve access to care and reduce maternal, newborn, and child morbidity and mortality-are re-emerging as a key strategy to achieve health-related Sustainable Development Goals (SDGs). However, recent evaluations of national programmes for CHW-led integrated communi...

journal_title：BMJ open

authors： Whidden C,Treleaven E,Liu J,Padian N,Poudiougou B,Bautista-Arredondo S,Fay MP,Samaké S,Cissé AB,Diakité D,Keita Y,Johnson AD,Kayentao K

更新日期：2019-08-26 00:00:00

abstract：OBJECTIVE:This study aimed to define the end-of-life (EOL) healthcare utilisation and its cost and determinants for cancer patients and to proactively inform related strategies in mainland China. DESIGN:A population-based retrospective study. SETTING AND PARTICIPANTS:Data from 894 cancer patients were collected in ur...

journal_title：BMJ open

authors： Li Z,Pan Z,Zhang L,He R,Jiang S,Xu C,Lu F,Zhang P,Li B

更新日期：2019-03-20 00:00:00

abstract：OBJECTIVES:To identify the sociodemographic factors associated with variation in area-based breastfeeding in England; to calculate the predicted breastfeeding rates adjusted for sociodemographic variations. DESIGN:Ecological analysis of routine data using random effects logistic regression. SETTING:All 151 primary ca...

journal_title：BMJ open

authors： Oakley LL,Renfrew MJ,Kurinczuk JJ,Quigley MA

更新日期：2013-06-20 00:00:00

abstract：:Objective A randomised controlled study performed from 2007 to 2008 showed beneficial effects of a composite clinical pharmacist service as regards a simple health status instrument. The present study aimed to evaluate if the intervention was cost-effective when evaluated in a decision-theoretic model. Design A piggy...

journal_title：BMJ open

authors： Wallerstedt SM,Bladh L,Ramsberg J

更新日期：2012-01-05 00:00:00

abstract：OBJECTIVE:To assess the effect that accreditation training in fetal growth surveillance and evidence-based protocols had on stillbirth rates in England and Wales. DESIGN:Analysis of mortality data from Office of National Statistics. SETTING:England and Wales, including three National Health Service (NHS) regions (Wes...

journal_title：BMJ open

authors： Gardosi J,Giddings S,Clifford S,Wood L,Francis A

更新日期：2013-12-17 00:00:00

abstract：OBJECTIVES:In response to public health concern about effects of arson at solid waste management plants in July 2012, we analysed vital statistics data to evaluate any potential effect on pregnancies at different gestational ages of pollutants emitted from the landfill on fire. SETTING:A community living near the larg...

journal_title：BMJ open

authors： Mazzucco W,Tavormina E,Macaluso M,Marotta C,Cusimano R,Alba D,Costantino C,Grammauta R,Cernigliaro A,Scondotto S,Vitale F

更新日期：2019-07-04 00:00:00

abstract：OBJECTIVE:To determine whether valproate (VPA) monotherapy influences homocysteine metabolism in patients with epilepsy. DESIGN:Systematic review and meta-analysis. DATA SOURCES:We searched all articles in English through PubMed, Web of Science and EMBASE published up to August 2013 concerning the homocysteine levels...

journal_title：BMJ open

authors： Ni G,Qin J,Fang Z,Chen Y,Chen Z,Zhou J,Zhou L

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:In recent years, there has been increased interest in the use of ultrasound technology in the evaluation of spinal and paraspinal regions. OBJECTIVE:This study aimed to investigate trends in spinal ultrasound research from 1994 to 2015 and compare the contributions of such research from different countries ...

journal_title：BMJ open

authors： Zhai X,Cui J,Shao J,Wang Q,Chen X,Wei X,Zhou X,Chen Z,Bai Y,Li M

更新日期：2017-10-22 00:00:00

abstract：INTRODUCTION:Controlled trials support the efficacy of exercise as a treatment modality for chronic conditions, yet effectiveness of real-world Exercise Physiology services is yet to be determined. This study will investigate the efficacy and cost-effectiveness of services provided by Accredited Exercise Physiologists ...

journal_title：BMJ open

authors： Kitic CM,Selig S,Davison K,Best TLB,Parmenter B,Pumpa K,Furzer B,Rice V,Hardcastle S,Cheney M,Palmer AJ,Fraser S,Williams AD

更新日期：2019-08-21 00:00:00