OPTIMUM: a protocol for a multicentre randomised controlled trial comparing Out Patient Talc slurry via Indwelling pleural catheter for Malignant pleural effusion vs Usual inpatient Management.

abstract：OBJECTIVES:To assess the current evidence on the effect pre-arrest comorbidity has on survival and neurological outcomes following out-of-hospital cardiac arrest (OHCA). DESIGN:Systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. DATA SOURCES:MEDLINE, Ovid Embase, Sco...

journal_title：BMJ open

authors： Majewski D,Ball S,Finn J

更新日期：2019-11-18 00:00:00

abstract：OBJECTIVE:The human leucocyte antigen-DO (HLA-DO) gene located in the HLA non-classical class-II region may play a role in treatment response to hepatitis C virus (HCV). This study was conducted to explore the role of single nucleotide polymorphisms (SNPs) in HLA-DO in responding to HCV therapy. SETTING:All patients w...

journal_title：BMJ open

authors： Yao Y,Liu M,Zang F,Yue M,Xia X,Feng Y,Fan H,Zhang Y,Huang P,Yu R

更新日期：2018-04-12 00:00:00

abstract：OBJECTIVES:To clarify the association between glucose intolerance and high altitudes (2900-4800 m) in a hypoxic environment in Tibetan highlanders and to verify the hypothesis that high altitude dwelling increases vulnerability to diabetes mellitus (DM) accelerated by lifestyle change or ageing. DESIGN:Cross-sectional...

journal_title：BMJ open

authors： Okumiya K,Sakamoto R,Ishimoto Y,Kimura Y,Fukutomi E,Ishikawa M,Suwa K,Imai H,Chen W,Kato E,Nakatsuka M,Kasahara Y,Fujisawa M,Wada T,Wang H,Dai Q,Xu H,Qiao H,Ge RL,Norboo T,Tsering N,Kosaka Y,Nose M,Yamaguchi

更新日期：2016-02-23 00:00:00

abstract：INTRODUCTION:Stroke is a major health problem and transient ischaemic attack (TIA) is an important risk factor for stroke. Primary prevention of stroke and TIA will have the greatest impact on reducing the burden of these conditions. Evidence-based guidelines for stroke/TIA prevention identify individuals eligible for ...

journal_title：BMJ open

authors： Moran GM,Calvert M,Feltham MG,Marshall T

更新日期：2014-11-11 00:00:00

abstract：OBJECTIVE:From 2011 to 2013, the Global Fund (GF) supported needle and syringe programmes in Mexico to prevent transmission of HIV among people who inject drugs. It remains unclear how GF withdrawal affected the costs, quality and coverage of needle and syringe programme provision. DESIGN:Costing study and longitudina...

journal_title：BMJ open

authors： Cepeda JA,Burgos JL,Kahn JG,Padilla R,Meza Martinez PE,Segovia LA,Gaines T,Abramovitz D,Rangel G,Magis-Rodriguez C,Vickerman P,Strathdee SA,Martin NK

更新日期：2019-01-29 00:00:00

abstract：OBJECTIVE:To describe, using data from the Newcastle 85+ cohort study, the use of primary care and other healthcare services by 85-year-olds as they age. DESIGN:Longitudinal population-based cohort study. SETTING:Newcastle on Tyne and North Tyneside, UK. PARTICIPANTS:Community dwelling and institutionalised men and ...

journal_title：BMJ open

authors： Yadegarfar ME,Jagger C,Duncan R,Fouweather T,Hanratty B,Parker S,Robinson L

更新日期：2018-01-24 00:00:00

abstract：:Background and objective The birth of a preterm infant can be an overwhelming experience of guilt, fear and helplessness for parents. Provision of interventions to support and engage parents in the care of their infant may improve outcomes for both the parents and the infant. The objective of this systematic review is...

journal_title：BMJ open

authors： Brett J,Staniszewska S,Newburn M,Jones N,Taylor L

更新日期：2011-06-02 00:00:00

abstract：OBJECTIVES:To examine which interventions healthcare professionals use to support patients with taking medicines and their perceptions about the effectiveness of those actions. DESIGN:Cross-sectional multinational study. SETTING:Online survey in Austria, Belgium, England, France, Germany, Hungary, The Netherlands, Po...

journal_title：BMJ open

authors： Clyne W,Mshelia C,McLachlan S,Jones P,de Geest S,Ruppar T,Siebens K,Dobbels F,Kardas P

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Administering medication to hospitalised infants and children is a complex process at high risk of error. Failure mode and effect analysis (FMEA) is a proactive tool used to analyse risks, identify failures before they happen and prioritise remedial measures. To examine the hazards associated with the process...

journal_title：BMJ open

authors： Lago P,Bizzarri G,Scalzotto F,Parpaiola A,Amigoni A,Putoto G,Perilongo G

更新日期：2012-12-18 00:00:00

abstract：OBJECTIVE:To examine the associations of change in body mass index (BMI) and waist circumference (WC) over an average of 4 years with subsequent mortality risk in middle-aged to older Chinese. DESIGN:Prospective cohort study based on the Guangzhou Biobank Cohort Study. SETTING:Community-based sample. PARTICIPANTS:17...

journal_title：BMJ open

authors： Huang YY,Jiang CQ,Xu L,Zhang WS,Zhu F,Jin YL,Thomas GN,Cheng KK,Lam TH

更新日期：2020-12-04 00:00:00

abstract：OBJECTIVE:To identify the main areas of uncertainty and subsequent research priorities to inform the ongoing debate around assisted dying. DESIGN:Two-round electronic modified Delphi consultation with experts and interested bodies. SETTING AND PARTICIPANTS:110 groups and individuals interested in the subject of end-o...

journal_title：BMJ open

authors： Rodgers M,Booth A,Norman G,Sowden A

更新日期：2016-06-07 00:00:00

abstract：OBJECTIVE:Hepatitis B reactivation (HBr) is strongly associated with rituximab therapy. Guidelines advise hepatitis B screening and use of preventive nucleoside analogue (NA) in patients at risk. In this study, we examined screening trends, post-screening interventions and outcomes in patients receiving rituximab in li...

journal_title：BMJ open

authors： Haider M,Flocco G,Lopez R,Carey W

更新日期：2020-12-15 00:00:00

abstract：INTRODUCTION:The absence of companionship during childbirth is known to be responsible for negative emotional birth experience, which can increase the risk of postpartum depression and post-traumatic stress disorder. The context of COVID-19 epidemic and the related confinement could increase the rate of negative experi...

journal_title：BMJ open

authors： Bertholdt C,Epstein J,Banasiak C,Ligier F,Dahlhoff S,Olieric MF,Mottet N,Beaumont M,Morel O

更新日期：2020-12-10 00:00:00

abstract：OBJECTIVES:To investigate the prognostic value of the neurocognitive status measured by screening instruments, the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE), individually and in combination with the stroke severity scale, the National Institute of Health Stroke Scale (NIHSS), obtaine...

journal_title：BMJ open

authors： Dong Y,Slavin MJ,Chan BP,Venketasubramanian N,Sharma VK,Crawford JD,Collinson SL,Sachdev P,Chen CL

更新日期：2013-09-03 00:00:00

abstract：OBJECTIVES:Serum ferritin and body mass index (BMI) have been reportedly associated with coronary artery disease (CAD) risk. The aim of the present study was to explore the interaction between serum ferritin and BMI on CAD risk. DESIGN:Hospital-based case-control study. SETTING:Patients with CAD and the controls were...

journal_title：BMJ open

authors： Zhou Y,Liu T,Jia C

更新日期：2013-11-27 00:00:00

abstract：OBJECTIVES:To prevent pain inhibiting their performance, many athletes ingest over-the-counter (OTC) analgesics before competing. We aimed at defining the use of analgesics and the relation between OTC analgesic use/dose and adverse events (AEs) during and after the race, a relation that has not been investigated to da...

journal_title：BMJ open

authors： Küster M,Renner B,Oppel P,Niederweis U,Brune K

更新日期：2013-04-19 00:00:00

abstract：OBJECTIVES:To assess people's procedural preferences for making medical surrogate decisions, from the perspectives of both a potential surrogate and an incapacitated patient. DESIGN:Computer-assisted telephone interviews. Respondents were randomly assigned either the role of an incapacitated patient or that of a poten...

journal_title：BMJ open

authors： Frey R,Herzog SM,Hertwig R

更新日期：2018-07-25 00:00:00

abstract：INTRODUCTION:Depressive disorders are very common diseases entailing a great burden on affected people. However, comprehensive information on long-term disease course in patients with severe depression is lacking so far. The objectives of the DELTA study are to examine long-term outcomes and their predicting factors, t...

journal_title：BMJ open

authors： Kirchberger I,Maleckar B,Meisinger C,Linseisen J,Schmauss M,Baumgärtner J

更新日期：2019-12-23 00:00:00

abstract：OBJECTIVE:To determine the feasibility of specialist screening practitioners (SSPs) offering patient navigation (PN) to facilitate uptake of bowel scope screening (BSS) among patients who do not confirm or attend their appointment. DESIGN:A single-stage phase II trial. SETTING:South Tyneside District Hospital, Tyne a...

journal_title：BMJ open

authors： McGregor LM,Skrobanski H,Ritchie M,Berkman L,Miller H,Freeman M,Patel N,Morris S,Rees C,von Wagner C

更新日期：2019-02-15 00:00:00

abstract：INTRODUCTION:Anaemia is a major global health problem affecting about 43% of preschool children globally and 60% of 6-24-month-old children in rural Bangladesh, half of which is attributed to iron deficiency (ID). Although WHO recommends universal supplementation with iron or home fortification with iron-containing mul...

journal_title：BMJ open

authors： Hasan MI,Hossain SJ,Braat S,Dibley MJ,Fisher J,Grantham-McGregor S,Tofail F,Simpson JA,Arifeen SE,Hamadani J,Biggs BA,Pasricha SR

更新日期：2017-11-15 00:00:00

abstract：OBJECTIVES:To evaluate the utility of different symptoms, alone or combined, presented to primary care for an adult brain tumour diagnosis. DESIGN AND SETTING:Matched case-control study, using the data from Clinical Practice Research Datalink (2000-2014) from primary care consultations in the UK. METHOD:All presentat...

journal_title：BMJ open

authors： Ozawa M,Brennan PM,Zienius K,Kurian KM,Hollingworth W,Weller D,Grant R,Hamilton W,Ben-Shlomo Y

更新日期：2019-08-30 00:00:00

abstract：INTRODUCTION:Randomised controlled trials (RCTs) provide high-quality evidence to inform practice. However, much routine care is not based on available RCT evidence. Understanding this disconnect may improve trial design, reporting and implementation. Published literature commenting on RCTs may yield relevant insights....

journal_title：BMJ open

authors： Byrne BE,Rooshenas L,Lambert H,Blazeby JM

更新日期：2018-11-08 00:00:00

abstract：OBJECTIVES:To update the estimation of the adult HIV prevalence and number of people living with HIV (PLHIV) in India for the year 2008-2009 with the combination of improved data and methods. DESIGN:Based on HIV sentinel surveillance (HSS) data and a set of epidemiological assumptions, estimates of HIV prevalence and ...

journal_title：BMJ open

authors： Pandey A,Sahu D,Bakkali T,Reddy D,Venkatesh S,Kant S,Bhattacharya M,Raj Y,Haldar P,Bhardwaj D,Chandra N

更新日期：2012-09-30 00:00:00

abstract：INTRODUCTION:Stroke is a leading cause of disability worldwide. The average hospital length of stay ranges from 3 to 28 days, and after discharge home the stroke survivors will live with physical, cognitive, even psychological disorders for the rest of their lives. It is essential to review the unmet needs of stroke su...

journal_title：BMJ open

authors： Lin B,Ding C,Mei Y,Wang P,Ma F,Zhang ZX

更新日期：2019-06-21 00:00:00

abstract：OBJECTIVE:This study examined the association of initial provider treatment with early and long-term opioid use in a national sample of patients with new-onset low back pain (LBP). DESIGN:A retrospective cohort study of patients with new-onset LBP from 2008 to 2013. SETTING:The study evaluated outpatient and inpatien...

journal_title：BMJ open

authors： Kazis LE,Ameli O,Rothendler J,Garrity B,Cabral H,McDonough C,Carey K,Stein M,Sanghavi D,Elton D,Fritz J,Saper R

更新日期：2019-09-20 00:00:00

abstract：OBJECTIVES:To assess whether a journal club model could improve comprehension and written and spoken medical English in a population of Chinese medical professionals. SETTING AND PARTICIPANTS:The study population consisted of 52 medical professionals who were residents or postgraduate master or PhD students in the Dep...

journal_title：BMJ open

authors： Tsui IK,Dodson WC,Kunselman AR,Kuang H,Han FJ,Legro RS,Wu XK

更新日期：2016-01-28 00:00:00

abstract：OBJECTIVES:To investigate the prevalence of diabetes mellitus (DM) and new detection of DM using fasting plasma glucose (FPG) and 2 h plasma glucose (2-hPG) in hypertensive outpatients in China. DESIGN:Multicenter cross-sectional study. SETTING:46 hospitals in China. PARTICIPANTS:Study patients were consecutively re...

journal_title：BMJ open

authors： Liu J,Zhao D,Liu J,Qi Y,Sun J,Wang W

更新日期：2013-11-20 00:00:00

abstract：OBJECTIVES:This study aimed to identify intrauterine growth differences according to infertility treatment compared with spontaneous conception and to describe intrauterine growth trajectories. DESIGN:Retrospective cohort study. SETTING:A single primary and tertiary medical centre in Japan. PARTICIPANTS:This study i...

journal_title：BMJ open

authors： Shinohara S,Hirata S,Suzuki K

更新日期：2020-04-28 00:00:00

abstract：OBJECTIVE:Long working hours have been shown to raise the risk of various health outcomes. However, epidemiological evidence has shown inconsistent result in relation to type 2 diabetes mellitus (T2DM) and the association between long working hours and pre-diabetes among non-diabetic adults remains largely unexplored. ...

journal_title：BMJ open

authors： Baek Y,Kim M,Kim GR,Park EC

更新日期：2019-12-17 00:00:00

abstract：INTRODUCTION:The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micronutrient fortified l...

journal_title：BMJ open

authors： Borg B,Mihrshahi S,Griffin M,Chamnan C,Laillou A,Wieringa FT

更新日期：2017-09-06 00:00:00