Abstract:
OBJECTIVES:To investigate the accuracy, reproducibility and costs of different laboratory assays for the monitoring of unfractionated heparin (UFH) in clinical practice and to study test utilisation in Switzerland. DESIGN:Prospective evaluation study and survey among Swiss hospitals and laboratories. SETTING:Secondary care hospital in rural Switzerland (evaluation study); all Swiss hospitals and laboratories (survey). PARTICIPANTS:All consecutive patients, monitored for treatment with UFH during two time periods, were included (May to July 2014 and January to February 2015; n=254). OUTCOME MEASURES:Results of activated partial thromboplastin time (aPTT), thrombin time (TT), prothrombinase-induced clotting time (PiCT) and anti-Xa activity with respect to UFH concentration RESULTS: Spearman's correlation coefficient (rs) with regard to anti-Xa activity was 0.68 (95% CI 0.60 to 0.75) for aPTT, 0.79 (0.69 to 0.86) for TT and 0.94 (0.93 to 0.95) for PiCT. The correlation (rs) between anti-Xa activity and heparin concentration as determined by spiking plasma samples was 1.0 (1.0 to 1.0). The coefficient of variation was at most 5% for PiCT and anti-Xa activity (within-run as well as day-to-day variability). The total costs per test in Swiss Francs (SFr) were SFr23.40 for aPTT, SFr33.30 for TT, SFr15.70 for PiCT and SFr24.15 for anti-Xa activity. The various tests were employed in Swiss institutions with the following frequencies: aPTT 53.2%, TT 21.6%, anti-Xa activity 7.2%, PiCT 1.4%; 16.6% of hospitals performed more than one test. CONCLUSIONS:The accuracy and reproducibility of PiCT and anti-Xa activity for monitoring of UFH was superior, and analytical costs were equivalent to or lower than aPTT and TT.
journal_name
BMJ Openjournal_title
BMJ openauthors
Bürki S,Brand B,Escher R,Wuillemin WA,Nagler Mdoi
10.1136/bmjopen-2018-022943subject
Has Abstractpub_date
2018-06-09 00:00:00pages
e022943issue
6issn
2044-6055pii
bmjopen-2018-022943journal_volume
8pub_type
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