ONS: an ontology for a standardized description of interventions and observational studies in nutrition.


Background:The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontology to structure and formalize the concepts used for the description of nutritional studies is still lacking. Results:We have developed the Ontology for Nutritional Studies (ONS) by harmonizing selected pre-existing de facto ontologies with novel health and nutritional terminology classifications. The ONS is the result of a scholarly consensus of 51 research centers in nine European countries. The ontology classes and relations are commonly encountered while conducting, storing, harmonizing, integrating, describing, and searching nutritional studies. The ONS facilitates the description and specification of complex nutritional studies as demonstrated with two application scenarios. Conclusions:The ONS is the first systematic effort to provide a solid and extensible formal ontology framework for nutritional studies. Integration of new information can be easily achieved by the addition of extra modules (i.e., nutrigenomics, metabolomics, nutrikinetics, and quality appraisal). The ONS provides a unified and standardized terminology for nutritional studies as a resource for nutrition researchers who might not necessarily be familiar with ontologies and standardization concepts.


Genes Nutr


Genes & nutrition


Vitali F,Lombardo R,Rivero D,Mattivi F,Franceschi P,Bordoni A,Trimigno A,Capozzi F,Felici G,Taglino F,Miglietta F,De Cock N,Lachat C,De Baets B,De Tré G,Pinart M,Nimptsch K,Pischon T,Bouwman J,Cavalieri D,ENPADASI




Has Abstract


2018-04-30 00:00:00












  • Nutritional systems biology of type 2 diabetes.

    abstract::Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been recognized as key risk factors for T2D, the underlying mechanisms remain unclear. The advent of nutritional sy...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Zhao Y,Barrere-Cain RE,Yang X

    更新日期:2015-09-01 00:00:00

  • Betaine reduces β-amyloid-induced paralysis through activation of cystathionine-β-synthase in an Alzheimer model of Caenorhabditis elegans.

    abstract:Background:The neurodegenerative disorder Alzheimer's disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer's disease. On the other hand, betaine has been demonstrated to atte...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Leiteritz A,Dilberger B,Wenzel U,Fitzenberger E

    更新日期:2018-07-27 00:00:00

  • Effects of polymorphisms in nucleotide-binding oligomerization domains 1 and 2 on biomarkers of the metabolic syndrome and type II diabetes.

    abstract::The innate immune receptor toll-like receptor 4 (TLR4) has been implicated in mediating some of the effects of dietary lipids on inflammation and type 2 diabetes (T2D). Similar to TLR4, the nucleotide-binding oligomerization domains (Nods) 1 and 2 are also proteins of innate immunity, which can respond to lipids and i...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Cuda C,Badawi A,Karmali M,El-Sohemy A

    更新日期:2012-07-01 00:00:00

  • Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology.

    abstract:BACKGROUND:Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Miousse IR,Pathak R,Garg S,Skinner CM,Melnyk S,Pavliv O,Hendrickson H,Landes RD,Lumen A,Tackett AJ,Deutz NEP,Hauer-Jensen M,Koturbash I

    更新日期:2017-09-06 00:00:00

  • Moderately decreased maternal dietary energy intake during pregnancy reduces fetal skeletal muscle mitochondrial biogenesis in the pigs.

    abstract:BACKGROUND:Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfunction during pregnancy is associated with the development of metabolic disorders in offspring. Here...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Zou T,Yu B,Yu J,Mao X,Zheng P,He J,Huang Z,Liu Y,Chen D

    更新日期:2016-06-23 00:00:00

  • Obesity and microbiota: an example of an intricate relationship.

    abstract::It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In this context, animal studies and human trials have demonstrated ...

    journal_title:Genes & nutrition

    pub_type: 杂志文章,评审


    authors: Duranti S,Ferrario C,van Sinderen D,Ventura M,Turroni F

    更新日期:2017-06-15 00:00:00

  • Decreased activity of folate transporters in lipid rafts resulted in reduced hepatic folate uptake in chronic alcoholism in rats.

    abstract::Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell. Chronic alcoholism is well known to be associated with folate deficiency, which is due in part to folate m...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Wani NA,Nada R,Khanduja KL,Kaur J

    更新日期:2013-03-01 00:00:00

  • Gene-nutrient interactions and susceptibility to human obesity.

    abstract::A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple en...

    journal_title:Genes & nutrition

    pub_type: 杂志文章,评审


    authors: Castillo JJ,Orlando RA,Garver WS

    更新日期:2017-10-30 00:00:00

  • Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial.

    abstract::The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet-gene interactions have been poorly evaluated. We aimed to investigate diet-gene interaction in the PREDIMED-NAVARRA randomized trial. A total of 522 participants (67 ± 6 years at baseline) enrolled in the...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Martínez-Lapiscina EH,Galbete C,Corella D,Toledo E,Buil-Cosiales P,Salas-Salvado J,Ros E,Martinez-Gonzalez MA

    更新日期:2014-05-01 00:00:00

  • Genetic variation in the hTAS2R38 taste receptor and food consumption among Finnish adults.

    abstract::Genetic variation in bitter taste receptors, such as hTAS2R38, may affect food preferences and intake. The aim of the present study was to investigate the association between bitter taste receptor haplotypes and the consumption of vegetables, fruits, berries and sweet foods among an adult Finnish population. A cross-s...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Sandell M,Hoppu U,Mikkilä V,Mononen N,Kähönen M,Männistö S,Rönnemaa T,Viikari J,Lehtimäki T,Raitakari OT

    更新日期:2014-11-01 00:00:00

  • Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses.

    abstract::Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more precise evaluation ...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Gichohi-Wainaina WN,Towers GW,Swinkels DW,Zimmermann MB,Feskens EJ,Melse-Boonstra A

    更新日期:2015-01-01 00:00:00

  • Is C. elegans a suitable model for nutritional science?

    abstract::The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the m...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Gottschling DC,Döring F

    更新日期:2019-01-09 00:00:00

  • Chemopreventive potential of curcumin in prostate cancer.

    abstract::The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention in order to prevent or eradicate prostate malignancies. We present here an overview of the chemopreventive potential of curcumin (diferuloylmethane), a well-known natural compound that exhibits the...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Teiten MH,Gaascht F,Eifes S,Dicato M,Diederich M

    更新日期:2010-03-01 00:00:00

  • Sex-specific interaction between APOE genotype and carbohydrate intake affects plasma HDL-C levels: the Strong Heart Family Study.

    abstract::Low plasma levels of high-density lipoprotein cholesterol (HDL-C) are identified as a risk factor for cardiovascular disease (CVD). Sexual dimorphism, however, is widely reported in both HDL-C and CVD, with the underlying explanations of these sexual differences not fully understood. HDL-C is a complex trait influence...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Mosher MJ,Lange LA,Howard BV,Lee ET,Best LG,Fabsitz RR,Maccluer JW,North KE

    更新日期:2008-07-01 00:00:00

  • Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study.

    abstract:BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic disorders, including obesity. Recent studies showed remarkable stability of miRNAs in both plasma an...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Iacomino G,Russo P,Stillitano I,Lauria F,Marena P,Ahrens W,De Luca P,Siani A

    更新日期:2016-03-21 00:00:00

  • A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet.

    abstract::The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and L: -carnitine (1.2:0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet (CD) or the 0.38% mixture-supple...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Kim YJ,Kim KY,Kim MS,Lee JH,Lee KP,Park T

    更新日期:2008-02-01 00:00:00

  • Improving the oral bioavailability of beneficial polyphenols through designed synergies.

    abstract::A substantial and growing consumer demand exists for plant-based functional foods that improve general health and wellbeing. Amongst consumed phytochemicals, the polyphenolic compounds tend to be the most bioactive. Many commonly consumed polyphenols have been shown to have specific and potent health-promoting activit...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Scheepens A,Tan K,Paxton JW

    更新日期:2010-03-01 00:00:00

  • Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice.

    abstract::The apolipoprotein E (APOE) genotype is an important risk factor for ageing and age-related diseases. The APOE4 genotype (in contrast to APOE3) has been shown to be associated with oxidative stress and chronic inflammation. Metallothioneins (MT) exhibit antioxidant and anti-inflammatory activity, and MT overexpression...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Graeser AC,Huebbe P,Storm N,Höppner W,Döring F,Wagner AE,Rimbach G

    更新日期:2012-04-01 00:00:00

  • Reduced expression of folate transporters in kidney of a rat model of folate oversupplementation.

    abstract::Folic acid is the key one-carbon donor required for de novo nucleotide and methionine synthesis. Its deficiency is associated with megaloblastic anemia, cancer and various complications of pregnancy. However, its supplementation results in reduction of neural tube defects and prevention of several types of cancer. The...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Thakur S,Thakur SD,Wani NA,Kaur J

    更新日期:2014-01-01 00:00:00

  • Adverse effects of vitamin E by induction of drug metabolism.

    abstract::Observational studies with healthy persons demonstrated an inverse association of vitamin E with the risk of coronary heart disease or cancer, the outcome of large-scale clinical trials conducted to prove a benefit of vitamin E in the recurrence and/or progression of such disease, however, was disappointing. Vitamin E...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Brigelius-Flohé R

    更新日期:2007-12-01 00:00:00

  • Advances in genomics for flatfish aquaculture.

    abstract::Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of high commercial interest because of their highly prized white flesh. However, the aquaculture of these fishes ...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Cerdà J,Manchado M

    更新日期:2013-01-01 00:00:00

  • Validation of biomarkers of food intake-critical assessment of candidate biomarkers.

    abstract::Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objec...

    journal_title:Genes & nutrition

    pub_type: 杂志文章,评审


    authors: Dragsted LO,Gao Q,Scalbert A,Vergères G,Kolehmainen M,Manach C,Brennan L,Afman LA,Wishart DS,Andres Lacueva C,Garcia-Aloy M,Verhagen H,Feskens EJM,Praticò G

    更新日期:2018-05-30 00:00:00

  • Modulation of gene expression in endothelial cells by hyperlipaemic postprandial serum from healthy volunteers.

    abstract:UNLABELLED:A single high-fat challenge induces plasmatic pro-inflammatory and pro-oxidative responses in the postprandial state, even in healthy men. This period is also associated with vascular endothelial dysfunction, which is an early event in the development of cardiovascular diseases. However, knowledge about the ...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Dejeans N,Maier JA,Tauveron I,Milenkovic D,Mazur A

    更新日期:2010-09-01 00:00:00

  • Values at stake: autonomy, responsibility, and trustworthiness in relation to genetic testing and personalized nutrition advice.

    abstract::Personalized nutrition has the potential to enhance individual health control. It could be seen as a means to strengthen people's autonomy as they learn more about their personal health risks, and receive dietary advice accordingly. We examine in what sense personalized nutrition strengthens or weakens individual auto...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Nordström K,Juth N,Kjellström S,Meijboom FL,Görman U,Food4Me project.

    更新日期:2013-07-01 00:00:00

  • Lactase persistence in Tunisia as a result of admixture with other Mediterranean populations.

    abstract:BACKGROUND:The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of LP-related genetic variants was investigated in many groups of Sub-Saharan African, Middle Easte...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Ben Halima Y,Kefi R,Sazzini M,Giuliani C,De Fanti S,Nouali C,Nagara M,Mengozzi G,Elouej S,Abid A,Jamoussi H,Chouchane L,Romeo G,Abdelhak S,Luiselli D

    更新日期:2017-08-24 00:00:00

  • Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women.

    abstract::Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host's a...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Al-Alem U,Gann PH,Dahl J,van Breemen RB,Mistry V,Lam PM,Evans MD,Van Horn L,Wright ME

    更新日期:2012-04-01 00:00:00

  • Gene regulation in β-sitosterol-mediated stimulation of adipogenesis, glucose uptake, and lipid mobilization in rat primary adipocytes.

    abstract::The nutraceutical benefits of β-sitosterol (SIT) are well documented. The present study investigated the in vitro effects of SIT on adipogenesis, glucose transport, and lipid mobilization in rat adipocytes. Primary cultures of rat preadipocytes and differentiated adipocytes were used in this study. Glucose uptake was ...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Chai JW,Lim SL,Kanthimathi MS,Kuppusamy UR

    更新日期:2011-05-01 00:00:00

  • Timed high-fat diet in the evening affects the hepatic circadian clock and PPARα-mediated lipogenic gene expressions in mice.

    abstract::A long-term high-fat diet may result in a fatty liver. However, whether or not high-fat diets affect the hepatic circadian clock is controversial. The objective of this study is to investigate the effects of timed high-fat diet on the hepatic circadian clock and clock-controlled peroxisome proliferator-activated recep...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Wang X,Xue J,Yang J,Xie M

    更新日期:2013-09-01 00:00:00

  • Transcriptome analysis of peripheral blood mononuclear cells in human subjects following a 36 h fast provides evidence of effects on genes regulating inflammation, apoptosis and energy metabolism.

    abstract::There is growing interest in the potential health benefits of diets that involve regular periods of fasting. While animal studies have provided compelling evidence that feeding patterns such as alternate-day fasting can increase longevity and reduce incidence of many chronic diseases, the evidence from human studies i...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Elliott RM,de Roos B,Duthie SJ,Bouwman FG,Rubio-Aliaga I,Crosley LK,Mayer C,Polley AC,Heim C,Coort SL,Evelo CT,Mulholland F,Daniel H,Mariman EC,Johnson IT

    更新日期:2014-11-01 00:00:00

  • Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.

    abstract::Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C...

    journal_title:Genes & nutrition

    pub_type: 杂志文章


    authors: Duell EJ,Lujan-Barroso L,Llivina C,Muñoz X,Jenab M,Boutron-Ruault MC,Clavel-Chapelon F,Racine A,Boeing H,Buijsse B,Canzian F,Johnson T,Dalgård C,Overvad K,Tjønneland A,Olsen A,Sánchez SC,Sánchez-Cantalejo E,Huerta JM

    更新日期:2013-11-01 00:00:00