Abstract：
Background:The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontology to structure and formalize the concepts used for the description of nutritional studies is still lacking. Results:We have developed the Ontology for Nutritional Studies (ONS) by harmonizing selected pre-existing de facto ontologies with novel health and nutritional terminology classifications. The ONS is the result of a scholarly consensus of 51 research centers in nine European countries. The ontology classes and relations are commonly encountered while conducting, storing, harmonizing, integrating, describing, and searching nutritional studies. The ONS facilitates the description and specification of complex nutritional studies as demonstrated with two application scenarios. Conclusions:The ONS is the first systematic effort to provide a solid and extensible formal ontology framework for nutritional studies. Integration of new information can be easily achieved by the addition of extra modules (i.e., nutrigenomics, metabolomics, nutrikinetics, and quality appraisal). The ONS provides a unified and standardized terminology for nutritional studies as a resource for nutrition researchers who might not necessarily be familiar with ontologies and standardization concepts.
journal_name
Genes Nutrjournal_title
Genes & nutritionauthors
Vitali F,Lombardo R,Rivero D,Mattivi F,Franceschi P,Bordoni A,Trimigno A,Capozzi F,Felici G,Taglino F,Miglietta F,De Cock N,Lachat C,De Baets B,De Tré G,Pinart M,Nimptsch K,Pischon T,Bouwman J,Cavalieri D,ENPADASIdoi
10.1186/s12263-018-0601-ysubject
Has Abstractpub_date
2018-04-30 00:00:00pages
12eissn
1555-8932issn
1865-3499pii
601journal_volume
13pub_type
杂志文章abstract：Background:Evidence suggests that prenatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease in children. LCPUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by the FADS1/2 and ELOVL5 genes. DNA methylation regulates gene ac...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-019-0644-8
更新日期：2019-06-18 00:00:00
abstract：:A complex and heterogeneous microflora performs sugar and lactic acid fermentations in food products. Depending on the fermentable food matrix (dairy, meat, vegetable etc.) as well as on the species composition of the microbiota, specific combinations of molecules are produced that confer unique flavor, texture, and t...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-011-0226-x
更新日期：2011-08-01 00:00:00
abstract：:The innate immune receptor toll-like receptor 4 (TLR4) has been implicated in mediating some of the effects of dietary lipids on inflammation and type 2 diabetes (T2D). Similar to TLR4, the nucleotide-binding oligomerization domains (Nods) 1 and 2 are also proteins of innate immunity, which can respond to lipids and i...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-012-0287-5
更新日期：2012-07-01 00:00:00
abstract：:Multiple factors have been implicated in the age-related declines in brain function. Thus, it is unlikely that modulating only a single factor will be effective at slowing this decline. A better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain functi...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0142-5
更新日期：2009-12-01 00:00:00
abstract：:Phytosterol (PS) intake may be used for hypercholesterolaemia in some groups although the presence of non-responders is well known. Carotenoids and PS/cholesterol may compete for the same transporters during absorption. As part of a randomized, double-blind, crossover, multiple-dose supplementation study with β-crypto...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0428-0
更新日期：2014-09-01 00:00:00
abstract：:The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet-gene interactions have been poorly evaluated. We aimed to investigate diet-gene interaction in the PREDIMED-NAVARRA randomized trial. A total of 522 participants (67 ± 6 years at baseline) enrolled in the...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0393-7
更新日期：2014-05-01 00:00:00
abstract：:The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and L: -carnitine (1.2:0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet (CD) or the 0.38% mixture-supple...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-007-0070-1
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Inflammation plays a central role in chronic diseases occurring in the contemporary society. The health benefits of omega-3 (n-3) fatty acids (FAs), mostly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been reported. However, their mechanisms of action are poorly understood. We explored do...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-017-0554-6
更新日期：2017-02-21 00:00:00
abstract：:Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objec...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-018-0603-9
更新日期：2018-05-30 00:00:00
abstract：:A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple en...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-017-0581-3
更新日期：2017-10-30 00:00:00
abstract：:There is a growing interest in assessing dietary intake more accurately across different population groups, and biomarkers have emerged as a complementary tool to replace traditional dietary assessment methods. The purpose of this study was to conduct a systematic review of the literature available and evaluate the ap...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-018-0614-6
更新日期：2018-09-10 00:00:00
abstract：:The nutraceutical benefits of β-sitosterol (SIT) are well documented. The present study investigated the in vitro effects of SIT on adipogenesis, glucose transport, and lipid mobilization in rat adipocytes. Primary cultures of rat preadipocytes and differentiated adipocytes were used in this study. Glucose uptake was ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-010-0196-4
更新日期：2011-05-01 00:00:00
abstract：Background:We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopausal symptoms in ovariectomized (OVX) rats and explored their mechanisms of action, including chan...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-017-0585-z
更新日期：2017-11-09 00:00:00
abstract：:A methyl-deficient diet (MD) lacking folic acid and the associated methyl donors choline and methionine, fed to the laboratory rat during the periods of oocyte and embryo development, has been shown to programme glucose metabolism in the offspring. The hepatic proteome of the male offspring of female rats fed MD diets...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-012-0314-6
更新日期：2013-03-01 00:00:00
abstract：:Phytoestrogens are naturally occurring plantderived polyphenols with estrogenic potency. They are ubiquitous in diet and therefore, generally consumed. Among Europeans, the diet is rich in multiple putative phytoestrogens including flavonoids, tannins, stilbenoids, and lignans. These compounds have been suggested to p...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/BF02829964
更新日期：2006-09-01 00:00:00
abstract：Background:Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors associated with psychological conditions including autism spectrum disorders and depression. We r...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-018-0605-7
更新日期：2018-07-11 00:00:00
abstract：:Genetic variation in bitter taste receptors, such as hTAS2R38, may affect food preferences and intake. The aim of the present study was to investigate the association between bitter taste receptor haplotypes and the consumption of vegetables, fruits, berries and sweet foods among an adult Finnish population. A cross-s...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0433-3
更新日期：2014-11-01 00:00:00
abstract：:Breast cancer is the second most frequent cancer affecting women worldwide after lung cancer. The toxicity factor associated with synthetic drugs has turned the attention toward natural compounds as the primary focus of interest as anticancer agents. Vitamin E derivatives consisting of the well-established tocopherols...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-011-0224-z
更新日期：2012-01-01 00:00:00
abstract：:Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-013-0346-6
更新日期：2013-11-01 00:00:00
abstract：Background:The neurodegenerative disorder Alzheimer's disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer's disease. On the other hand, betaine has been demonstrated to atte...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-018-0611-9
更新日期：2018-07-27 00:00:00
abstract：:The nuclear factor (NF)-kappaB is a primary regulator of inflammatory responses and may be linked to pathology associated with obesity. We investigated the progression of NF-kappaB activity during a 12-week feeding period on a high-fat diet (HFD) or a low-fat diet (LFD) using NF-kappaB luciferase reporter mice. In viv...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0133-6
更新日期：2009-09-01 00:00:00
abstract：:The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the m...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-018-0625-3
更新日期：2019-01-09 00:00:00
abstract：BACKGROUND:Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-017-0576-0
更新日期：2017-09-06 00:00:00
abstract：BACKGROUND:Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-020-00674-0
更新日期：2020-08-27 00:00:00
abstract：:A substantial and growing consumer demand exists for plant-based functional foods that improve general health and wellbeing. Amongst consumed phytochemicals, the polyphenolic compounds tend to be the most bioactive. Many commonly consumed polyphenols have been shown to have specific and potent health-promoting activit...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0148-z
更新日期：2010-03-01 00:00:00
abstract：:In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in maintaining/altering physiological processes, including energy balance and metabolic homeostasis. Altered miRNAs ...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-017-0577-z
更新日期：2017-09-25 00:00:00
abstract：:Anthocyanins (AC) are water-soluble natural pigments found in various parts of higher plants. Despite their limited oral bioavailability and very low post-absorption plasma concentrations, the dietary consumption of these pigments has been proposed to be associated with a significant protection against several human p...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0404-8
更新日期：2014-07-01 00:00:00
abstract：:The demand for diet products is continuously increasing, together with that for natural food ingredients. Stevioside and other steviol glycosides extracted from the leaves of the plant Stevia rebaudiana Bertoni are the first natural high-potency sweeteners to be approved for consumption in the United States and the Eu...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0401-y
更新日期：2014-05-01 00:00:00
abstract：:A long-term high-fat diet may result in a fatty liver. However, whether or not high-fat diets affect the hepatic circadian clock is controversial. The objective of this study is to investigate the effects of timed high-fat diet on the hepatic circadian clock and clock-controlled peroxisome proliferator-activated recep...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-013-0333-y
更新日期：2013-09-01 00:00:00
abstract：UNLABELLED:Intake of anthocyanin-rich foods has been associated with a reduced risk of cardiovascular diseases. Supplementation with anthocyanin-rich extracts from black rice or purple sweet potato was reported to attenuate atherosclerotic lesion development in apolipoprotein E-deficient (apo E(-/-)) mice. However, the...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-010-0171-0
更新日期：2010-12-01 00:00:00
