abstract：BACKGROUND:Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ...

journal_title：Genes & nutrition

authors： Barrón-Cabrera E,González-Becerra K,Rosales-Chávez G,Mora-Jiménez A,Hernández-Cañaveral I,Martínez-López E

更新日期：2020-08-27 00:00:00

abstract：Background:Evidence suggests that prenatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease in children. LCPUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by the FADS1/2 and ELOVL5 genes. DNA methylation regulates gene ac...

journal_title：Genes & nutrition

authors： Losol P,Rezwan FI,Patil VK,Venter C,Ewart S,Zhang H,Arshad SH,Karmaus W,Holloway JW

更新日期：2019-06-18 00:00:00

abstract：:The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the m...

journal_title：Genes & nutrition

authors： Gottschling DC,Döring F

更新日期：2019-01-09 00:00:00

abstract：:There is a growing interest in assessing dietary intake more accurately across different population groups, and biomarkers have emerged as a complementary tool to replace traditional dietary assessment methods. The purpose of this study was to conduct a systematic review of the literature available and evaluate the ap...

journal_title：Genes & nutrition

authors： Sri Harsha PSC,Wahab RA,Garcia-Aloy M,Madrid-Gambin F,Estruel-Amades S,Watzl B,Andrés-Lacueva C,Brennan L

更新日期：2018-09-10 00:00:00

abstract：Background:The neurodegenerative disorder Alzheimer's disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer's disease. On the other hand, betaine has been demonstrated to atte...

journal_title：Genes & nutrition

authors： Leiteritz A,Dilberger B,Wenzel U,Fitzenberger E

更新日期：2018-07-27 00:00:00

abstract：Background:Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors associated with psychological conditions including autism spectrum disorders and depression. We r...

journal_title：Genes & nutrition

authors： Sabir MS,Haussler MR,Mallick S,Kaneko I,Lucas DA,Haussler CA,Whitfield GK,Jurutka PW

更新日期：2018-07-11 00:00:00

abstract：:Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objec...

journal_title：Genes & nutrition

authors： Dragsted LO,Gao Q,Scalbert A,Vergères G,Kolehmainen M,Manach C,Brennan L,Afman LA,Wishart DS,Andres Lacueva C,Garcia-Aloy M,Verhagen H,Feskens EJM,Praticò G

更新日期：2018-05-30 00:00:00

abstract：Background:The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontol...

journal_title：Genes & nutrition

authors： Vitali F,Lombardo R,Rivero D,Mattivi F,Franceschi P,Bordoni A,Trimigno A,Capozzi F,Felici G,Taglino F,Miglietta F,De Cock N,Lachat C,De Baets B,De Tré G,Pinart M,Nimptsch K,Pischon T,Bouwman J,Cavalieri D,ENPADASI

更新日期：2018-04-30 00:00:00

abstract：:Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying ...

journal_title：Genes & nutrition

authors： Praticò G,Gao Q,Scalbert A,Vergères G,Kolehmainen M,Manach C,Brennan L,Pedapati SH,Afman LA,Wishart DS,Vázquez-Fresno R,Andres-Lacueva C,Garcia-Aloy M,Verhagen H,Feskens EJM,Dragsted LO

更新日期：2018-02-20 00:00:00

abstract：Background:We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopausal symptoms in ovariectomized (OVX) rats and explored their mechanisms of action, including chan...

journal_title：Genes & nutrition

authors： Jeong SY,Kang S,Hua CS,Ting Z,Park S

更新日期：2017-11-09 00:00:00

abstract：:A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple en...

journal_title：Genes & nutrition

authors： Castillo JJ,Orlando RA,Garver WS

更新日期：2017-10-30 00:00:00

abstract：:In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in maintaining/altering physiological processes, including energy balance and metabolic homeostasis. Altered miRNAs ...

journal_title：Genes & nutrition

authors： Iacomino G,Siani A

更新日期：2017-09-25 00:00:00

abstract：BACKGROUND:Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term...

journal_title：Genes & nutrition

authors： Miousse IR,Pathak R,Garg S,Skinner CM,Melnyk S,Pavliv O,Hendrickson H,Landes RD,Lumen A,Tackett AJ,Deutz NEP,Hauer-Jensen M,Koturbash I

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of LP-related genetic variants was investigated in many groups of Sub-Saharan African, Middle Easte...

journal_title：Genes & nutrition

authors： Ben Halima Y,Kefi R,Sazzini M,Giuliani C,De Fanti S,Nouali C,Nagara M,Mengozzi G,Elouej S,Abid A,Jamoussi H,Chouchane L,Romeo G,Abdelhak S,Luiselli D

更新日期：2017-08-24 00:00:00

abstract：:It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In this context, animal studies and human trials have demonstrated ...

journal_title：Genes & nutrition

authors： Duranti S,Ferrario C,van Sinderen D,Ventura M,Turroni F

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:Inflammation plays a central role in chronic diseases occurring in the contemporary society. The health benefits of omega-3 (n-3) fatty acids (FAs), mostly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been reported. However, their mechanisms of action are poorly understood. We explored do...

journal_title：Genes & nutrition

authors： Allam-Ndoul B,Guénard F,Barbier O,Vohl MC

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfunction during pregnancy is associated with the development of metabolic disorders in offspring. Here...

journal_title：Genes & nutrition

authors： Zou T,Yu B,Yu J,Mao X,Zheng P,He J,Huang Z,Liu Y,Chen D

更新日期：2016-06-23 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic disorders, including obesity. Recent studies showed remarkable stability of miRNAs in both plasma an...

journal_title：Genes & nutrition

authors： Iacomino G,Russo P,Stillitano I,Lauria F,Marena P,Ahrens W,De Luca P,Siani A

更新日期：2016-03-21 00:00:00

abstract：:Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been recognized as key risk factors for T2D, the underlying mechanisms remain unclear. The advent of nutritional sy...

journal_title：Genes & nutrition

authors： Zhao Y,Barrere-Cain RE,Yang X

更新日期：2015-09-01 00:00:00

abstract：:Two cases of zinc deficiency in breastfed neonates were investigated where zinc levels in the mothers' milk were reduced by more than 75 % compared to normal. The objective of this study was to find the molecular basis of the maternal zinc deficiency condition. Significant reductions in mRNA expression and protein lev...

journal_title：Genes & nutrition

authors： Kumar L,Michalczyk A,McKay J,Ford D,Kambe T,Hudek L,Varigios G,Taylor PE,Ackland ML

更新日期：2015-09-01 00:00:00

abstract：:Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more precise evaluation ...

journal_title：Genes & nutrition

authors： Gichohi-Wainaina WN,Towers GW,Swinkels DW,Zimmermann MB,Feskens EJ,Melse-Boonstra A

更新日期：2015-01-01 00:00:00

abstract：:Genetic variation in bitter taste receptors, such as hTAS2R38, may affect food preferences and intake. The aim of the present study was to investigate the association between bitter taste receptor haplotypes and the consumption of vegetables, fruits, berries and sweet foods among an adult Finnish population. A cross-s...

journal_title：Genes & nutrition

authors： Sandell M,Hoppu U,Mikkilä V,Mononen N,Kähönen M,Männistö S,Rönnemaa T,Viikari J,Lehtimäki T,Raitakari OT

更新日期：2014-11-01 00:00:00

abstract：:There is growing interest in the potential health benefits of diets that involve regular periods of fasting. While animal studies have provided compelling evidence that feeding patterns such as alternate-day fasting can increase longevity and reduce incidence of many chronic diseases, the evidence from human studies i...

journal_title：Genes & nutrition

authors： Elliott RM,de Roos B,Duthie SJ,Bouwman FG,Rubio-Aliaga I,Crosley LK,Mayer C,Polley AC,Heim C,Coort SL,Evelo CT,Mulholland F,Daniel H,Mariman EC,Johnson IT

更新日期：2014-11-01 00:00:00

abstract：:Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), riboflavin-dependent enzymes, participate in homocysteine metabolism. Reported effects of riboflavin status on the association between the MTHFR 677C>T polymorphism and homocysteine vary, and the effects of the MTRR 66A>G or MTRR 524...

journal_title：Genes & nutrition

authors： García-Minguillán CJ,Fernandez-Ballart JD,Ceruelo S,Ríos L,Bueno O,Berrocal-Zaragoza MI,Molloy AM,Ueland PM,Meyer K,Murphy MM

更新日期：2014-11-01 00:00:00

abstract：:Phytosterol (PS) intake may be used for hypercholesterolaemia in some groups although the presence of non-responders is well known. Carotenoids and PS/cholesterol may compete for the same transporters during absorption. As part of a randomized, double-blind, crossover, multiple-dose supplementation study with β-crypto...

journal_title：Genes & nutrition

authors： Granado-Lorencio F,de Las Heras L,Millán CS,Garcia-López FJ,Blanco-Navarro I,Pérez-Sacristán B,Domínguez G

更新日期：2014-09-01 00:00:00

abstract：:Anthocyanins (AC) are water-soluble natural pigments found in various parts of higher plants. Despite their limited oral bioavailability and very low post-absorption plasma concentrations, the dietary consumption of these pigments has been proposed to be associated with a significant protection against several human p...

journal_title：Genes & nutrition

authors： Speciale A,Cimino F,Saija A,Canali R,Virgili F

更新日期：2014-07-01 00:00:00

abstract：:The demand for diet products is continuously increasing, together with that for natural food ingredients. Stevioside and other steviol glycosides extracted from the leaves of the plant Stevia rebaudiana Bertoni are the first natural high-potency sweeteners to be approved for consumption in the United States and the Eu...

journal_title：Genes & nutrition

authors： Risso D,Morini G,Pagani L,Quagliariello A,Giuliani C,De Fanti S,Sazzini M,Luiselli D,Tofanelli S

更新日期：2014-05-01 00:00:00

abstract：:The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet-gene interactions have been poorly evaluated. We aimed to investigate diet-gene interaction in the PREDIMED-NAVARRA randomized trial. A total of 522 participants (67 ± 6 years at baseline) enrolled in the...

journal_title：Genes & nutrition

authors： Martínez-Lapiscina EH,Galbete C,Corella D,Toledo E,Buil-Cosiales P,Salas-Salvado J,Ros E,Martinez-Gonzalez MA

更新日期：2014-05-01 00:00:00

abstract：:Current evidence indicates that genetic testing for obesity risk has limited affective or behavioral impact, but few studies have explored the effects among individuals who self-identify as having weight problems. Here, we report findings from in-depth telephone interviews with seven overweight or obese volunteers who...

journal_title：Genes & nutrition

authors： Meisel SF,Wardle J

更新日期：2014-01-01 00:00:00

abstract：:Moderate maternal calorie restriction during lactation protects rat offspring against obesity development in adulthood, due to an improved ability to handle and store excess dietary fuel. We used this model to identify early transcriptome-based biomarkers of metabolic health using peripheral blood mononuclear cells (P...

journal_title：Genes & nutrition

authors： Konieczna J,Sánchez J,van Schothorst EM,Torrens JM,Bunschoten A,Palou M,Picó C,Keijer J,Palou A

更新日期：2014-01-01 00:00:00

abstract：:Folic acid is the key one-carbon donor required for de novo nucleotide and methionine synthesis. Its deficiency is associated with megaloblastic anemia, cancer and various complications of pregnancy. However, its supplementation results in reduction of neural tube defects and prevention of several types of cancer. The...

journal_title：Genes & nutrition

authors： Thakur S,Thakur SD,Wani NA,Kaur J

更新日期：2014-01-01 00:00:00

abstract：:Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C...

journal_title：Genes & nutrition

authors： Duell EJ,Lujan-Barroso L,Llivina C,Muñoz X,Jenab M,Boutron-Ruault MC,Clavel-Chapelon F,Racine A,Boeing H,Buijsse B,Canzian F,Johnson T,Dalgård C,Overvad K,Tjønneland A,Olsen A,Sánchez SC,Sánchez-Cantalejo E,Huerta JM

更新日期：2013-11-01 00:00:00

abstract：:A long-term high-fat diet may result in a fatty liver. However, whether or not high-fat diets affect the hepatic circadian clock is controversial. The objective of this study is to investigate the effects of timed high-fat diet on the hepatic circadian clock and clock-controlled peroxisome proliferator-activated recep...

journal_title：Genes & nutrition

authors： Wang X,Xue J,Yang J,Xie M

更新日期：2013-09-01 00:00:00

abstract：:Personalized nutrition has the potential to enhance individual health control. It could be seen as a means to strengthen people's autonomy as they learn more about their personal health risks, and receive dietary advice accordingly. We examine in what sense personalized nutrition strengthens or weakens individual auto...

journal_title：Genes & nutrition

authors： Nordström K,Juth N,Kjellström S,Meijboom FL,Görman U,Food4Me project.

更新日期：2013-07-01 00:00:00

abstract：:Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell. Chronic alcoholism is well known to be associated with folate deficiency, which is due in part to folate m...

journal_title：Genes & nutrition

authors： Wani NA,Nada R,Khanduja KL,Kaur J

更新日期：2013-03-01 00:00:00

abstract：:A methyl-deficient diet (MD) lacking folic acid and the associated methyl donors choline and methionine, fed to the laboratory rat during the periods of oocyte and embryo development, has been shown to programme glucose metabolism in the offspring. The hepatic proteome of the male offspring of female rats fed MD diets...

journal_title：Genes & nutrition

authors： Maloney CA,Hay SM,Reid MD,Duncan G,Nicol F,Sinclair KD,Rees WD

更新日期：2013-03-01 00:00:00

abstract：:Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of high commercial interest because of their highly prized white flesh. However, the aquaculture of these fishes ...

journal_title：Genes & nutrition

authors： Cerdà J,Manchado M

更新日期：2013-01-01 00:00:00

abstract：:The innate immune receptor toll-like receptor 4 (TLR4) has been implicated in mediating some of the effects of dietary lipids on inflammation and type 2 diabetes (T2D). Similar to TLR4, the nucleotide-binding oligomerization domains (Nods) 1 and 2 are also proteins of innate immunity, which can respond to lipids and i...

journal_title：Genes & nutrition

authors： Cuda C,Badawi A,Karmali M,El-Sohemy A

更新日期：2012-07-01 00:00:00

abstract：:The apolipoprotein E (APOE) genotype is an important risk factor for ageing and age-related diseases. The APOE4 genotype (in contrast to APOE3) has been shown to be associated with oxidative stress and chronic inflammation. Metallothioneins (MT) exhibit antioxidant and anti-inflammatory activity, and MT overexpression...

journal_title：Genes & nutrition

authors： Graeser AC,Huebbe P,Storm N,Höppner W,Döring F,Wagner AE,Rimbach G

更新日期：2012-04-01 00:00:00

abstract：:Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host's a...

journal_title：Genes & nutrition

authors： Al-Alem U,Gann PH,Dahl J,van Breemen RB,Mistry V,Lam PM,Evans MD,Van Horn L,Wright ME

更新日期：2012-04-01 00:00:00