Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial.

abstract：:The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and L: -carnitine (1.2:0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet (CD) or the 0.38% mixture-supple...

journal_title：Genes & nutrition

authors： Kim YJ,Kim KY,Kim MS,Lee JH,Lee KP,Park T

更新日期：2008-02-01 00:00:00

abstract：:A methyl-deficient diet (MD) lacking folic acid and the associated methyl donors choline and methionine, fed to the laboratory rat during the periods of oocyte and embryo development, has been shown to programme glucose metabolism in the offspring. The hepatic proteome of the male offspring of female rats fed MD diets...

journal_title：Genes & nutrition

authors： Maloney CA,Hay SM,Reid MD,Duncan G,Nicol F,Sinclair KD,Rees WD

更新日期：2013-03-01 00:00:00

abstract：:The long latency and high incidence of prostate carcinogenesis provides the opportunity to intervene with chemoprevention in order to prevent or eradicate prostate malignancies. We present here an overview of the chemopreventive potential of curcumin (diferuloylmethane), a well-known natural compound that exhibits the...

journal_title：Genes & nutrition

authors： Teiten MH,Gaascht F,Eifes S,Dicato M,Diederich M

更新日期：2010-03-01 00:00:00

abstract：:Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been recognized as key risk factors for T2D, the underlying mechanisms remain unclear. The advent of nutritional sy...

journal_title：Genes & nutrition

authors： Zhao Y,Barrere-Cain RE,Yang X

更新日期：2015-09-01 00:00:00

abstract：:The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and represe...

journal_title：Genes & nutrition

authors： Martínez-Salazar MF,Almenares-López D,García-Jiménez S,Sánchez-Alemán MA,Juantorena-Ugás A,Ríos C,Monroy-Noyola A

更新日期：2011-11-01 00:00:00

abstract：:Personalized nutrition has the potential to enhance individual health control. It could be seen as a means to strengthen people's autonomy as they learn more about their personal health risks, and receive dietary advice accordingly. We examine in what sense personalized nutrition strengthens or weakens individual auto...

journal_title：Genes & nutrition

authors： Nordström K,Juth N,Kjellström S,Meijboom FL,Görman U,Food4Me project.

更新日期：2013-07-01 00:00:00

abstract：:Moderate maternal calorie restriction during lactation protects rat offspring against obesity development in adulthood, due to an improved ability to handle and store excess dietary fuel. We used this model to identify early transcriptome-based biomarkers of metabolic health using peripheral blood mononuclear cells (P...

journal_title：Genes & nutrition

authors： Konieczna J,Sánchez J,van Schothorst EM,Torrens JM,Bunschoten A,Palou M,Picó C,Keijer J,Palou A

更新日期：2014-01-01 00:00:00

abstract：:A complex and heterogeneous microflora performs sugar and lactic acid fermentations in food products. Depending on the fermentable food matrix (dairy, meat, vegetable etc.) as well as on the species composition of the microbiota, specific combinations of molecules are produced that confer unique flavor, texture, and t...

journal_title：Genes & nutrition

authors： Devirgiliis C,Barile S,Perozzi G

更新日期：2011-08-01 00:00:00

abstract：:In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in maintaining/altering physiological processes, including energy balance and metabolic homeostasis. Altered miRNAs ...

journal_title：Genes & nutrition

authors： Iacomino G,Siani A

更新日期：2017-09-25 00:00:00

abstract：:A long-term high-fat diet may result in a fatty liver. However, whether or not high-fat diets affect the hepatic circadian clock is controversial. The objective of this study is to investigate the effects of timed high-fat diet on the hepatic circadian clock and clock-controlled peroxisome proliferator-activated recep...

journal_title：Genes & nutrition

authors： Wang X,Xue J,Yang J,Xie M

更新日期：2013-09-01 00:00:00

abstract：UNLABELLED:A single high-fat challenge induces plasmatic pro-inflammatory and pro-oxidative responses in the postprandial state, even in healthy men. This period is also associated with vascular endothelial dysfunction, which is an early event in the development of cardiovascular diseases. However, knowledge about the ...

journal_title：Genes & nutrition

authors： Dejeans N,Maier JA,Tauveron I,Milenkovic D,Mazur A

更新日期：2010-09-01 00:00:00

abstract：:Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying ...

journal_title：Genes & nutrition

authors： Praticò G,Gao Q,Scalbert A,Vergères G,Kolehmainen M,Manach C,Brennan L,Pedapati SH,Afman LA,Wishart DS,Vázquez-Fresno R,Andres-Lacueva C,Garcia-Aloy M,Verhagen H,Feskens EJM,Dragsted LO

更新日期：2018-02-20 00:00:00

abstract：:Phytosterol (PS) intake may be used for hypercholesterolaemia in some groups although the presence of non-responders is well known. Carotenoids and PS/cholesterol may compete for the same transporters during absorption. As part of a randomized, double-blind, crossover, multiple-dose supplementation study with β-crypto...

journal_title：Genes & nutrition

authors： Granado-Lorencio F,de Las Heras L,Millán CS,Garcia-López FJ,Blanco-Navarro I,Pérez-Sacristán B,Domínguez G

更新日期：2014-09-01 00:00:00

abstract：:While the effects of chronic ethanol consumption on liver have been well studied and documented, its effect on the cardiovascular system is bimodal. Thus, moderate drinking in many population studies is related to lower prevalence of coronary artery disease (CAD). In contrast, heavy drinking correlates with higher pre...

journal_title：Genes & nutrition

authors： Lakshman R,Garige M,Gong M,Leckey L,Varatharajalu R,Zakhari S

更新日期：2010-06-01 00:00:00

abstract：:Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell. Chronic alcoholism is well known to be associated with folate deficiency, which is due in part to folate m...

journal_title：Genes & nutrition

authors： Wani NA,Nada R,Khanduja KL,Kaur J

更新日期：2013-03-01 00:00:00

abstract：:Recent immunohistochemical characterization of the copper transport protein, Ctr1, reported enriched levels in mouse choroid plexus, and enhancement by copper deficiency. To extend and confirm this, experiments were conducted with Holtzman rats. Following perinatal copper deficiency there was an 80% reduction in brain...

journal_title：Genes & nutrition

authors： Gybina AA,Prohaska JR

更新日期：2006-03-01 00:00:00

abstract：:Folic acid is the key one-carbon donor required for de novo nucleotide and methionine synthesis. Its deficiency is associated with megaloblastic anemia, cancer and various complications of pregnancy. However, its supplementation results in reduction of neural tube defects and prevention of several types of cancer. The...

journal_title：Genes & nutrition

authors： Thakur S,Thakur SD,Wani NA,Kaur J

更新日期：2014-01-01 00:00:00

abstract：:Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of high commercial interest because of their highly prized white flesh. However, the aquaculture of these fishes ...

journal_title：Genes & nutrition

authors： Cerdà J,Manchado M

更新日期：2013-01-01 00:00:00

abstract：:There is a growing interest in assessing dietary intake more accurately across different population groups, and biomarkers have emerged as a complementary tool to replace traditional dietary assessment methods. The purpose of this study was to conduct a systematic review of the literature available and evaluate the ap...

journal_title：Genes & nutrition

authors： Sri Harsha PSC,Wahab RA,Garcia-Aloy M,Madrid-Gambin F,Estruel-Amades S,Watzl B,Andrés-Lacueva C,Brennan L

更新日期：2018-09-10 00:00:00

abstract：UNLABELLED:Intake of anthocyanin-rich foods has been associated with a reduced risk of cardiovascular diseases. Supplementation with anthocyanin-rich extracts from black rice or purple sweet potato was reported to attenuate atherosclerotic lesion development in apolipoprotein E-deficient (apo E(-/-)) mice. However, the...

journal_title：Genes & nutrition

authors： Mauray A,Felgines C,Morand C,Mazur A,Scalbert A,Milenkovic D

更新日期：2010-12-01 00:00:00

abstract：:The goal of this study was to investigate the effect of a short-term nutritional intervention on gene expression in adipose tissue from lean and overweight subjects. Gene expression profiles were measured after consumption of an intervention spread (increased levels of polyunsaturated fatty acids, conjugated linoleic ...

journal_title：Genes & nutrition

authors： van Erk MJ,Pasman WJ,Wortelboer HM,van Ommen B,Hendriks HF

更新日期：2008-12-01 00:00:00

abstract：Background:The neurodegenerative disorder Alzheimer's disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer's disease. On the other hand, betaine has been demonstrated to atte...

journal_title：Genes & nutrition

authors： Leiteritz A,Dilberger B,Wenzel U,Fitzenberger E

更新日期：2018-07-27 00:00:00

abstract：:The apolipoprotein E (APOE) genotype is an important risk factor for ageing and age-related diseases. The APOE4 genotype (in contrast to APOE3) has been shown to be associated with oxidative stress and chronic inflammation. Metallothioneins (MT) exhibit antioxidant and anti-inflammatory activity, and MT overexpression...

journal_title：Genes & nutrition

authors： Graeser AC,Huebbe P,Storm N,Höppner W,Döring F,Wagner AE,Rimbach G

更新日期：2012-04-01 00:00:00

abstract：:Current evidence indicates that genetic testing for obesity risk has limited affective or behavioral impact, but few studies have explored the effects among individuals who self-identify as having weight problems. Here, we report findings from in-depth telephone interviews with seven overweight or obese volunteers who...

journal_title：Genes & nutrition

authors： Meisel SF,Wardle J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfunction during pregnancy is associated with the development of metabolic disorders in offspring. Here...

journal_title：Genes & nutrition

authors： Zou T,Yu B,Yu J,Mao X,Zheng P,He J,Huang Z,Liu Y,Chen D

更新日期：2016-06-23 00:00:00

abstract：BACKGROUND:Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ...

journal_title：Genes & nutrition

authors： Barrón-Cabrera E,González-Becerra K,Rosales-Chávez G,Mora-Jiménez A,Hernández-Cañaveral I,Martínez-López E

更新日期：2020-08-27 00:00:00

abstract：:The innate immune receptor toll-like receptor 4 (TLR4) has been implicated in mediating some of the effects of dietary lipids on inflammation and type 2 diabetes (T2D). Similar to TLR4, the nucleotide-binding oligomerization domains (Nods) 1 and 2 are also proteins of innate immunity, which can respond to lipids and i...

journal_title：Genes & nutrition

authors： Cuda C,Badawi A,Karmali M,El-Sohemy A

更新日期：2012-07-01 00:00:00

abstract：:The nuclear factor (NF)-kappaB is a primary regulator of inflammatory responses and may be linked to pathology associated with obesity. We investigated the progression of NF-kappaB activity during a 12-week feeding period on a high-fat diet (HFD) or a low-fat diet (LFD) using NF-kappaB luciferase reporter mice. In viv...

journal_title：Genes & nutrition

authors： Carlsen H,Haugen F,Zadelaar S,Kleemann R,Kooistra T,Drevon CA,Blomhoff R

更新日期：2009-09-01 00:00:00

abstract：:The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the m...

journal_title：Genes & nutrition

authors： Gottschling DC,Döring F

更新日期：2019-01-09 00:00:00

abstract：:Multiple factors have been implicated in the age-related declines in brain function. Thus, it is unlikely that modulating only a single factor will be effective at slowing this decline. A better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain functi...

journal_title：Genes & nutrition

authors： Maher P

更新日期：2009-12-01 00:00:00