Abstract：
:Breast cancer is the second most frequent cancer affecting women worldwide after lung cancer. The toxicity factor associated with synthetic drugs has turned the attention toward natural compounds as the primary focus of interest as anticancer agents. Vitamin E derivatives consisting of the well-established tocopherols and their analogs namely tocotrienols have been extensively studied due to their remarkable biological properties. While tocopherols have failed to offer protection, tocotrienols, in particular, α-, δ-, and γ-tocotrienols alone and in combination have demonstrated anticancer properties. The discovery of the antiangiogenic, antiproliferative, and apoptotic effects of tocotrienols, as well as their role as an inducer of immunological functions, not only reveals a new horizon as a potent antitumor agent but also reinforces the notion that tocotrienols are indeed more than antioxidants. On the basis of a transcriptomic platform, we have recently demonstrated a novel mechanism for tocotrienol activity that involves estrogen receptor (ER) signaling. In silico simulations and in vitro binding analyses indicate a high affinity of specific forms of tocotrienols for ERβ, but not for ERα. Moreover, we have demonstrated that specific tocotrienols increase ERβ translocation into the nucleus which, in turn, activates the expression of estrogen-responsive genes (MIC-1, EGR-1 and Cathepsin D) in breast cancer cells only expressing ERβ cells (MDA-MB-231) and in cells expressing both ER isoforms (MCF-7). The binding of specific tocotrienol forms to ERβ is associated with the alteration of cell morphology, caspase-3 activation, DNA fragmentation, and apoptosis. Furthermore, a recently concluded clinical trial seems to suggest that tocotrienols in combination with tamoxifen may have the potential to extend breast cancer-specific survival.
journal_name
Genes Nutrjournal_title
Genes & nutritionauthors
Nesaretnam K,Meganathan P,Veerasenan SD,Selvaduray KRdoi
10.1007/s12263-011-0224-zsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
3-9issue
1eissn
1555-8932issn
1865-3499journal_volume
7pub_type
杂志文章abstract：:The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, biological principles of nutritional behavior, and the biochemical function of vitamins. In this case, the m...
journal_title：Genes & nutrition
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doi：10.1186/s12263-018-0625-3
更新日期：2019-01-09 00:00:00
abstract：:Phytoestrogens are naturally occurring plantderived polyphenols with estrogenic potency. They are ubiquitous in diet and therefore, generally consumed. Among Europeans, the diet is rich in multiple putative phytoestrogens including flavonoids, tannins, stilbenoids, and lignans. These compounds have been suggested to p...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/BF02829964
更新日期：2006-09-01 00:00:00
abstract：:Current evidence indicates that genetic testing for obesity risk has limited affective or behavioral impact, but few studies have explored the effects among individuals who self-identify as having weight problems. Here, we report findings from in-depth telephone interviews with seven overweight or obese volunteers who...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-013-0374-2
更新日期：2014-01-01 00:00:00
abstract：:Moderate maternal calorie restriction during lactation protects rat offspring against obesity development in adulthood, due to an improved ability to handle and store excess dietary fuel. We used this model to identify early transcriptome-based biomarkers of metabolic health using peripheral blood mononuclear cells (P...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-013-0366-2
更新日期：2014-01-01 00:00:00
abstract：:Recent immunohistochemical characterization of the copper transport protein, Ctr1, reported enriched levels in mouse choroid plexus, and enhancement by copper deficiency. To extend and confirm this, experiments were conducted with Holtzman rats. Following perinatal copper deficiency there was an 80% reduction in brain...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/BF02829936
更新日期：2006-03-01 00:00:00
abstract：:Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been recognized as key risk factors for T2D, the underlying mechanisms remain unclear. The advent of nutritional sy...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-015-0481-3
更新日期：2015-09-01 00:00:00
abstract：:Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host's a...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-011-0257-3
更新日期：2012-04-01 00:00:00
abstract：:A substantial and growing consumer demand exists for plant-based functional foods that improve general health and wellbeing. Amongst consumed phytochemicals, the polyphenolic compounds tend to be the most bioactive. Many commonly consumed polyphenols have been shown to have specific and potent health-promoting activit...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0148-z
更新日期：2010-03-01 00:00:00
abstract：:A methyl-deficient diet (MD) lacking folic acid and the associated methyl donors choline and methionine, fed to the laboratory rat during the periods of oocyte and embryo development, has been shown to programme glucose metabolism in the offspring. The hepatic proteome of the male offspring of female rats fed MD diets...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-012-0314-6
更新日期：2013-03-01 00:00:00
abstract：Background:Evidence suggests that prenatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease in children. LCPUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by the FADS1/2 and ELOVL5 genes. DNA methylation regulates gene ac...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-019-0644-8
更新日期：2019-06-18 00:00:00
abstract：:Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-013-0346-6
更新日期：2013-11-01 00:00:00
abstract：:The nutraceutical benefits of β-sitosterol (SIT) are well documented. The present study investigated the in vitro effects of SIT on adipogenesis, glucose transport, and lipid mobilization in rat adipocytes. Primary cultures of rat preadipocytes and differentiated adipocytes were used in this study. Glucose uptake was ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-010-0196-4
更新日期：2011-05-01 00:00:00
abstract：:The aim of the present study was to investigate the anti-obesity effect of a mixture composed of Garcinia cambogia extract, soypeptide, and L: -carnitine (1.2:0.3:0.02, w/w/w) in rats rendered obese by a high-fat diet (HFD). Sprague-Dawley rats were fed either the high-fat control diet (CD) or the 0.38% mixture-supple...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-007-0070-1
更新日期：2008-02-01 00:00:00
abstract：:The innate immune receptor toll-like receptor 4 (TLR4) has been implicated in mediating some of the effects of dietary lipids on inflammation and type 2 diabetes (T2D). Similar to TLR4, the nucleotide-binding oligomerization domains (Nods) 1 and 2 are also proteins of innate immunity, which can respond to lipids and i...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-012-0287-5
更新日期：2012-07-01 00:00:00
abstract：:Candidate gene association studies in cardiovascular diseases have provided evidence on the molecular basis of phenotypic differences between individuals. The comprehension of how inherited genetic variants are able to affect protein functions has increased the knowledge of how genes interact with environment in order...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-010-0193-7
更新日期：2011-02-01 00:00:00
abstract：:The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and represe...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-011-0215-0
更新日期：2011-11-01 00:00:00
abstract：:The traditional Mediterranean diet (MedDiet) has shown beneficial effects on cognitive decline. Nevertheless, diet-gene interactions have been poorly evaluated. We aimed to investigate diet-gene interaction in the PREDIMED-NAVARRA randomized trial. A total of 522 participants (67 ± 6 years at baseline) enrolled in the...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0393-7
更新日期：2014-05-01 00:00:00
abstract：:Low plasma levels of high-density lipoprotein cholesterol (HDL-C) are identified as a risk factor for cardiovascular disease (CVD). Sexual dimorphism, however, is widely reported in both HDL-C and CVD, with the underlying explanations of these sexual differences not fully understood. HDL-C is a complex trait influence...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-008-0075-4
更新日期：2008-07-01 00:00:00
abstract：:Two cases of zinc deficiency in breastfed neonates were investigated where zinc levels in the mothers' milk were reduced by more than 75 % compared to normal. The objective of this study was to find the molecular basis of the maternal zinc deficiency condition. Significant reductions in mRNA expression and protein lev...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-015-0487-x
更新日期：2015-09-01 00:00:00
abstract：:Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), riboflavin-dependent enzymes, participate in homocysteine metabolism. Reported effects of riboflavin status on the association between the MTHFR 677C>T polymorphism and homocysteine vary, and the effects of the MTRR 66A>G or MTRR 524...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0435-1
更新日期：2014-11-01 00:00:00
abstract：:A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple en...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-017-0581-3
更新日期：2017-10-30 00:00:00
abstract：:Genetic variation in bitter taste receptors, such as hTAS2R38, may affect food preferences and intake. The aim of the present study was to investigate the association between bitter taste receptor haplotypes and the consumption of vegetables, fruits, berries and sweet foods among an adult Finnish population. A cross-s...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0433-3
更新日期：2014-11-01 00:00:00
abstract：:Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying ...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-018-0592-8
更新日期：2018-02-20 00:00:00
abstract：BACKGROUND:The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of LP-related genetic variants was investigated in many groups of Sub-Saharan African, Middle Easte...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-017-0573-3
更新日期：2017-08-24 00:00:00
abstract：:The nuclear factor (NF)-kappaB is a primary regulator of inflammatory responses and may be linked to pathology associated with obesity. We investigated the progression of NF-kappaB activity during a 12-week feeding period on a high-fat diet (HFD) or a low-fat diet (LFD) using NF-kappaB luciferase reporter mice. In viv...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-009-0133-6
更新日期：2009-09-01 00:00:00
abstract：:It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In this context, animal studies and human trials have demonstrated ...
journal_title：Genes & nutrition
pub_type： 杂志文章,评审
doi：10.1186/s12263-017-0566-2
更新日期：2017-06-15 00:00:00
abstract：Background:The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontol...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-018-0601-y
更新日期：2018-04-30 00:00:00
abstract：:Phytosterol (PS) intake may be used for hypercholesterolaemia in some groups although the presence of non-responders is well known. Carotenoids and PS/cholesterol may compete for the same transporters during absorption. As part of a randomized, double-blind, crossover, multiple-dose supplementation study with β-crypto...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0428-0
更新日期：2014-09-01 00:00:00
abstract：UNLABELLED:A single high-fat challenge induces plasmatic pro-inflammatory and pro-oxidative responses in the postprandial state, even in healthy men. This period is also associated with vascular endothelial dysfunction, which is an early event in the development of cardiovascular diseases. However, knowledge about the ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-010-0166-x
更新日期：2010-09-01 00:00:00
abstract：:The demand for diet products is continuously increasing, together with that for natural food ingredients. Stevioside and other steviol glycosides extracted from the leaves of the plant Stevia rebaudiana Bertoni are the first natural high-potency sweeteners to be approved for consumption in the United States and the Eu...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0401-y
更新日期：2014-05-01 00:00:00
