Abstract：
:The nuclear factor (NF)-kappaB is a primary regulator of inflammatory responses and may be linked to pathology associated with obesity. We investigated the progression of NF-kappaB activity during a 12-week feeding period on a high-fat diet (HFD) or a low-fat diet (LFD) using NF-kappaB luciferase reporter mice. In vivo imaging of luciferase activity showed that NF-kappaB activity was higher in the HFD mice compared with LFD-fed mice. Thorax region of HFD females displayed fourfold higher activity compared with LFD females, while no such increase was evident in males. In male HFD mice, abdominal NF-kappaB activity was increased twofold compared with the LFD males, while females had unchanged NF-kappaB activity in the abdomen by HFD. HFD males, but not females, exhibited evident glucose intolerance during the study. In conclusion, HFD increased NF-kappaB activity in both female and male mice. However, HFD differentially increased activity in males and females. The moderate increase in abdomen of male mice may be linked to glucose intolerance.
journal_name
Genes Nutrjournal_title
Genes & nutritionauthors
Carlsen H,Haugen F,Zadelaar S,Kleemann R,Kooistra T,Drevon CA,Blomhoff Rdoi
10.1007/s12263-009-0133-6subject
Has Abstractpub_date
2009-09-01 00:00:00pages
215-22issue
3eissn
1555-8932issn
1865-3499journal_volume
4pub_type
杂志文章abstract：:Breast cancer is the second most frequent cancer affecting women worldwide after lung cancer. The toxicity factor associated with synthetic drugs has turned the attention toward natural compounds as the primary focus of interest as anticancer agents. Vitamin E derivatives consisting of the well-established tocopherols...
journal_title：Genes & nutrition
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journal_title：Genes & nutrition
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更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12263-014-0401-y
更新日期：2014-05-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Genes & nutrition
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更新日期：2010-06-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/BF02829964
更新日期：2006-09-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-011-0226-x
更新日期：2011-08-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-016-0535-1
更新日期：2016-06-23 00:00:00
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journal_title：Genes & nutrition
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journal_title：Genes & nutrition
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Genes & nutrition
pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-010-0171-0
更新日期：2010-12-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
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更新日期：2019-01-09 00:00:00
abstract：UNLABELLED:A single high-fat challenge induces plasmatic pro-inflammatory and pro-oxidative responses in the postprandial state, even in healthy men. This period is also associated with vascular endothelial dysfunction, which is an early event in the development of cardiovascular diseases. However, knowledge about the ...
journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-010-0166-x
更新日期：2010-09-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章,评审
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更新日期：2017-10-30 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-011-0257-3
更新日期：2012-04-01 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1186/s12263-018-0611-9
更新日期：2018-07-27 00:00:00
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journal_title：Genes & nutrition
pub_type： 杂志文章
doi：10.1007/s12263-014-0393-7
更新日期：2014-05-01 00:00:00
