Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort.

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic disorders, including obesity. Recent studies showed remarkable stability of miRNAs in both plasma an...

journal_title：Genes & nutrition

authors： Iacomino G,Russo P,Stillitano I,Lauria F,Marena P,Ahrens W,De Luca P,Siani A

更新日期：2016-03-21 00:00:00

abstract：:A methyl-deficient diet (MD) lacking folic acid and the associated methyl donors choline and methionine, fed to the laboratory rat during the periods of oocyte and embryo development, has been shown to programme glucose metabolism in the offspring. The hepatic proteome of the male offspring of female rats fed MD diets...

journal_title：Genes & nutrition

authors： Maloney CA,Hay SM,Reid MD,Duncan G,Nicol F,Sinclair KD,Rees WD

更新日期：2013-03-01 00:00:00

abstract：:While the effects of chronic ethanol consumption on liver have been well studied and documented, its effect on the cardiovascular system is bimodal. Thus, moderate drinking in many population studies is related to lower prevalence of coronary artery disease (CAD). In contrast, heavy drinking correlates with higher pre...

journal_title：Genes & nutrition

authors： Lakshman R,Garige M,Gong M,Leckey L,Varatharajalu R,Zakhari S

更新日期：2010-06-01 00:00:00

abstract：:The demand for diet products is continuously increasing, together with that for natural food ingredients. Stevioside and other steviol glycosides extracted from the leaves of the plant Stevia rebaudiana Bertoni are the first natural high-potency sweeteners to be approved for consumption in the United States and the Eu...

journal_title：Genes & nutrition

authors： Risso D,Morini G,Pagani L,Quagliariello A,Giuliani C,De Fanti S,Sazzini M,Luiselli D,Tofanelli S

更新日期：2014-05-01 00:00:00

abstract：:The goal of this study was to investigate the effect of a short-term nutritional intervention on gene expression in adipose tissue from lean and overweight subjects. Gene expression profiles were measured after consumption of an intervention spread (increased levels of polyunsaturated fatty acids, conjugated linoleic ...

journal_title：Genes & nutrition

authors： van Erk MJ,Pasman WJ,Wortelboer HM,van Ommen B,Hendriks HF

更新日期：2008-12-01 00:00:00

abstract：:Genetic variation in bitter taste receptors, such as hTAS2R38, may affect food preferences and intake. The aim of the present study was to investigate the association between bitter taste receptor haplotypes and the consumption of vegetables, fruits, berries and sweet foods among an adult Finnish population. A cross-s...

journal_title：Genes & nutrition

authors： Sandell M,Hoppu U,Mikkilä V,Mononen N,Kähönen M,Männistö S,Rönnemaa T,Viikari J,Lehtimäki T,Raitakari OT

更新日期：2014-11-01 00:00:00

abstract：:The nuclear factor (NF)-kappaB is a primary regulator of inflammatory responses and may be linked to pathology associated with obesity. We investigated the progression of NF-kappaB activity during a 12-week feeding period on a high-fat diet (HFD) or a low-fat diet (LFD) using NF-kappaB luciferase reporter mice. In viv...

journal_title：Genes & nutrition

authors： Carlsen H,Haugen F,Zadelaar S,Kleemann R,Kooistra T,Drevon CA,Blomhoff R

更新日期：2009-09-01 00:00:00

abstract：:Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more precise evaluation ...

journal_title：Genes & nutrition

authors： Gichohi-Wainaina WN,Towers GW,Swinkels DW,Zimmermann MB,Feskens EJ,Melse-Boonstra A

更新日期：2015-01-01 00:00:00

abstract：:Anthocyanins (AC) are water-soluble natural pigments found in various parts of higher plants. Despite their limited oral bioavailability and very low post-absorption plasma concentrations, the dietary consumption of these pigments has been proposed to be associated with a significant protection against several human p...

journal_title：Genes & nutrition

authors： Speciale A,Cimino F,Saija A,Canali R,Virgili F

更新日期：2014-07-01 00:00:00

abstract：:Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at multiple sites. Although it is presumed that these germline variants impact disease risk by altering the host's a...

journal_title：Genes & nutrition

authors： Al-Alem U,Gann PH,Dahl J,van Breemen RB,Mistry V,Lam PM,Evans MD,Van Horn L,Wright ME

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investigate the effects of short-term...

journal_title：Genes & nutrition

authors： Miousse IR,Pathak R,Garg S,Skinner CM,Melnyk S,Pavliv O,Hendrickson H,Landes RD,Lumen A,Tackett AJ,Deutz NEP,Hauer-Jensen M,Koturbash I

更新日期：2017-09-06 00:00:00

abstract：:The nutraceutical benefits of β-sitosterol (SIT) are well documented. The present study investigated the in vitro effects of SIT on adipogenesis, glucose transport, and lipid mobilization in rat adipocytes. Primary cultures of rat preadipocytes and differentiated adipocytes were used in this study. Glucose uptake was ...

journal_title：Genes & nutrition

authors： Chai JW,Lim SL,Kanthimathi MS,Kuppusamy UR

更新日期：2011-05-01 00:00:00

abstract：:Folic acid is the key one-carbon donor required for de novo nucleotide and methionine synthesis. Its deficiency is associated with megaloblastic anemia, cancer and various complications of pregnancy. However, its supplementation results in reduction of neural tube defects and prevention of several types of cancer. The...

journal_title：Genes & nutrition

authors： Thakur S,Thakur SD,Wani NA,Kaur J

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and represe...

journal_title：Genes & nutrition

authors： Martínez-Salazar MF,Almenares-López D,García-Jiménez S,Sánchez-Alemán MA,Juantorena-Ugás A,Ríos C,Monroy-Noyola A

更新日期：2011-11-01 00:00:00

abstract：:Current evidence indicates that genetic testing for obesity risk has limited affective or behavioral impact, but few studies have explored the effects among individuals who self-identify as having weight problems. Here, we report findings from in-depth telephone interviews with seven overweight or obese volunteers who...

journal_title：Genes & nutrition

authors： Meisel SF,Wardle J

更新日期：2014-01-01 00:00:00

abstract：Background:The neurodegenerative disorder Alzheimer's disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer's disease. On the other hand, betaine has been demonstrated to atte...

journal_title：Genes & nutrition

authors： Leiteritz A,Dilberger B,Wenzel U,Fitzenberger E

更新日期：2018-07-27 00:00:00

abstract：:Low plasma levels of high-density lipoprotein cholesterol (HDL-C) are identified as a risk factor for cardiovascular disease (CVD). Sexual dimorphism, however, is widely reported in both HDL-C and CVD, with the underlying explanations of these sexual differences not fully understood. HDL-C is a complex trait influence...

journal_title：Genes & nutrition

authors： Mosher MJ,Lange LA,Howard BV,Lee ET,Best LG,Fabsitz RR,Maccluer JW,North KE

更新日期：2008-07-01 00:00:00

abstract：:Phytoestrogens are naturally occurring plantderived polyphenols with estrogenic potency. They are ubiquitous in diet and therefore, generally consumed. Among Europeans, the diet is rich in multiple putative phytoestrogens including flavonoids, tannins, stilbenoids, and lignans. These compounds have been suggested to p...

journal_title：Genes & nutrition

authors： Saarinen NM,Bingham C,Lorenzetti S,Mortensen A,Mäkelä S,Penttinen P,Sørensen IK,Valsta LM,Virgili F,Vollmer G,Wärri A,Zierau O

更新日期：2006-09-01 00:00:00

abstract：:A long-term high-fat diet may result in a fatty liver. However, whether or not high-fat diets affect the hepatic circadian clock is controversial. The objective of this study is to investigate the effects of timed high-fat diet on the hepatic circadian clock and clock-controlled peroxisome proliferator-activated recep...

journal_title：Genes & nutrition

authors： Wang X,Xue J,Yang J,Xie M

更新日期：2013-09-01 00:00:00

abstract：:Candidate gene association studies in cardiovascular diseases have provided evidence on the molecular basis of phenotypic differences between individuals. The comprehension of how inherited genetic variants are able to affect protein functions has increased the knowledge of how genes interact with environment in order...

journal_title：Genes & nutrition

authors： Dias RG,Gowdak MM,Pereira AC

更新日期：2011-02-01 00:00:00

abstract：Background:Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors associated with psychological conditions including autism spectrum disorders and depression. We r...

journal_title：Genes & nutrition

authors： Sabir MS,Haussler MR,Mallick S,Kaneko I,Lucas DA,Haussler CA,Whitfield GK,Jurutka PW

更新日期：2018-07-11 00:00:00

abstract：:It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In this context, animal studies and human trials have demonstrated ...

journal_title：Genes & nutrition

authors： Duranti S,Ferrario C,van Sinderen D,Ventura M,Turroni F

更新日期：2017-06-15 00:00:00

abstract：:Two cases of zinc deficiency in breastfed neonates were investigated where zinc levels in the mothers' milk were reduced by more than 75 % compared to normal. The objective of this study was to find the molecular basis of the maternal zinc deficiency condition. Significant reductions in mRNA expression and protein lev...

journal_title：Genes & nutrition

authors： Kumar L,Michalczyk A,McKay J,Ford D,Kambe T,Hudek L,Varigios G,Taylor PE,Ackland ML

更新日期：2015-09-01 00:00:00

abstract：:Multiple factors have been implicated in the age-related declines in brain function. Thus, it is unlikely that modulating only a single factor will be effective at slowing this decline. A better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain functi...

journal_title：Genes & nutrition

authors： Maher P

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfunction during pregnancy is associated with the development of metabolic disorders in offspring. Here...

journal_title：Genes & nutrition

authors： Zou T,Yu B,Yu J,Mao X,Zheng P,He J,Huang Z,Liu Y,Chen D

更新日期：2016-06-23 00:00:00

abstract：:The apolipoprotein E (APOE) genotype is an important risk factor for ageing and age-related diseases. The APOE4 genotype (in contrast to APOE3) has been shown to be associated with oxidative stress and chronic inflammation. Metallothioneins (MT) exhibit antioxidant and anti-inflammatory activity, and MT overexpression...

journal_title：Genes & nutrition

authors： Graeser AC,Huebbe P,Storm N,Höppner W,Döring F,Wagner AE,Rimbach G

更新日期：2012-04-01 00:00:00

abstract：:Personalized nutrition has the potential to enhance individual health control. It could be seen as a means to strengthen people's autonomy as they learn more about their personal health risks, and receive dietary advice accordingly. We examine in what sense personalized nutrition strengthens or weakens individual auto...

journal_title：Genes & nutrition

authors： Nordström K,Juth N,Kjellström S,Meijboom FL,Görman U,Food4Me project.

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of LP-related genetic variants was investigated in many groups of Sub-Saharan African, Middle Easte...

journal_title：Genes & nutrition

authors： Ben Halima Y,Kefi R,Sazzini M,Giuliani C,De Fanti S,Nouali C,Nagara M,Mengozzi G,Elouej S,Abid A,Jamoussi H,Chouchane L,Romeo G,Abdelhak S,Luiselli D

更新日期：2017-08-24 00:00:00

abstract：:Moderate maternal calorie restriction during lactation protects rat offspring against obesity development in adulthood, due to an improved ability to handle and store excess dietary fuel. We used this model to identify early transcriptome-based biomarkers of metabolic health using peripheral blood mononuclear cells (P...

journal_title：Genes & nutrition

authors： Konieczna J,Sánchez J,van Schothorst EM,Torrens JM,Bunschoten A,Palou M,Picó C,Keijer J,Palou A

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:A single high-fat challenge induces plasmatic pro-inflammatory and pro-oxidative responses in the postprandial state, even in healthy men. This period is also associated with vascular endothelial dysfunction, which is an early event in the development of cardiovascular diseases. However, knowledge about the ...

journal_title：Genes & nutrition

authors： Dejeans N,Maier JA,Tauveron I,Milenkovic D,Mazur A

更新日期：2010-09-01 00:00:00