Abstract:
BACKGROUND:Genetic risk assessment for breast cancer and ovarian cancer (BCOC) is expected to make major inroads into mainstream clinical practice. It is important to evaluate the potential impact on women ahead of its implementation in order to maximise health benefits, as predictive genetic testing without adequate support could lead to adverse psychological and behavioural responses to risk disclosure. OBJECTIVE:To examine anticipated health behaviour changes and perceived control to disclosure of genetic risk for BCOC and establish demographic and person-specific correlates of adverse anticipated responses in a population-based sample of women. DESIGN:Cross-sectional quantitative survey study carried out by the UK Office for National Statistics in January and March 2014. SETTING:Face-to-face computer-assisted interviews conducted by trained researchers in participants' homes. PARTICIPANTS:837 women randomly chosen from households across the UK identified from the Royal Mail's Postcode Address File. OUTCOME MEASURES:Anticipated health behaviour change and perceived control to disclosure of BCOC risk. RESULTS:In response to a genetic test result, most women (72%) indicated 'I would try harder to have a healthy lifestyle', and over half (55%) felt 'it would give me more control over my life'. These associations were independent of demographic factors or perceived risk of BCOC in Bonferroni-corrected multivariate analyses. However, a minority of women (14%) felt 'it isn't worth making lifestyle changes' and that 'I would feel less free to make choices in my life' (16%) in response to BCOC risk disclosure. The former belief was more likely to be held by women who were educated below university degree level (P<0.001) after adjusting for other demographic and person-specific correlates. CONCLUSION:These findings indicate that women in the UK largely anticipate that they would engage in positive health behaviour changes in response to BCOC risk disclosure.
journal_name
BMJ Openjournal_title
BMJ openauthors
Meisel SF,Fraser LSM,Side L,Gessler S,Hann KEJ,Wardle J,Lanceley A,PROMISE study team.doi
10.1136/bmjopen-2017-017675subject
Has Abstractpub_date
2017-12-22 00:00:00pages
e017675issue
12issn
2044-6055pii
bmjopen-2017-017675journal_volume
7pub_type
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