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Effect of multimorbidity on survival of patients diagnosed with heart failure: a retrospective cohort study in Singapore.

Abstract：

OBJECTIVE:Multimorbidity in patients with heart failure (HF) results in poor prognosis and is an increasing public health concern. We aim to examine the effect of multimorbidity focusing on type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) on all-cause and cardiovascular disease (CVD)-specific mortality among patients diagnosed with HF in Singapore. DESIGN:Retrospective cohort study. SETTING:Primary and tertiary care in three (out of six) Regional Health Systems in Singapore. PARTICIPANTS:Patients diagnosed with HF between 2003 and 2016 from three restructured hospitals and nine primary care polyclinics were included in this retrospective cohort study. PRIMARY OUTCOMES:All-cause mortality and CVD-specific mortality. RESULTS:A total of 34 460 patients diagnosed with HF from 2003 to 2016 were included in this study and were followed up until 31 December 2016. The median follow-up time was 2.1 years. Comorbidities prior to HF diagnosis were considered. Patients were categorised as (1) HF only, (2) T2DM+HF, (3) CKD+HF and (4) T2DM+CKD+HF. Cox regression model was used to determine the effect of multimorbidity on (1) all-cause mortality and (2) CVD-specific mortality. Adjusting for demographics, other comorbidities, baseline treatment and duration of T2DM prior to HF diagnosis, 'T2DM+CKD+HF' patients had a 56% higher risk of all-cause mortality (HR: 1.56, 95% CI 1.48 to 1.63) and a 44% higher risk of CVD-specific mortality (HR: 1.44, 95% CI 1.32 to 1.56) compared with patients diagnosed with HF only. CONCLUSION:All-cause and CVD-specific mortality risks increased with increasing multimorbidity. This study highlights the need for a new model of care that focuses on holistic patient management rather than disease management alone to improve survival among patients with HF with multimorbidity.

journal_name

BMJ Open

journal_title

BMJ open

authors

Kaur P,Saxena N,You AX,Wong RCC,Lim CP,Loh SY,George PP

doi

10.1136/bmjopen-2017-021291

subject

Has Abstract

pub_date

2018-05-20 00:00:00

pages

e021291

issue

issn

2044-6055

pii

bmjopen-2017-021291

journal_volume

pub_type

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Effect of multimorbidity on survival of patients diagnosed with heart failure: a retrospective cohort study in Singapore.