Abstract:
BACKGROUND:Surgical stress index (SSI) is an established indicator for intraoperative nociception. Opioids are used to block stimulus of cranial pinning in neurosurgery. We investigated the effect of different infusion rates of sufentanil on SSI during cranial pinning in children under general anaesthesia. METHODS:Forty-nine children (2-12 years of age) underwent neurosurgery with pinning. The children were randomized into three groups based on the rate of sufentanil infusion: 0.2, 0.5, and 0.8 μg·kg-1·hr.-1. Continuous sufentanil infusion began following neuromuscular blockade administration, at a rate determined by each patient's assigned treatment group. Following preparation for surgery, cranial pinning was performed. Systolic, diastolic, and mean blood pressures, along with heart rate and photoplethysmographic data, were continuously recorded from 1 min prior to cranial pinning through 5 min after cranial pinning, in 1-min intervals. SSI was calculated following the completion of surgery. Differences in measured outcomes over time among the three groups were evaluated using a generalized estimation equation. Differences in pinning outcomes in the same group were evaluated with Freidman test. RESULTS:We found no statistical differences in long-term SSI that were associated with different infusion rates of sufentanil during cranial pinning. Blood pressures in all groups increased for 2 min after cranial pinning, and then decreased; we found no statistical difference in long-term blood pressure values among the groups. Heart rate increased after pinning in the group that received a low-dose infusion of sufentanil. CONCLUSIONS:Since SSI was intended to measure the blunting effects of sufentanil towards the noxious stimulus of cranial pinning, our results suggest that SSI might not be sufficiently sensitive to monitor the nociceptive response in children. TRIAL REGISTRATION:( KCT0000978 , Jan-07, 2014).
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Song IK,Ji SH,Kim EH,Lee JH,Kim JT,Kim HSdoi
10.1186/s12871-017-0448-6subject
Has Abstractpub_date
2017-12-08 00:00:00pages
167issue
1issn
1471-2253pii
10.1186/s12871-017-0448-6journal_volume
17pub_type
杂志文章,随机对照试验abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:BMC anesthesiology
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