Abstract：
BACKGROUND:Quick and complete recovery of cognitive function after general anesthesia is desirable, particularly for working-age patients. Desflurane is less likely to have long-term effects than older-generation inhalational anesthetics, however, its short-term effects have not been fully investigated. Our objective was to elucidate the short-term effects of desflurane exposure on learning and memory in young adult rats. METHODS:Seven-week old male Sprague-Dawley rats were exposed to air (control), or desflurane at 0.7 or 1.2 minimum alveolar concentration (MAC) for 2 h (day 0). The inhibitory avoidance (IA) test was performed on day 1 to delineate the effects on contextual learning. Separate groups of control and 1.2 MAC desflurane animals underwent the IA test on days 3 and 7 to examine the time-dependent changes. Because the IA test is known to be dependent on the long-term potentiation (LTP) of the hippocampus and the trafficking of the GluR1 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor into the synapses, the effects of 1.2 MAC desflurane on these phenomena were evaluated on day 1. RESULTS:Desflurane at 1.2 MAC, but not 0.7 MAC, significantly decreased the IA latencies on day 1 compared with the control (one-way ANOVA, F [2,48] = 5.974, P = 0.005, post hoc Tukey's, mean difference [95% confidence interval], control vs. 1.2 MAC, 168 [49.9 to 287], P = 0.004; control vs. 0.7 MAC, 67.5 [- 51.2 to 186], P = 0.362). The latencies were not affected on days 3 and 7 (day 3, control vs. desflurane, P = 0.861; day 7, control vs. desflurane, P > 0.999). Consistently, hippocampal LTP on day 1 was significantly suppressed in the desflurane group compared with the control group (P = 0.006). Moreover, immunoblotting analysis of synaptic GluR1 expression revealed that desflurane exposure significantly suppressed GluR1 delivery to the synapses after IA training. CONCLUSION:Exposure to a relatively high concentration of desflurane caused reversible learning and memory impairment in young adult rats associated with suppression of GluR1 delivery to the synapses in the hippocampus.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Tojo A,Uchimoto K,Inagawa G,Goto Tdoi
10.1186/s12871-019-0793-8subject
Has Abstractpub_date
2019-07-04 00:00:00pages
119issue
1issn
1471-2253pii
10.1186/s12871-019-0793-8journal_volume
19pub_type
杂志文章abstract：BACKGROUND:Carbohydrate-rich liquid drinks (CRLDs) have been recommended to attenuate insulin resistance by shortening the preoperative fasting interval. The aim of our study the effect of preoperative oral administration of CRLDs on the well-being and clinical status of patients. METHODS:A randomized, double blind, p...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2253-14-93
更新日期：2014-10-17 00:00:00
abstract：UNLABELLED: BACKGROUND:Hyperventilation may be used to hasten recovery from general anesthesia with potent inhaled anesthetics. However, its effect may be less pronounced with the newer, less soluble agents, and it may result in rehypnotization if subsequent hypoventilation occurs because more residual anesthetic will...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-12-22
更新日期：2012-09-18 00:00:00
abstract：BACKGROUND:Tramadol is an atypical centrally acting analgesic agent available as both oral and parenteral preparations. For patients who are unable to take tramadol orally, the subcutaneous route of administration offers an easy alternative to intravenous or intramuscular routes. This study aimed to characterise the ab...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-14-33
更新日期：2014-05-12 00:00:00
abstract：BACKGROUND:Sugammadex is a modified gamma-cyclodextrin that acts by selectively encapsulating free amino-steroidal neuromuscular relaxants. Several case reports have been published on the use of sugammadex in patients with neuromuscular disorders that include neuromuscular junction diseases, myopathies, neuropathies, a...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-019-0887-3
更新日期：2019-11-19 00:00:00
abstract：BACKGROUND:Mismanagement of remifentanil leads to severe side effects such as opioid-induced tolerance and hyperalgesia. Recently studies revealed an alternative withdrawal method to limit these side effects. A gradual withdrawal of remifentanil seems to be associated with less pain. The hypothesis of this double-blind...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-019-0731-9
更新日期：2019-04-25 00:00:00
abstract：BACKGROUND:Persistently variable success has been experienced in locally translating even well-grounded national clinical practice guidelines, including in the perioperative setting. We have sought greater applicability and acceptance of clinical practice guidelines and protocols with our novel Perioperative Risk Optim...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-016-0187-0
更新日期：2016-03-22 00:00:00
abstract：BACKGROUND:Early aggressive therapy can reduce the mortality associated with severe sepsis but this relies on prompt recognition, which is hindered by variation among published severity criteria. Our aim was to test the performance of different severity scores in predicting mortality among a cohort of hospital inpatien...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-14-1
更新日期：2014-01-02 00:00:00
abstract：BACKGROUND:Carbon monoxide (CO) poisoning can be a life threatening condition. Systemic hyperbaric oxygen (HBO) therapy is used to induce CO detoxification. However, little is known about the hemodynamic response to HBO in severely intoxicated patients. METHODS:We retrospectively analyzed the medical records of 6 CO-p...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-13-26
更新日期：2013-09-27 00:00:00
abstract：BACKGROUND:Intracranial-pressure (ICP) monitoring is useful for patients with increased ICP following hemorrhagic stroke. In this study, the changes in pressure gradients between the two cerebral hemispheres were investigated after hemorrhagic stroke of one side, and after a craniotomy. METHODS:Twenty-four patients wi...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-14-112
更新日期：2014-12-03 00:00:00
abstract：BACKGROUND:It has been hypothesized that dexamethasone can inhibit persistent postoperative pain, but data on humans is lacking and results from animal studies are conflicting. We explored the effect of 16 mg dexamethasone IV administered preoperatively on persistent pain 1 year after lumbar discectomy. METHODS:This i...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-016-0277-z
更新日期：2016-11-16 00:00:00
abstract：:We have developed a two-step procedure for preparing the skin before peripheral venous catheter (PVC) insertions. This procedure involves two successive swabbings with wipes soaked in alcoholic antiseptic. We investigated whether this two-step procedure was as effective and safe as the standard four-step procedure--wa...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-7-1
更新日期：2007-01-31 00:00:00
abstract：BACKGROUND:Obstetric dfficult airway is a leading cause of maternal morbidity and mortality. The laryngeal mask airway (LMA) is often used as a rescue airway device after failed intubation, however, little is known about predictors of difficult LMA insertion, particularly in obstetrics. Since Mallampati scores of III/I...
journal_title：BMC anesthesiology
pub_type： 临床试验,杂志文章
doi：10.1186/s12871-019-0796-5
更新日期：2019-07-08 00:00:00
abstract：BACKGROUND:Breast cancer surgery is one of the most common surgeries among the female population. Nearly half of the patients suffer chronic pain following breast cancer surgery, and 24% of them categorizing their pain as moderate to high. In this study, effects of ultrasound-guided erector spinae plane (ESP) block per...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-019-0700-3
更新日期：2019-03-04 00:00:00
abstract：BACKGROUND:The present study aimed to compare the intravenous bolus effect of oxycodone and fentanyl on hemodynamic response after endotracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture. METHODS:In this prospective randomized double-blinded study, 64 patients unde...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-016-0279-x
更新日期：2016-11-17 00:00:00
abstract：BACKGROUND:Splenectomy performed with a curved incision results in severe postoperative pain. The aim of this study was to evaluate the effect of transversus abdominis plane block and rectus sheath block on postoperative pain relief and recovery. METHODS:A total of 150 patients were randomized into the control (C), le...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-020-0941-1
更新日期：2020-01-23 00:00:00
abstract：BACKGROUND:Sugammadex reverses neuromuscular block (NMB) through binding aminosteroid neuromuscular blocking agents. Although sugammadex appears to be highly selective, it can interact with other drugs, like corticosteroids. A prospective single-blinded randomized clinical trial was designed to explore the significance...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-016-0254-6
更新日期：2016-10-21 00:00:00
abstract：BACKGROUND:Acute kidney injury (AKI) occurs frequently after liver transplant surgery and is associated with significant morbidity and mortality. While the impact of intraoperative hypotension (IOH) on postoperative AKI has been well demonstrated in patients undergoing a wide variety of non-cardiac surgeries, it remain...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01228-y
更新日期：2021-01-11 00:00:00
abstract：BACKGROUND:General anesthesia has been linked to impaired brain development in immature animals and young children. In this study the influence of orthopedic surgery under general anesthesia on the intelligence of school age children has been evaluated. METHODS:A total of 209 subjects aged 6-12 years were recruited an...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-017-0462-8
更新日期：2017-12-19 00:00:00
abstract：BACKGROUND:A mouth gag is usually used during tonsillectomy and adenotonsillectomy surgeries, cleft palate repair, obstructive sleep apnea surgery, and intraoral tumor excision. The placement of the gag causes hemodynamic changes similar to laryngoscopy. The aim of this study was to evaluate the effect of mouth gag pla...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01079-7
更新日期：2020-07-03 00:00:00
abstract：BACKGROUND:To identify changes in cefoperazone/sulbactam penetration into cerebrospinal fluid (CSF) after craniotomy and to investigate preliminarily whether cefoperazone/sulbactam CSF concentration can reach therapeutic level when administered intravenously after neurosurgical operation. METHODS:Neurosurgical patient...
journal_title：BMC anesthesiology
pub_type： 临床试验,杂志文章
doi：10.1186/s12871-015-0012-1
更新日期：2015-03-13 00:00:00
abstract：OBJECTIVE:To compare the analgesic effects of patient-controlled intravenous analgesia (PCA) with hydromorphone and sufentanil after thoracic surgery on postoperative pulmonary complications (PPCs). METHODS:A total of 142 patients who were scheduled for thoracic surgery were randomly allocated to receive PCA with hydr...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-018-0657-7
更新日期：2018-12-19 00:00:00
abstract：BACKGROUND:Current pain assessment and treatment does not address every patient's requirements. Although the Polish national guidelines for post-operative pain management have been published, many patients experience severe pain in the postoperative period. The main goal of our study was to assess pain severity among p...
journal_title：BMC anesthesiology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12871-018-0551-3
更新日期：2018-07-18 00:00:00
abstract：BACKGROUND:Mortality from anaesthesia and surgery in many countries in Sub-Saharan Africa remain at levels last seen in high-income countries 70 years ago. With many factors contributing to these poor outcomes, the World Health Organization (WHO) launched the "Safe Surgery Saves Lives" campaign in 2007. This program in...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-016-0228-8
更新日期：2016-08-11 00:00:00
abstract：BACKGROUND:Tracheostomy is recommended for patients receiving mechanical ventilation (MV) for 14 days or more in the intensive care unit (ICU). Nevertheless, many patients undergoing prolonged MV remain intubated via the translaryngeal route. The aim of this study was to examine the influence of tracheostomy and persis...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-015-0159-9
更新日期：2015-12-15 00:00:00
abstract：BACKGROUND:In what way volume, concentration and dose affect block duration is controversial. The purpose of the present study is to investigate the effect of dose, volume and concentration of mepivacaine on the duration of sensory and motor blockade in ultrasound-guided single shot axillary brachial plexus blockade. ...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-015-0110-0
更新日期：2015-09-30 00:00:00
abstract：BACKGROUND:Post-operative delirium (POD) is a common post-operative complication in elderly individuals and imposes a significant health and financial burden. Identifying predictive biomarkers may help understand the pathophysiology of POD. Our objective is to summarize the evidence of pre-operative biomarkers and imag...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-019-0693-y
更新日期：2019-02-23 00:00:00
abstract：BACKGROUND:McGrath MAC video laryngoscope offers excellent laryngosopic views and increases the success rate of orotracheal intubation in some cases. The aim of this study was to determine the usefulness of McGrath MAC for routine nasotracheal intubation by comparing McGrath MAC with Airway scope and Macintosh laryngos...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-017-0451-y
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Few studies have investigated the effect of dexmedetomidine on postoperative nausea and vomiting (PONV) in patients underwent gynecological laparoscopic surgery. We investigated if adding dexmedetomidine to a morphine-based patient-controlled analgesia (PCA) could decrease the incidence of PONV in this high-...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-019-0928-y
更新日期：2020-01-08 00:00:00
abstract：BACKGROUND:The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. METHODS:A ...
journal_title：BMC anesthesiology
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2253-14-16
更新日期：2014-03-10 00:00:00
abstract：BACKGROUND:Desflurane during early reperfusion has been shown to postcondition human myocardium, in vitro. We investigated the role of adenosine and bradykinin receptors, and generation of radical oxygen species in desflurane-induced postconditioning in human myocardium. METHODS:We recorded isometric contraction of hu...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-10-12
更新日期：2010-07-29 00:00:00
