Abstract：
BACKGROUND:Tramadol is an atypical centrally acting analgesic agent available as both oral and parenteral preparations. For patients who are unable to take tramadol orally, the subcutaneous route of administration offers an easy alternative to intravenous or intramuscular routes. This study aimed to characterise the absorption pharmacokinetics of a single subcutaneous dose of tramadol in severely ill patients and in healthy subjects. METHODS/DESIGN:Blood samples (5 ml) taken at intervals from 2 minutes to 24 hours after a subcutaneous dose of tramadol (50 mg) in 15 patients (13 male, two female) and eight healthy male subjects were assayed using high performance liquid chromatography. Pharmacokinetic parameters were derived using a non-compartmental approach. RESULTS:There were no statistically significant differences between the two groups in the following parameters (mean ± SD): maximum venous concentration 0.44 ± 0.18 (patients) vs. 0.47 ± 0.13 (healthy volunteers) mcg/ml (p = 0.67); area under the plasma concentration-time curve 177 ± 109 (patients) vs. 175 ± 75 (healthy volunteers) mcg/ml*min (p = 0.96); time to maximum venous concentration 23.3 ± 2 (patients) vs. 20.6 ± 18.8 (healthy volunteers) minutes (p = 0.73) and mean residence time 463 ± 233 (patients) vs. 466 ± 224 (healthy volunteers) minutes (p = 0.97). CONCLUSIONS:The similar time to maximum venous concentration and mean residence time suggest similar absorption rates between the two groups. These results indicate that the same dosing regimens for subcutaneous tramadol administration may therefore be used in both healthy subjects and severely ill patients. TRIAL REGISTRATION:ACTRN12611001018909.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Dooney NM,Sundararajan K,Ramkumar T,Somogyi AA,Upton RN,Ong J,O'Connor SN,Chapman MJ,Ludbrook GLdoi
10.1186/1471-2253-14-33subject
Has Abstractpub_date
2014-05-12 00:00:00pages
33issn
1471-2253pii
1471-2253-14-33journal_volume
14pub_type
杂志文章abstract：BACKGROUND:Ultrasound gels may contain propylene glycol and glycerol, which are neurotoxic in high concentrations. If the needle passes through gel during regional anesthesia, gel may be injected near the nerve. It is unknown if this practice poses a risk for neurotoxicity. Using an animal model, we assessed the histol...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-13-18
更新日期：2013-09-03 00:00:00
abstract：BACKGROUND:We report a case of severe upper airway obstruction due to a retropharyngeal hematoma that presented nearly one day after a precipitating traumatic injury. Retropharyngeal hematomas are rare, but may cause life-threatening airway compromise. CASE PRESENTATION:A 50 year-old man developed severe dyspnea with ...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-7-2
更新日期：2007-03-12 00:00:00
abstract：BACKGROUND:Most trauma patients admitted to the hospital alive and die later on, decease during the initial care in the emergency department or the intensive care unit (ICU). However, a number of patients pass away after having been discharged from the ICU during the initial hospital stay. On first sight these cases co...
journal_title：BMC anesthesiology
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doi：10.1186/s12871-020-01159-8
更新日期：2020-09-23 00:00:00
abstract：BACKGROUND:Local anesthetic Bupivacaine commonly used in gastric cancer resection operation has been reported to suppress the progression of gastric cancer. However, the specific mechanism by which Bupivacaine functions is largely unexplored. METHODS:The viability and metastasis of gastric cancer cells were assessed b...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01179-4
更新日期：2020-10-30 00:00:00
abstract：BACKGROUND:Acute kidney injury (AKI) is a common complication following non-cardiac surgery with adverse short- and long- term morbidity and mortality. Evidence shows that hypoalbuminemia is associated with increased AKI risk in patients with infectious diseases and cancer and following cardiac surgery and transplant s...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-019-0842-3
更新日期：2019-09-02 00:00:00
abstract：BACKGROUND:Lumbar puncture for spinal or epidural anesthesia is commonly performed by palpating bony landmarks, but identification of the desired intervertebral level is often inaccurate. It is unclear whether such inaccuracy is related to patient factors, such as body mass index and degree of lumbar flexion. We hypoth...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-15-9
更新日期：2015-01-21 00:00:00
abstract：BACKGROUND:The peri-operative effectiveness of ultrasound-guided great auricular nerve block (GANB) in patients, especially in adult patients undergoing middle ear microsurgery remains unclear. We hypothesized that ultrasound-guided GANB would decrease the hemodynamic responsiveness to incision and opioid consumption i...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01155-y
更新日期：2020-09-15 00:00:00
abstract：BACKGROUND:This paper describes the design of a multifunction alerting display for intraoperative anesthetic care. The design was inspired by the multifunction primary flight display used in modern aviation. RESULTS:The display retrieves live data from multiple sources; the physiologic monitors, the anesthesia informa...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-018-0478-8
更新日期：2018-02-05 00:00:00
abstract：BACKGROUND:Endotracheal tube (ETT) designs to decrease the risk of ventilator associated pneumonia (VAP) include supraglottic suctioning, and/or modifications of the cuff shape. The TaperGuard™ ETT has a tapered, polyvinylchloride cuff designed to reduce microaspiration around channels that form with a standard barrel-...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01117-4
更新日期：2020-08-24 00:00:00
abstract：BACKGROUND:Tenascin-C is a pro-inflammatory glycoprotein with various biological functions. High expression of tenascin-C is found in inflammation, tissue remodeling, and autoimmune diseases. However, its expression and clinical significance in sepsis remain unclear. This study was designed to investigate the relations...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-018-0634-1
更新日期：2018-11-15 00:00:00
abstract：BACKGROUND:Isoflurane-induced neuroapoptosis and cognitive impairment has been previously reported. Hydrogen sulfide (H2S) has been shown to be a neuromodulator that is thought to have anti-apoptotic, anti-inflammatory, and anti-oxidative benefits. However, it is not known if H2S is protective against anesthesia-induce...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-017-0419-y
更新日期：2017-09-05 00:00:00
abstract：BACKGROUND:Hyperthermia is relatively rare during general anesthesia; however, a few studies have been conducted on hyperthermia and the neuromuscular blockade (NMB) induced by rocuronium, and the reversal of NMB by sugammadex. We investigated the effect of hyperthermia status on the NMB induced by rocuronium, and its ...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01114-7
更新日期：2020-08-07 00:00:00
abstract：BACKGROUND:Rotational elastometry (ROTEM) has been shown useful to monitor coagulation in trauma patients and in major elective surgery. In this study, we aimed to evaluate the utility of ROTEM to identify hemostatic disturbances and to predict the need for transfusion, compared with standard coagulation tests (SCTs) i...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-017-0440-1
更新日期：2017-10-24 00:00:00
abstract：BACKGROUND:The anaesthetic management of patients with Morquio syndrome is complicated by a number of factors including odontoid hypoplasia, atlantoaxial instability, thoracic kyphosis, and deposition of mucopolysaccharides in the soft tissue of the oropharnyx. CASE PRESENTATION:Herein we describe the anaesthetic cons...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-10-2
更新日期：2010-02-26 00:00:00
abstract：BACKGROUND:Since blood pressure tends to be unstable during induction of anesthesia in patients undergoing cardiovascular surgery, an artery catheter is often inserted before induction to continuously monitor arterial pressure during induction of anesthesia. ClearSight System™ enables noninvasive continuous measurement...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01091-x
更新日期：2020-07-20 00:00:00
abstract：UNLABELLED: BACKGROUND:Hyperventilation may be used to hasten recovery from general anesthesia with potent inhaled anesthetics. However, its effect may be less pronounced with the newer, less soluble agents, and it may result in rehypnotization if subsequent hypoventilation occurs because more residual anesthetic will...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-12-22
更新日期：2012-09-18 00:00:00
abstract：BACKGROUND:Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory upregulation of the N-methyl-D-aspartate (NMDA) receptor NR1 subunit. ...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-018-0511-y
更新日期：2018-05-10 00:00:00
abstract：BACKGROUND:Noise levels in hospitals, especially in intensive care units (ICUs) are known to be high, potentially affecting not only the patients' well-being but also their clinical outcomes. In an observational study, we made a long-term measurement of noise levels in an ICU, and investigated the influence of various ...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-015-0019-7
更新日期：2015-03-31 00:00:00
abstract：:BACKGROUND: Propofol is widely used for both short-term anesthesia and long-term sedation. It has unusual pharmacokinetics because of its high lipid solubility. The standard approach to describing the pharmacokinetics is by a multi-compartmental model. This paper presents the first detailed human physiologically based...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/1471-2253-5-4
更新日期：2005-04-22 00:00:00
abstract：BACKGROUND:Induction of the COX-2 isoenzyme appears to play a major role in the genesis of central sensitization after nociceptive stimulation. This study aimed to investigate the efficacy of a single, oral dose of the specific COX-2 inhibitor-valdecoxib in attenuating the central sensitization - induced secondary hype...
journal_title：BMC anesthesiology
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doi：10.1186/1471-2253-6-3
更新日期：2006-03-10 00:00:00
abstract：BACKGROUND:Cataract surgery is one of the most common procedures performed worldwide in the elderly. Various medications can provide effective anesthesia and analgesia for cataract surgery, but undesirable side effects limit the utility of each medication or combination of medications. Dexmedetomidine may serve as an a...
journal_title：BMC anesthesiology
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更新日期：2020-04-04 00:00:00
abstract：BACKGROUND:Aspiration-induced lung injury can decrease gas exchange and increase mortality. Acute lung injury following acid aspiration is characterized by elevated pulmonary blood flow (PBF) in damaged lung areas in the early inflammation stage. Knowledge of PBF patterns after acid aspiration is important for targetin...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-015-0013-0
更新日期：2015-03-18 00:00:00
abstract：BACKGROUND:General anesthesia has been linked to impaired brain development in immature animals and young children. In this study the influence of orthopedic surgery under general anesthesia on the intelligence of school age children has been evaluated. METHODS:A total of 209 subjects aged 6-12 years were recruited an...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-017-0462-8
更新日期：2017-12-19 00:00:00
abstract：BACKGROUND:Many cases of coronary artery spasm (CAS) during general plus epidural anesthesia have been reported. But transversus abdominis plane(TAP) block in combination with general anesthesia has not been reported to be a cause of CAS, let alone a life-threatening CAS. CASE PRESENTATION:In this case report, we pres...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-018-0616-3
更新日期：2018-10-20 00:00:00
abstract：BACKGROUND:Breast cancer surgery is one of the most common surgeries among the female population. Nearly half of the patients suffer chronic pain following breast cancer surgery, and 24% of them categorizing their pain as moderate to high. In this study, effects of ultrasound-guided erector spinae plane (ESP) block per...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-019-0700-3
更新日期：2019-03-04 00:00:00
abstract：BACKGROUND:Data on the best norepinephrine bolus dose for management of hypotension are limited. The aim of this study was to compare the efficacy and safety of two norepinephrine bolus doses in the rescue management of maternal hypotension during cesarean delivery. METHODS:This randomized, controlled trial included m...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-020-01004-y
更新日期：2020-04-17 00:00:00
abstract：BACKGROUND:The significance of intraoperative anesthesia handoffs on patient outcomes are unclear. One aspect differentiating the disparate results is the treatment of confounding factors, such as patient comorbidities and surgery time of day. We performed this study to quantify the significance of confounding variable...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-019-0858-8
更新日期：2019-10-15 00:00:00
abstract：BACKGROUND:To determine the median effective concentration of sufentanil as an analgesic during wake-up tests after sevoflurane anesthesia during surgery for adolescent idiopathic scoliosis (AIS). METHODS:This is a randomised controlled trial. Sixty patients aged 13-18 years scheduled for AIS surgery were randomized i...
journal_title：BMC anesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12871-015-0003-2
更新日期：2015-03-08 00:00:00
abstract：BACKGROUND:Laryngeal mask airway is a supraglottic airway device which has led to a fundamental change in the management of modern general anesthesia. In the present study; we evaluated the laryngeal mask airway insertion conditions and hemodynamic changes comparing ketamine-propofol mixture (ketofol) with propofol. Th...
journal_title：BMC anesthesiology
pub_type： 杂志文章
doi：10.1186/s12871-019-0711-0
更新日期：2019-03-20 00:00:00
abstract：BACKGROUND:The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. METHODS:A ...
journal_title：BMC anesthesiology
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2253-14-16
更新日期：2014-03-10 00:00:00
