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Clinical significance and prognosis of serum tenascin-C in patients with sepsis.

Abstract：

BACKGROUND:Tenascin-C is a pro-inflammatory glycoprotein with various biological functions. High expression of tenascin-C is found in inflammation, tissue remodeling, and autoimmune diseases. However, its expression and clinical significance in sepsis remain unclear. This study was designed to investigate the relationship between serum tenascin-C levels and disease severity and prognosis in patients with sepsis. METHODS:A total of 167 patients with sepsis admitted to the ICU were enrolled. Lood samples were collected within 24 h of admission. Serum tenascin-C levels were measured by enzyme-linked immunosorbent assay (ELISA). Follow-up was performed to observe 30-day mortality. RESULTS:Serum tenascin-C levels were significantly elevated in patients with sepsis compared with non-sepsis controls (P < 0.001). Serum tenascin-C levels were higher in nonsurvivors (58 cases) who died within 30 days (34.5%) compared to survivors (109 cases) (P < 0.001). In patients with sepsis, serum tenascin-C levels were significantly positively correlated with SOFA scores (P = 0.011), serum creatinine (P = 0.006), C-reactive protein (CRP) (P = 0.001), interleukin-6 (IL-6) (P < 0.001), and tumor necrosis factor α (TNF-α) (P = 0.026). Logistic multivariate regression models showed that serum tenascin-C levels were independent contributor of 30-day mortality. Kaplan-Meier curves showed that septic patients with high levels of serum tenascin-C (≥56.9 pg/mL) had significantly higher 30-day mortality than those with lower serum tenascin-C (< 56.9 pg/mL) (P < 0.001). CONCLUSION:Elevated serum tenascin-C was found in septic patients and associated with severity and poor prognosis.

journal_name

BMC Anesthesiol

journal_title

BMC anesthesiology

authors

Yuan W,Zhang W,Yang X,Zhou L,Hanghua Z,Xu K

doi

10.1186/s12871-018-0634-1

subject

Has Abstract

pub_date

2018-11-15 00:00:00

pages

170

issue

1

issn

1471-2253

pii

10.1186/s12871-018-0634-1

journal_volume

18

pub_type

杂志文章

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