Abstract:
BACKGROUND:The peri-operative effectiveness of ultrasound-guided great auricular nerve block (GANB) in patients, especially in adult patients undergoing middle ear microsurgery remains unclear. We hypothesized that ultrasound-guided GANB would decrease the hemodynamic responsiveness to incision and opioid consumption in middle ear microsurgery as well as the post-operative analgesia requirement. METHODS:Sixty patients undergoing middle ear microsurgery were randomized into two equal groups to receive either a GANB with 2 ml of 0.25% ropivacaine under ultrasound guidance (GANB group) or to receive a blank control intervention (without any performed injection) before general anesthesia inductions. The primary outcomes were hemodynamic changes of MAP (mean artery pressure) and HR (heart rate) to skin incision. The secondary endpoints were to determine the consumptions of propofol and remifentanil during the operation and the incidence of remedial analgesia 48 h post-operation to maintain VAS ≤ 3. RESULTS:The MAP post incision in GANB group was significantly lower than that in control group (GANB group 93.83 ± 11.72 mmHg vs. control group 100.87 ± 12.65 mmHg, P = 0.029). The increases for MAP and HR post incision were also lower in GANB group (∆MAP GANB group 11.90 ± 8.32 mmHg vs. control group 19.83 ± 10.37 mmHg, P = 0.002; ∆HR GANB group 3.67 ± 5.30 beat min- 1 vs. control group 8.23 ± 8.56 beat min- 1, P = 0.016). Remifentanil consumption was significantly decreased in GANB group (GANB group 401.55 ± 100.51 μg h- 1 vs. control group 697.34 ± 215.45 μg h- 1, P = 0.000). The incidence of remedial analgesia post-operation in GANB group (5/30) was significantly lower than that in control group (20/30, P = 0.000). CONCLUSION:Ultrasound-guided GANB decreases the hemodynamic responsiveness to incision and remifentanil consumption in middle ear microsurgery as well as the post-operative analgesia requirement. TRIAL REGISTRATION:This trial was retrospectively registered at http://www.chictr.org.cn with the registration number of ChiCTR1800014333 on 6 January, 2018.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Liu J,Yuan K,Zhou H,Li L,Wang G,Li Tdoi
10.1186/s12871-020-01155-ysubject
Has Abstractpub_date
2020-09-15 00:00:00pages
234issue
1issn
1471-2253pii
10.1186/s12871-020-01155-yjournal_volume
20pub_type
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-01-17 00:00:00
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journal_title:BMC anesthesiology
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journal_title:BMC anesthesiology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1186/1471-2253-14-25
更新日期:2014-04-07 00:00:00
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journal_title:BMC anesthesiology
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更新日期:2006-03-10 00:00:00
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更新日期:2012-09-18 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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doi:10.1186/s12871-015-0159-9
更新日期:2015-12-15 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-10-24 00:00:00
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更新日期:2020-03-06 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-11-21 00:00:00
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更新日期:2020-04-04 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2020-01-31 00:00:00
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pub_type: 杂志文章
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更新日期:2015-01-21 00:00:00
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更新日期:2021-01-08 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:The effect of adding clonidine to local anesthetics for nerve or plexus blocks remains unclear. Most of the studies in adults have demonstrated the positive effects of clonidine on intra- and postoperative analgesia when used as an adjunctive agent or in some cases as a single to regional techniques. In the ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-12-2
更新日期:2012-02-01 00:00:00