Abstract:
BACKGROUND:The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. METHODS:A total of 1440 patients admitted to 22 ICUs (medical, 14; surgical, six; multidisciplinary, two) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were assessed. Patient data, including NT-pro-BNP levels and Simplified Acute Physiology Score (SAPS) 3 scores, were recorded prospectively in a web-based database. RESULTS:The median age was 64 years (range, 53-73 years), and 906 (62.9%) patients were male. The median NT-pro-BNP level was 341 pg/mL (104-1,637 pg/mL), and the median SAPS 3 score was 57 (range, 47-69). The ICU mortality rate was 18.9%, and hospital mortality was 24.5%. Hospital survivors showed significantly lower NT-pro-BNP values than nonsurvivors (245 pg/mL [range, 82-1,053 pg/mL] vs. 875 pg/mL [241-5,000 pg/mL], respectively; p < 0.001). In prediction of hospital mortality, the area under the curve (AUC) for NT-pro-BNP was 0.67 (95% confidence interval [CI], 0.64-0.70) and SAPS 3 score was 0.83 (95% CI, 0.81-0.85). AUC increment by adding NT-pro-BNP is minimal and likely no different to SAPS 3 alone. CONCLUSIONS:The NT-pro-BNP level was more elevated in nonsurvivors in a multicenter cohort of critically ill patients. However, there was little additional prognostic power when adding NT-pro-BNP to SAPS 3 score.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Rhee CK,Lim SY,Koh SO,Choi WI,Lee YJ,Chon GR,Kim JH,Kim JY,Lim J,Park S,Kim HC,Lee JH,Lee JH,Park J,Koh Y,Suh GY,Kim SC,Validation of Simplified acute physiology score3 in Korean Intensive care unit (VSKI) study group &doi
10.1186/1471-2253-14-16subject
Has Abstractpub_date
2014-03-10 00:00:00pages
16issn
1471-2253pii
1471-2253-14-16journal_volume
14pub_type
杂志文章,多中心研究abstract:BACKGROUND:Despite international data indicating that Enhanced Recovery After Surgery (ERAS) programs, which combine evidence-based perioperative strategies, expedite recovery after surgery, few centers have successfully adopted this approach within the U.S. We describe the implementation and efficacy of an ERAS progra...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-016-0223-0
更新日期:2016-08-03 00:00:00
abstract:UNLABELLED: BACKGROUND:Hyperventilation may be used to hasten recovery from general anesthesia with potent inhaled anesthetics. However, its effect may be less pronounced with the newer, less soluble agents, and it may result in rehypnotization if subsequent hypoventilation occurs because more residual anesthetic will...
journal_title:BMC anesthesiology
pub_type: 杂志文章
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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journal_title:BMC anesthesiology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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