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A double blind randomized trial of wound infiltration with ropivacaine after breast cancer surgery with axillary nodes dissection.

Abstract：

BACKGROUND:The effect of local infiltration after breast surgery is controversial. This prospective double blind randomized study sought to document the analgesic effect of local anaesthetic infiltration after breast cancer surgery. METHODS:Patients scheduled for mastectomy or tumorectomy and axillary nodes dissection had immediate postoperative infiltration of the surgical wound with 20 ml of ropivacaine 7.5 mg.ml-1 or isotonic saline. Pain was assessed on a visual analogue scale at H2, H4, H6, H12, H24, H72, and at 2 month, at rest and on mobilization of the arm. Patient'comfort was evaluated with numerical 0-3 scales for fatigue, quality of sleep, state of mood, social function and activity. RESULTS:Twenty-two and 24 patients were included in the ropivacaine and saline groups respectively. Postoperative pain was lower at rest and on mobilization at 2, 4 and 6 hour after surgery in the ropivacaine group. No other difference in pain intensity and patient 'comfort scoring was documented during the first 3 postoperative days. Patients did not differ at 2 month for pain and comfort scores. CONCLUSION:Single shot infiltration with ropivacaine transiently improves postoperative pain control after breast cancer surgery. TRIAL REGISTRATION NUMBER:NCT01404377.

journal_name

BMC Anesthesiol

journal_title

BMC anesthesiology

authors

Vigneau A,Salengro A,Berger J,Rouzier R,Barranger E,Marret E,Bonnet F

doi

10.1186/1471-2253-11-23

subject

Has Abstract

pub_date

2011-11-24 00:00:00

pages

23

issn

1471-2253

pii

1471-2253-11-23

journal_volume

11

pub_type

杂志文章

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