Abstract:
BACKGROUND:Neuropathic pain is evasive to treat once developed, however evidence suggests that local administration of anesthetics near the time of injury reduces the development of neuropathic pain. As abnormal electrical signaling in the damaged nerve contributes to the initiation and maintenance of neuropathic pain, local administration of anesthetics prior to injury may reduce its development. We hypothesized that local treatment with bupivacaine prior to nerve injury in a rat model of spinal nerve ligation (SNL) would attenuate the initiation and/or maintenance of neuropathic pain behaviors. METHODS:On the day prior to SNL, baseline measures of pre-injury mechanical, thermal, and/or cold sensitivity were recorded in adult male Sprague-Dawley rats. Immediately prior to SNL or sham treatment, the right L5 nerve was perineurally bathed in either 0.05 mL bupivacaine (0.5 %) or sterile saline (0.9 %) for 30 min. Mechanical allodynia, thermal hyperalgesia, and/or cold allodynia were then examined at 3, 7, 10, 14 and 21 days following SNL. RESULTS:Rats exhibited both mechanical and cold allodynia, but not thermal hyperalgesia, within 3 days and up to 21 days post-SNL. No significant pain behaviors were observed in sham controls. Preemptive local bupivacaine significantly attenuated both mechanical and cold allodynia as early as 10 days following SNL compared to saline controls and were not significantly different from sham controls. CONCLUSIONS:These data indicate that local treatment with bupivacaine prior to surgical manipulations that are known to cause nerve damage may protect against the maintenance of chronic neuropathic pain.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Clifford JL,Mares A,Hansen J,Averitt DLdoi
10.1186/s12871-015-0113-xsubject
Has Abstractpub_date
2015-10-06 00:00:00pages
135issn
1471-2253pii
10.1186/s12871-015-0113-xjournal_volume
15pub_type
杂志文章abstract:BACKGROUND:The double lumen endotracheal tube (DLT) is the most widely-used device for single lung ventilation in current thoracic anesthesia practice. In recent years, the routine application of the videolaryngoscope for single lumen endotracheal intubation has increased; nevertheless there are few studies of the use ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
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journal_title:BMC anesthesiology
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-019-0700-3
更新日期:2019-03-04 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-01-18 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-018-0511-y
更新日期:2018-05-10 00:00:00
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更新日期:2015-03-13 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-09-30 00:00:00
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journal_title:BMC anesthesiology
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更新日期:2017-12-02 00:00:00
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journal_title:BMC anesthesiology
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更新日期:2007-01-31 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
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更新日期:2017-10-17 00:00:00
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journal_title:BMC anesthesiology
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更新日期:2020-04-25 00:00:00
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journal_title:BMC anesthesiology
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更新日期:2016-03-22 00:00:00
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更新日期:2016-11-16 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2018-07-24 00:00:00
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更新日期:2019-08-14 00:00:00
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更新日期:2019-10-09 00:00:00
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更新日期:2010-07-29 00:00:00
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