Abstract:
BACKGROUND:Conventionally, ultrasonographic assessment of diaphragm contractility has involved measuring respiratory changes in diaphragm thickness (thickening fraction) using B-mode or caudal displacement with M-mode. Two-dimensional speckle-tracking has been increasingly used to assess muscle deformation ('strain') in echocardiography. We sought to determine in a pilot study if this technology could be utilized to analyze diaphragmatic contraction. METHODS:Fifty healthy adult volunteers with normal exercise capacity underwent ultrasound imaging. A linear array transducer was used for the assessment of diaphragm thickness, thickening fraction (TF), and strain in the right anterior axillary line at approximately the ninth intercostal space. A phased array transducer was applied subcostally for the assessment of diaphragm displacement on the right mid-clavicular line. Diaphragmatic images were recorded from the end of expiration through the end of inspiration at 60 % maximal inspiratory capacity. Diaphragm strain was analyzed off-line by speckle tracking imaging. Blinded inter- and intra-rater variability was tested in 10 cases. RESULTS:Mean right diaphragm thickness at end-expiration (±SD: standard deviation) was 0.24 cm (±0.1), with TF of 45.1 % (±12) at 60 % peak inspiratory effort. Mean right diaphragm caudal displacement was 4.9 cm (±1). Mean right diaphragm strain was -40.3 % (±9). A moderate correlation was seen between longitudinal strain and TF (R(2) 0.44, p < 0.0001). A weak correlation was seen between strain and caudal displacement (R(2) 0.14, p < 0.01), and an even weaker correlation was seen between caudal displacement and TF (R(2) 0.1, p = 0.04). Age, gender, and body mass index were not significantly associated with right diaphragm strain or TF. Although inter- and intra-rater variability was overall good for TF, caudal displacement, and strain (inter-rater R(2); 0.8, 0.9, and 0.7, respectively [p < 0.01], intra-rater R(2); 0.9, 0.7, and 0.9, respectively [p < 0.01]), strain values did have a slightly lower inter-rater repeatability. CONCLUSIONS:Diaphragmatic strain estimated by speckle tracking imaging was associated with conventional ultrasound measures of diaphragmatic function (TF and caudal displacement). Further clinical studies are warranted to investigate its clinical utility.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Orde SR,Boon AJ,Firth DG,Villarraga HR,Sekiguchi Hdoi
10.1186/s12871-016-0201-6subject
Has Abstractpub_date
2016-07-25 00:00:00pages
43issue
1issn
1471-2253pii
10.1186/s12871-016-0201-6journal_volume
16pub_type
临床试验,杂志文章abstract::BACKGROUND: We report a case of a patient with apparent resistance to local anesthetics. While similar cases of failure of regional anesthetics are often attributed to technical failure, the overall clinical presentation and history of this patient suggests a true resistance to local anesthetics. CASE PRESENTATION: Th...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-4-1
更新日期:2004-01-16 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-018-0495-7
更新日期:2018-04-02 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-020-01114-7
更新日期:2020-08-07 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-018-0634-1
更新日期:2018-11-15 00:00:00
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pub_type: 杂志文章
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更新日期:2019-09-02 00:00:00
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doi:10.1186/s12871-018-0616-3
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pub_type: 杂志文章,多中心研究
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-016-0264-4
更新日期:2016-10-14 00:00:00
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journal_title:BMC anesthesiology
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pub_type: 杂志文章
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更新日期:2020-07-04 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-06-06 00:00:00
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pub_type: 杂志文章
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更新日期:2020-09-23 00:00:00
abstract::BACKGROUND: Propofol is widely used for both short-term anesthesia and long-term sedation. It has unusual pharmacokinetics because of its high lipid solubility. The standard approach to describing the pharmacokinetics is by a multi-compartmental model. This paper presents the first detailed human physiologically based...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-5-4
更新日期:2005-04-22 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-015-0132-7
更新日期:2015-10-15 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-09 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-13-15
更新日期:2013-07-17 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-11-16 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-04-27 00:00:00
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pub_type: 已发布勘误
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更新日期:2020-11-09 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-03-09 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2020-01-31 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
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更新日期:2019-05-15 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-01-29 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-17 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-10-21 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
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更新日期:2012-09-18 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-27 00:00:00