Abstract:
BACKGROUND:Volume replacement therapy with colloid is still worth studying in major pediatric surgery with potential risk of bleeding. This study assessed the effects of 6% hydroxyethyl starch (HES) 130/0.4 and 5% Human Albumin (HA) on coagulation tested by thromboelastography (TEG) during elective intracranial tumor surgery in pediatric patients. METHODS:In this randomized controlled trial, 60 patients undergoing intracranial tumor resection under general anesthesia were assigned to HES and HA groups (n = 30), and administered preloads of 20 mL · kg-1 HES 130/0.4 and 5% HA, respectively, prior to dura opening. Primary outcomes were perioperative thromboelastography findings, and hemodynamic and hematological parameters. Blood transfusion, perioperative fluid balance, intracranial pressure, mortality, intensive care unit stay, and hospital stay were also assessed. RESULTS:TEG parameters did not differ after preloading compared to baseline values in either group, except for a decrease in maximum amplitude immediately after infusion (HES group, 57.6 ± 6.0 mm vs. 50.9 ± 9.2 mm; HA group, 60.1 ± 7.9 mm vs. 56.6 ± 7.1 mm; p < 0.01), which was restored to preoperative levels 1 h after fluid infusion. Total perioperative fluid balance, blood loss or transfusion, intracranial pressure, and hematological and hemodynamic variables were similar between both groups (p > 0.05). Mortality, length of hospital stay, and clinical complications were similar between both groups. CONCLUSION:These findings suggest that HES and HA might have no significant differences regarding coagulation as assessed by TEG during pediatric intracranial tumor surgery with 20 ml/kg volume pre-loading, which can maintain stable hemodynamics and may represent a new avenue for volume therapy during brain tumor resection in pediatrics. TRIAL REGISTRATION:ChiCTR-IPR- 16009333 , retrospectively registered October 8, 2016.
journal_name
BMC Anesthesioljournal_title
BMC anesthesiologyauthors
Peng Y,Du J,Zhao X,Shi X,Wang Ydoi
10.1186/s12871-017-0353-zsubject
Has Abstractpub_date
2017-04-27 00:00:00pages
62issue
1issn
1471-2253pii
10.1186/s12871-017-0353-zjournal_volume
17pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Blood biomarkers are increasingly used to diagnose, guide therapy in, and risk-stratify community-acquired pneumonia (CAP) patients in emergency departments (EDs). How pre-analytic factors affect these markers' initial levels in this population is unknown. METHODS:In this secondary analysis of consecutive E...
journal_title:BMC anesthesiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2253-14-102
更新日期:2014-11-15 00:00:00
abstract:BACKGROUND:Laryngeal mask airway is a supraglottic airway device which has led to a fundamental change in the management of modern general anesthesia. In the present study; we evaluated the laryngeal mask airway insertion conditions and hemodynamic changes comparing ketamine-propofol mixture (ketofol) with propofol. Th...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0711-0
更新日期:2019-03-20 00:00:00
abstract::We have developed a two-step procedure for preparing the skin before peripheral venous catheter (PVC) insertions. This procedure involves two successive swabbings with wipes soaked in alcoholic antiseptic. We investigated whether this two-step procedure was as effective and safe as the standard four-step procedure--wa...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-7-1
更新日期:2007-01-31 00:00:00
abstract:BACKGROUND:The present anonymous multicenter online survey was conducted to evaluate the application of regional anaesthesia techniques as well as the used local anaesthetics and adjuncts at German and Austrian university hospitals. METHODS:39 university hospitals were requested to fill in an online questionnaire, to ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-10-4
更新日期:2010-04-17 00:00:00
abstract:BACKGROUND:There is no defined gold standard for pain management after video-assisted thoracic surgery (VATS) for pneumothorax. In addition to systemic analgesia, various loco-regional analgesic techniques have been proposed but remain poorly evaluated in this context. We aimed to assess the analgesic efficacy of sever...
journal_title:BMC anesthesiology
pub_type: 杂志文章
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更新日期:2019-07-06 00:00:00
abstract:BACKGROUND:We sought to evaluate the effect of mild hypercapnia on brain tissue oxygen tension (Pbto2) and diffusion limitation (impaired ability of oxygen extraction) in a porcine post asphyxial cardiac arrest model. METHODS:In 16 Bama pigs, asphyxial cardiac arrest was induced by endotracheal tube clamping and remai...
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pub_type: 杂志文章
doi:10.1186/s12871-020-01162-z
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abstract:BACKGROUND:Obstetric dfficult airway is a leading cause of maternal morbidity and mortality. The laryngeal mask airway (LMA) is often used as a rescue airway device after failed intubation, however, little is known about predictors of difficult LMA insertion, particularly in obstetrics. Since Mallampati scores of III/I...
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pub_type: 临床试验,杂志文章
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更新日期:2019-07-08 00:00:00
abstract:BACKGROUND:Splenectomy performed with a curved incision results in severe postoperative pain. The aim of this study was to evaluate the effect of transversus abdominis plane block and rectus sheath block on postoperative pain relief and recovery. METHODS:A total of 150 patients were randomized into the control (C), le...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-020-0941-1
更新日期:2020-01-23 00:00:00
abstract:BACKGROUND:As the field of interventional pulmonology (IP) expands, anesthesia services are increasingly being utilized when complex procedures of longer duration are performed on sicker patients with high risk co-morbidities and lung pathology. Yet, evidence on the optimal anesthetic management for these patients rema...
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pub_type: 杂志文章
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更新日期:2019-10-31 00:00:00
abstract:BACKGROUND:Abnormal laryngeal structures are likely to be associated with a difficult laryngoscopy procedure. Currently, laryngeal structures can be measured by ultrasonography, however, little research has been performed on the potential role of ultrasound on the evaluation of a difficult laryngoscopy. The present stu...
journal_title:BMC anesthesiology
pub_type: 杂志文章
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更新日期:2020-06-02 00:00:00
abstract:BACKGROUND:Abnormal acute pain after burn injury still torments patients severely. In this study, we investigated that one voltage gated sodium channel Nav1.7 plays a vital role in lowering heat pain threshold after burn injury, and the hypothesis that knockdown of Nav1.7 attenuates pain following burn injury. METHODS...
journal_title:BMC anesthesiology
pub_type: 杂志文章
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更新日期:2016-08-11 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the effect of the steep Trendelenburg position (STP) with pneumoperitoneum on whole-blood viscosity (WBV) in patients undergoing robot-assisted laparoscopic prostatectomy (RALP). The study also analyzed the associations of clinical patient-specific and time-dependent ...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-019-0919-z
更新日期:2020-01-07 00:00:00
abstract:BACKGROUND:Continuous epidural infusion (CEI) is the standard application setting for epidural infusion. A new mode, the programmed intermittent epidural bolus (PIEB) technique, showed reduced local anesthetic (LA) consumption and improved analgesia in obstetric analgesia. Goal of this trial was to evaluate the effects...
journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12871-018-0613-6
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:The aim of the present study was to verify whether propofol impaired learning and memory through the interplay of N-methyl-D-aspartate (NMDA) receptor with brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) signaling pathway. METHODS:120 Sprague-Dawley (SD) rats were randomly assigned into ei...
journal_title:BMC anesthesiology
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更新日期:2018-04-05 00:00:00
abstract:BACKGROUND:Tramadol is an atypical centrally acting analgesic agent available as both oral and parenteral preparations. For patients who are unable to take tramadol orally, the subcutaneous route of administration offers an easy alternative to intravenous or intramuscular routes. This study aimed to characterise the ab...
journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/1471-2253-14-33
更新日期:2014-05-12 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-018-0511-y
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:In Sweden, airway guidelines aimed toward improving patient safety have been recommended by the Swedish Society of Anaesthesia and Intensive Care Medicine. Adherence to evidence-based airway guidelines is known to be generally poor in Sweden. The aim of this study was to determine whether airway guidelines a...
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pub_type: 杂志文章
doi:10.1186/1471-2253-14-25
更新日期:2014-04-07 00:00:00
abstract:BACKGROUND:The passive ventilation of nonventilated lung results in tidal gas movement (TGM) and thus affects lung collapse. The present study aimed to measure the volume of TGM and to analyse the relevant factors of the TGM index (TGM/body surface area). METHODS:One hundred eight patients scheduled for elective thora...
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journal_title:BMC anesthesiology
pub_type: 杂志文章
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journal_title:BMC anesthesiology
pub_type: 杂志文章
doi:10.1186/s12871-018-0495-7
更新日期:2018-04-02 00:00:00
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pub_type: 杂志文章
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更新日期:2020-04-17 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-12-19 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-05-17 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
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更新日期:2010-07-29 00:00:00
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pub_type: 杂志文章
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journal_title:BMC anesthesiology
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-10-20 00:00:00
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journal_title:BMC anesthesiology
pub_type: 杂志文章
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