Does the association between adherence to statin medications and mortality depend on measurement approach? A retrospective cohort study.

Abstract:

BACKGROUND:The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures). METHODS:A retrospective cohort study was conducted using administrative data from Saskatchewan, Canada between 1994 and 2008. Eligible individuals received a prescription for a statin following hospitalization for acute coronary syndrome (ACS). Adherence was measured using proportion of days covered (PDC) expressed either as: 1) a fixed summary measure, or 2) as a repeatedly measured covariate. Multivariable Cox-proportional hazards models were used to estimate the association between adherence and mortality. RESULTS:Among 9,051 individuals, optimal adherence (≥80%) modeled with a fixed summary measure was not associated with mortality benefits (adjusted HR 0.97, 95% CI 0.86 to 1.09, p = 0.60). In contrast, repeated-measures approach resulted in a significant 25% reduction in the risk of death (adjusted HR 0.75, 95% CI 0.67 to 0.85, p < 0.01). CONCLUSIONS:Unlike the summary measure, the repeated measures approach produces a significant reduction of all-cause mortality with optimal adherence. This effect may be a result of the repeated measures approach being more sensitive, or more prone to survival bias. Our findings clearly demonstrate the need to undertake (and report) multiple approaches when assessing the benefits of medication adherence.

journal_name

BMC Med Res Methodol

authors

Alsabbagh MW,Eurich D,Lix LM,Wilson TW,Blackburn DF

doi

10.1186/s12874-017-0339-z

subject

Has Abstract

pub_date

2017-04-20 00:00:00

pages

66

issue

1

issn

1471-2288

pii

10.1186/s12874-017-0339-z

journal_volume

17

pub_type

杂志文章
  • Simulation-based estimation of mean and standard deviation for meta-analysis via Approximate Bayesian Computation (ABC).

    abstract:BACKGROUND:When conducting a meta-analysis of a continuous outcome, estimated means and standard deviations from the selected studies are required in order to obtain an overall estimate of the mean effect and its confidence interval. If these quantities are not directly reported in the publications, they must be estima...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-015-0055-5

    authors: Kwon D,Reis IM

    更新日期:2015-08-12 00:00:00

  • The new COSMIN guidelines confront traditional concepts of responsiveness.

    abstract::The recently published "COSMIN" guidelines aim to rate properties of outcome instruments and state two issues with regard to responsiveness which is the instrument's ability to detect change over time. These issues are comparison of score changes with change of an external criterion using correlations and the judgemen...

    journal_title:BMC medical research methodology

    pub_type: 评论,信件

    doi:10.1186/1471-2288-11-152

    authors: Angst F

    更新日期:2011-11-18 00:00:00

  • Maximising response to postal questionnaires--a systematic review of randomised trials in health research.

    abstract:BACKGROUND:Postal self-completion questionnaires offer one of the least expensive modes of collecting patient based outcomes in health care research. The purpose of this review is to assess the efficacy of methods of increasing response to postal questionnaires in health care studies on patient populations. METHODS:Th...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2288-6-5

    authors: Nakash RA,Hutton JL,Jørstad-Stein EC,Gates S,Lamb SE

    更新日期:2006-02-23 00:00:00

  • Likelihood-based random-effects meta-analysis with few studies: empirical and simulation studies.

    abstract:BACKGROUND:Standard random-effects meta-analysis methods perform poorly when applied to few studies only. Such settings however are commonly encountered in practice. It is unclear, whether or to what extent small-sample-size behaviour can be improved by more sophisticated modeling. METHODS:We consider likelihood-based...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-018-0618-3

    authors: Seide SE,Röver C,Friede T

    更新日期:2019-01-11 00:00:00

  • Which resources should be used to identify RCT/CCTs for systematic reviews: a systematic review.

    abstract:BACKGROUND:Systematic reviewers seek to comprehensively search for relevant studies and summarize these to present the most valid estimate of intervention effectiveness. The more resources searched, the higher the yield, and thus time and costs required to conduct a systematic review. While there is an abundance of evi...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2288-5-24

    authors: Crumley ET,Wiebe N,Cramer K,Klassen TP,Hartling L

    更新日期:2005-08-10 00:00:00

  • Defeat and entrapment: more than meets the eye? Applying network analysis to estimate dimensions of highly correlated constructs.

    abstract:BACKGROUND:Defeat and entrapment have been shown to be of central relevance to the development of different disorders. However, it remains unclear whether they represent two distinct constructs or one overall latent variable. One reason for the unclarity is that traditional factor analytic techniques have trouble estim...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-018-0470-5

    authors: Forkmann T,Teismann T,Stenzel JS,Glaesmer H,de Beurs D

    更新日期:2018-01-25 00:00:00

  • The efficiency and effectiveness of utilizing diagrams in interviews: an assessment of participatory diagramming and graphic elicitation.

    abstract:BACKGROUND:This paper focuses on measuring the efficiency and effectiveness of two diagramming methods employed in key informant interviews with clinicians and health care administrators. The two methods are 'participatory diagramming', where the respondent creates a diagram that assists in their communication of answe...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-8-53

    authors: Umoquit MJ,Dobrow MJ,Lemieux-Charles L,Ritvo PG,Urbach DR,Wodchis WP

    更新日期:2008-08-08 00:00:00

  • Item response models for the longitudinal analysis of health-related quality of life in cancer clinical trials.

    abstract:BACKGROUND:The use of health-related quality of life (HRQoL) as an endpoint in cancer clinical trials is growing rapidly. Hence, research into the statistical approaches used to analyze HRQoL data is of major importance, and could lead to a better understanding of the impact of treatments on the everyday life and care ...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,评审

    doi:10.1186/s12874-017-0410-9

    authors: Barbieri A,Peyhardi J,Conroy T,Gourgou S,Lavergne C,Mollevi C

    更新日期:2017-09-26 00:00:00

  • Suitability of administrative claims databases for bariatric surgery research - is the glass half-full or half-empty?

    abstract:BACKGROUND:Claims databases are generally considered inadequate for obesity research due to suboptimal capture of body mass index (BMI) measurements. This might not be true for bariatric surgery because of reimbursement requirements and changes in coding systems. We assessed the availability and validity of claims-base...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-020-01106-8

    authors: Li X,Lewis KH,Callaway K,Wharam JF,Toh S

    更新日期:2020-09-07 00:00:00

  • Flexible parametric modelling of cause-specific hazards to estimate cumulative incidence functions.

    abstract:BACKGROUND:Competing risks are a common occurrence in survival analysis. They arise when a patient is at risk of more than one mutually exclusive event, such as death from different causes, and the occurrence of one of these may prevent any other event from ever happening. METHODS:There are two main approaches to mode...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-13-13

    authors: Hinchliffe SR,Lambert PC

    更新日期:2013-02-06 00:00:00

  • Effectiveness of motivational interviewing, health education and brief advice in a population of smokers who are not ready to quit.

    abstract:BACKGROUND:Motivational Interviewing (MI), Brief Advice (BA) and Health Education (HE) are established smoking cessation induction methods for smokers with low desire to quit. Although randomized controlled trials (RCT's) have been frequently used to assess these interventions the temporal efficacy and effectiveness of...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12874-018-0511-0

    authors: Bani-Yaghoub M,Elhomani A,Catley D

    更新日期:2018-06-13 00:00:00

  • Lifetime body size and reproductive factors: comparisons of data recorded prospectively with self reports in middle age.

    abstract:BACKGROUND:Data on lifetime exposures are often self-reported in epidemiologic studies, sometimes many years after the relevant age. Validity of self-reported data is usually inferred from their agreement with measured values, but few studies directly quantify the likely effects of reporting errors in body size and rep...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-11-7

    authors: Cairns BJ,Liu B,Clennell S,Cooper R,Reeves GK,Beral V,Kuh D

    更新日期:2011-01-17 00:00:00

  • Variance constraints strongly influenced model performance in growth mixture modeling: a simulation and empirical study.

    abstract:BACKGROUND:Growth Mixture Modeling (GMM) is commonly used to group individuals on their development over time, but convergence issues and impossible values are common. This can result in unreliable model estimates. Constraining variance parameters across classes or over time can solve these issues, but can also serious...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-020-01154-0

    authors: Sijbrandij JJ,Hoekstra T,Almansa J,Peeters M,Bültmann U,Reijneveld SA

    更新日期:2020-11-12 00:00:00

  • A factorial cluster-randomised controlled trial combining home-environmental and early child development interventions to improve child health and development: rationale, trial design and baseline findings.

    abstract:BACKGROUND:Exposure to unhealthy environments and inadequate child stimulation are main risk factors that affect children's health and wellbeing in low- and middle-income countries. Interventions that simultaneously address several risk factors at the household level have great potential to reduce these negative effect...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-020-00950-y

    authors: Hartinger SM,Nuño N,Hattendorf J,Verastegui H,Karlen W,Ortiz M,Mäusezahl D

    更新日期:2020-04-02 00:00:00

  • Industry-supported meta-analyses compared with meta-analyses with non-profit or no support: differences in methodological quality and conclusions.

    abstract:BACKGROUND:Studies have shown that industry-sponsored meta-analyses of drugs lack scientific rigour and have biased conclusions. However, these studies have been restricted to certain medical specialities. We compared all industry-supported meta-analyses of drug-drug comparisons with those without industry support. ME...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-8-60

    authors: Jørgensen AW,Maric KL,Tendal B,Faurschou A,Gøtzsche PC

    更新日期:2008-09-09 00:00:00

  • Positive predictive value of a case definition for diabetes mellitus using automated administrative health data in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid study.

    abstract:BACKGROUND:We developed and validated an automated database case definition for diabetes in children and youth to facilitate pharmacoepidemiologic investigations of medications and the risk of diabetes. METHODS:The present study was part of an in-progress retrospective cohort study of antipsychotics and diabetes in Te...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-12-128

    authors: Bobo WV,Cooper WO,Stein CM,Olfson M,Mounsey J,Daugherty J,Ray WA

    更新日期:2012-08-24 00:00:00

  • Assembling and validating a heart failure-free cohort from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.

    abstract:BACKGROUND:Studies examining incident heart failure (HF) have been limited to select populations. To examine incident HF with broader generalizability, there is need to assemble a HF-free cohort using a geographically-diverse sample. We aimed to develop and validate a simple medication-based strategy for assembling a H...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-019-0890-x

    authors: Goyal P,Mefford MT,Chen L,Sterling MR,Durant RW,Safford MM,Levitan EB

    更新日期:2020-03-04 00:00:00

  • Consensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholders.

    abstract:BACKGROUND:The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multiple threats to their validity such as participant recruitment and retention, identifying a meaningful...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-019-0772-2

    authors: Hall CL,Brown S,James M,Martin JL,Brown N,Selby K,Clarke J,Williams L,Sayal K,Hollis C,Groom MJ

    更新日期:2019-06-18 00:00:00

  • Measurement and control of bias in patient reported outcomes using multidimensional item response theory.

    abstract:BACKGROUND:Patient-reported outcome (PRO) measures play a key role in the advancement of patient-centered care research. The accuracy of inferences, relevance of predictions, and the true nature of the associations made with PRO data depend on the validity of these measures. Errors inherent to self-report measures can ...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-016-0161-z

    authors: Dowling NM,Bolt DM,Deng S,Li C

    更新日期:2016-05-26 00:00:00

  • Evaluation of survival extrapolation in immuno-oncology using multiple pre-planned data cuts: learnings to aid in model selection.

    abstract:BACKGROUND:Due to limited duration of follow up in clinical trials of cancer treatments, estimates of lifetime survival benefits are typically derived using statistical extrapolation methods. To justify the method used, a range of approaches have been proposed including statistical goodness-of-fit tests and comparing e...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-020-00997-x

    authors: Bullement A,Willis A,Amin A,Schlichting M,Hatswell AJ,Bharmal M

    更新日期:2020-05-06 00:00:00

  • Is a large scale community programme as effective as a community rehabilitation programme delivered in the setting of a clinical trial?

    abstract:BACKGROUND:The rationale for commissioning community pulmonary rehabilitation programmes is based on evidence from randomised clinical trials. However, there are a number of reasons why similar programmes might be less effective outside the environment of a clinical trial. These include a less highly selected patient g...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-13-103

    authors: Goyder EC,Strong M,Green A,Holmes MW,Miles G,Reddington O,Lawson R,Lee A,Basran G

    更新日期:2013-08-13 00:00:00

  • Misclassification of incident conditions using claims data: impact of varying the period used to exclude pre-existing disease.

    abstract:BACKGROUND:Estimating the incidence of medical conditions using claims data often requires constructing a prevalence period that predates an event of interest, for instance the diagnosis of cancer, to exclude those with pre-existing conditions from the incidence risk set. Those conditions missed during the prevalence p...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-13-32

    authors: Griffiths RI,O'Malley CD,Herbert RJ,Danese MD

    更新日期:2013-03-06 00:00:00

  • Measurement properties of the Danish version of the Awareness and Beliefs about Cancer (ABC) measure.

    abstract:BACKGROUND:The International Cancer Benchmarking Partnership aims to study international differences in cancer survival and the possible causes. Participating countries are Australia, Canada, Norway, Sweden, Denmark and the UK and a particular focus area is differences in awareness and beliefs about cancer. In this con...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-017-0352-2

    authors: Hvidberg L,Pedersen AF,Wulff CN,Carlsen AH,Vedsted P

    更新日期:2017-04-26 00:00:00

  • Collecting household water usage data: telephone questionnaire or diary?

    abstract:BACKGROUND:Quantitative Microbial Risk Assessment (QMRA), a modelling approach, is used to assess health risks. Inputs into the QMRA process include data that characterise the intensity, frequency and duration of exposure to risk(s). Data gaps for water exposure assessment include the duration and frequency of urban no...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-9-72

    authors: O'Toole JE,Sinclair MI,Leder K

    更新日期:2009-11-09 00:00:00

  • Recruitment strategies and yields for the Pathobiology of Prediabetes in a Biracial Cohort: a prospective natural history study of incident dysglycemia.

    abstract:BACKGROUND:The Pathobiology of Prediabetes in A Biracial Cohort study is a prospective evaluation of the transition from normal to impaired glucose regulation among African American and Caucasian adults with parental type 2 diabetes. This report describes recruitment strategies and relative yields for the 376 enrolled ...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-13-64

    authors: Ebenibo S,Edeoga C,Ammons A,Egbuonu N,Dagogo-Jack S,Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) Research Group.

    更新日期:2013-05-10 00:00:00

  • Optimal likelihood-ratio multiple testing with application to Alzheimer's disease and questionable dementia.

    abstract:BACKGROUND:Controlling the false discovery rate is important when testing multiple hypotheses. To enhance the detection capability of a false discovery rate control test, we applied the likelihood ratio-based multiple testing method in neuroimage data and compared the performance with the existing methods. METHODS:We ...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-15-9

    authors: Lee D,Kang H,Kim E,Lee H,Kim H,Kim YK,Lee Y,Lee DS

    更新日期:2015-01-30 00:00:00

  • Factors associated with reporting multiple causes of death.

    abstract:BACKGROUND:There is analytical potential for multiple cause of death data collected from death certificates. This study examines relationships of multiple causes of death as a function of factors available on the death certificate (demographics of decedent, place of death, type of certifier, disposal method, whether an...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-5-4

    authors: Wall MM,Huang J,Oswald J,McCullen D

    更新日期:2005-01-17 00:00:00

  • Maximising response from GPs to questionnaire surveys: do length or incentives make a difference?

    abstract:BACKGROUND:General Practitioners (GPs) respond poorly to postal surveys. Consequently there is potential for reduced data quality and bias in the findings. In general population surveys, response to postal questionnaires may be improved by reducing their length and offering incentives. The aim of this study was to inve...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/1471-2288-15-3

    authors: Cottrell E,Roddy E,Rathod T,Thomas E,Porcheret M,Foster NE

    更新日期:2015-01-06 00:00:00

  • Longitudinal studies that use data collected as part of usual care risk reporting biased results: a systematic review.

    abstract:BACKGROUND:Longitudinal studies using data collected as part of usual care risk providing biased results if visit times are related to the outcome of interest. Statistical methods for mitigating this bias are available but rarely used. This lack of use could be attributed to a lack of need or to a lack of awareness of ...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章,评审

    doi:10.1186/s12874-017-0418-1

    authors: Farzanfar D,Abumuamar A,Kim J,Sirotich E,Wang Y,Pullenayegum E

    更新日期:2017-09-06 00:00:00

  • Using bundle embeddings to predict daily cortisol levels in human subjects.

    abstract:BACKGROUND:Many biological variables sampled from human subjects show a diurnal pattern, which poses special demands on the techniques used to analyze such data. Furthermore, most biological variables belong to nonlinear dynamical systems, which may make linear statistical techniques less suitable to analyze their dyna...

    journal_title:BMC medical research methodology

    pub_type: 杂志文章

    doi:10.1186/s12874-018-0485-y

    authors: Toonen RB,Wardenaar KJ,Bos EH,van Ockenburg SL,de Jonge P

    更新日期:2018-03-21 00:00:00