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Assembling and validating a heart failure-free cohort from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.

Abstract：

BACKGROUND:Studies examining incident heart failure (HF) have been limited to select populations. To examine incident HF with broader generalizability, there is need to assemble a HF-free cohort using a geographically-diverse sample. We aimed to develop and validate a simple medication-based strategy for assembling a HF-free cohort from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. METHODS:We examined REGARDS participants with ≥6 months of Medicare inpatient and outpatient claims data at the time of the baseline in-home study examination. To assemble a HF-free cohort, we identified and excluded participants taking HF-specific medications. To validate this approach, we evaluated event rates among this cohort and assessed diagnostic performance using Medicare claims-based definitions of HF as the referent standard. RESULTS:Among 28,884 eligible participants, 3125 were excluded from the proposed HF-free cohort, leaving a total of 25,759 (89%) participants. Depending on the Medicare definition used as the referent, the negative predictive value of this approach ranged from 95.0-99.2%. Negative predictive value was stable across age, sex, and race strata. CONCLUSIONS:The approach to assemble a HF-free cohort in REGARDS can serve as the basis for future studies to examine incident HF in REGARDS and similar studies.

journal_name

BMC Med Res Methodol

journal_title

BMC medical research methodology

authors

Goyal P,Mefford MT,Chen L,Sterling MR,Durant RW,Safford MM,Levitan EB

doi

10.1186/s12874-019-0890-x

subject

Has Abstract

pub_date

2020-03-04 00:00:00

pages

53

issue

1

issn

1471-2288

pii

10.1186/s12874-019-0890-x

journal_volume

20

pub_type

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