Optimal likelihood-ratio multiple testing with application to Alzheimer's disease and questionable dementia.

abstract：BACKGROUND:The purpose of this study was to determine the standard tasks performed by clinical research coordinators (CRCs) in oncology clinical trials. METHODS:Forty-one CRCs were anonymously surveyed, using a four-page self-administered questionnaire focused on demographics, qualifications, and professional experien...

journal_title：BMC medical research methodology

authors： Rico-Villademoros F,Hernando T,Sanz JL,López-Alonso A,Salamanca O,Camps C,Rosell R

更新日期：2004-03-25 00:00:00

abstract：BACKGROUND:The Patient Reported Outcomes Measurement Information System 43-item short form (PROMIS-43) and the five-level EQ-5D (EQ-5D-5L) are recently developed measures of health-related quality of life (HRQL) that have potentially broad application in evaluating treatments and capturing burden of respiratory-related...

journal_title：BMC medical research methodology

authors： Lin FJ,Pickard AS,Krishnan JA,Joo MJ,Au DH,Carson SS,Gillespie S,Henderson AG,Lindenauer PK,McBurnie MA,Mularski RA,Naureckas ET,Vollmer WM,Lee TA,CONCERT Consortium.

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:Longitudinal studies using data collected as part of usual care risk providing biased results if visit times are related to the outcome of interest. Statistical methods for mitigating this bias are available but rarely used. This lack of use could be attributed to a lack of need or to a lack of awareness of ...

journal_title：BMC medical research methodology

authors： Farzanfar D,Abumuamar A,Kim J,Sirotich E,Wang Y,Pullenayegum E

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:The prevailing view in therapeutic clinical research today is that observational studies are useful for generating new hypotheses and that controlled experiments (i.e., randomized clinical trials, RCTs) are the most appropriate method for assessing and confirming the efficacy of interventions. DISCUSSION:Th...

journal_title：BMC medical research methodology

authors： Sacristán JA

更新日期：2011-04-25 00:00:00

abstract：BACKGROUND:Cluster randomised controlled trials (CRCTs) are frequently used in health service evaluation. Assuming an average cluster size, required sample sizes are readily computed for both binary and continuous outcomes, by estimating a design effect or inflation factor. However, where the number of clusters are fix...

journal_title：BMC medical research methodology

authors： Hemming K,Girling AJ,Sitch AJ,Marsh J,Lilford RJ

更新日期：2011-06-30 00:00:00

abstract：BACKGROUND:Primary care databases are a major source of data for epidemiological and health services research. However, most studies are based on coded information, ignoring information stored in free text. Using the early presentation of rheumatoid arthritis (RA) as an exemplar, our objective was to estimate the exten...

journal_title：BMC medical research methodology

authors： Ford E,Nicholson A,Koeling R,Tate A,Carroll J,Axelrod L,Smith HE,Rait G,Davies KA,Petersen I,Williams T,Cassell JA

更新日期：2013-08-21 00:00:00

abstract：BACKGROUND:Health researchers undertake studies which combine qualitative and quantitative methods. Little attention has been paid to the structural issues affecting this mixed methods approach. We explored the facilitators and barriers to undertaking mixed methods studies in health research. METHODS:Face-to-face semi...

journal_title：BMC medical research methodology

authors： O'Cathain A,Nicholl J,Murphy E

更新日期：2009-12-09 00:00:00

abstract：BACKGROUND:Systematic reviews often require substantial resources, partially due to the large number of records identified during searching. Although artificial intelligence may not be ready to fully replace human reviewers, it may accelerate and reduce the screening burden. Using DistillerSR (May 2020 release), we eva...

journal_title：BMC medical research methodology

authors： Hamel C,Kelly SE,Thavorn K,Rice DB,Wells GA,Hutton B

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Variation in counts between subjects at a given speed or work rate are the most important source of error in physical activity (PA) measurements with accelerometers. The aim of this study was to explore how the use of individual accelerometer cut points (ICPs) affected the analysis of PA field data. METHODS...

journal_title：BMC medical research methodology

authors： Aadland E,Steene-Johannessen J

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:We demonstrate an application of Group-Based Trajectory Modeling (GBTM) based on the beta distribution. It is offered as an alternative to the normal distribution for modeling continuous longitudinal data that are poorly fit by the normal distribution even with censoring. The primary advantage of the beta di...

journal_title：BMC medical research methodology

authors： Elmer J,Jones BL,Nagin DS

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:Multiple Imputation as usually implemented assumes that data are Missing At Random (MAR), meaning that the underlying missing data mechanism, given the observed data, is independent of the unobserved data. To explore the sensitivity of the inferences to departures from the MAR assumption, we applied the meth...

journal_title：BMC medical research methodology

authors： Héraud-Bousquet V,Larsen C,Carpenter J,Desenclos JC,Le Strat Y

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:The primary aim of this study was to provide an estimate of effect size for the functional outcome of operative versus non-operative treatment for patients with an acute rupture of the Achilles tendon using accelerated rehabilitation for both groups of patients. The secondary aim was to assess the use of a c...

journal_title：BMC medical research methodology

authors： Kearney RS,Achten J,Parsons NR,Costa ML

更新日期：2011-04-05 00:00:00

abstract：BACKGROUND:Postal questionnaires are widely used to collect outcome data on participants. However, a poor response to questionnaires will reduce the statistical power of the study and may introduce bias. A meta analysis of ten trials offering study results, largely in the fields of education and marketing, was shown to...

journal_title：BMC medical research methodology

authors： Cockayne S,Torgerson DJ

更新日期：2005-10-26 00:00:00

abstract：BACKGROUND:Precise predictions of incidence and mortality rates due to breast cancer (BC) are required for planning of public health programs as well as for clinical services. A number of approaches has been established for prediction of mortality using stochastic models. The performance of these models intensely depen...

journal_title：BMC medical research methodology

authors： Mubarik S,Hu Y,Yu C

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:The systematic collection of high-quality mortality data is a prerequisite in designing relevant drowning prevention programmes. This descriptive study aimed to assess the quality (i.e., level of specificity) of cause-of-death reporting using ICD-10 drowning codes across 69 countries. METHODS:World Health O...

journal_title：BMC medical research methodology

authors： Lu TH,Lunetta P,Walker S

更新日期：2010-04-08 00:00:00

abstract：BACKGROUND:Evidence syntheses, and in particular systematic reviews (SRs), have become one of the cornerstones of evidence-based health care. The Assessment of Multiple Systematic Reviews (AMSTAR) tool has become the most widely used tool for investigating the methodological quality of SRs and is currently undergoing r...

journal_title：BMC medical research methodology

authors： Wegewitz U,Weikert B,Fishta A,Jacobs A,Pieper D

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Models of hepatitis C virus (HCV) kinetics are increasingly used to estimate and to compare in vivo drug's antiviral effectiveness of new potent anti-HCV agents. Viral kinetic parameters can be estimated using non-linear mixed effect models (NLMEM). Here we aimed to evaluate the performance of this approach ...

journal_title：BMC medical research methodology

authors： Laouénan C,Guedj J,Mentré F

更新日期：2013-04-25 00:00:00

abstract：BACKGROUND:The Public Population Project in Genomics (P3G) is an organisation that aims to promote collaboration between researchers in the field of population-based genomics. The main objectives of P3G are to encourage collaboration between researchers and biobankers, optimize study design, promote the harmonization o...

journal_title：BMC medical research methodology

authors： Bennett DA,Little J,Masson LF,Minelli C

更新日期：2011-10-05 00:00:00

abstract：BACKGROUND:Measuring body mass index (BMI) has been proposed as a method of screening for preventive primary care and population surveillance of childhood obesity. However, the accuracy of routinely collected measurements has been questioned. The purpose of this study was to assess the reliability of height, length and...

journal_title：BMC medical research methodology

authors： Carsley S,Parkin PC,Tu K,Pullenayegum E,Persaud N,Maguire JL,Birken CS,TARGet Kids! Collaboration.

更新日期：2019-04-24 00:00:00

abstract：BACKGROUND:A strong need exists for a validated tool that clearly defines peer review report quality in biomedical research, as it will allow evaluating interventions aimed at improving the peer review process in well-performed trials. We aim to identify and describe existing tools for assessing the quality of peer rev...

journal_title：BMC medical research methodology

authors： Superchi C,González JA,Solà I,Cobo E,Hren D,Boutron I

更新日期：2019-03-06 00:00:00

abstract：BACKGROUND:There is a recognised need to build primary care medication adherence services which are tailored to patients' needs. Continuous quality improvement of such services requires a regular working method of measuring adherence in order to monitor effectiveness. Self report has been considered the method of choic...

journal_title：BMC medical research methodology

authors： Garfield S,Clifford S,Eliasson L,Barber N,Willson A

更新日期：2011-11-03 00:00:00

abstract：BACKGROUND:Meta-analysis typically involves combining the estimates from independent studies in order to estimate a parameter of interest across a population of studies. However, outliers often occur even under the random effects model. The presence of such outliers could substantially alter the conclusions in a meta-a...

journal_title：BMC medical research methodology

authors： Gumedze FN,Jackson D

更新日期：2011-02-16 00:00:00

abstract：BACKGROUND:In order to accurately measure and monitor levels of moderate-to-vigorous physical activity (MVPA) and sedentary behaviour (SB) in older adults, cost efficient and valid instruments are required. To date, the International Physical Activity Questionnaire (IPAQ) has not been validated with older adults (aged ...

journal_title：BMC medical research methodology

authors： Cleland C,Ferguson S,Ellis G,Hunter RF

更新日期：2018-12-22 00:00:00

abstract：BACKGROUND:Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES) was developed to study active commuters' perceptions of their route environments. However, bicycle commuters represent a small portion of the pop...

journal_title：BMC medical research methodology

authors： Wahlgren L,Schantz P

更新日期：2011-01-17 00:00:00

abstract：BACKGROUND:The Community Reintegration of Service Members (CRIS) is a new measure of community reintegration developed to measure veteran's participation in life roles. It consists of three sub-scales: Extent of Participation (Extent), Perceived Limitations with Participation (Perceived), and Satisfaction with Particip...

journal_title：BMC medical research methodology

authors： Resnik LJ,Clark MA,Borgia M

更新日期：2011-06-25 00:00:00

abstract：BACKGROUND:The Anglia Menorrhagia Education Study (AMES) is a randomized controlled trial testing the effectiveness of an education package applied to general practices. Binary data are available from two sources; general practitioner reported referrals to hospital, and referrals to hospital determined by independent a...

journal_title：BMC medical research methodology

authors： Nixon RM,Duffy SW,Fender GR

更新日期：2003-09-24 00:00:00

abstract：BACKGROUND:Diagnostic tests are performed in a subset of the population who are at higher risk, resulting in undiagnosed cases among those who do not receive the test. This poses a challenge for estimating the prevalence of the disease in the study population, and also for studying the risk factors for the disease. ME...

journal_title：BMC medical research methodology

authors： Zhang N,Cheng S,Ambroggio L,Florin TA,Macaluso M

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:While randomised controlled trials (RCTs) provide high-quality evidence to guide practice, much routine care is not based upon available RCTs. This disconnect between evidence and practice is not sufficiently well understood. This case study explores this relationship using a novel approach. Better understan...

journal_title：BMC medical research methodology

authors： Byrne BE,Rooshenas L,Lambert HS,Blazeby JM

更新日期：2020-05-12 00:00:00

abstract：:The quality of a consultation provided by a physician can have a profound impact on the quality of care and patient engagement in treatment decisions. When the COPD Assessment Test (CAT) was developed, one of its aims was to aid the communication between physician and patient about the impact of COPD. We developed a n...

journal_title：BMC medical research methodology

authors： Gruffydd-Jones K,Marsden H,Holmes S,Kardos P,Escamilla R,Dal Negro R,Roberts J,Nadeau G,Leather D,Jones P

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Defeat and entrapment have been shown to be of central relevance to the development of different disorders. However, it remains unclear whether they represent two distinct constructs or one overall latent variable. One reason for the unclarity is that traditional factor analytic techniques have trouble estim...

journal_title：BMC medical research methodology

authors： Forkmann T,Teismann T,Stenzel JS,Glaesmer H,de Beurs D

更新日期：2018-01-25 00:00:00