Is a large scale community programme as effective as a community rehabilitation programme delivered in the setting of a clinical trial?

abstract：BACKGROUND:For practical reasons it is not easy to obtain fasting samples in large population health surveys. Non-fasting triglyceride (Tg) values are difficult to interpret. The authors compared the accuracy of statistically corrected non-fasting Tg values with true fasting values and estimated the misclassification o...

journal_title：BMC medical research methodology

authors： Sundvall J,Leiviskä J,Laatikainen T,Peltonen M,Salomaa V,Vanhala M,Korpi-Hyövälti E,Lauronen J,Alfthan G

更新日期：2011-05-10 00:00:00

abstract：BACKGROUND:One of the main challenges for drug evaluation in rare diseases is the often heterogeneous course of these diseases. Traditional outcome measures may not be applicable for all patients, when they are in different stages of their disease. For instance, in Duchenne Muscular Dystrophy, the Six Minute Walk Test ...

journal_title：BMC medical research methodology

authors： Gaasterland CM,Jansen-van der Weide MC,Weinreich SS,van der Lee JH

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Network meta-analysis can be used to combine results from several randomized trials involving more than two treatments. Potential inconsistency among different types of trial (designs) differing in the set of treatments tested is a major challenge, and application of procedures for detecting and locating inc...

journal_title：BMC medical research methodology

authors： Piepho HP

更新日期：2014-05-10 00:00:00

abstract：BACKGROUND:A key component of the implementation process is identifying potential barriers and facilitators that need to be addressed. The Theoretical Domains Framework (TDF) is one of the most commonly used frameworks for this purpose. When applying the TDF, it is critical to understand the context in which behaviours...

journal_title：BMC medical research methodology

authors： Etherington N,Rodrigues IB,Giangregorio L,Graham ID,Hoens AM,Kasperavicius D,Kelly C,Moore JE,Ponzano M,Presseau J,Sibley KM,Straus S

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:In the present article, we propose an alternative method for dealing with negative affectivity (NA) biases in research, while investigating the association between a deleterious psychosocial environment at work and poor mental health. First, we investigated how strong NA must be to cause an observed correlat...

journal_title：BMC medical research methodology

authors： Arial M,Wild P

更新日期：2011-08-24 00:00:00

abstract：BACKGROUND:Two most important considerations in evaluation of survival prediction models are 1) predictability - ability to predict survival risks accurately and 2) reproducibility - ability to generalize to predict samples generated from different studies. We present approaches for assessment of reproducibility of sur...

journal_title：BMC medical research methodology

authors： Chen HC,Chen JJ

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in many developed countries appears to be increasing. There is some evidence from Latin America that COPD is a growing cause of death, but information on prevalence is scant. It is possible that, due to the high frequency of smoking in these coun...

journal_title：BMC medical research methodology

authors： Menezes AM,Victora CG,Perez-Padilla R,PLATINO Team.

更新日期：2004-06-17 00:00:00

abstract：BACKGROUND:In many studies the information of patients who are dying in the hospital is censored when examining the change in length of hospital stay (cLOS) due to hospital-acquired infections (HIs). While appropriate estimators of cLOS are available in literature, the existence of the bias due to censoring of deaths w...

journal_title：BMC medical research methodology

authors： Rahman S,von Cube M,Schumacher M,Wolkewitz M

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:The occurrence of communicable diseases (CD) depends on exposure to contagious persons. The effects of exposure to CD are delayed in time and contagious persons remain contagious for several days during which their contagiousness varies. Moreover when multiple exposures occur, it is difficult to know which e...

journal_title：BMC medical research methodology

authors： Payet C,Voirin N,Vanhems P,Ecochard R

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:Compelled by the intuitive appeal of predicting each individual patient's risk of an outcome, there is a growing interest in risk prediction models. While the statistical methods used to build prediction models are increasingly well understood, the literature offers little insight to researchers seeking to g...

journal_title：BMC medical research methodology

authors： Schummers L,Himes KP,Bodnar LM,Hutcheon JA

更新日期：2016-09-21 00:00:00

abstract：BACKGROUND:Meta-analysis typically involves combining the estimates from independent studies in order to estimate a parameter of interest across a population of studies. However, outliers often occur even under the random effects model. The presence of such outliers could substantially alter the conclusions in a meta-a...

journal_title：BMC medical research methodology

authors： Gumedze FN,Jackson D

更新日期：2011-02-16 00:00:00

abstract：BACKGROUND:In order to accurately measure and monitor levels of moderate-to-vigorous physical activity (MVPA) and sedentary behaviour (SB) in older adults, cost efficient and valid instruments are required. To date, the International Physical Activity Questionnaire (IPAQ) has not been validated with older adults (aged ...

journal_title：BMC medical research methodology

authors： Cleland C,Ferguson S,Ellis G,Hunter RF

更新日期：2018-12-22 00:00:00

abstract：BACKGROUND:Measuring body mass index (BMI) has been proposed as a method of screening for preventive primary care and population surveillance of childhood obesity. However, the accuracy of routinely collected measurements has been questioned. The purpose of this study was to assess the reliability of height, length and...

journal_title：BMC medical research methodology

authors： Carsley S,Parkin PC,Tu K,Pullenayegum E,Persaud N,Maguire JL,Birken CS,TARGet Kids! Collaboration.

更新日期：2019-04-24 00:00:00

abstract：BACKGROUND:The likelihood ratio function (LR), the ratio of conditional probabilities of obtaining a specific marker value among those with the event of interest over those without, provides an easily interpretable way to quantify the update of the risk prediction due to the knowledge of the marker value. The LR has be...

journal_title：BMC medical research methodology

authors： Smith AM,Christodouleas JP,Hwang WT

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:In low-income settings, key outcomes such as biomarkers or clinical assessments are often missing for a substantial proportion of the study population. The aim of this study was to assess the extent to which Heckman-type selection models can create unbiased estimates in such settings. METHODS:We introduce t...

journal_title：BMC medical research methodology

authors： Koné S,Bonfoh B,Dao D,Koné I,Fink G

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:To determine if the search technique that is used to sample randomized controlled trial (RCT) manuscripts from a field of medical science can influence the measurement of the change in quality over time in that field. METHODS:RCT manuscripts in the field of brain injury were identified using two readily-ava...

journal_title：BMC medical research methodology

authors： Borsody MK,Yamada C

更新日期：2005-02-07 00:00:00

abstract：BACKGROUND:The reporting of randomised controlled trial (RCT) abstracts is of vital importance. The primary objective of this study was to investigate the association between structure format and RCT abstracts' quality of methodology reporting, informed by the current requirement and usage of structure formats by leadi...

journal_title：BMC medical research methodology

authors： Hua F,Walsh T,Glenny AM,Worthington H

更新日期：2018-01-10 00:00:00

abstract：BACKGROUND:Growth Mixture Modeling (GMM) is commonly used to group individuals on their development over time, but convergence issues and impossible values are common. This can result in unreliable model estimates. Constraining variance parameters across classes or over time can solve these issues, but can also serious...

journal_title：BMC medical research methodology

authors： Sijbrandij JJ,Hoekstra T,Almansa J,Peeters M,Bültmann U,Reijneveld SA

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:E1684 was the pivotal adjuvant melanoma trial for establishment of high-dose interferon (IFN) as effective therapy of high-risk melanoma patients. E1690 was an intriguing effort to corroborate E1684, and the differences between the outcomes of these trials have embroiled the field in controversy over the pas...

journal_title：BMC medical research methodology

authors： Ibrahim JG,Chen MH,Chu H

更新日期：2012-11-29 00:00:00

abstract：BACKGROUND:It is notoriously difficult to recruit patients to randomised controlled trials in primary care. This is particularly true when the disease process under investigation occurs relatively infrequently and must be investigated during a brief time window. Bell's palsy, an acute unilateral paralysis of the facial...

journal_title：BMC medical research methodology

authors： McKinstry B,Hammersley V,Daly F,Sullivan F

更新日期：2007-03-28 00:00:00

abstract：BACKGROUND:Collection of buccal cells from saliva for DNA extraction offers a less invasive and convenient alternative to venipuncture blood collection that may increase participation in genetic epidemiologic studies. However, dried blood spot collection, which is also a convenient method, offers a means of collecting ...

journal_title：BMC medical research methodology

authors： Bhatti P,Kampa D,Alexander BH,McClure C,Ringer D,Doody MM,Sigurdson AJ

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:Methods for describing one's confidence in the available evidence are useful for end-users of evidence reviews. Analysts inevitably make judgments about the quality, quantity consistency, robustness, and magnitude of effects observed in the studies identified. The subjectivity of these judgments in several a...

journal_title：BMC medical research methodology

authors： Treadwell JR,Tregear SJ,Reston JT,Turkelson CM

更新日期：2006-10-19 00:00:00

abstract：BACKGROUND:Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling techniques to obtain the estimates of ...

journal_title：BMC medical research methodology

authors： Marshall A,Altman DG,Holder RL,Royston P

更新日期：2009-07-28 00:00:00

abstract：BACKGROUND:Participants in voluntary research present a different demographic profile than those who choose not to participate, affecting the generalizability of many studies. Efforts to evaluate these differences have faced challenges, as little information is available from non-participants. Leveraging data from a re...

journal_title：BMC medical research methodology

authors： Dahrouge S,Armstrong CD,Hogg W,Singh J,Liddy C

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:It is widely recognised that the pursuit of sustainable development cannot be accomplished without addressing inequality, or observed differences between subgroups of a population. Monitoring health inequalities allows for the identification of health topics where major group differences exist, dimensions of...

journal_title：BMC medical research methodology

authors： Hosseinpoor AR,Nambiar D,Schlotheuber A,Reidpath D,Ross Z

更新日期：2016-10-19 00:00:00

abstract：BACKGROUND:Postal questionnaires are widely used to collect outcome data on participants. However, a poor response to questionnaires will reduce the statistical power of the study and may introduce bias. A meta analysis of ten trials offering study results, largely in the fields of education and marketing, was shown to...

journal_title：BMC medical research methodology

authors： Cockayne S,Torgerson DJ

更新日期：2005-10-26 00:00:00

abstract：BACKGROUND:Estimating the incidence of medical conditions using claims data often requires constructing a prevalence period that predates an event of interest, for instance the diagnosis of cancer, to exclude those with pre-existing conditions from the incidence risk set. Those conditions missed during the prevalence p...

journal_title：BMC medical research methodology

authors： Griffiths RI,O'Malley CD,Herbert RJ,Danese MD

更新日期：2013-03-06 00:00:00

abstract：BACKGROUND:The prevailing view in therapeutic clinical research today is that observational studies are useful for generating new hypotheses and that controlled experiments (i.e., randomized clinical trials, RCTs) are the most appropriate method for assessing and confirming the efficacy of interventions. DISCUSSION:Th...

journal_title：BMC medical research methodology

authors： Sacristán JA

更新日期：2011-04-25 00:00:00

abstract：BACKGROUND:Route environments can positively influence people's active commuting and thereby contribute to public health. The Active Commuting Route Environment Scale (ACRES) was developed to study active commuters' perceptions of their route environments. However, bicycle commuters represent a small portion of the pop...

journal_title：BMC medical research methodology

authors： Wahlgren L,Schantz P

更新日期：2011-01-17 00:00:00

abstract：BACKGROUND:Technical advances following the Human Genome Project revealed that high-quality and -quantity DNA may be obtained from whole saliva samples. However, usability of previously collected samples and the effects of environmental conditions on the samples during collection have not been assessed in detail. In fi...

journal_title：BMC medical research methodology

authors： Nemoda Z,Horvat-Gordon M,Fortunato CK,Beltzer EK,Scholl JL,Granger DA

更新日期：2011-12-19 00:00:00