Structure formats of randomised controlled trial abstracts: a cross-sectional analysis of their current usage and association with methodology reporting.

abstract：BACKGROUND:Modern modelling techniques may potentially provide more accurate predictions of binary outcomes than classical techniques. We aimed to study the predictive performance of different modelling techniques in relation to the effective sample size ("data hungriness"). METHODS:We performed simulation studies bas...

journal_title：BMC medical research methodology

authors： van der Ploeg T,Austin PC,Steyerberg EW

更新日期：2014-12-22 00:00:00

abstract：BACKGROUND:International clinical trials are now rapidly expanding into Asia. However, the proportion of global trials is higher in South Korea compared to Japan despite implementation of similar governmental support in both countries. The difference in clinical trial environment might influence the respective physicia...

journal_title：BMC medical research methodology

authors： Ito-Ihara T,Hong JH,Kim OJ,Sumi E,Kim SY,Tanaka S,Narita K,Hatta T,Choi EK,Choi KJ,Miyagawa T,Minami M,Murayama T,Yokode M

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Within cancer care, dynamic evaluations of the loss in expectation of life provides useful information to patients as well as physicians. The loss of lifetime function yields the conditional loss in expectation of life given survival up to a specific time point. Due to the inevitable censoring in time-to-eve...

journal_title：BMC medical research methodology

authors： Jakobsen LH,Andersson TM,Biccler JL,El-Galaly TC,Bøgsted M

更新日期：2019-01-28 00:00:00

abstract：BACKGROUND:The Pathobiology of Prediabetes in A Biracial Cohort study is a prospective evaluation of the transition from normal to impaired glucose regulation among African American and Caucasian adults with parental type 2 diabetes. This report describes recruitment strategies and relative yields for the 376 enrolled ...

journal_title：BMC medical research methodology

authors： Ebenibo S,Edeoga C,Ammons A,Egbuonu N,Dagogo-Jack S,Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) Research Group.

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Greater transparency and, in particular, sharing of patient-level data for further scientific research is an increasingly important topic for the pharmaceutical industry and other organisations who sponsor and conduct clinical trials as well as generally in the interests of patients participating in studies....

journal_title：BMC medical research methodology

authors： Tucker K,Branson J,Dilleen M,Hollis S,Loughlin P,Nixon MJ,Williams Z

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:Multiple imputation is frequently used to deal with missing data in healthcare research. Although it is known that the outcome should be included in the imputation model when imputing missing covariate values, it is not known whether it should be imputed. Similarly no clear recommendations exist on: the util...

journal_title：BMC medical research methodology

authors： Kontopantelis E,White IR,Sperrin M,Buchan I

更新日期：2017-01-09 00:00:00

abstract：:Clinical Decision Support Systems (CDSS) provide aid in clinical decision making and therefore need to take into consideration human, data interactions, and cognitive functions of clinical decision makers. The objective of this paper is to introduce a high level reference model that is intended to be used as a foundat...

journal_title：BMC medical research methodology

authors： Zikos D,DeLellis N

更新日期：2018-11-16 00:00:00

abstract：BACKGROUND:Joint models of longitudinal and time-to-event data are increasingly used to perform individual dynamic prediction of a risk of event. However the difficulty to perform inference in nonlinear models and to calculate the distribution of individual parameters has long limited this approach to linear mixed-effe...

journal_title：BMC medical research methodology

authors： Desmée S,Mentré F,Veyrat-Follet C,Sébastien B,Guedj J

更新日期：2017-07-17 00:00:00

abstract：BACKGROUND:Evidence suggests that differences exist in physical activity (PA) participation among Culturally and Linguistically Diverse (CALD) children and adolescents. It is possible that these differences could be influenced by variations in measurement technique and instrument reliability. However, culturally sensit...

journal_title：BMC medical research methodology

authors： Strugnell C,Renzaho A,Ridley K,Burns C

更新日期：2011-08-25 00:00:00

abstract：BACKGROUND:Diet plays an important role in chronic disease, and the use of dietary pattern analysis has grown rapidly as a way of deconstructing the complexity of nutritional intake and its relation to health. Pattern analysis methods, such as principal component analysis (PCA), have been used to investigate various di...

journal_title：BMC medical research methodology

authors： Zhang F,Tapera TM,Gou J

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:There is increasing awareness that meta-analyses require a sufficiently large information size to detect or reject an anticipated intervention effect. The required information size in a meta-analysis may be calculated from an anticipated a priori intervention effect or from an intervention effect suggested b...

journal_title：BMC medical research methodology

authors： Wetterslev J,Thorlund K,Brok J,Gluud C

更新日期：2009-12-30 00:00:00

abstract：BACKGROUND:Cross-cultural research with patient-reported outcomes measures (PROMs) assumes that the PROM in the target language will measure the same construct in the same way as the PROM in the source language. Yet translation methods are rarely used to qualitatively maximise construct equivalence or to describe the i...

journal_title：BMC medical research methodology

authors： Hawkins M,Cheng C,Elsworth GR,Osborne RH

更新日期：2020-05-26 00:00:00

abstract：BACKGROUND:Action research (AR) and randomized controlled trials (RCTs) are usually considered to be theoretically and practically incompatible. However, we argue that their respective strengths and weaknesses can be complementary. We illustrate our argument from a recent study assessing the effect of telemonitoring on...

journal_title：BMC medical research methodology

authors： Day K,Kenealy TW,Sheridan NF

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:Clinical practice guidelines have become increasingly widely used to guide quality improvement of clinical practice. Qualitative research may be a useful way to improve the quality and implementation of guidelines. The methodology for qualitative evidence used in guidelines development is worthy of further r...

journal_title：BMC medical research methodology

authors： Wang YY,Liang DD,Lu C,Shi YX,Zhang J,Cao Y,Fang C,Huang D,Jin YH

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:The weighted estimators generally used for analyzing case-cohort studies are not fully efficient and naive estimates of the predictive ability of a model from case-cohort data depend on the subcohort size. However, case-cohort studies represent a special type of incomplete data, and methods for analyzing inc...

journal_title：BMC medical research methodology

authors： Marti H,Carcaillon L,Chavance M

更新日期：2012-03-09 00:00:00

abstract：BACKGROUND:One of the main challenges for drug evaluation in rare diseases is the often heterogeneous course of these diseases. Traditional outcome measures may not be applicable for all patients, when they are in different stages of their disease. For instance, in Duchenne Muscular Dystrophy, the Six Minute Walk Test ...

journal_title：BMC medical research methodology

authors： Gaasterland CM,Jansen-van der Weide MC,Weinreich SS,van der Lee JH

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Identifying and assessing degree and type of frailty among older persons is a major challenge when targeting high risk populations to identify preventive interventions. The Vulnerable Elders Survey-(VES-13) is a simple instrument to identify frailty defined as risk for death, functional decline or institutio...

journal_title：BMC medical research methodology

authors： Belmin J,Khellaf L,Pariel S,Jarzebowski W,Valembois L,Zeisel J,Lafuente-Lafuente C

更新日期：2020-02-05 00:00:00

abstract：BACKGROUND:Participants in voluntary research present a different demographic profile than those who choose not to participate, affecting the generalizability of many studies. Efforts to evaluate these differences have faced challenges, as little information is available from non-participants. Leveraging data from a re...

journal_title：BMC medical research methodology

authors： Dahrouge S,Armstrong CD,Hogg W,Singh J,Liddy C

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:Aboriginal and Torres Strait Islander peoples are under-reported in administrative health datasets in NSW, Australia. Correct reporting of Aboriginal and Torres Strait Islander peoples is essential to measure the effectiveness of policies and programmes aimed at reducing the health disadvantage experienced b...

journal_title：BMC medical research methodology

authors： Taylor LK,Bentley J,Hunt J,Madden R,McKeown S,Brandt P,Baker D

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:A recent paper found that terminal digits of statistical values in Nature deviated significantly from an equiprobable distribution, indicating errors or inconsistencies in rounding. This finding, as well as the discovery that a large percentage of p values were inconsistent with reported test statistics, led...

journal_title：BMC medical research methodology

authors： Jeng M

更新日期：2006-09-13 00:00:00

abstract：BACKGROUND:Missing data are common in medical research, which can lead to a loss in statistical power and potentially biased results if not handled appropriately. Multiple imputation (MI) is a statistical method, widely adopted in practice, for dealing with missing data. Many academic journals now emphasise the importa...

journal_title：BMC medical research methodology

authors： Hayati Rezvan P,Lee KJ,Simpson JA

更新日期：2015-04-07 00:00:00

abstract：BACKGROUND:Postal self-completion questionnaires offer one of the least expensive modes of collecting patient based outcomes in health care research. The purpose of this review is to assess the efficacy of methods of increasing response to postal questionnaires in health care studies on patient populations. METHODS:Th...

journal_title：BMC medical research methodology

authors： Nakash RA,Hutton JL,Jørstad-Stein EC,Gates S,Lamb SE

更新日期：2006-02-23 00:00:00

abstract：BACKGROUND:Posttraumatic growth is the positive change resulting from traumatic experiences and is typically assessed with retrospective measures like the Posttraumatic Growth Inventory (PTGI). The PTGI was designed to include reference to a specific traumatic event, making it difficult to implement, without change, in...

journal_title：BMC medical research methodology

authors： Kaur N,Porter B,LeardMann CA,Tobin LE,Lemus H,Luxton DD,Millennium Cohort Study Team.

更新日期：2017-04-20 00:00:00

abstract：BACKGROUND:Multi-centre randomized controlled clinical trials play an important role in modern evidence-based medicine. Advantages of collecting data from more than one site are numerous, including accelerated recruitment and increased generalisability of results. Mixed models can be applied to account for potential cl...

journal_title：BMC medical research methodology

authors： Harden M,Friede T

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Centralisation of thrombolysis may offer substantial benefits. The aim of this study was to assess short term costs and effects of centralisation of thrombolysis and optimised care in a decentralised system. METHODS:Using simulation modelling, three scenarios to improve decentralised settings in the North o...

journal_title：BMC medical research methodology

authors： Lahr MM,van der Zee DJ,Luijckx GJ,Vroomen PC,Buskens E

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Researchers and policy makers have determined that accounting for productivity costs, or "indirect costs," may be as important as including direct medical expenditures when evaluating the societal value of health interventions. These costs are also important when estimating the global burden of disease. The ...

journal_title：BMC medical research methodology

authors： Menzin J,Marton JP,Menzin JA,Willke RJ,Woodward RM,Federico V

更新日期：2012-06-25 00:00:00

abstract：BACKGROUND:Typically, randomization software should allow users to exert control over the different aspects of randomization including block design, provision of unique identifiers and control over the format and type of program output. While some of these characteristics have been addressed by available software, none...

journal_title：BMC medical research methodology

authors： Saghaei M

更新日期：2004-11-09 00:00:00

abstract：BACKGROUND:Recruitment to clinical trials can be challenging. Methods that improve the efficiency of trial recruitment are needed to increase successful study completions. The aim of this study was to ascertain whether sending an audio-visual presentation on a digital versatile disc (DVD), along with usual study invita...

journal_title：BMC medical research methodology

authors： Rogers A,Flynn RWV,Mackenzie IS,MacDonald TM

更新日期：2019-01-30 00:00:00

abstract：BACKGROUND:In Routine Outcome Monitoring (ROM) there is a high demand for short assessments. Computerized Adaptive Testing (CAT) is a promising method for efficient assessment. In this article, the efficiency of a CAT version of the Mood and Anxiety Symptom Questionnaire, - Anhedonic Depression scale (MASQ-AD) for use ...

journal_title：BMC medical research methodology

authors： Smits N,Zitman FG,Cuijpers P,den Hollander-Gijsman ME,Carlier IV

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:Cancer relapses may be useful to predict the risk of death. To take into account relapse information, the Landmark approach is popular. As an alternative, we propose the joint frailty model for a recurrent event and a terminal event to derive dynamic predictions of the risk of death. METHODS:The proposed pr...

journal_title：BMC medical research methodology

authors： Mauguen A,Rachet B,Mathoulin-Pélissier S,Lawrence GM,Siesling S,MacGrogan G,Laurent A,Rondeau V

更新日期：2015-04-01 00:00:00