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A potential marker of bare metal stent restenosis: monocyte count - to- HDL cholesterol ratio.

Abstract：

BACKGROUND:Oxidation and inflammation play significant roles in the pathogenesis of coronary artery diseases. Monocyte count to high-density lipoprotein (HDL) cholesterol ratio (MHR) is a new marker and has revealed as an indicator of inflammation in the literature. The present study aimed to search the effect of MHR on in-stent restenosis (ISR) in patients with stable or unstable angina pectoris undergoing bare-metal stent (BMS) implantation. METHODS:A total of 468 consecutive stable or unstable angina pectoris patients (mean age 60.3 ± 10.1 and 70 % men) who had undergone successful BMS implantation were included the study. Serum samples were obtained before the procedure. RESULTS:The mean period between two coronary angiography procedures was 14 ± 7.9 months. The baseline MHR levels were significantly higher in patients that had ISR (odds ratio, 3.64; 95 % confidence interval, 2.45- 4.84; P < 0.001). Stent diameter, the time between the two coronary angiographic studies, uric acid and MHR levels emerged as independent predictors of ISR. CONCLUSIONS:Our results indicate that elevated MHR is an independent and powerful predictor of ISR in patients with stable or unstable angina pectoris who underwent successful BMS implantation.

journal_name

BMC Cardiovasc Disord

journal_title

BMC cardiovascular disorders

authors

Ucar FM

doi

10.1186/s12872-016-0367-3

subject

Has Abstract

pub_date

2016-10-03 00:00:00

pages

186

issue

1

issn

1471-2261

pii

10.1186/s12872-016-0367-3

journal_volume

16

pub_type

杂志文章

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