Abstract：
BACKGROUND:Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population. METHODS:In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic regression. RESULTS:Although we did not find any significant association for MMP-2 SNPs using single-marker analysis, we identified many windows with haplotype frequencies significantly different between case participants and control participants using a variable-sized sliding-window strategy. In particular, the most significant association was shown by a 2-SNP window consisting of rs2241145 and rs9928731 (omnibus test: asymptotic Pasym = 7.48 × 10 (-5) and empirical Pemp = 0.001867). There were two protective haplotypes: CT (Pasym = 0.00303; odds ratio [OR], 0.403) and GC (Pasym = 0.000976; OR, 0.448). CONCLUSIONS:MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Liu O,Li J,Xin Y,Qin Y,Li H,Gong M,Liu Y,Wang X,Li J,Zhang Hdoi
10.1186/s12872-016-0188-4subject
Has Abstractpub_date
2016-01-14 00:00:00pages
11issn
1471-2261pii
10.1186/s12872-016-0188-4journal_volume
16pub_type
杂志文章abstract：BACKGROUND:We performed a systematic review and meta-analysis of the Matrix metalloproteinases (MMP)-9 (C1562T), MMP-9 (R279Q), MMP-9 (P574R) and MMP-9 (R668Q) polymorphisms and risk of Coronary Artery Disease (CAD). METHODS:After a systematic literature search, pooled odds ratio (OR) and their corresponding 95% confi...
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,多中心研究
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