Abstract:
BACKGROUND:Preoperative low left ventricular ejection fraction (LVEF) has been reported as an independent risk factor for in-hospital mortality. However, there were few studies evaluating the long-term mortality in these patients. We, therefore, conducted this study to investigate long-term outcomes of surgery on patients with LVEF≤35% undergoing a broad range of cardiac procedures. METHODS:We performed a retrospective cohort study in 510 patients from January 1, 2007 to September 1, 2019. These patients were divided into survival group (n = 386) and non-survival group (n = 124). The multivariate Cox analysis was used to estimate the risk factors for survival. In Cox analysis, β-blockers were indicated to be associated with long-term mortality. To further address bias, we derived a propensity score predicting the function of β-blockers on survival, and matched 52 cases to 52 controls with similar risk profiles. RESULTS:Patients were followed for a median period of 24 months (interquartile range: 11-44 months). Multivariate Cox regression analysis indicated that the non-survival group had higher weight, higher EuroSCORE, more smoking patients, longer time of cardiopulmonary bypass (CPB), more intra-aortic balloon pump (IABP) use, and more patients who always used β-blocker (HR: 2.056, 95%CI:1.236-3.420, P = 0.005) compared with survival group. After propensity matching, the group which always used β-blocker showed higher rate of all-cause death compare with the control group (61.54% vs 80.77%, P = 0.030). CONCLUSIONS:The risk factors for long-term survival were weight, EuroSCORE, smoking, CPB, IABP, always used β-blockers in patients with LVEF≤35%. The discharge prescription of β-blocker should be cautiously administrated in those patients.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Fan FD,Zhang HT,Pan T,Tang XL,Wang DJdoi
10.1186/s12872-020-01651-6subject
Has Abstractpub_date
2020-08-20 00:00:00pages
379issue
1issn
1471-2261pii
10.1186/s12872-020-01651-6journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Ticagrelor and clopidogrel, P2Y12 receptor antagonists, can prevent thrombotic events and are used to treat cardiovascular diseases such as acute coronary syndrome and chronic obstructive pulmonary disease, in which inflammation is involved. Moreover, NF-B is the central regulator of inflammation. Thus, we s...
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pub_type: 杂志文章
doi:10.1186/s12872-019-01287-1
更新日期:2019-12-30 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 已发布勘误
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journal_title:BMC cardiovascular disorders
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doi:10.1186/s12872-020-01817-2
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-10-56
更新日期:2010-11-10 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-019-1201-5
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pub_type: 杂志文章
doi:10.1186/1471-2261-13-4
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pub_type: 杂志文章,多中心研究
doi:10.1186/s12872-015-0094-1
更新日期:2015-09-23 00:00:00
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pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12872-016-0244-0
更新日期:2016-04-19 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12872-016-0422-0
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pub_type: 杂志文章
doi:10.1186/1471-2261-11-67
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-06-19 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-017-0659-2
更新日期:2017-08-16 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2018-08-20 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-017-0503-8
更新日期:2017-02-23 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type:
doi:10.1186/s12872-020-01515-z
更新日期:2020-05-19 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0514-5
更新日期:2017-03-15 00:00:00
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pub_type: 杂志文章
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更新日期:2020-05-24 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-06-03 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2014-10-03 00:00:00