Decrease expression and clinicopathological significance of miR-148a with poor survival in hepatocellular carcinoma tissues.

abstract：BACKGROUND:Advancing knowledge in molecular pathogenesis of hepatocellular carcinoma (HCC) opens up new horizons in the diagnostic, prognostic and therapeutic perspectives. Assessing the expression of molecular targets prior to definitive treatment is gaining importance in clinical practice. In this study, we investiga...

journal_title：Diagnostic pathology

authors： Lo RC,Leung CO,Chok KS,Ng IO

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Patients with pathologic stage (p-Stage) IA non-small cell lung cancer (NSCLC) have a good survival rate because of possible curative resection. However, up to 10% of these patients relapse postoperatively. To identify unfavorable prognostic factors, we retrospectively analyzed the clinicopathological featur...

journal_title：Diagnostic pathology

authors： Hamanaka R,Yokose T,Sakuma Y,Tsuboi M,Ito H,Nakayama H,Yamada K,Masuda R,Iwazaki M

更新日期：2015-04-02 00:00:00

abstract：:Endometriosis is a clinical entity characterized by the presence of normal endometrial mucosa abnormally implanted in locations other than the uterine cavity. Endometriosis can be either endopelvic or extrapelvic depending on the location of endometrial tissue implantation. Despite the rarity of extrapelvic endometrio...

journal_title：Diagnostic pathology

authors： Machairiotis N,Stylianaki A,Dryllis G,Zarogoulidis P,Kouroutou P,Tsiamis N,Katsikogiannis N,Sarika E,Courcoutsakis N,Tsiouda T,Gschwendtner A,Zarogoulidis K,Sakkas L,Baliaka A,Machairiotis C

更新日期：2013-12-02 00:00:00

abstract：BACKGROUND:70-80% of sporadic endometrial carcinomas are defined as endometrioid carcinoma (EC). Early-stage, well differentiated endometrial carcinomas usually retain expression of estrogen and progesterone receptors (ER and PR, respectively), as advanced stage, poorly differentiated tumors often lack one or both of t...

journal_title：Diagnostic pathology

authors： Kreizman-Shefer H,Pricop J,Goldman S,Elmalah I,Shalev E

更新日期：2014-03-31 00:00:00

abstract：UNLABELLED:A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary lining, that expressed cytokeratins 7, 5/6 and calretinin as well as nuclear WT-1 and apical membra...

journal_title：Diagnostic pathology

authors： Stolnicu S,Quiñonez E,Boros M,Molnar C,Dulcey I,Nogales FF

更新日期：2013-09-25 00:00:00

abstract：UNLABELLED:Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, gen...

journal_title：Diagnostic pathology

authors： Tatangelo F,Cantile M,Pelella A,Losito NS,Scognamiglio G,Bianco F,Belli A,Botti G

更新日期：2014-03-12 00:00:00

abstract：:Primary pleural angiosarcoma is a rare and clinically aggressive tumor. Patients usually present with chest pain, dyspnea, hemoptysis and/or cough. Radiologic studies reveal diffuse pleural thickening and pleural effusion with or without mass lesion. The clinical and radiological features both resemble those of mesoth...

journal_title：Diagnostic pathology

authors： Kao YC,Chow JM,Wang KM,Fang CL,Chu JS,Chen CL

更新日期：2011-12-30 00:00:00

abstract：BACKGROUND:The optimal course of clinical follow-up after a diagnosis of breast papillary lesion on a core needle biopsy (CNB) remains elusive. In particular, no reports in literature have addressed this question in African-American population. We describe our experience with breast papillary lesions in a primarily Afr...

journal_title：Diagnostic pathology

authors： Wang H,Tsang P,D'Cruz C,Clarke K

更新日期：2014-04-24 00:00:00

abstract：BACKGROUND:Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding...

journal_title：Diagnostic pathology

authors： Lund-Iversen M,Grøholt KK,Helland Å,Borgen E,Brustugun OT

更新日期：2015-09-05 00:00:00

abstract：BACKGROUND:Adult granulosa cell tumors of the ovary (GCTs) are sex cord stromal tumors of unpredictable behaviour. Up to now, the prediction of the relapsing/malignant potential remains difficult. CD56 (NCAM) in GCTs was previously described in only two studies. However, the expression of its isoforms was not examined....

journal_title：Diagnostic pathology

authors： Völker HU,Engert S,Cramer A,Schmidt M,Kämmerer U,Müller-Hermelink HK,Gattenlöhner S

更新日期：2008-07-09 00:00:00

abstract：UNLABELLED:As rare condition, mucoepidermoid carcinoma may occur in liver although its etiology and pathogenesis is still unclear. We report here a case of intrahepatic mucoepidermoid carcinoma misdiagnosed as cholangiocarcinoma and squamous cell carcinoma by preoperative radiologic and intraoperative histological exam...

journal_title：Diagnostic pathology

authors： Guo XQ,Li B,Li Y,Tian XY,Li Z

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Rapid ("warm") autopsies of patients with advanced metastatic cancer provide important insight into the natural history, pathobiology and histomorphology of disease in treatment-resistant tumors. Plasmacytoid urothelial carcinoma (PUC) is a rare variant of urothelial carcinoma characterized by neoplastic cel...

journal_title：Diagnostic pathology

authors： Simon CT,Skala SL,Killen PD,Siddiqui J,Cao X,Qiao Y,Al-Ahmadie H,Camelo-Piragua SI,Jentzen J,Chinnaiyan AM,Dhanasekaran SM,Reichert ZR,Mehra R

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:After introduction of the concept of critical value (CV) in laboratory medicine, some efforts were performed to define possible critical values in surgical pathology. Critical diagnosis (critical value) is a concept recently established in surgical pathology and is a challenging issue among pathologists and ...

journal_title：Diagnostic pathology

authors： Mireskandari M

更新日期：2008-07-12 00:00:00

abstract：:Sclerosing rhabdomyosarcoma (SRMS) is an infrequent variant of rhabdomyosarcoma characterized by extensive intercellular hyaline fibrosis. We report the case of a 37 year-old male with a 9 x 6 cm SRMS on the right elbow. Histologically, the tumor showed an abundant extracellular hyaline matrix with extratumoral vascul...

journal_title：Diagnostic pathology

authors： Martorell M,Ortiz CM,Garcia JA

更新日期：2010-08-11 00:00:00

abstract：BACKGROUND:Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a rare intracranial tumor, defined as DLBCL arising from the brain, spinal cord, leptomeninges and eye, with an overall annual incidence of 5 cases per million. The primary CNS anaplastic variant of DLBCL (A-DLBCL) is even less com...

journal_title：Diagnostic pathology

authors： Xu T,Jia Q,Wang Y,Liu Y,Han D,Li P,Ma J,Fan L,Yan Q,Guo S,Li M,Wang Z

更新日期：2019-05-20 00:00:00

abstract：:Cutaneous apocrine carcinoma (AC) is a rare adnexal neoplasm that histologically can mimic breast carcinoma metastatic to the skin or apocrine carcinoma arising in ectopic breast tissue. As extremely rare condition, neuroendocrine differentiation may be observed in AC although its etiology and pathogenesis is still un...

journal_title：Diagnostic pathology

authors： Li Y,Chen LL,Li B,Tian XY,Li Z

更新日期：2015-06-10 00:00:00

abstract：UNLABELLED:Perivascular epithelioid cell tumors (PEComas) encompass a group of rare mesenchymal neoplasms, which typically have a perivascular location with dual melanocytic and muscular differentiation. They are found in a variety of localizations, though lesions in the liver are exceedingly rare. Because of their rar...

journal_title：Diagnostic pathology

authors： Ameurtesse H,Chbani L,Bennani A,Toughrai I,Beggui N,Kamaoui I,Elfatemi H,Harmouch T,Amarti A

更新日期：2014-07-17 00:00:00

abstract：BACKGROUND:Assessment of hemoglobin is one of the most reliable indicators for anemia, and is widely used to screen for anemia among pregnant women. The HemoCue® has been widely used for as a point-of-care device for hemoglobin estimation in health facilities. Previous studies showed contradictory results regarding the...

journal_title：Diagnostic pathology

authors： Adam I,Ahmed S,Mahmoud MH,Yassin MI

更新日期：2012-03-21 00:00:00

abstract：BACKGROUND:Tubular adenoma of the breast is a rare benign epithelial tumor and only a few literatures have been reported; so far, no cases of tubular adenoma occurred in the accessory breast have been reported in the English literature. Clinical presentation and management of our patient are discussed along with a revi...

journal_title：Diagnostic pathology

authors： Huang Y,Zhang H,Zhou Q,Ling L,Wang S

更新日期：2015-06-04 00:00:00

abstract：BACKGROUND:Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features observed at diagnosis are related to a worse outcome of the patients. METHODS:In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73...

journal_title：Diagnostic pathology

authors： De Mello MR,Albuquerque DM,Pereira-Cunha FG,Albanez KB,Pagnano KB,Costa FF,Metze K,Lorand-Metze I

更新日期：2012-06-28 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR (ddPCR) and cobas enables quantification of T790M mutation. Whether these methods can predict clinical r...

journal_title：Diagnostic pathology

authors： Li C,Jia R,Liu H,Zhang B,Wang C

更新日期：2018-08-13 00:00:00

abstract：:Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)/T-cell lymphoma (I...

journal_title：Diagnostic pathology

authors： Alhumidi A

更新日期：2015-07-16 00:00:00

abstract：BACKGROUND:Maspin is a unique member of the serine protease inhibitor superfamily and its expression is found in myoepithelial cells of normal mammary glands; therefore, it has been considered to be a myoepithelial marker. We previously reported that maspin was frequently expressed in biologically aggressive breast can...

journal_title：Diagnostic pathology

authors： Umekita Y,Ohi Y,Souda M,Rai Y,Sagara Y,Sagara Y,Tamada S,Tanimoto A

更新日期：2011-04-16 00:00:00

abstract：BACKGROUND:Previous studies suggested that apolipoprotein A5 (ApoA5) genetic polymorphisms (SNPs) may result in lipid metabolism disorders. Therefore, genetic polymorphisms in ApoA5 may be associated with the occurrence of osteonecrosis of femoral head (ONFH). METHODS:We designed a case-control study including 223 pat...

journal_title：Diagnostic pathology

authors： Cui Y,Kaisaierjiang A,Cao P,Wu ZY,Lv Q

更新日期：2014-12-17 00:00:00

abstract：:Over two million Americans are afflicted with schizophrenia, a debilitating mental health disorder with a unique symptomatic and epidemiological profile. Genomics studies have hinted towards candidate schizophrenia susceptibility chromosomal loci and genes. Modern proteomic tools, particularly mass spectrometry and ex...

journal_title：Diagnostic pathology

authors： Lakhan SE

更新日期：2006-07-17 00:00:00

abstract：BACKGROUND:Somatostatin receptor 2 (SSTR2) encodes somatostatin receptor that can inhibit the cell proliferation of solid tumors. Promoter hypermethylation is likely to silence the expression of SSTR2. The goal of our study was to investigate the association between SSTR2 promoter methylation and the risk and progressi...

journal_title：Diagnostic pathology

authors： Shen Z,Chen X,Li Q,Zhou C,Li J,Ye H,Duan S

更新日期：2016-01-22 00:00:00

abstract：UNLABELLED:Lung cancer is the leading cause of death among malignant diseases in humans worldwide. In the last decade development of new targeted drugs for the treatment of non-small cell lung cancer proved to be a promising approach to prolong the otherwise very poor prognosis of patients with advanced UICC stages. Ep...

journal_title：Diagnostic pathology

authors： Otto C,Csanadi A,Fisch P,Werner M,Kayser G

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:Mixed adeno-neuroendocrine carcinoma (MANEC) of the biliary tract is rare with only a few reported cases. Consequently, knowledge about their pathogenesis, histopathological characteristics and outcomes is sparce. CASE PRESENTATION:A 53-year old man presented with epigastric pain on a background of excessiv...

journal_title：Diagnostic pathology

authors： Zheng SL,Yip VS,Pedica F,Prachalias A,Quaglia A

更新日期：2015-11-20 00:00:00

abstract：BACKGROUND:Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in Rheumatoid Arthritis. The Multidrug resistance Related Protein and Multi Drug Resistance protein 1,...

journal_title：Diagnostic pathology

authors： Micsik T,Lőrincz A,Gál J,Schwab R,Peták I

更新日期：2015-12-30 00:00:00

abstract：BACKGROUND:Mesonephric adenocarcinoma (MNAC) is a rare tumor of the female genital tract, which originates from mesonephric duct remnants. Its diagnosis is pathologically challenging, because MNAC may exhibit a mixture of morphological patterns that complicates the differential diagnosis. CASE PRESENTATION:The patient...

journal_title：Diagnostic pathology

authors： Montalvo N,Redrobán L,Galarza D

更新日期：2019-07-03 00:00:00