Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems.

abstract：BACKGROUND:The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex with the redox partner NADPH-cytochrome P450 oxidoreductase (CPR) fo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Dos Santos AC,Conley AJ,de Oliveira MF,Oliveira GB,Viana DC,Assis Neto AC

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:The aim of this randomized controlled trial was to compare the efficacy of extended letrozole regimen with clomiphene citrate in women with unexplained infertility undergoing superovulation and intrauterine insemination (IUI). METHODS:Two hundred and fourteen patients with unexplained infertility were rando...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Fouda UM,Sayed AM

更新日期：2011-06-21 00:00:00

abstract：:The prolonged lockdown of health services providing high-complexity fertility treatments -as currently recommended by many reproductive medicine entities- is detrimental for society as a whole, and infertility patients in particular. Globally, approximately 0.3% of all infants born every year are conceived using assis...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Alviggi C,Esteves SC,Orvieto R,Conforti A,La Marca A,Fischer R,Andersen CY,Bühler K,Sunkara SK,Polyzos NP,Strina I,Carbone L,Bento FC,Galliano D,Yarali H,Vuong LN,Grynberg M,Drakopoulos P,Xavier P,Llacer J,Neuspil

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Cole LA

更新日期：2010-08-24 00:00:00

abstract：BACKGROUND:We characterized the spectrum and etiology of hypogonadism in a cohort of Prader-Willi syndrome (PWS) adolescents and adults. METHODS:Reproductive hormonal profiles and physical examination were performed on 19 males and 16 females ages 16-34 years with PWS. Gonadotropins, sex-steroids, inhibin B (INB) and ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gross-Tsur V,Hirsch HJ,Benarroch F,Eldar-Geva T

更新日期：2012-05-06 00:00:00

abstract：BACKGROUND:Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregulation remain unknown, but it has been hypothesized that it is a compensatory response to improve pl...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Christians JK,Lennie KI,Huicochea Munoz MF,Binning N

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:Dehydroepinadrosterone (DHEA) supplementation improves pregnancy chances in women with diminished ovarian reserve (DOR), by possibly reducing aneuploidy. Since a large majority of spontaneous miscarriages are associated with aneuploidy, one can speculate that DHEA supplementation may also reduce miscarriage ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gleicher N,Ryan E,Weghofer A,Blanco-Mejia S,Barad DH

更新日期：2009-10-07 00:00:00

abstract：:Transient receptor potential cation channel, subfamily V, member 6 (TRPV6) is an epithelial Ca2+ channel protein expressed in calcium absorbing organs. In the present study, we investigated the expression and regulation of uterine and placental TRPV6 during gestation in rodents. Uterine TRPV6 peaked at pregnancy day (...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lee BM,Lee GS,Jung EM,Choi KC,Jeung EB

更新日期：2009-05-21 00:00:00

abstract：BACKGROUND:Despite significant advances in contraceptive options for women, vasectomy and condoms are the only options available for male contraception. Due to this limitation, the burden of contraception resides on the shoulders of females only. Therefore, there is an urgent need to develop a safe, effective and rever...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Chauhan A,Thaper D,Prabha V

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:Endocrine mechanisms governing canine reproductive function remain still obscure. Progesterone (P4) of luteal origin is required for maintenance of pregnancy. Corpora lutea (CL) are gonadotrop-independent during the first third of dioestrus; afterwards prolactin (PRL) is the primary luteotropic factor. Inter...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Kowalewski MP,Michel E,Gram A,Boos A,Guscetti F,Hoffmann B,Aslan S,Reichler I

更新日期：2011-08-03 00:00:00

abstract：BACKGROUND:This study was aimed at screening out the potential key genes and pathways associated with gestational diabetes mellitus (GDM). METHODS:The GSE70493 dataset used for this study was obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in the placental tissue of women with...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Wang Y,Yu H,Liu F,Song X

更新日期：2019-11-29 00:00:00

abstract：:For the extrapolation of data obtained from experimental animals to the human situation, it is important to know the similarities and differences between human and animal species. Some important characteristics of nitric oxide synthase (NOS) in myometrium and vagina from human and rat were compared. NOS-activity was m...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Batra S,Iosif C,Al-Hijji J,Larsson I

更新日期：2003-02-06 00:00:00

abstract：BACKGROUND:Mammalian oocyte meiotic maturation involves a number of important processes, including spindle assembly and migration, cortical reorganization and polar body extrusion. Numerous proteins contribute to these processes, but it is unknown whether MKlp2 (mitotic kinesin-like protein 2; also called KIF20A), a mi...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Liu J,Wang QC,Cui XS,Wang ZB,Kim NH,Sun SC

更新日期：2013-12-21 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, abdominal obesity, hyperandrogenism, hypertension, and insulin resistance. METHODS:Our objectives in this study were (1) to estimate sympathetic-adrenal medullary (SAM) activity by measuring...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Stener-Victorin E,Ploj K,Larsson BM,Holmäng A

更新日期：2005-09-07 00:00:00

abstract：BACKGROUND:To evaluate the association between leukocytes (polymorphonuclear granulocytes -PMNL) and semen parameters at different leukocyte concentrations. METHODS:This was a retrospective clinical study at a university hospital andrology clinic. Semen samples from infertile men were analyzed for sperm morphology and...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lackner JE,Agarwal A,Mahfouz R,du Plessis SS,Schatzl G

更新日期：2010-02-05 00:00:00

abstract：:Decidualization is an intricate biological process where extensive morphological, functional, and genetic changes take place in endometrial stromal cells to support the development of an implanting blastocyst. Deficiencies in decidualization are associated with pregnancy complications and reproductive diseases. Decidu...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Ni N,Li Q

更新日期：2017-10-13 00:00:00

abstract：BACKGROUND:ATF6α, one of the sensor proteins in the stress signaling pathway of the endoplasmic reticulum, is located in the membrane of the endoplasmic reticulum. To date, the physiological function of ATF6α in the process of embryo implantation has not been reported. METHODS:In this study, the expression pattern of ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Xiong Y,Li W,Lin P,Wang L,Wang N,Chen F,Li X,Wang A,Jin Y

更新日期：2016-10-07 00:00:00

abstract：BACKGROUND:It is not well established whether the increased number of leukocytes in the seminal fluid impairs the outcomes of assisted reproductive technology (ART). This investigation analysed the outcomes of the intracytoplasmic sperm injection (ICSI) and intracytoplasmic morphologically selected sperm injection (IMS...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Cavagna M,Oliveira JB,Petersen CG,Mauri AL,Silva LF,Massaro FC,Baruffi RL,Franco JG Jr

更新日期：2012-06-15 00:00:00

abstract：OBJECTIVE:To assess the effectiveness and safety of omega-3 fatty acid for patients with PCOS. METHODS:In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of omega-3 fatty acid versus placebo or western medicine in women with PCOS. The study's registration number is CRD420...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Yang K,Zeng L,Bao T,Ge J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:This study was designed to determine whether small diameter needles for oocyte retrieval alter oocyte yields in patients undergoing IVF in comparison to standard large diameter needles. METHODS:We conducted a prospective pilot study of 21 consecutive favorable prognosis patients. In each patient one ovary w...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Kushnir VA,Kim A,Gleicher N,Barad DH

更新日期：2013-03-20 00:00:00

abstract：BACKGROUND:Gestational diabetes mellitus (GDM) is a common complication in pregnancy that poses a serious threat to the health of both mother and child. While the specific etiology and pathogenesis of this disease are not fully understood, it is thought to arise due to a combination of insulin resistance, inflammation,...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Wang H,Zhou W,She G,Yu B,Sun L

更新日期：2020-05-20 00:00:00

abstract：:The endometrium undergoes cyclic remodelling throughout the menstrual cycle in preparation for embryo implantation which occurs in a short window during the mid-secretory phase. It is during this short 'receptive window' that the endometrial luminal epithelium acquires adhesive capacity permitting blastocysts firm adh...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Santos LL,Ling CK,Dimitriadis E

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:Previous caesarean scar pregnancy is one type of ectopic pregnancy in myometrium and fibrous tissue of previous caesarean scar. One of the therapeutic methods of this type of ectopic pregnancy is treatment with methotrexate. Given various findings on the treatment of caesarean scar pregnancy with methotrexat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Salari N,Kazeminia M,Shohaimi S,Nankali AA,Mohammadi M

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:A decrease in HOXA11 expression in eutopic mid-secretory endometrium has been found in women with endometriosis-associated infertility. METHODS:Using Real-time quantitative PCR (RQ-PCR) and western blotting analysis we studied the HOXA11 transcript and protein levels in mid-luteal eutopic endometrium from e...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Szczepańska M,Wirstlein P,Skrzypczak J,Jagodziński PP

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if X-chromosome inactivation skew (sXCI) is associated with variations in FMR1 CGG repeat length and, ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Barad DH,Darmon S,Weghofer A,Latham GJ,Filipovic-Sadic,Wang Q,Kushnir VA,Albertini DF,Gleicher N

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential ri...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Huang J,Ni R,Chen X,Huang L,Mo Y,Yang D

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:Low functional ovarian reserve (LFOR) has been associated with hypoandrogenemia and increased embryo aneuploidy, while androgen supplementation has been reported to improve aneuploidy rates. We, therefore, assessed whether in infertile women undergoing in vitro fertilization (IVF) androgen concentrations are...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gleicher N,McCulloh DH,Kushnir VA,Ganguly N,Barad DH,Goldman KN,Kushnir MM,Albertini DF,Grifo JA

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:Recent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation. METHODS:To investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin re...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Yang Y,Qiao J,Li R,Li MZ

更新日期：2011-01-18 00:00:00

abstract：BACKGROUND:To examine the effects of IVF, ICSI and FET, as well as in vitro culture, on the safety of offspring, this study was conducted from the perspective of genetic imprinting to investigate whether assisted reproductive technology would influence the parental and maternal imprinting genes. METHODS:Eighteen foetu...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Ji M,Wang X,Wu W,Guan Y,Liu J,Wang J,Liu W,Shen C

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:Endocannabinoids (ECs) are important contributors to implantation and decidualization and are suppressed in early pregnancy. Elevated levels of anandamide (AEA), the endogenous ligand for the CB1 and CB2 receptors (R), interfere with receptivity of the blastocyst. Ang-(1-7) is down-regulated in the implantat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Brosnihan KB,Pulgar VM,Gallagher PE,Neves LA,Yamaleyeva LM

更新日期：2015-01-17 00:00:00