Is there an androgen level threshold for aneuploidy risk in infertile women?

Abstract:

BACKGROUND:Low functional ovarian reserve (LFOR) has been associated with hypoandrogenemia and increased embryo aneuploidy, while androgen supplementation has been reported to improve aneuploidy rates. We, therefore, assessed whether in infertile women undergoing in vitro fertilization (IVF) androgen concentrations are associated with aneuploidy rates. METHODS:This study was performed in 2 academically affiliated fertility centers in New York City and an academically affiliated steroid chemistry laboratory in Utah. Androgen concentrations were measured in blinded fashion from 84 infertile women (age 40.3+/-2.4 years) at New York University (NYU), using a validated LC-MS/MS method, in cryopreserved serum samples of patients who had undergone IVF with concomitant preimplantation genetic screening (PGS), utilizing a 24-chromosome platform. The Center for Human Reproduction (CHR) provided plasma samples of 100 historical controls (ages 38.6+/-5.0 years) undergoing IVF without PGS. Statistical comparisons were made of androgen concentrations, and of associations between androgen concentrations and embryo aneuploidy. RESULTS:Women undergoing IVF+PGS at NYU revealed no association between embryo aneuploidy and androgen concentrations but demonstrated significantly lower androgen concentrations than the 100 control patients from CHR, CONCLUSIONS: Though this study revealed no association between androgen levels and embryo ploidy, the extremely low androgen levels in the NYU study group raise the possibility of a threshold effect below which testosterone no longer affects aneuploidy. Before an androgen effect on embryo ploidy can be completely ruled out, a patient population with more normal androgen levels has to be investigated.

journal_name

Reprod Biol Endocrinol

authors

Gleicher N,McCulloh DH,Kushnir VA,Ganguly N,Barad DH,Goldman KN,Kushnir MM,Albertini DF,Grifo JA

doi

10.1186/s12958-015-0034-z

subject

Has Abstract

pub_date

2015-05-06 00:00:00

pages

38

issn

1477-7827

pii

10.1186/s12958-015-0034-z

journal_volume

13

pub_type

杂志文章
  • Red blood cell glutathione peroxidase activity in female nulligravid and pregnant rats.

    abstract:BACKGROUND:The alterations of the glutathione peroxidase enzyme complex system occur in physiological conditions such as aging and oxidative stress consequent to strenuous exercise. METHODS:Authors optimize the spectrophotometric method to measure glutathione peroxidase activity in rat red blood cell membranes. RESUL...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-7-7

    authors: Gallo G,Martino G

    更新日期:2009-01-26 00:00:00

  • Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: involvement of integrin beta3 and focal adhesion kinase.

    abstract::Endometrial carcinoma is the most common neoplasm of the female genital tract, accounting for nearly one half of all gynecologic cancers in the Western world. Although intensive research on pathological phenomena of endometrial cancer is currently going on, but exact cause and biological aspects of this disease are no...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-7-81

    authors: Park DW,Choi KC,MacCalman CD,Leung PC

    更新日期:2009-08-05 00:00:00

  • Easy and rapid method for the determination of gene expression in cumulus cells incubated for oocyte maturation.

    abstract:BACKGROUND:The objectives of this study were to develop an easy and rapid method for measuring gene expression in a small number of cells by real-time PCR without RNA extraction and purification, and to use this method to determine more precisely IGF-I gene expression in the cumulus cells surrounding oocytes. METHODS:...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-3-59

    authors: Kumamoto K,Wang H,Yamashiro H,Terada T

    更新日期:2005-10-27 00:00:00

  • Reproductive outcome after hysteroscopic septoplasty in patients with septate uterus--a retrospective cohort study and systematic review of the literature.

    abstract:BACKGROUND:Septate uterus, one of the most common forms of congenital uterine malformations, negatively affects female reproductive health. METHODS:In a retrospective cohort study, we evaluated the reproductive outcome after hysteroscopic septoplasty in 64 women with septate uterus and primary or secondary infertility...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章,评审

    doi:10.1186/1477-7827-8-52

    authors: Nouri K,Ott J,Huber JC,Fischer EM,Stögbauer L,Tempfer CB

    更新日期:2010-05-21 00:00:00

  • Expression of HOXA11 in the mid-luteal endometrium from women with endometriosis-associated infertility.

    abstract:BACKGROUND:A decrease in HOXA11 expression in eutopic mid-secretory endometrium has been found in women with endometriosis-associated infertility. METHODS:Using Real-time quantitative PCR (RQ-PCR) and western blotting analysis we studied the HOXA11 transcript and protein levels in mid-luteal eutopic endometrium from e...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-10-1

    authors: Szczepańska M,Wirstlein P,Skrzypczak J,Jagodziński PP

    更新日期:2012-01-10 00:00:00

  • SOLD1 is expressed in bovine trophoblast cell lines and regulates cell invasiveness.

    abstract:BACKGROUND:Secreted protein of Ly-6 domain 1 (SOLD1), a secretory-type member of the Ly-6 superfamily, is expressed in both fetal and maternal tissues throughout gestation. SOLD1 mRNA is expressed in the endometrium and in trophoblast mononucleate and binucleate cells, suggesting it plays an important role not only in ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-12-55

    authors: Awad M,Koshi K,Kizaki K,Takahashi T,Hashizume K

    更新日期:2014-06-21 00:00:00

  • Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation.

    abstract:BACKGROUND:Spermatozoa are extremely vulnerable to oxidative stress caused by the unbalance between concentrations of reactive oxygen species and antioxidant scavenging systems present inside the male reproductive tract. In spite of a large number of clinical studies that claimed the beneficial effects of antioxidant o...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-11-81

    authors: Talevi R,Barbato V,Fiorentino I,Braun S,Longobardi S,Gualtieri R

    更新日期:2013-08-16 00:00:00

  • Luteal phase stimulation versus follicular phase stimulation in poor ovarian responders: results of a randomized controlled trial.

    abstract:BACKGROUND:In young women with poor ovarian response, luteal-phase ovarian stimulation (LPOS) is a potential method for collecting competent oocytes. The aim of this study was to assess the efficacy of LPOS compared with follicular phase ovarian stimulation (FPOS) in young women with poor ovarian response (POR). METHO...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12958-020-00570-7

    authors: Llácer J,Moliner B,Luque L,Bernabéu A,Lledó B,Castillo JC,Guerrero J,Ten J,Bernabéu R

    更新日期:2020-02-07 00:00:00

  • Is it time for a paradigm shift in understanding embryo selection?

    abstract:BACKGROUND:Embryo selection has been an integral feature of in vitro fertilization (IVF) almost since its inception. Since the advent of extended blastocyst stage embryo culture, and especially with increasing popularity of elective single embryo transfer (eSET), the concept of embryo selection has increasingly become ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-13-3

    authors: Gleicher N,Kushnir VA,Barad DH

    更新日期:2015-01-11 00:00:00

  • A prepartum diet supplemented with oilseeds high in oleic or linoleic acid reduced GnRH-induced LH release in dairy cows during second week postpartum.

    abstract:BACKGROUND:The objective was to determine the effect of prepartum diets supplemented with rolled canola seed (high in oleic acid) or sunflower seed (high in linoleic acid) on luteinizing hormone (LH) pulsatility and gonadotropin releasing hormone (GnRH)-induced LH release during early postpartum. METHODS:Thirty-one pr...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-015-0060-x

    authors: Salehi R,Colazo MG,Oba M,Ambrose DJ

    更新日期:2015-07-03 00:00:00

  • Maternal nutrient restriction and the fetal left ventricle: decreased angiotensin receptor expression.

    abstract:BACKGROUND:Adequate maternal nutrition during gestation is requisite for fetal nutrition and development. While a large group of epidemiological studies indicate poor fetal nutrition increases heart disease risk and mortality in later life, little work has focused on the effects of impaired maternal nutrition on fetal ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-3-27

    authors: Gilbert JS,Lang AL,Nijland MJ

    更新日期:2005-07-14 00:00:00

  • Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study.

    abstract:BACKGROUND:Dehydroepinadrosterone (DHEA) supplementation improves pregnancy chances in women with diminished ovarian reserve (DOR), by possibly reducing aneuploidy. Since a large majority of spontaneous miscarriages are associated with aneuploidy, one can speculate that DHEA supplementation may also reduce miscarriage ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-7-108

    authors: Gleicher N,Ryan E,Weghofer A,Blanco-Mejia S,Barad DH

    更新日期:2009-10-07 00:00:00

  • ART manipulation after controlled ovarian stimulation may not increase the risk of abnormal expression and DNA methylation at some CpG sites of H19,IGF2 and SNRPN in foetuses: a pilot study.

    abstract:BACKGROUND:To examine the effects of IVF, ICSI and FET, as well as in vitro culture, on the safety of offspring, this study was conducted from the perspective of genetic imprinting to investigate whether assisted reproductive technology would influence the parental and maternal imprinting genes. METHODS:Eighteen foetu...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-018-0344-z

    authors: Ji M,Wang X,Wu W,Guan Y,Liu J,Wang J,Liu W,Shen C

    更新日期:2018-07-05 00:00:00

  • Endometrial claudin-4 and leukemia inhibitory factor are associated with assisted reproduction outcome.

    abstract:BACKGROUND:Claudin-4 (CLDN4) is one of several proteins that act as molecular mediators of embryo implantation. Recently, we examined immunolabeling of leukemia inhibitory factor (LIF) in the endometrial tissue of 52 IVF patients, and found that LIF staining intensity was strongly correlated with successful pregnancy i...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-7-30

    authors: Serafini PC,Silva ID,Smith GD,Motta EL,Rocha AM,Baracat EC

    更新日期:2009-04-19 00:00:00

  • Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats.

    abstract:BACKGROUND:Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-017-0254-5

    authors: Han X,He Y,Zeng G,Wang Y,Sun W,Liu J,Sun Y,Yu J

    更新日期:2017-05-02 00:00:00

  • Antral follicle count (AFC) and serum anti-Müllerian hormone (AMH) are the predictors of natural fecundability have similar trends irrespective of fertility status and menstrual characteristics among fertile and infertile women below the age of 40 years.

    abstract:BACKGROUND:Despite being born with a significant number of primordial cells which representing the ancestor cells of the germ-line, women experience a depletion of ovarian reserve and sub-fertility mid-way into their healthy lives. The poor ovarian response is a substantial limiting factor amplified with higher materna...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-019-0464-0

    authors: Khan HL,Bhatti S,Suhail S,Gul R,Awais A,Hamayun H,Enver F,Abbas S,Hassan Z,Nisar R,Sardar S,Asif W

    更新日期:2019-02-11 00:00:00

  • SET protein up-regulated testosterone production in the cultured preantral follicles.

    abstract:BACKGROUND:We found previously that the expression of SET gene was up-regulated in polycystic ovaries. Evidences suggested that SET protein was essential for regulating both the promoter activity of CYP17A1 and the biological activity of P450c17. In this study, we explored whether SET regulated androgen production in p...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-11-9

    authors: Xu B,Gao L,Cui Y,Gao L,Dai X,Li M,Zhang Y,Ma X,Diao F,Liu J

    更新日期:2013-02-19 00:00:00

  • Membrane-initiated actions of estradiol (E2) in the regulation of LH secretion in ovariectomized (OVX) ewes.

    abstract:BACKGROUND:We demonstrated that E2 conjugated to BSA (E2BSA) induces a rapid membrane-initiated inhibition of LH secretion followed hours later by a slight increase in LH secretion. Whether these actions of E2BSA are restricted to the pituitary gland and whether the membrane-initiated pathway of E2BSA contributes to th...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-8-40

    authors: Arreguin-Arevalo JA,Ashley RL,Wagenmaker ER,Oakley AE,Karsch FJ,Nett TM

    更新日期:2010-05-10 00:00:00

  • Does the sex ratio of singleton births after frozen single blastocyst transfer differ in relation to blastocyst development?

    abstract:PURPOSE:To investigate the associations between blastocyst development and the sex ratio (male:female) among singleton live births resulting from single-blastocyst frozen embryo transfer (FET) cycles. METHODS:Patients with singleton live births following the first autologous single FET of non- preimplantation genetic ...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-020-00623-x

    authors: Lou H,Li N,Zhang X,Sun L,Wang X,Hao D,Cui S

    更新日期:2020-07-15 00:00:00

  • Progesterone, estradiol, arachidonic acid, oxytocin, forskolin and cAMP influence on aquaporin 1 and 5 expression in porcine uterine explants during the mid-luteal phase of the estrous cycle and luteolysis: an in vitro study.

    abstract:BACKGROUND:The cell membrane water channel protein, aquaporins (AQPs), regulate cellular water transport and cell volume and play a key role in water homeostasis. Recently, AQPs are considered as important players in the field of reproduction. In previous studies, we have established the presence of AQP1 and 5 in porci...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-015-0004-5

    authors: Skowronska A,Młotkowska P,Wojciechowicz B,Okrasa S,Nielsen S,Skowronski MT

    更新日期:2015-02-18 00:00:00

  • Biology and physiology of Calbindin-D9k in female reproductive tissues: involvement of steroids and endocrine disruptors.

    abstract::Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity rela...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章,评审

    doi:10.1186/1477-7827-3-66

    authors: Choi KC,Leung PC,Jeung EB

    更新日期:2005-11-16 00:00:00

  • Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capacity implying a role in receptivity.

    abstract::The endometrium undergoes cyclic remodelling throughout the menstrual cycle in preparation for embryo implantation which occurs in a short window during the mid-secretory phase. It is during this short 'receptive window' that the endometrial luminal epithelium acquires adhesive capacity permitting blastocysts firm adh...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-020-00682-0

    authors: Santos LL,Ling CK,Dimitriadis E

    更新日期:2020-12-14 00:00:00

  • Sperm impairing microbial factor: potential candidate for male contraception.

    abstract:BACKGROUND:Despite significant advances in contraceptive options for women, vasectomy and condoms are the only options available for male contraception. Due to this limitation, the burden of contraception resides on the shoulders of females only. Therefore, there is an urgent need to develop a safe, effective and rever...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-020-00654-4

    authors: Chauhan A,Thaper D,Prabha V

    更新日期:2020-09-30 00:00:00

  • Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig.

    abstract::Establishment and maintenance of pregnancy in the pig involves intricate communication between the developing conceptuses and the maternal endometrium. This process occurs during trophoblast elongation which is spaciotemporally associated with conceptus synthesis and release of IL1B concomitant with pregnancy-specific...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-8-39

    authors: Ross JW,Ashworth MD,Mathew D,Reagan P,Ritchey JW,Hayashi K,Spencer TE,Lucy M,Geisert RD

    更新日期:2010-04-28 00:00:00

  • A massive ovarian mucinous cystadenoma: a case report.

    abstract:OBJECTIVES:To report the occurrence of a rare case of a huge benign ovarian tumour (mucinous cystadenoma) in Jazan city, Saudi Arabia. PATIENTS:Our reported case was a middle-aged Saudi woman presented with marked abdominal distension and discomfort at the gynaecology clinic of Jazan General Hospital, Jazan city, Saud...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/1477-7827-8-24

    authors: Kamel RM

    更新日期:2010-03-11 00:00:00

  • Parental genetic material and oxygen concentration affect hatch dynamics of mouse embryo in vitro.

    abstract:BACKGROUND:Hatching is crucial for mammalian embryo implantation, since difficulties during this process can lead to implantation failure, ectopic pregnancy and consequent infertility. Despite years of intensive researches, how internal and external factors affecting embryo hatch are still largely unclear. METHODS:The...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-018-0356-8

    authors: Zhan S,Cao S,Du H,Sun Y,Li L,Ding C,Zheng H,Huang J

    更新日期:2018-04-21 00:00:00

  • Cloning animals by somatic cell nuclear transfer--biological factors.

    abstract::Cloning by nuclear transfer using mammalian somatic cells has enormous potential application. However, somatic cloning has been inefficient in all species in which live clones have been produced. High abortion and fetal mortality rates are commonly observed. These developmental defects have been attributed to incomple...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章,评审

    doi:10.1186/1477-7827-1-98

    authors: Tian XC,Kubota C,Enright B,Yang X

    更新日期:2003-11-13 00:00:00

  • First intention IVF protocol for polycystic ovaries: does oral contraceptive pill pretreatment influence COH outcome?

    abstract:BACKGROUND:Morphological aspect of polycystic ovaries (PCO) is a very common finding in an IVF center population: this includes PCOS patients identified in 18-25% of the couples presenting with infertility and so called "sonographic PCO only" the prevalence of which has been estimated as high as 33% in asymptomatic pat...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 临床试验,杂志文章

    doi:10.1186/1477-7827-11-54

    authors: Decanter C,Robin G,Thomas P,Leroy M,Lefebvre C,Soudan B,Lefebvre-Khalil V,Leroy-Martin B,Dewailly D

    更新日期:2013-06-19 00:00:00

  • Epigenetic regulation in mammalian preimplantation embryo development.

    abstract::Preimplantation embryo development involves four stages: fertilization, cell cleavage, morula and blastocyst formation. During these stages, maternal and zygotic epigenetic factors play crucial roles. The gene expression profile is changed dramatically, chromatin is modified and core histone elements undergo significa...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章,评审

    doi:10.1186/1477-7827-7-59

    authors: Shi L,Wu J

    更新日期:2009-06-05 00:00:00

  • Evaluation of treatment of previous cesarean scar pregnancy with methotrexate: a systematic review and meta-analysis.

    abstract:BACKGROUND:Previous caesarean scar pregnancy is one type of ectopic pregnancy in myometrium and fibrous tissue of previous caesarean scar. One of the therapeutic methods of this type of ectopic pregnancy is treatment with methotrexate. Given various findings on the treatment of caesarean scar pregnancy with methotrexat...

    journal_title:Reproductive biology and endocrinology : RB&E

    pub_type: 杂志文章

    doi:10.1186/s12958-020-00666-0

    authors: Salari N,Kazeminia M,Shohaimi S,Nankali AA,Mohammadi M

    更新日期:2020-11-09 00:00:00