Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old.

abstract：BACKGROUND:We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa. METHODS:Freshly ejaculated semen was collected from forty-eight normozoospermic human donors. We analyzed the expression of substance P, neurokinin A, neur...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Pinto FM,Ravina CG,Subiran N,Cejudo-Román A,Fernández-Sánchez M,Irazusta J,Garrido N,Candenas L

更新日期：2010-08-26 00:00:00

abstract：BACKGROUND:Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if X-chromosome inactivation skew (sXCI) is associated with variations in FMR1 CGG repeat length and, ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Barad DH,Darmon S,Weghofer A,Latham GJ,Filipovic-Sadic,Wang Q,Kushnir VA,Albertini DF,Gleicher N

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) international body mass index (BMI) cut-off points defining pre-pregnancy BMI categories in the Institute of Medicine (IOM) guidelines are not directly applicable to Asians. We aimed to define the optimal gestational weight gain (GWG) for the Korean population based on Asi...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Choi SK,Lee G,Kim YH,Park IY,Ko HS,Shin JC

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:To evaluate the association between leukocytes (polymorphonuclear granulocytes -PMNL) and semen parameters at different leukocyte concentrations. METHODS:This was a retrospective clinical study at a university hospital andrology clinic. Semen samples from infertile men were analyzed for sperm morphology and...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Lackner JE,Agarwal A,Mahfouz R,du Plessis SS,Schatzl G

更新日期：2010-02-05 00:00:00

abstract：BACKGROUND:The aim of this randomized controlled trial was to compare the efficacy of extended letrozole regimen with clomiphene citrate in women with unexplained infertility undergoing superovulation and intrauterine insemination (IUI). METHODS:Two hundred and fourteen patients with unexplained infertility were rando...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Fouda UM,Sayed AM

更新日期：2011-06-21 00:00:00

abstract：:During rat estrous cycle, the endometrium proliferates in response to sex steroids and specific endometrial epithelial cells undergo apoptosis in absence of embryonic factors. The central executioner of apoptosis is a family of aspartic acid-specific cysteine proteases known as caspases. Smac/DIABLO is released from t...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Leblanc V,Dery MC,Shooner C,Asselin E

更新日期：2003-08-27 00:00:00

abstract：BACKGROUND:Peripheral and uterine natural killer cells (pNK and uNK cells) are key players in the establishment and maintenance of pregnancy and are disturbed in patients with recurrent miscarriage (RM). Different immunologic risk factors have been proposed between patients with primary RM (pRM, no previous live birth)...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Toth B,Vomstein K,Togawa R,Böttcher B,Hudalla H,Strowitzki T,Daniel V,Kuon RJ

更新日期：2019-08-31 00:00:00

abstract：:The aim of our research was to examine the ability of density gradient preparation BoviPure and swim up method on bull sperm separation and in vitro embryo production (IVP) systems. Frozen/thawed semen from six Simmental bulls was pooled and treated using both methods. The sperm motility, concentration, membrane activ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Samardzija M,Karadjole M,Getz I,Makek Z,Cergolj M,Dobranic T

更新日期：2006-11-13 00:00:00

abstract：BACKGROUND:Despite significant advances in contraceptive options for women, vasectomy and condoms are the only options available for male contraception. Due to this limitation, the burden of contraception resides on the shoulders of females only. Therefore, there is an urgent need to develop a safe, effective and rever...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Chauhan A,Thaper D,Prabha V

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:The transformation of endometrium into decidua is essential for normal implantation of the blastocyst. However, the post-transcriptional regulation and the miRNAs involved in decidualization remain poorly understood. Here, we examined microRNA-181a (miR-181a) expression in decidualized human endometrial stro...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Zhang Q,Zhang H,Jiang Y,Xue B,Diao Z,Ding L,Zhen X,Sun H,Yan G,Hu Y

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ovarian hyperstimulation (COH). METHODS:This was a prospective study of 172 patients undergoing COH at the Fer...

journal_title：Reproductive biology and endocrinology : RB&E

authors： O'Brien TJ,Kalmin MM,Harralson AF,Clark AM,Gindoff I,Simmens SJ,Frankfurter D,Gindoff P

更新日期：2013-07-25 00:00:00

abstract：:Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity rela...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Choi KC,Leung PC,Jeung EB

更新日期：2005-11-16 00:00:00

abstract：BACKGROUND:In-situ hybridisation studies demonstrate that Notch receptors and ligands are expressed in granulosa cells (GCs) and in the theca layer vasculature of growing follicles. Notch signaling involves cell-to-cell interaction mediated by transmembrane receptors and ligands. This signaling pathway may represent a ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Jovanovic VP,Sauer CM,Shawber CJ,Gomez R,Wang X,Sauer MV,Kitajewski J,Zimmermann RC

更新日期：2013-05-15 00:00:00

abstract：:We have investigated the effects of indomethacin (IM), a non-steroidal anti-inflammatory drug, and the role of prostaglandins on the accumulation of leukocytes in the rat ovary during the periovulatory period. Adult cycling rats were injected sc with 1 mg of IM in olive oil or vehicle on the morning of proestrus. Some...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gaytán F,Morales C,Bellido C,Tarradas E,Sánchez-Criado JE

更新日期：2003-02-14 00:00:00

abstract：BACKGROUND:Endocannabinoids (ECs) are important contributors to implantation and decidualization and are suppressed in early pregnancy. Elevated levels of anandamide (AEA), the endogenous ligand for the CB1 and CB2 receptors (R), interfere with receptivity of the blastocyst. Ang-(1-7) is down-regulated in the implantat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Brosnihan KB,Pulgar VM,Gallagher PE,Neves LA,Yamaleyeva LM

更新日期：2015-01-17 00:00:00

abstract：BACKGROUND:Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential ri...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Huang J,Ni R,Chen X,Huang L,Mo Y,Yang D

更新日期：2010-11-17 00:00:00

abstract：BACKGROUND:The in vitro maturation (IVM) technique has physical and financial benefits, but a lower efficiency and outcome that is still unclear whether it is related to polycystic ovary syndrome (PCOS) itself or the IVM procedure. In this study, we analyzed the clinical and laboratory outcomes of an optimized IVM prot...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Elshewy N,Ji D,Zhang Z,Chen D,Chen B,Xue R,Wu H,Wang J,Zhou P,Cao Y

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND:This study was designed to determine whether small diameter needles for oocyte retrieval alter oocyte yields in patients undergoing IVF in comparison to standard large diameter needles. METHODS:We conducted a prospective pilot study of 21 consecutive favorable prognosis patients. In each patient one ovary w...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Kushnir VA,Kim A,Gleicher N,Barad DH

更新日期：2013-03-20 00:00:00

abstract：BACKGROUND:Stereology is an established method to extrapolate three-dimensional quantities from two-dimensional images. It was applied to placentation in the mouse, but not yet for other rodents. Herein, we provide the first study on quantitative placental development in a sigmodontine rodent species with relatively si...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Favaron PO,Mess AM,de Oliveira MF,Gabory A,Miglino MA,Chavatte-Palmer P,Tarrade A

更新日期：2013-02-21 00:00:00

abstract：BACKGROUND:Doxorubicin is a potent chemotherapeutic drug used against a variety of cancers. It acts through interaction with polymerases and topoisomerase II and free radical production. Doxorubicin activity is not specific to cancer cells and can also damage healthy cells, especially those undergoing rapid proliferati...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Brilhante O,Okada FK,Sasso-Cerri E,Stumpp T,Miraglia SM

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Cole LA

更新日期：2010-08-24 00:00:00

abstract：BACKGROUND:Low functional ovarian reserve (LFOR) has been associated with hypoandrogenemia and increased embryo aneuploidy, while androgen supplementation has been reported to improve aneuploidy rates. We, therefore, assessed whether in infertile women undergoing in vitro fertilization (IVF) androgen concentrations are...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gleicher N,McCulloh DH,Kushnir VA,Ganguly N,Barad DH,Goldman KN,Kushnir MM,Albertini DF,Grifo JA

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:The full maturational capability of mammalian oocytes is accompanied by nuclear and cytoplasmic modifications, which are associated with proliferation and differentiation of surrounding cumulus cells. These events are regulated on molecular level by the expression of target genes involved in signal transduct...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Budna J,Rybska M,Ciesiółka S,Bryja A,Borys S,Kranc W,Wojtanowicz-Markiewicz K,Jeseta M,Sumelka E,Bukowska D,Antosik P,Brüssow KP,Bruska M,Nowicki M,Zabel M,Kempisty B

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:Oocyte donation is a medical technique used principally for woman with ovarian failure. Optimizing donor recruitment is essential to obtain the best results with this technique. Understanding how donor parameters influence outcome for the recipients is fundamental. The aim of this study was to determine whet...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Delesalle AS,Robin G,Thomas-Desrousseaux P,Dewailly D,Catteau-Jonard S

更新日期：2016-01-19 00:00:00

abstract：:The corpus luteum is an endocrine gland whose limited lifespan is hormonally programmed. This debate article summarizes findings of our research group that challenge the principle that the end of function of the corpus luteum or luteal regression, once triggered, cannot be reversed. Overturning luteal regression by ph...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Telleria CM

更新日期：2006-10-30 00:00:00

abstract：BACKGROUND:The objectives of this study were to develop an easy and rapid method for measuring gene expression in a small number of cells by real-time PCR without RNA extraction and purification, and to use this method to determine more precisely IGF-I gene expression in the cumulus cells surrounding oocytes. METHODS:...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Kumamoto K,Wang H,Yamashiro H,Terada T

更新日期：2005-10-27 00:00:00

abstract：BACKGROUND:Embryo selection has been an integral feature of in vitro fertilization (IVF) almost since its inception. Since the advent of extended blastocyst stage embryo culture, and especially with increasing popularity of elective single embryo transfer (eSET), the concept of embryo selection has increasingly become ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gleicher N,Kushnir VA,Barad DH

更新日期：2015-01-11 00:00:00

abstract：BACKGROUND:The aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst. METHODS:This observational cohort study included a total of 3091 patients undergoing their first frozen-thawed ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Bu Z,Yang X,Song L,Kang B,Sun Y

更新日期：2019-11-25 00:00:00

abstract：BACKGROUND:New anticancer treatments have increased survival rates for cancer patients, but often at the cost of sterility. Several strategies are currently available for preserving fertility. However, the chances of achieving a pregnancy with one technique are still limited. A combination of methods is therefore recom...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Dittrich R,Lotz L,Mueller A,Hoffmann I,Wachter DL,Amann KU,Beckmann MW,Hildebrandt T

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:It is not well established whether the increased number of leukocytes in the seminal fluid impairs the outcomes of assisted reproductive technology (ART). This investigation analysed the outcomes of the intracytoplasmic sperm injection (ICSI) and intracytoplasmic morphologically selected sperm injection (IMS...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Cavagna M,Oliveira JB,Petersen CG,Mauri AL,Silva LF,Massaro FC,Baruffi RL,Franco JG Jr

更新日期：2012-06-15 00:00:00